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1. 发明专利

IL264415A Pharmaceutical compounds 未知
公开(公告)号：IL264415A
公开(公告)日：2022-02-01
申请号：IL26441519
申请日：2019-01-22
申请人： ALMAC DISCOVERY LTD , HEWITT PETER , MCFARLAND MARY MELISSA , ROUNTREE JAMES SAMUEL SHANE , BURKAMP FRANK , BELL CHRISTINA , PROCTOR LAUREN , HELM MATTHEW DUNCAN , ODOWD COLIN , HARRISON TIMOTHY
发明人： HEWITT PETER , MCFARLAND MARY MELISSA , ROUNTREE JAMES SAMUEL SHANE , BURKAMP FRANK , BELL CHRISTINA , PROCTOR LAUREN , HELM MATTHEW DUNCAN , O'DOWD COLIN , HARRISON TIMOTHY
摘要： The present invention relates to compounds of Formula (I) that are useful as inhibitors of the activity of the ubiquitin specific protease USP19. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in therapy.

2. 发明专利

GB0105125D0 Data reader 未知
公开(公告)号：GB0105125D0
公开(公告)日：2001-04-18
申请号：GB0105125
申请日：2001-03-02
申请人： HARRISON TIMOTHY N
IPC分类号： H04J14/02 , H04Q11/00
摘要： Monitoring one or more objects, especially people, within a zone, e.g. a building, convention centre, or shopping mall, by remotely reading data from tags carried by the objects, analysing the data and generating output information in response to specified data. A unique reference number (URN) on each tag is linked to data records of the corresponding object on a computer, which is linked to a central database. The tag could be read using a hand-held reader. A recognised URN causes the computer to initiate a variety of possible actions: on-screen or audible message (e.g. greeting for a conference attendee), alarm, specific message delivery elsewhere to another piece of equipment, person (e.g. security staff) or software application (e.g. for administrative purposes). Many possible applications are described. In a security system embodiment, two or more people (e.g. parent and child) each carrying a tag are prevented from passing through a security station unless in the presence of a designated complementary tag. The system could be used for locating e.g. a missing child within a monitored zone. The tags could be used to enable access to the person's medical history, stored in a central (e.g hospital) database. The tags could be read/write (Fig. 2) as well as read-only (Fig. 1), e.g. in an exhibition, attendees could download information into their tag at "self-service" stations.

3. 发明专利

CH578968A5 Signal equipment for man overboard - has balloon inflated by gas and anchored by long rope 未知
公开(公告)号：CH578968A5
公开(公告)日：1976-08-31
申请号：CH580974
申请日：1974-04-29
申请人： HARRISON TIMOTHY
IPC分类号： B63C9/20 , G08B5/00 , B63C9/21 , A62B33/00 , G08B1/00
摘要： The equipment comprises an inflatable component and a bottle containing compressed gas which is lighter than air, connected together via a release valve. A flexible link attaches the inflatable marker component to the life-saving equipment. The component can be a balloon, and can have wings so as to maintain it at the desired height, even in a high wind. The equipment may be housed in a box whose lid opens automatically under the action of a release accessible from outside. Helium can be used as the gas, and the marker balloon can be anchored by a rope of longer than 10 metres, folded or coiled inside the box.

4. 发明专利

IL283706D0 Pharmaceutical compounds and their use as inhibitors of ubiquitin specific protease 19 (usp19) 未知
公开(公告)号：IL283706D0
公开(公告)日：2021-07-29
申请号：IL28370621
申请日：2021-06-03
申请人： ALMAC DISCOVERY LTD , ROUNTREE JAMES SAMUEL SHANE , WHITEHEAD STEVEN KRISTOPHER , TREDER ADAM PIOTR , PROCTOR LAUREN EMMA , SHEPHERD STEVEN DAVID , BURKAMP FRANK , COSTA JOANA RITA CASTRO , ODOWD COLIN , HARRISON TIMOTHY , HELM MATTHEW DUNCAN , ROZYKA EWELINA , CRANSTON AARON , JACQ XAVIER
发明人： ROUNTREE JAMES SAMUEL SHANE , WHITEHEAD STEVEN KRISTOPHER , TREDER ADAM PIOTR , PROCTOR LAUREN EMMA , SHEPHERD STEVEN DAVID , BURKAMP FRANK , COSTA JOANA RITA CASTRO , O'DOWD COLIN , HARRISON TIMOTHY , HELM MATTHEW DUNCAN , ROZYKA EWELINA , CRANSTON AARON , JACQ XAVIER
IPC分类号： A61P3/04 , A61P3/10 , A61P21/00
摘要： Provided are USP19 inhibitors, methods of treating obesity, metabolic syndrome and/or diabetes using the USP19 inhibitor compounds, as well as those compounds for use in methods of treating obesity, metabolic syndrome and/or diabetes. Also provided are methods of treating muscular atrophy, for example cachexia or sarcopenia with USP19 inhibitor compounds, plus those a compounds for use in methods of treating muscular atrophy.

5. 发明专利

GB2360862A Monitoring objects using remotely readable tags 未知
公开(公告)号：GB2360862A
公开(公告)日：2001-10-03
申请号：GB0105125
申请日：2001-03-02
申请人： HARRISON TIMOTHY NIGEL
发明人： HARRISON TIMOTHY NIGEL
IPC分类号： H04J14/02 , H04Q11/00 , G06K17/00 , G06K7/00 , G07C9/00
摘要： Monitoring one or more objects, especially people, within a zone, e.g. a building, convention centre, or shopping mall, by remotely reading data from tags carried by the objects, analysing the data and generating output information in response to specified data. A unique reference number (URN) on each tag is linked to data records of the corresponding object on a computer, which is linked to a central database. The tag could be read using a hand-held reader. A recognised URN causes the computer to initiate a variety of possible actions: on-screen or audible message (e.g. greeting for a conference attendee), alarm, specific message delivery elsewhere to another piece of equipment, person (e.g. security staff) or software application (e.g. for administrative purposes). Many possible applications are described. In a security system embodiment, two or more people (e.g. parent and child) each carrying a tag are prevented from passing through a security station unless in the presence of a designated complementary tag. The system could be used for locating e.g. a missing child within a monitored zone. The tags could be used to enable access to the person's medical history, stored in a central (e.g hospital) database. The tags could be read/write (Fig. 2) as well as read-only (Fig. 1), e.g. in an exhibition, attendees could download information into their tag at "self-service" stations.

6. 发明专利

GB0002129D0 Toilet roll former 未知
公开(公告)号：GB0002129D0
公开(公告)日：2000-03-22
申请号：GB0002129
申请日：2000-02-01
申请人： HARRISON TIMOTHY D G

7. 发明专利

IL283687D0 Usp19 inhibitors for use in therapy 未知
公开(公告)号：IL283687D0
公开(公告)日：2021-07-29
申请号：IL28368721
申请日：2021-06-03
申请人： ALMAC DISCOVERY LTD , ROUNTREE JAMES SAMUEL SHANE , HEWITT PETER , MCFARLAND MARY MELISSA , BURKAMP FRANK , BELL CHRISTINA , ODOWD COLIN , HARRISON TIMOTHY , HELM MATTHEW DUNCAN , ROZYKA EWELINA , CRANSTON AARON , JACQ XAVIER , PROCTOR LAUREN
发明人： ROUNTREE JAMES SAMUEL SHANE , HEWITT PETER , MCFARLAND MARY MELISSA , BURKAMP FRANK , BELL CHRISTINA , O'DOWD COLIN , HARRISON TIMOTHY , HELM MATTHEW DUNCAN , ROZYKA EWELINA , CRANSTON AARON , JACQ XAVIER , PROCTOR LAUREN
IPC分类号： A61K31/4545 , A61K31/496 , A61K31/513 , A61K31/5377 , A61P3/04 , A61P5/48 , A61P21/00 , A61P35/00
摘要： Provided are USP19 inhibitors, methods of treating obesity, metabolic syndrome and/or diabetes using the USP19 inhibitor compounds, as well as those compounds for use in methods of treating obesity, metabolic syndrome and/or diabetes. Also provided are methods of treating muscular atrophy, for example cachexia or sarcopenia with USP19 inhibitor compounds, plus those compounds for use in methods of treating muscular atrophy.

8. 发明专利

IL276324D0 4-hydroxypiperidine derivatives and their use as inhibitors of ubiquitin specific protease 19 (usp19) 未知
公开(公告)号：IL276324D0
公开(公告)日：2020-09-30
申请号：IL27632420
申请日：2020-07-27
申请人： ALMAC DISCOVERY LTD , ROUNTREE JAMES SAMUEL SHANE , WHITEHEAD STEVEN KRISTOPHER , TREDER ADAM PIOTR , PROCTOR LAUREN EMMA , SHEPHERD STEVEN DAVID , BURKAMP FRANK , COSTA JOANA RITA CASTRO , ODOWD COLIN , HARRISON TIMOTHY
发明人： ROUNTREE JAMES SAMUEL SHANE , WHITEHEAD STEVEN KRISTOPHER , TREDER ADAM PIOTR , PROCTOR LAUREN EMMA , SHEPHERD STEVEN DAVID , BURKAMP FRANK , COSTA JOANA RITA CASTRO , O'DOWD COLIN , HARRISON TIMOTHY
IPC分类号： A61K31/438 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/541 , A61K31/55 , A61P3/04 , A61P3/10 , A61P21/00
摘要： Inhibitors of ubiquitin specific protease 19 (USP19) of Formula (I) are provided, together with pharmaceutical compositions comprising said inhibitors, and methods of use thereof. The compounds can be used in in the treatment of muscular atrophy, obesity, insulin resistance or type II diabetes or in reducing the loss of muscle mass.

9. 发明专利

IL266146D0 Piperidine derivatives as inhibitors of ubiquitin specific protease 未知
公开(公告)号：IL266146D0
公开(公告)日：2019-06-30
申请号：IL26614619
申请日：2019-04-18
申请人： HEWITT PETER , BURKAMP FRANK , HARRISON TIMOTHY , ODOWD COLIN , ROUNTREE SHANE , HUGUES MIEL , JORDAN LINDA , HELM MATTHEW , BROCCATELLI FABIO , CRAWFORD JAMES JOHN , GAZZARD LEWIS , WERTZ INGRID , LEE WENDY , ALMAC DISCOVERY LTD
发明人： HEWITT PETER , BURKAMP FRANK , HARRISON TIMOTHY , O'DOWD COLIN , ROUNTREE SHANE , HUGUES MIEL , JORDAN LINDA , HELM MATTHEW , BROCCATELLI FABIO , CRAWFORD JAMES JOHN , GAZZARD LEWIS , WERTZ INGRID , LEE WENDY
IPC分类号： C07D20060101
摘要： The present invention concerns the identification of inhibitors of ubiquitin specific protease 7 (USP7), and methods of use thereof.

10. 发明专利

IL264415D0 Pharmaceutical compounds 未知
公开(公告)号：IL264415D0
公开(公告)日：2019-02-28
申请号：IL26441519
申请日：2019-01-22
申请人： ALMAC DISCOVERY LTD , HEWITT PETER , MCFARLAND MARY MELISSA , ROUNTREE JAMES SAMUEL SHANE , BURKAMP FRANK , BELL CHRISTINA , PROCTOR LAUREN , HELM MATTHEW DUNCAN , ODOWD COLIN , HARRISON TIMOTHY
发明人： HEWITT PETER , MCFARLAND MARY MELISSA , ROUNTREE JAMES SAMUEL SHANE , BURKAMP FRANK , BELL CHRISTINA , PROCTOR LAUREN , HELM MATTHEW DUNCAN , O'DOWD COLIN , HARRISON TIMOTHY
IPC分类号： C07D20060101
摘要： The present invention relates to compounds of Formula (I) that are useful as inhibitors of the activity of the ubiquitin specific protease USP19. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in therapy.

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