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1. 发明申请

WO2018013531A8 AUTOANTIBODY BIOMARKERS FOR THE EARLY DETECTION OF OVARIAN CANCER 审中-公开
公开(公告)号：WO2018013531A8
公开(公告)日：2018-01-18
申请号：PCT/US2017/041487
申请日：2017-07-11
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , KATCHMAN, Benjamin , ANDERSON, Karen , WALLSTROM, Garrick , LABAER, Joshua , CRAMER, Daniel
发明人： KATCHMAN, Benjamin , ANDERSON, Karen , WALLSTROM, Garrick , LABAER, Joshua , CRAMER, Daniel
IPC分类号： A61B10/02 , C07K16/28 , C07K16/30 , C12Q1/68 , G01N33/53 , G01N33/536 , G01N33/573 , G01N33/574
摘要： Compositions and methods relating to a panel of antigen biomarkers for the early detection of ovarian cancer. The compositions and methods encompass antigen biomarkers coupled to a substrate, with the biomarkers being selected from the group consisting of one or more of ICAM3, CTAG2, p53, STYXL1, PVR, POMC, NUDT11, TRIM39, UHMK1, KSR1, and NXF3.

2. 发明申请

WO2018013531A1 AUTOANTIBODY BIOMARKERS FOR THE EARLY DETECTION OF OVARIAN CANCER 审中-公开
标题翻译：自体抗体生物标志物用于早期检测卵巢癌
公开(公告)号：WO2018013531A1
公开(公告)日：2018-01-18
申请号：PCT/US2017/041487
申请日：2017-07-11
申请人： ARIZONA BOPARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , KATCHMAN, Benjamin , ANDERSON, Karen , WALLSTROM, Garrick , LABAER, Joshua , CRAMER, Daniel
发明人： KATCHMAN, Benjamin , ANDERSON, Karen , WALLSTROM, Garrick , LABAER, Joshua , CRAMER, Daniel
IPC分类号： A61B10/02 , C07K16/28 , C07K16/30 , C12Q1/68 , G01N33/53 , G01N33/536 , G01N33/573 , G01N33/574
摘要： Compositions and methods relating to a panel of antigen biomarkers for the early detection of ovarian cancer. The compositions and methods encompass antigen biomarkers coupled to a substrate, with the biomarkers being selected from the group consisting of one or more of ICAM3, CTAG2, p53, STYXL1, PVR, POMC, NUDT11, TRIM39, UHMK1, KSR1, and NXF3.
摘要翻译：涉及用于早期检测卵巢癌的一组抗原生物标志物的组合物和方法。组合物和方法涵盖了与底物偶联的抗原生物标记，其中生物标记选自ICAM3，CTAG2，p53，STYXL1，PVR，POMC，NUDT11，TRIM39，UHMK1，KSR1和NXF3中的一种或多种。 / p>

3. 发明公开

EP3137903A1 FLEXIBLE OPTICAL BIOSENSOR FOR POINT OF USE MULTI-PATHOGEN DETECTION 审中-公开
标题翻译：柔性机OPTISCHER生物传感器ZUR DETEKTION MEHRERER PATHOGENE AM VERWENDUNGSORT
公开(公告)号：EP3137903A1
公开(公告)日：2017-03-08
申请号：EP15786337.4
申请日：2015-05-01
申请人： Arizona Board of Regents on behalf of Arizona State University
发明人： SMITH, Joseph , CHRISTEN, Jennifer, Blain , ANDERSON, Karen , KATCHMAN, Benjamin
IPC分类号： G01N33/53 , G01N33/533 , G01N33/569 , G01N21/17
CPC分类号： G01N33/54366 , A61B5/0071 , A61B5/6802 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L2200/025 , B01L2200/12 , B01L2300/0636 , B01L2300/0654 , B01L2300/0819 , B01L2300/0825 , B01L2300/087 , B01L2300/123 , G01N21/05 , G01N21/6428 , G01N21/6454 , G01N33/54373 , G01N2021/6439 , G01N2201/0221
摘要： A fully integrated miniaturized optical biosensor and methods of making the same are disclosed. The biosensor may include a fluid transport system and an optical system.
摘要翻译：公开了一种完全集成的微型光学生物传感器及其制造方法。生物传感器可以包括流体输送系统和光学系统。

4. 发明申请

WO2015168515A1 FLEXIBLE OPTICAL BIOSENSOR FOR POINT OF USE MULTI-PATHOGEN DETECTION 审中-公开
标题翻译：灵活的光生物传感器，用于多种病原体检测
公开(公告)号：WO2015168515A1
公开(公告)日：2015-11-05
申请号：PCT/US2015/028734
申请日：2015-05-01
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
发明人： SMITH, Joseph , CHRISTEN, Jennifer, Blain , ANDERSON, Karen , KATCHMAN, Benjamin
IPC分类号： G01N33/53 , G01N33/533 , G01N33/569 , G01N21/17
CPC分类号： G01N33/54366 , A61B5/0071 , A61B5/6802 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L2200/025 , B01L2200/12 , B01L2300/0636 , B01L2300/0654 , B01L2300/0819 , B01L2300/0825 , B01L2300/087 , B01L2300/123 , G01N21/05 , G01N21/6428 , G01N21/6454 , G01N33/54373 , G01N2021/6439 , G01N2201/0221
摘要： A fully integrated miniaturized optical biosensor and methods of making the same are disclosed. The biosensor may include a fluid transport system and an optical system.
摘要翻译：公开了一种完全集成的小型化光学生物传感器及其制造方法。生物传感器可以包括流体输送系统和光学系统。

5. 发明公开

EP3482202A1 SWEAT AS A BIOFLUID FOR ANALYSIS AND DISEASE IDENTIFICATION 审中-公开
公开(公告)号：EP3482202A1
公开(公告)日：2019-05-15
申请号：EP17828316.4
申请日：2017-07-11
申请人： Arizona Board of Regents on behalf of Arizona State University
发明人： KATCHMAN, Benjamin , ANDERSON, Karen , CHRISTEN, Jennifer, Blain
IPC分类号： G01N33/53 , G01N33/533 , G01N33/569 , G01N21/17 , A61B10/00

6. 发明申请

WO2016195918A1 POINT-OF-CARE FLUORESCENT IMMUNOASSAY FOR IDENTIFYING BIOMARKERS IN PATIENT BIOFLUID SAMPLES 审中-公开
标题翻译：在患者生物流体样本中识别生物标志物的点保护荧光免疫
公开(公告)号：WO2016195918A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/031203
申请日：2016-05-06
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
发明人： KATCHMAN, Benjamin , ANDERSON, Karen , SMITH, Joseph , BLAIN CHRISTEN, Jennifer
IPC分类号： G01N33/53 , G01N33/569 , C12Q1/70
CPC分类号： G01N33/54373 , B01L3/502715 , G01N21/6428 , G01N33/54386 , G01N33/58 , G01N33/582 , G01N33/6857 , G01N2333/025
摘要： Systems and methods for low-cost point-of-care immunoassay are provided. The system comprises an emitter, two optical interference filters, a microscope slide, a photodiode detector, a circuit, and a measuring unit. The detector is placed upon the second filter, the slide, the first filter, and then the emitter. The emitter comprises non-organic light emitting diodes (LEDs) or organic light emitting diodes (OLEDs) that emits light of a first color. The slide is spotted with biofluid from a patient. Biomarkers in the biofluid is bound with immobilized fluorophores that emit light of a second color when stimulated by the light of the first color. The first and second filters band-pass the light of the first and second colors, respectively. The detector detects light of the second color. The current outputted from the detector is converted into a relatively-large output voltage by a circuit. A measuring unit measures the ramp time of the output voltage. The ramp time is to be used to determine the concentration of the fluorophores, which in turn is related to the concentration of the biomarkers.
摘要翻译：提供了低成本免疫检测方法。该系统包括发射器，两个光学干涉滤光器，显微镜载玻片，光电二极管检测器，电路和测量单元。检测器放置在第二个过滤器，滑块，第一个过滤器，然后是发射器。发射器包括发射第一种颜色的光的非有机发光二极管（LED）或有机发光二极管（OLED）。从患者的生物流中发现载玻片。当被第一种颜色的光刺激时，生物流体中的生物标志物与固定的发出第二种颜色的荧光团结合。第一和第二滤光器分别对第一和第二颜色的光进行带通。检测器检测第二种颜色的光。从检测器输出的电流被电路转换成相对较大的输出电压。测量单元测量输出电压的斜坡时间。斜坡时间用于确定荧光团的浓度，这又与生物标志物的浓度有关。

7. 发明申请

WO2012040095A1 QSOX1 AS AN ANTI-NEOPLASTIC DRUG TARGET 审中-公开
标题翻译： QSOX1作为抗神经药物靶标
公开(公告)号：WO2012040095A1
公开(公告)日：2012-03-29
申请号：PCT/US2011/052122
申请日：2011-09-19
申请人： ARIZONA BOARD OF REGENTS , LAKE, Douglas , KATCHMAN, Benjamin
发明人： LAKE, Douglas , KATCHMAN, Benjamin
IPC分类号： A61K38/44 , C12N9/02 , C12N15/113 , A61P35/04
CPC分类号： A61K38/44 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/16 , C12N2310/531 , C12Y108/03002
摘要： The present invention provides methods for tumor treatment by administering an inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1), compositions comprising such inhibitors, and methods for identifying such inhibitors.
摘要翻译：本发明提供了通过施用静滴蛋白巯基氧化酶1（QSOX1）的抑制剂，包含这种抑制剂的组合物以及鉴定这种抑制剂的方法来进行肿瘤治疗的方法。

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