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1. 发明申请

WO2007068929A1 CYCLIC AMINE DERIVATIVES AND THEIR USES 审中-公开
标题翻译：循环胺衍生物及其用途
公开(公告)号：WO2007068929A1
公开(公告)日：2007-06-21
申请号：PCT/GB2006/004675
申请日：2006-12-14
申请人： ARGENTA DISCOVERY LTD. , FINCH, Harry , RAY, Nicholas, Charles , BODIL VAN NIEL, Monique , SMITH, Phillip
发明人： FINCH, Harry , RAY, Nicholas, Charles , BODIL VAN NIEL, Monique , SMITH, Phillip
IPC分类号： C07C271/38 , C07C217/52 , C07C219/24 , C07D311/86 , C07D333/24 , A61K31/27 , A61K31/381 , A61K31/14 , A61K31/216 , A61K31/352 , A61P11/00
CPC分类号： C07C271/38 , C07C217/52 , C07C219/24 , C07C2602/42 , C07D311/86 , C07D333/24
摘要： Compounds of formula (I) have muscarinic M3 receptor modulating activity; formula (I) wherein R 1 is C 1 -C 6 -alkyl or a hydrogen atom; and R 2 is a hydrogen atom or a group -R 5 , or a group, -Z-Y-R 5 , or a group -Z-NR 9 R 10 , or a group -Z-N(R 9 )C(O)R 11 ; and R 3 is a lone pair, or C 1 -C 6 -alkyl; R 4 is selected from one of the groups of formula (a), (b), (c) or (d); formulae (a), (b), (c), (d), Z is a C 1 -C 16 -alkylene, C 2 -C 16 -alkenylene or C 2 -C 16 -alkynylene group; Y is a bond or oxygen atom; R 5 is an C 1 -C 6 -alkyl, aryl, arylalkyl; aryl-fused-cycloalkyl, aryl-fused- heterocycloalkyl, heteroaryl, aryl(C 1 -C 8 -alkyl)-, heteroaryl(C 1 -C 8 -alkyl)-, cycloalkyl or heterocycloalkyl group; R 6 is C 1 -C 6 -alkyl or a hydrogen atom; R 7a and R 7b are a C 1 -C 6 - alkyl group or halogen; n and m are independently 0, 1 , 2 or 3; R 8a and R 8b are independently selected from the group consisting of aryl, aryl-fused-heterocycloalkyl, heteroaryl, C 1 -C 6 -alkyl, cycloalkyl and hydrogen; R 8c is -OH, C 1 -C 6 -alkyl, hydroxy-C 1 -C 6 -alkyl, or a hydrogen atom; R 8d is C 1 -C 6 -alkyl or a hydrogen atom; R 9 and R 10 are independently a hydrogen atom, C 1 -C 6 -alkyl, aryl, aryl-fused-heterocycloalkyl, aryl- fused-cycloalkyl, heteroaryl, aryl(C 1 -C 6 -alkyl)-, or heteroaryl(C 1 -C 6 -alkyl)- group; or R 9 and R 10 together with the nitrogen atom to which they are attached form a heterocyclic ring of 4-8 atoms, optionally containing a further nitrogen or oxygen atom; R 11 is C 1 -C 6 -alkyl or a hydrogen atom; Ar 1 is aryl, heteroaryl or cycloalkyl; Ar 2 are independently aryl, heteroaryl or cycloalkyl; and Q is an oxygen atom, -CH 2 -, -CH 2 CH 2 - or a bond.
摘要翻译：式（I）化合物具有毒蕈碱M3受体调节活性; 式（I）其中R 1是C 1 -C 6 - 烷基或氢原子; 和R 2是氢原子或基团-R 5或基团-ZYR 5或基团-Z-NR 或者是基团-ZN（R 9）C（O）R 11; 且R 3是一对或C 1 -C 6 - 烷基; R 4选自式（a），（b），（c）或（d）中的一个：式（a），（b），（c），（d），Z是C 1 -C 16 - 亚烷基，C 2 -C 16 - 亚烯基或C 2 -C 16 - 亚炔基; Y是键或氧原子; R 5是C 1 -C 6 - 烷基，芳基，芳基烷基; 芳基 - 稠合环烷基，芳基 - 稠合 - 杂环烷基，杂芳基，芳基（C 1 -C 8 - 烷基） - ，杂芳基（C 1 -C 12 - -C≡8烷 - 烷基） - ，环烷基或杂环烷基; R 6是C 1 -C 6 - 烷基或氢原子; R 7a和R 7b是C 1 -C 6 - 烷基或卤素; n和m独立地为0,1,2或3; R 8a和R 8b独立地选自芳基，芳基 - 稠合 - 杂环烷基，杂芳基，C 1 -C 3 烷基，环烷基和氢; R 8c是-OH，C 1 -C 6 - 烷基，羟基-C 1 -C 3 > 6个 - 烷基或氢原子; R 8是C 1 -C 6 - 烷基或氢原子; R 9和R 10独立地是氢原子，C 1 -C 6 - 烷基，芳基，芳基 - 杂芳基（C 1 -C 6 - 烷基） - 或杂芳基（C 1 -C 6 - 烷基） - 杂芳基（C 1 -C 6 - -C 6 -C 6 - 烷基） - 基; 或R 9和R 10与它们所连接的氮原子一起形成4-8个原子的杂环，任选地含有另外的氮或氧原子; R 11是C 1 -C 6 - 烷基或氢原子; Ar 1是芳基，杂芳基或环烷基; Ar 2独立地是芳基，杂芳基或环烷基; 和Q是氧原子，-CH 2 - ， - CH 2 CH 2 - 或键。

2. 发明申请

WO2009098453A1 AZONIA BICYCLOALKANES AS M3 MUSCARINIC ACETYLCHOLIN RECEPTOR ANTAGONISTS 审中-公开
标题翻译： AZONIA BICYCLOALKANES as M3 MUSCARINIC ACETYLCHOLIN RECEPTOR ANTAGONISTS
公开(公告)号：WO2009098453A1
公开(公告)日：2009-08-13
申请号：PCT/GB2009/000306
申请日：2009-02-05
申请人： ASTRAZENECA AB , ARGENTA DISCOVERY LIMITED , BULL, Richard, James , NADIN, Alan, John , RAY, Nicholas, Charles , SMITH, Phillip
发明人： BULL, Richard, James , NADIN, Alan, John , RAY, Nicholas, Charles , SMITH, Phillip
IPC分类号： C07D453/02 , A61K31/439 , A61P11/06
CPC分类号： C07D453/02
摘要： This invention relates to M3 antagonists of formula (I): wherein R 2 , R 4 , R 5 , R 6 , W, V, A, D, X, t, u and v are as defined herein; pharmaceutical compositions containing them; methods for their preparation; and their use in the treatment of diseases where enhanced M3 receptor activation is implicated.
摘要翻译：本发明涉及式（I）的M3拮抗剂：其中R2，R4，R5，R6，W，V，A，D，X，t，u和v如本文所定义; 含有它们的药物组合物; 其准备方法; 以及它们用于治疗涉及M3受体活化增强的疾病。

3. 发明申请

WO2010138795A1 MINIATURE PHASE-CORRECTED ANTENNAS FOR HIGH RESOLUTION FOCAL PLANE THZ IMAGING ARRAYS 审中-公开
标题翻译：用于高分辨率焦平面THZ成像阵列的微小相位校正天线
公开(公告)号：WO2010138795A1
公开(公告)日：2010-12-02
申请号：PCT/US2010/036534
申请日：2010-05-28
申请人： THE OHIO STATE UNIVERSITY , MOSBACKER, H., Lee , MUMCU, Gokhan , SERTEL, Kubilay , SMITH, Phillip
发明人： MOSBACKER, H., Lee , MUMCU, Gokhan , SERTEL, Kubilay , SMITH, Phillip
IPC分类号： H01L29/51
CPC分类号： H01L27/14605 , G01J1/4228 , G01J5/0837 , H01L27/14625 , H01Q3/40 , H01Q19/062 , H01Q25/007
摘要： An array of backward diodes of a cathode layer adjacent to a first side of a non-uniform doping profile and an Antimonide-based tunnel barrier layer adjacent to a second side of the spacer layer have a monolithically integrated antenna bonded to each backward diode. The Antimonide-based tunnel barrier may be doped with, for example, a non-uniform delta doping profile. An imaging/detection device includes a 2D focal plane array of an array of backward diodes, wherein each backward diode is monolithically bonded to an antenna, which array is located at the back of an extended hemispherical lens, and wherein certain of the arrays are tilted for correcting optics aberrations. The antennas may be a bow-tie antenna, a planar log-periodic antenna, a double-slot with microstrip feed antenna, a spiral antenna, a helical antenna, a ring antenna, a dielectric rod antenna, or a double slot antenna with co-planar waveguide feed antenna.
摘要翻译：与非均匀掺杂分布的第一侧相邻的阴极层的反向二极管的阵列和与间隔层的第二侧相邻的基于锑化物的隧道势垒层具有结合到每个后向二极管的单片集成天线。基于锑酸盐的隧道势垒可以掺杂例如不均匀的δ掺杂分布。成像/检测装置包括后向二极管阵列的2D焦平面阵列，其中每个后向二极管单片地结合到天线，该天线位于延伸的半球形透镜的背面，并且其中某些阵列倾斜用于校正光学像差。天线可以是弓形天线，平面对数周期性天线，具有微带馈电天线的双槽，螺旋天线，螺旋天线，环形天线，介电棒天线或具有co的双槽天线平面波导馈线天线。

4. 发明申请

WO2006050069A2 METHODS AND SYSTEMS FOR SCANNING AND MONITORING CONTENT ON A NETWORK 审中-公开
标题翻译：网络扫描和监控内容的方法和系统
公开(公告)号：WO2006050069A2
公开(公告)日：2006-05-11
申请号：PCT/US2005/038893
申请日：2005-10-28
申请人： TRUSTWAVE CORPORATION , GREEN, Kenneth , PATANELLA, Joseph , SMITH, Phillip
发明人： GREEN, Kenneth , PATANELLA, Joseph , SMITH, Phillip
IPC分类号： G06F17/00 , G06F7/00
CPC分类号： H04L63/123 , G06F17/30864 , H04L63/1408 , H04L63/1483 , H04L67/02
摘要： The invention addressed methods and systems of scanning and. monitoring network locations and resources such as websites and webpages. The method scans the webpages for content and compliance with predefined standards, and reports the results in a non-technical format. The method can also scan and monitor any website on the Internet, categorize its content, and validate its compliance with application, presentation or content standards, or any combination of the above.
摘要翻译：本发明解决了扫描方法和系统。监控网络位置和资源，如网站和网页。该方法扫描网页以获取内容并遵守预定义的标准，并以非技术格式报告结果。该方法还可以扫描和监控互联网上的任何网站，对其内容进行分类，并验证其符合应用程序，演示文稿或内容标准，或上述任何组合。

5. 发明申请

WO2011033265A1 PHARMACEUTICAL COMPOUNDS 审中-公开
标题翻译：药物化合物
公开(公告)号：WO2011033265A1
公开(公告)日：2011-03-24
申请号：PCT/GB2010/001746
申请日：2010-09-17
申请人： ALMAC DISCOVERY LIMITED , BELL, Mark Peter , O'DOWD, Colin Roderick , ZHANG, Lixin , TEVITT, Graham Peter , HARRISON, Timothy , BATTACHARYYA, Sumita , ROUNTREE, James Samuel Shane , BURKAMP, Frank , PRICE, Stephen , MACLEOD, Calum , ELLIOTT, Richard Leonard , SMITH, Phillip , BLENCH, Toby Jonathan , DYKE, Hazel Joan
发明人： BELL, Mark Peter , O'DOWD, Colin Roderick , ZHANG, Lixin , TEVITT, Graham Peter , HARRISON, Timothy , BATTACHARYYA, Sumita , ROUNTREE, James Samuel Shane , BURKAMP, Frank , PRICE, Stephen , MACLEOD, Calum , ELLIOTT, Richard Leonard , SMITH, Phillip , BLENCH, Toby Jonathan , DYKE, Hazel Joan
IPC分类号： C07D311/26 , C07D407/04 , C07D491/04 , A61K31/353 , A61K31/4155 , A61K31/4162 , A61K31/436 , A61P35/00
CPC分类号： C07D311/26 , C07D407/04 , C07D491/04
摘要： The invention relates to a series of compounds with particular activity as inhibitors of the serine-threonine kinase AKT. Also provided are pharmaceutical compositions comprising same as well as methods for treating cancer.
摘要翻译：本发明涉及具有特定活性的一系列化合物作为丝氨酸 - 苏氨酸激酶AKT的抑制剂。还提供了包含其的药物组合物以及治疗癌症的方法。

6. 发明申请

WO2007043896A1 MODULAR ASSEMBLY 审中-公开
标题翻译：模块化装配
公开(公告)号：WO2007043896A1
公开(公告)日：2007-04-19
申请号：PCT/NZ2006/000257
申请日：2006-10-06
申请人： SMITH, Phillip
发明人： SMITH, Phillip
IPC分类号： H01R13/60
CPC分类号： H01R25/003 , H01R13/64 , H01R13/652 , H01R13/70 , H01R24/30 , H01R31/02 , H01R31/06 , H01R2103/00
摘要： The present invention generally relates to a modular assembly including electrically conductive modular units. More particularly, the assembly provides a freestanding supportive structure for supplying power through the assembly to electrical utility members, such as lights or power points.
摘要翻译：本发明一般涉及包括导电模块单元的模块化组件。更具体地，组件提供了一种独立的支撑结构，用于通过组件向诸如灯或动力点的电力公用设施提供动力。

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