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1. 发明申请

US20140018639A1 In Vivo Biosensor 审中-公开
标题翻译：体内生物传感器
公开(公告)号：US20140018639A1
公开(公告)日：2014-01-16
申请号：US13942692
申请日：2013-07-15
申请人： Diagnostic Biochips LLC
发明人： Brian Jamieson , Mary Emma Gorham Bigelow
IPC分类号： A61B5/1473 , A61B5/00 , A61N1/05 , A61B5/04
CPC分类号： A61B5/14735 , A61B5/04001 , A61B5/0476 , A61B5/14546 , A61B5/4836 , A61B5/4845 , A61B5/4848 , A61B5/6852 , A61B5/6876 , A61B2562/028 , A61B2562/125 , A61N1/0529 , A61N1/0534 , A61N1/36139 , B82Y15/00
摘要： Certain embodiments comprise an implantable probe for rapid measurement of multiple neurochemicals on the cellular scale in the brain. Rapid detection of multiple chemicals in vivo (animal or humans) may provide an improved understanding of acute changes in neurochemicals that occur over several seconds. The neurotransmitter chemical sensing platform may provide for continuous in vivo sensing in trials of psychoactive drugs in the laboratory animal market. The high spatial resolution of the probe may allow for chemical detection around small groups of neurons, which may help to isolate the endogenous activity of different neuron types due to disease states. Neurochemical detection may also be used to measure tissue response to exogenous stimuli, such as pharmacodynamics of drugs. The high temporal and spatial resolutions and multi-neurochemical sensing of the probe may allow for detailed studies on in vivo brain response to both endogenous and exogenous stimuli.
摘要翻译：某些实施方案包括用于在脑中的细胞规模上快速测量多种神经化学物质的可植入探针。体内多种化学物质（动物或人类）的快速检测可以提供对几秒钟内发生的神经化学物质的急性变化的改善的了解。神经递质化学感测平台可以在实验动物市场中提供精神药物试验中的连续体内感测。探针的高空间分辨率可以允许围绕小组神经元的化学检测，这可能有助于分离由于疾病状态引起的不同神经元类型的内源性活性。也可以使用神经化学检测来测量组织对外源性刺激的反应，如药物的药效学。探针的高时空分辨率和多神经化学感测可以允许对内源性和外源性刺激的体内脑反应的详细研究。

2. 发明申请

WO2014014849A1 IN VIVO BIOSENSOR 审中-公开
标题翻译： IN VIVO生物传感器
公开(公告)号：WO2014014849A1
公开(公告)日：2014-01-23
申请号：PCT/US2013/050576
申请日：2013-07-15
申请人： DIAGNOSTIC BIOCHIPS, LLC
发明人： JAMIESON, Brian , BIGELOW, Mary Emma Gorham
IPC分类号： A61B5/00
CPC分类号： A61B5/14735 , A61B5/04001 , A61B5/0476 , A61B5/14546 , A61B5/4836 , A61B5/4845 , A61B5/4848 , A61B5/6852 , A61B5/6876 , A61B2562/028 , A61B2562/125 , A61N1/0529 , A61N1/0534 , A61N1/36139 , B82Y15/00
摘要： Certain embodiments comprise an implantable probe for rapid measurement of multiple neurochemicals on the cellular scale in the brain. Rapid detection of multiple chemicals in vivo (animal or humans) may provide an improved understanding of acute changes in neurochemicals that occur over several seconds. The neurotransmitter chemical sensing platform may provide for continuous in vivo sensing in trials of psychoactive drugs in the laboratory animal market. The high spatial resolution of the probe may allow for chemical detection around small groups of neurons, which may help to isolate the endogenous activity of different neuron types due to disease states. Neurochemical detection may also be used to measure tissue response to exogenous stimuli, such as pharmacodynamics of drugs. The high temporal and spatial resolutions and multi-neurochemical sensing of the probe may allow for detailed studies on in vivo brain response to both endogenous and exogenous stimuli.
摘要翻译：某些实施方案包括用于在脑中的细胞规模上快速测量多种神经化学物质的可植入探针。体内多种化学物质（动物或人类）的快速检测可以提供对几秒钟内发生的神经化学物质的急性变化的改进的了解。神经递质化学感测平台可以在实验动物市场中提供精神药物试验中的连续体内感测。探针的高空间分辨率可以允许围绕小组神经元的化学检测，这可能有助于分离由于疾病状态引起的不同神经元类型的内源性活性。也可以使用神经化学检测来测量组织对外源性刺激的反应，如药物的药效学。探针的高时空分辨率和多神经化学感测可以允许对内源性和外源性刺激的体内脑反应的详细研究。

3. 发明申请

WO2013016350A2 INTEGRATED OPTICAL NEURAL PROBE 审中-公开
标题翻译：综合光学神经探针
公开(公告)号：WO2013016350A2
公开(公告)日：2013-01-31
申请号：PCT/US2012/047997
申请日：2012-07-24
申请人： DIAGNOSTIC BIOCHIPS, LLC , JAMIESON, Brian , MATEO, Jennette
发明人： JAMIESON, Brian , MATEO, Jennette
IPC分类号： A61B5/04 , A61B6/00
CPC分类号： A61B5/6868 , A61B5/0084 , A61B5/04001 , A61B5/6848 , A61B2018/2266 , A61B2018/2272 , A61B2562/046 , A61N5/0622 , A61N2005/0612 , A61N2005/065
摘要： In certain embodiments, a neural probe comprises a substrate comprising elongated shanks for penetrating neural tissue, each comprising a proximal end and a distal end; at least one optical source integral to the neural probe for illuminating the neural tissue; and microelectrodes located proximate the distal end of the elongated shanks for monitoring neuronal activity. In certain embodiments, a method of monitoring neuronal activity comprises implanting the neural probe into a test subject such that the elongated shanks protrude into neural tissue of the test subject; illuminating the neural tissue with the at least one optical source; and measuring neuronal activity in response to illuminating the neural tissue. In certain embodiments, a device comprises a semiconductor chip; at least one optical source integral to the semiconductor chip; and sensor elements integral to the semiconductor chip for collecting data responsive to light emitted from the at least one optical source.
摘要翻译：在某些实施例中，神经探针包括基底，其包括用于穿透神经组织的细长柄，每个包括近端和远端; 至少一个与神经探针成一体的光源，用于照射神经组织; 和微电极位于细长柄的远端附近，用于监测神经元活动。在某些实施方案中，监测神经元活性的方法包括将神经探针植入测试对象中，使得细长柄突出到测试对象的神经组织中; 用所述至少一个光源照亮所述神经组织; 并测量响应照射神经组织的神经元活动。在某些实施例中，装置包括半导体芯片; 至少一个与半导体芯片成一体的光源; 以及与所述半导体芯片成一体的传感器元件，用于响应于从所述至少一个光源发射的光收集数据。

4. 发明专利

CA2879831C IN VIVO APTAMER-BASED BIOSENSOR 未知
公开(公告)号：CA2879831C
公开(公告)日：2019-04-30
申请号：CA2879831
申请日：2013-07-15
申请人： DIAGNOSTIC BIOCHIPS LLC
发明人： JAMIESON BRIAN , BIGELOW MARY EMMA GORHAM
IPC分类号： A61B5/1473 , A61B5/00 , C12M1/34 , G01N27/327
摘要： The present disclosure describes a biosensor, comprising: a substrate comprising one or more elongated shanks for penetrating biological tissue, and a microfabricated electrode array proximate the distal end of one or more of the elongated shanks, wherein the array comprises one or more recording sites; and at least one aptamer affixed to one or more of the recording sites, wherein the at least one aptarner is selected to selectively react with one or more chemical compounds. Methods of using the biosensor are also described.

5. 发明专利

CA2842950A1 INTEGRATED OPTICAL NEURAL PROBE 未知
公开(公告)号：CA2842950A1
公开(公告)日：2013-01-31
申请号：CA2842950
申请日：2012-07-24
申请人： DIAGNOSTIC BIOCHIPS LLC
发明人： JAMIESON BRIAN , MATEO JENNETTE
IPC分类号： A61B5/04 , A61B6/00
摘要： In certain embodiments, a neural probe comprises a substrate comprising elongated shanks for penetrating neural tissue, each comprising a proximal end and a distal end; at least one optical source integral to the neural probe for illuminating the neural tissue; and microelectrodes located proximate the distal end of the elongated shanks for monitoring neuronal activity. In certain embodiments, a method of monitoring neuronal activity comprises implanting the neural probe into a test subject such that the elongated shanks protrude into neural tissue of the test subject; illuminating the neural tissue with the at least one optical source; and measuring neuronal activity in response to illuminating the neural tissue. In certain embodiments, a device comprises a semiconductor chip; at least one optical source integral to the semiconductor chip; and sensor elements integral to the semiconductor chip for collecting data responsive to light emitted from the at least one optical source.

6. 发明专利

CA2879831A1 IN VIVO BIOSENSOR 未知
公开(公告)号：CA2879831A1
公开(公告)日：2014-01-23
申请号：CA2879831
申请日：2013-07-15
申请人： DIAGNOSTIC BIOCHIPS LLC
发明人： JAMIESON BRIAN , BIGELOW MARY EMMA GORHAM
IPC分类号： A61B5/1473 , A61B5/00 , C12M1/34 , C12Q1/68 , G01N27/327
摘要： Certain embodiments comprise an implantable probe for rapid measurement of multiple neurochemicals on the cellular scale in the brain. Rapid detection of multiple chemicals in vivo (animal or humans) may provide an improved understanding of acute changes in neurochemicals that occur over several seconds. The neurotransmitter chemical sensing platform may provide for continuous in vivo sensing in trials of psychoactive drugs in the laboratory animal market. The high spatial resolution of the probe may allow for chemical detection around small groups of neurons, which may help to isolate the endogenous activity of different neuron types due to disease states. Neurochemical detection may also be used to measure tissue response to exogenous stimuli, such as pharmacodynamics of drugs. The high temporal and spatial resolutions and multi-neurochemical sensing of the probe may allow for detailed studies on in vivo brain response to both endogenous and exogenous stimuli.

7. 发明申请

WO2013016350A3 INTEGRATED OPTICAL NEURAL PROBE 审中-公开
标题翻译：综合光学神经探针
公开(公告)号：WO2013016350A3
公开(公告)日：2014-05-01
申请号：PCT/US2012047997
申请日：2012-07-24
申请人： DIAGNOSTIC BIOCHIPS LLC , JAMIESON BRIAN , MATEO JENNETTE
发明人： JAMIESON BRIAN , MATEO JENNETTE
IPC分类号： A61B5/04
CPC分类号： A61B5/6868 , A61B5/0084 , A61B5/04001 , A61B5/6848 , A61B2018/2266 , A61B2018/2272 , A61B2562/046 , A61N5/0622 , A61N2005/0612 , A61N2005/065
摘要： In certain embodiments, a neural probe comprises a substrate comprising elongated shanks for penetrating neural tissue, each comprising a proximal end and a distal end; at least one optical source integral to the neural probe for illuminating the neural tissue; and microelectrodes located proximate the distal end of the elongated shanks for monitoring neuronal activity. In certain embodiments, a method of monitoring neuronal activity comprises implanting the neural probe into a test subject such that the elongated shanks protrude into neural tissue of the test subject; illuminating the neural tissue with the at least one optical source; and measuring neuronal activity in response to illuminating the neural tissue. In certain embodiments, a device comprises a semiconductor chip; at least one optical source integral to the semiconductor chip; and sensor elements integral to the semiconductor chip for collecting data responsive to light emitted from the at least one optical source.
摘要翻译：在某些实施例中，神经探针包括基底，其包括用于穿透神经组织的细长柄，每个包括近端和远端; 至少一个与神经探针成一体的光源，用于照射神经组织; 和微电极位于细长柄的远端附近，用于监测神经元活动。在某些实施方案中，监测神经元活性的方法包括将神经探针植入测试对象中，使得细长柄突出到测试对象的神经组织中; 用所述至少一个光源照亮所述神经组织; 并测量响应照射神经组织的神经元活动。在某些实施例中，装置包括半导体芯片; 至少一个与半导体芯片成一体的光源; 以及与所述半导体芯片成一体的传感器元件，用于响应于从所述至少一个光源发射的光收集数据。

8. 发明专利

CA2842950C INTEGRATED OPTICAL NEURAL PROBE 未知
公开(公告)号：CA2842950C
公开(公告)日：2019-11-12
申请号：CA2842950
申请日：2012-07-24
申请人： DIAGNOSTIC BIOCHIPS LLC
发明人： JAMIESON BRIAN , MATEO JENNETTE
IPC分类号： A61B5/04 , A61B6/00
摘要： In certain embodiments, a neural probe comprises a substrate comprising elongated shanks for penetrating neural tissue, each comprising a proximal end and a distal end; at least one optical source integral to the neural probe for illuminating the neural tissue; and microelectrodes located proximate the distal end of the elongated shanks for monitoring neuronal activity. In certain embodiments, a method of monitoring neuronal activity comprises implanting the neural probe into a test subject such that the elongated shanks protrude into neural tissue of the test subject; illuminating the neural tissue with the at least one optical source; and measuring neuronal activity in response to illuminating the neural tissue. In certain embodiments, a device comprises a semiconductor chip; at least one optical source integral to the semiconductor chip; and sensor elements integral to the semiconductor chip for collecting data responsive to light emitted from the at least one optical source.

9. 发明公开

EP2872036A4 IN VIVO BIOSENSOR 审中-公开
标题翻译：体内生物传感器
公开(公告)号：EP2872036A4
公开(公告)日：2016-06-29
申请号：EP13820353
申请日：2013-07-15
申请人： DIAGNOSTIC BIOCHIPS LLC
发明人： JAMIESON BRIAN , BIGELOW MARY EMMA GORHAM
IPC分类号： A61B5/00
CPC分类号： A61B5/14735 , A61B5/04001 , A61B5/0476 , A61B5/14546 , A61B5/4836 , A61B5/4845 , A61B5/4848 , A61B5/6852 , A61B5/6876 , A61B2562/028 , A61B2562/125 , A61N1/0529 , A61N1/0534 , A61N1/36139 , B82Y15/00
摘要： Certain embodiments comprise an implantable probe for rapid measurement of multiple neurochemicals on the cellular scale in the brain. Rapid detection of multiple chemicals in vivo (animal or humans) may provide an improved understanding of acute changes in neurochemicals that occur over several seconds. The neurotransmitter chemical sensing platform may provide for continuous in vivo sensing in trials of psychoactive drugs in the laboratory animal market. The high spatial resolution of the probe may allow for chemical detection around small groups of neurons, which may help to isolate the endogenous activity of different neuron types due to disease states. Neurochemical detection may also be used to measure tissue response to exogenous stimuli, such as pharmacodynamics of drugs. The high temporal and spatial resolutions and multi-neurochemical sensing of the probe may allow for detailed studies on in vivo brain response to both endogenous and exogenous stimuli.

10. 发明授权

EP2872036B1 IN VIVO BIOSENSOR 有权
公开(公告)号：EP2872036B1
公开(公告)日：2019-06-05
申请号：EP13820353.4
申请日：2013-07-15
申请人： Diagnostic Biochips, LLC
发明人： JAMIESON, Brian , BIGELOW, Mary Emma Gorham
IPC分类号： A61B5/00

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