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1. 发明申请

WO2005116653A2 HUMAN G PROTEIN-COUPLED RECEPTOR AND MODULATORS THEREOF FOR THE TREATMENT OF HYPERGLYCEMIA AND RELATED DISORDERS 审中-公开
标题翻译：人G蛋白偶联受体及其调节剂治疗高血压和相关疾病
公开(公告)号：WO2005116653A2
公开(公告)日：2005-12-08
申请号：PCT/US2005/012447
申请日：2005-04-12
申请人： ARENA PHARMACEUTICALS, INC. , QIU, Jun , WEBB, Robert R. , UNETT, David J. , GATLIN, Joel E. , CONNOLLY, Daniel T.
发明人： QIU, Jun , WEBB, Robert R. , UNETT, David J. , GATLIN, Joel E. , CONNOLLY, Daniel T.
IPC分类号： G01N33/566
CPC分类号： C07D417/04 , A61K31/427 , A61K31/4439 , G01N33/76 , G01N2333/726
摘要： The present invention relates to methods of identifying whether one or more candidate compounds is a modulator of a G protein-coupled receptor (GPCR) or a modulator of blood glucose concentration. In certain embodiments, the GPCR is human. The present invention also relates to methods of using a modulator of the GPCR. A preferred modulator is agonist. Agonists of the invention are useful as therapeutic agents for lowering blood glucose concentration, for preventing or treating certain metabolic disorders, such as insulin resistance, impaired glucose tolerance, and diabetes, and for preventing or treating a complication of an elevated blood glucose concentration, such as atherosclerosis, heart disease, stroke, hypertension and peripheral vascular disease.
摘要翻译：本发明涉及鉴定一种或多种候选化合物是G蛋白偶联受体（GPCR）或血糖浓度调节剂的调节剂的方法。在某些实施方案中，GPCR是人。本发明还涉及使用GPCR调制器的方法。优选的调节剂是激动剂。本发明的激动剂可用作降低血糖浓度的治疗剂，用于预防或治疗某些代谢紊乱，例如胰岛素抵抗，葡萄糖耐量异常和糖尿病，以及用于预防或治疗血糖浓度升高的并发症，作为动脉粥样硬化，心脏病，中风，高血压和外周血管疾病。

2. 发明申请

WO2005119252A2 GPR35 AND MODULATORS THEREOF FOR THE TREATMENT OF METABOLIC-RELATED DISORDERS 审中-公开
标题翻译： GPR35的调节剂用于治疗与代谢相关的疾病
公开(公告)号：WO2005119252A2
公开(公告)日：2005-12-15
申请号：PCT/US2005/018082
申请日：2005-05-23
申请人： ARENA PHARMACEUTICALS, INC. , LEONARD, James N. , CHU, Zhi Liang , UNETT, David J. , GATLIN, Joel E. , GAIDAROV, Ibragim , QIU, Jun , SKINNER, Philip J. , BOATMAN, P. Douglas
发明人： LEONARD, James N. , CHU, Zhi Liang , UNETT, David J. , GATLIN, Joel E. , GAIDAROV, Ibragim , QIU, Jun , SKINNER, Philip J. , BOATMAN, P. Douglas
IPC分类号： G01N33/50
CPC分类号： G01N33/6893 , A61K31/425 , G01N2333/726 , G01N2500/00
摘要： The present invention relates to a method for identifying a metabolic stabilizing compound, comprising: a) contacting a candidate compound with GPR35, and b) determining whether GPR35 functionality is increased, wherein an increase in GPR35 functionality is indicative of the candidate compound being a metabolic stabilizing compound. The invention further relates to use of a GPR35 modulator for the manufacture of a medicament for use as a metabolic stabilizing agent. In addition, the invention relates to a method for increasing GPR35 function, comprising contacting GPR35 with an effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein X is O or S; and R1, R2, R3, R4, and R5 are each independently selected from the group consisting of H, C1-4 alkoxy, C1-4 alkyl, halogen, hydroxyl, and nitro; wherein said C1-4 alkoxy is optionally substituted with carbo-C1-4-alkoxy or carboxy.
摘要翻译：本发明涉及用于鉴定代谢稳定化合物的方法，包括：a）使候选化合物与GPR35接触，和b）确定GPR35的功能是否增加，其中GPR35功能的增加指示候选化合物是代谢稳定化合物。本发明还涉及GPR35调节剂在制备用作代谢稳定剂的药物中的用途。另外，本发明涉及增加GPR35功能的方法，包括使GPR35与有效量的式（I）化合物或其可药用盐接触，其中X为O或S; R 1，R 2，R 3，R 4和R 5各自独立地选自H，C 1-4烷氧基，C 1-4烷基，卤素，羟基和硝基; 其中所述C 1-4烷氧基任选被C 1-4 - 烷氧基或羧基取代。

3. 发明申请

WO2008034581A1 GASTRENN-MEMBRAN 审中-公开
标题翻译： GUEST RACING REED
公开(公告)号：WO2008034581A1
公开(公告)日：2008-03-27
申请号：PCT/EP2007/008112
申请日：2007-09-18
申请人： GKSS-FORSCHUNGSZENTRUM GEESTHACHT GMBH , QIU, Jun , PEINEMANN, Klaus-Viktor , WIND, Jan , PINGEL, Holger
发明人： QIU, Jun , PEINEMANN, Klaus-Viktor , WIND, Jan , PINGEL, Holger
IPC分类号： B01D71/00 , B01D71/02
CPC分类号： B01D69/10 , B01D53/228 , B01D71/08 , B01D71/12 , B01D71/16 , B01D2256/12 , C01B13/0255 , C01B2210/0046 , Y10S55/05
摘要： Die Erfindung betrifft eine Membran zur Gastrennung, ein Verfahren zur Herstellung einer entsprechenden Membran, ein Gastrennmodul mit einer entsprechenden Membran sowie ein Verfahren zum Betrieb eines solchen Gastrennmoduls. Die Membran umfasst: eine poröse Trägerschicht aus Polymer oder anorganischem Material, insbesondere keramischem Material, eine Trennschicht, umfassend eine Mischung aus Saccharid- Derivaten und Homopolymer, insbesondere umfassend Ethylzellulose, Zelluloseacetat oder Poly-4-Methyl-1-Penten, wobei die Saccharid-Derivate eine zyklische Struktur mit fünf oder sechs Ringatomen oder eine lineare Struktur aufweisen oder Monosaccharid-Derivate sind, die über Glykosidbindungen verbunden sind, wobei die Anzahl der auf diese Weise verbundenen Monosaccharide zwischen 2 und 1.000 liegt. Dabei hat sich überraschenderweise herausgestellt, dass der Sauerstofffluss durch eine solche Membran erheblich ansteigt, wenn der Membran Saccharid-Derivate zugesetzt werden.
摘要翻译：本发明涉及一种气体分离膜，用于产生相应的膜，具有相应的隔膜以及用于操作这种气体分离组件的方法的气体分离组件的方法。所述膜包括：聚合物或无机材料制成的多孔载体层，特别是陶瓷材料，剥离层，其包含糖衍生物和均聚物，特别是包括乙基纤维素，醋酸纤维素或聚-4-甲基-1-戊烯的混合物，其中糖衍生物的环状结构具有五个或六个环原子或一个直链结构或包括单糖衍生物，其通过糖苷键连接，其中的连接在位于这样的单糖2-1000数。在这种情况下，已经令人惊奇地发现，当添加显著氧气流量的增加通过这样的膜的膜糖衍生物。

4. 发明公开

EP1735622A2 MODULATORS OF HUMAN G PROTEIN-COUPLED RECEPTORS FOR THE TREATMENT OF HYPERGLYCEMIA AND RELATED DISORDERS 审中-公开
标题翻译：人G蛋白偶联受体，用于治疗，高血糖症及相关疾病的调节剂
公开(公告)号：EP1735622A2
公开(公告)日：2006-12-27
申请号：EP05780020.3
申请日：2005-04-12
申请人： Arena Pharmaceuticals, Inc.
发明人： QIU, Jun , WEBB, Robert R. , UNETT, David J. , GATLIN, Joel E. , CONNOLLY, Daniel T.
IPC分类号： G01N33/566
CPC分类号： C07D417/04 , A61K31/427 , A61K31/4439 , G01N33/76 , G01N2333/726
摘要： The present invention relates to methods of identifying whether one or more candidate compounds is a modulator of a G protein-coupled receptor (GPCR) or a modulator of blood glucose concentration. In certain embodiments, the GPCR is human. The present invention also relates to methods of using a modulator of the GPCR. A preferred modulator is agonist. Agonists of the invention are useful as therapeutic agents for lowering blood glucose concentration, for preventing or treating certain metabolic disorders, such as insulin resistance, impaired glucose tolerance, and diabetes, and for preventing or treating a complication of an elevated blood glucose concentration, such as atherosclerosis, heart disease, stroke, hypertension and peripheral vascular disease.

5. 发明申请

WO2010108985A1 IMPROVED ANTI-BIOFOULING COATING 审中-公开
标题翻译：改进抗生素涂料
公开(公告)号：WO2010108985A1
公开(公告)日：2010-09-30
申请号：PCT/EP2010/053924
申请日：2010-03-25
申请人： DSM IP Assets B.V. , BUSKENS, Pascal Jozef Paul , VERMEULEN, Jacobus Adriaan Antonius , RIJK, de, Ronnie , THIES, Jens Christoph , QIU, Jun
发明人： BUSKENS, Pascal Jozef Paul , VERMEULEN, Jacobus Adriaan Antonius , RIJK, de, Ronnie , THIES, Jens Christoph , QIU, Jun
IPC分类号： C09D5/16 , C08J7/04 , C09D201/00 , C08G83/00
CPC分类号： C08F283/12 , C08F291/00 , C08J7/047 , C08L51/003 , C08L51/085 , C09D5/1637 , C09D151/003 , C09D151/085 , C09D201/005 , C08L2666/02
摘要： The invention relates to a coating material suitable for providing a substrate with an anti-biofouling coating, the coating material comprising a macromolecule comprising: (A) a macromolecular scaffold comprising a reactive group capable of undergoing a Michael type reaction between a Michael type acceptor group and a Michael type donor group, (B) at least one functional moiety attached to the macromolecular scaffold, said at least one functional moiety comprising a hydrophilic moiety, wherein the functional moiety is derivable from a Michael type reaction, involving the reactive group on the macromolecular scaffold and a reactive hydrophilic moiety and (C) at least one moiety capable of crosslinking the coating material.
摘要翻译：本发明涉及一种适用于提供具有抗生物污损涂层的基材的涂层材料，所述涂层材料包含大分子，其包含：（A）大分子支架，其包含能够在迈克尔型受体基团之间经历迈克尔型反应的反应性基团和（B）至少一个与大分子支架连接的功能部分，所述至少一个功能部分包含亲水部分，其中所述功能部分可衍生自迈克尔型反应，涉及所述反应性基团大分子支架和反应性亲水部分和（C）能够交联涂层材料的至少一个部分。

6. 发明申请

WO2009013340A1 HYDROPHILIC MEMBRANE 审中-公开
标题翻译：水解膜
公开(公告)号：WO2009013340A1
公开(公告)日：2009-01-29
申请号：PCT/EP2008/059724
申请日：2008-07-24
申请人： DSM IP Assets B.V. , HOVING, Hendrik Derk , QIU, Jun , THIES, Jens Christoph , CALIS, Gijsbertus Hendrikus Maria , KAMP, OP DEN, Johannes Leonardus Maria
发明人： HOVING, Hendrik Derk , QIU, Jun , THIES, Jens Christoph , CALIS, Gijsbertus Hendrikus Maria , KAMP, OP DEN, Johannes Leonardus Maria
IPC分类号： B01D67/00 , B01D69/14 , B01D71/02 , B01D71/52 , B01D71/70
CPC分类号： B01D69/02 , B01D71/024 , B01D71/025 , B01D71/027 , B01D71/52 , B01D71/70 , B01D2323/345 , B01D2325/36
摘要： The invention relates to an hydrophilic membrane comprising a membrane carrier and a hydrophilic coating with good properties. The coating may comprise covalently bound inorganic-organic hybrid material; or the coating may comprise ring-opening polymerized components like epoxy resins. The coating composition preferably is applied in a solvent, the solvent is evaporated, and the coating is cured with UV radiation. The hydrophilic membrane is very useful in water purification, and in other applications.
摘要翻译：本发明涉及包含膜载体和具有良好性能的亲水涂层的亲水膜。涂层可以包括共价结合的无机 - 有机杂化材料; 或涂层可以包括开环聚合的组分如环氧树脂。涂料组合物优选在溶剂中进行，蒸发溶剂，并用UV辐射固化涂层。亲水膜在水净化和其他应用中非常有用。

7. 发明申请

WO2011151314A1 MEMBRANE SUITABLE FOR BLOOD FILTRATION 审中-公开
标题翻译：膜适用于血液过滤
公开(公告)号：WO2011151314A1
公开(公告)日：2011-12-08
申请号：PCT/EP2011/058921
申请日：2011-05-31
申请人： DSM IP Assets B.V. , DULLAERT, Konraad , DORSCHU, Marko , QIU, Jun , THIES, Jens Christoph
发明人： DULLAERT, Konraad , DORSCHU, Marko , QIU, Jun , THIES, Jens Christoph
IPC分类号： B01D71/56 , B01D67/00 , B01D69/10 , D01F6/60 , D01F6/80 , D01F6/90 , B01D39/16
CPC分类号： B01D71/56 , B01D65/08 , B01D67/0088 , B01D69/12 , B01D71/26 , B01D2239/025 , B01D2239/1233 , B01D2321/28 , B01D2323/39 , B01D2325/36 , D01F6/60 , D01F6/80 , D01F6/90 , D04H1/728 , G01N33/491
摘要： The invention relates to a membrane construction comprising multiple layers wherein at least one of the layers is a nanoweb made of polymeric nanofibers, wherein the mean flow pore size of the nanoweb is in the range from 50 nm to 5 μm, wherein the number average diameter of the nanofibers is in the range from 100 to 600 nm, wherein the basis weight of the nanoweb is in the range from 1 to 20 g/m 2 , wherein the porosity of the nanoweb is in the range from 60 to 95%, wherein at least one of the layers is a support layer and wherein the nanoweb is hydrophilic.
摘要翻译：本发明涉及包括多个层的膜结构，其中至少一个层是由聚合物纳米纤维制成的纳米网，其中纳米纤维网的平均流动孔径在50nm至5μm的范围内，其中数均直径的纳米纤维的范围在100至600nm的范围内，其中纳米纤维网的基重在1至20g / m 2的范围内，其中纳米纤维网的孔隙率在60至95％的范围内，其中在层中的至少一层是支撑层，其中纳米网是亲水性的。

8. 发明申请

WO2010049535A1 ANTIFOULING COATING COMPOSITION COMPRISING FUNCTIONALIZED NANOPARTICULES 审中-公开
标题翻译：包含功能化纳米粒子的抗磨涂料组合物
公开(公告)号：WO2010049535A1
公开(公告)日：2010-05-06
申请号：PCT/EP2009/064407
申请日：2009-10-30
申请人： DSM IP Assets B.V. , QIU, Jun , de RIJK, Ronnie Bernardus Maria , THIES, Jens Christoph
发明人： QIU, Jun , de RIJK, Ronnie Bernardus Maria , THIES, Jens Christoph
IPC分类号： C09D5/16 , C09D7/12 , C09C1/30 , C09C3/10
CPC分类号： C09C1/3081 , B82Y30/00 , C01G23/047 , C01P2004/64 , C01P2004/84 , C09C1/043 , C09C1/3684 , C09C1/40 , C09C3/12 , C09D5/1637 , C09D5/1687 , Y10T428/31507 , Y10T428/31544 , Y10T428/31663 , Y10T428/31678 , Y10T428/31721 , Y10T428/31739 , Y10T428/31786 , Y10T428/31855 , Y10T428/31935 , Y10T428/31938
摘要： Method for providing a substrate with an anti-biofouling coating the method comprising: a. obtaining a coating composition comprising nanoparticles being grafted with reactive groups and hydrophilic polymer chains and a solvent; b. applying the coating composition to the substrate; and c. optionally curing the coating composition. herein the surface tension of the coating composition at 25°C is below 40 mN/m.
摘要翻译：用于向基材提供抗生物污损涂层的方法，所述方法包括：a。获得包含用反应性基团和亲水性聚合物链和溶剂接枝的纳米颗粒的涂料组合物; 湾将涂料组合物施加到基材上; 和c。任选地固化涂料组合物。这里，涂料组合物在25℃下的表面张力低于40mN / m。

9. 发明申请

WO2009149258A2 CRYSTALLINE FORM OF 6-[(4S)-2-METHYL-4-(2-NAPHTHYL)-1,2,3,4-TETRAHYDROISOQUINOLIN-7-YL]PYRIDAZIN-3-AMINE 审中-公开
标题翻译： 6 - [（4S）-2-甲基-4-（2-萘基）-1,2,3,4-四氢喹啉-7-YL]吡啶-3-胺的晶体形式
公开(公告)号：WO2009149258A2
公开(公告)日：2009-12-10
申请号：PCT/US2009/046256
申请日：2009-06-04
申请人： BRISTOL-MYERS SQUIBB COMPANY , ALBANY MOLECULAR RESEARCH, INC. , QIU, Jun , GAO, Qi , LIU, Shuang , HU, Min , YANG, Yuh-lin, Allen , ISHERWOOD, Matthew , AMIN, Rasidul
发明人： QIU, Jun , GAO, Qi , LIU, Shuang , HU, Min , YANG, Yuh-lin, Allen , ISHERWOOD, Matthew , AMIN, Rasidul
IPC分类号： C07D401/04 , A61K31/497 , A61P3/04
CPC分类号： C07F5/04 , C07C215/20 , C07C217/58 , C07C223/02 , C07D217/04 , C07D237/20 , C07D401/04 , C07D413/10 , C07F5/022 , C07F5/025
摘要： The present disclosure generally relates to a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. The present disclosure also generally relates to pharmaceutical compositions comprising the crystalline form, as well of methods of using a crystalline form in the treatment of depression and other conditions and methods for obtaining such crystalline form.
摘要翻译：本公开内容通常涉及6 - [（4S）-2-甲基-4-（萘基）-1,2,3,4-四氢异喹啉-7-基]哒嗪-3-胺的结晶形式。本公开还通常涉及包含结晶形式的药物组合物，以及在治疗抑郁症和其它病症中使用结晶形式的方法以及获得这种结晶形式的方法。

10. 发明申请

WO2009074477A1 EXTRUSION PROCESS FOR GRAFTING RUBBERS 审中-公开
标题翻译：挤压挤出工艺
公开(公告)号：WO2009074477A1
公开(公告)日：2009-06-18
申请号：PCT/EP2008/066534
申请日：2008-12-01
申请人： DSM IP ASSETS B.V. , OLIVIER, Errol, Joseph , MEESSEN, Patric , HOUTVAST, Franciscus, Victoire, Paulus , GEESINK, Johannes, Hendrik , QIU, Jun
发明人： MEESSEN, Patric , HOUTVAST, Franciscus, Victoire, Paulus , GEESINK, Johannes, Hendrik , QIU, Jun
IPC分类号： C08F255/04 , B29C47/00 , B29C47/78 , C08F255/00 , C08F255/02
CPC分类号： C08F255/04 , B29C47/0011 , B29C47/822 , B29C47/8895 , C08F255/00 , C08F255/02 , C08F291/00
摘要： The invention relates to a process for producing a grafted rubber comprising: a) providing an ethylene propylene rubber having a weight average molecular weight (Mw) of at least 80 kg/mol in a continuous extrusion reactor by feeding the rubber in a slab/melt dosing unit and transporting the rubber to the continuous extrusion reactor by a melt pump; b) drying the rubber in the continuous extrusion reactor to a moisture content of between about 0.2 and about 0.5 wt%; c) providing the dried rubber to a first injection zone of the continuous extrusion reactor at a temperature of between 190 and 250°C, d) in the first injection zone, providing successively a first amount of maleic anhydride and a first free-radical initiator to the dried rubber; e) reacting maleic anhydride with the rubber in a first reaction zone of the continuous extrusion reactor to produce a grafted rubber; f) in a second injection zone, providing successively a second amount of maleic anhydride and a second free-radical initiator,the first and the second free radical initiator is an organic peroxide with a half-life (ty2) of more than 1 second if measured in mono-chlorobenzene at 220°C. g) applying shear to the grafted rubber in a second reaction zone of the continuous extrusion reactor, the shear sufficient to reduce the weight average molecular weight (Mw) of the grafted rubber by a factor of at least 2.
摘要翻译：本发明涉及一种生产接枝橡胶的方法，包括：a）在连续挤出反应器中通过将橡胶进料到板/熔体中提供重均分子量（Mw）至少为80kg / mol的乙丙橡胶并通过熔体泵将橡胶输送到连续挤出反应器; b）将连续挤出反应器中的橡胶干燥至约0.2至约0.5重量％的水分含量; c）在190-250℃的温度下将干燥的橡胶提供给连续挤出反应器的第一注入区，d）在第一注入区中，连续提供第一量的马来酸酐和第一自由基引发剂到干燥的橡胶; e）在连续挤出反应器的第一反应区中使马来酸酐与橡胶反应，生产接枝橡胶; f）在第二注射区域中，连续提供第二量的马来酸酐和第二自由基引发剂，第一和第二自由基引发剂是半衰期（ty2）大于1秒的有机过氧化物，如果在220℃的单氯苯中测定。 g）在连续挤出反应器的第二反应区中对接枝橡胶施加剪切力，剪切力足以将接枝橡胶的重均分子量（Mw）降低至少2倍。

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