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1. 发明申请

WO2010117457A3 SYSTEM COMPRISING DUAL-SIDED THERMAL CYCLER AND EMULSION PCR IN POUCH 审中-公开
标题翻译：系统包含双面热循环和乳液中的乳液PCR
公开(公告)号：WO2010117457A3
公开(公告)日：2011-03-24
申请号：PCT/US2010001053
申请日：2010-04-08
申请人： APPLIED BIOSYSTEMS LLC , LIU DAVID , YANG JOON MO , SHARIATI MARYAM , WOO SAM , COX DAVID M , LEHTO DENNIS
发明人： LIU DAVID , YANG JOON MO , SHARIATI MARYAM , WOO SAM , COX DAVID M , LEHTO DENNIS
IPC分类号： C12M1/38 , C12Q1/68
CPC分类号： B01F3/0807 , B01F7/161 , B01F7/22 , B01F2215/0422 , B01F2215/0431 , B01F2215/0481
摘要： A system and method are provided for large volume sample amplification adaptable for use with conventional PCR-based reactions as well as emulsion-based PCR reactions. A sample is retained in a pouch or flexible bag which permits bulk PCR amplification with efficient heat-transfer properties. For applications involving emulsion-based PCR amplification, the system and method provide improved uniformity in emulsion amplification and can be used to amplify large or small volume emulsions rapidly and reproducibly.
摘要翻译：提供适用于常规基于PCR的反应以及基于乳液的PCR反应的大体积样品扩增的系统和方法。将样品保留在袋或柔性袋中，其允许具有有效的热传递性质的大量PCR扩增。对于涉及基于乳液的PCR扩增的应用，该系统和方法提供了乳液扩增的改进的均匀性，并可用于快速和可重复地扩增大体积或小体积的乳液。

2. 发明申请

WO2011026128A2 FLOWCELLS AND METHODS OF FILLING AND USING SAME 审中-公开
标题翻译：流动和填充和使用相同的方法
公开(公告)号：WO2011026128A2
公开(公告)日：2011-03-03
申请号：PCT/US2010047377
申请日：2010-08-31
申请人： LIFE TECHNOLOGIES CORP , HIRANO KIRK , ANDERSEN MARK , GONG JIAN , WOO SAM , COX DAVID , YANG JOON MO , YUE MIN , SHARIATI MARYAM , BRIDGHAM JOHN , LIU DAVID
发明人： HIRANO KIRK , ANDERSEN MARK , GONG JIAN , WOO SAM , COX DAVID , YANG JOON MO , YUE MIN , SHARIATI MARYAM , BRIDGHAM JOHN , LIU DAVID
IPC分类号： B01J19/00 , B01L3/00 , G01N35/10
CPC分类号： C12Q1/6869 , B01F13/0059 , B01F13/0222 , B01J19/0046 , B01J2219/00317 , B01J2219/00466 , B01J2219/00527 , B01J2219/00576 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , B01L3/502707 , B01L3/50273 , B01L2200/027 , B01L2200/0647 , B01L2200/0684 , B01L2200/16 , B01L2300/0819 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/1822 , B01L2400/0427 , C12Q1/6874 , G01N35/00069 , G01N35/1002 , G01N35/1097 , G01N2035/00148 , G01N2035/00237 , G01N2035/1034 , G02B21/34 , Y10T436/11 , Y10T436/143333
摘要： Various flowcell configurations and systems are provided as are methods of making and using same. The flowcells, systems, and methods of use can be useful in carrying out sequencing reactions and next generation sequencing methods.
摘要翻译：提供了各种流通池配置和系统以及制造和使用它们的方法。流通池，系统和使用方法可用于进行测序反应和下一代测序方法。

3. 发明专利

IL278225D0 Anti-sez6 antibody drug conjugates and methods of use 未知
公开(公告)号：IL278225D0
公开(公告)日：2020-11-30
申请号：IL27822520
申请日：2020-10-21
申请人： ABBVIE STEMCENTRX LLC , GAVRILYUK JULIA , LIU DAVID , SCHAMMEL ALEXANDER
发明人： GAVRILYUK JULIA , LIU DAVID , SCHAMMEL ALEXANDER
IPC分类号： A61K47/68 , C07K16/28
摘要： Provided are novel anti-SEZ6 antibodies and antibody drug conjugates, and methods of using such anti-SEZ6 antibodies and antibody drug conjugates to treat cancer.

4. 发明申请

WO2010062678A3 MICRO-SPHERICAL POROUS BIOCOMPATIBLE SCAFFOLDS AND METHODS AND APPARATUS FOR FABRICATING SAME 审中-公开
标题翻译：微球形多孔生物相容性及其制备方法及装置
公开(公告)号：WO2010062678A3
公开(公告)日：2011-04-07
申请号：PCT/US2009062744
申请日：2009-10-30
申请人： LIU DAVID
发明人： LIU DAVID
IPC分类号： C08J9/28 , A61L27/18 , A61L27/56 , C08J9/26
CPC分类号： C08J9/26 , A61K9/0019 , A61K9/5031 , A61K9/5089 , A61K48/00 , A61K51/1255 , A61L24/0036 , A61L27/38 , A61L27/3834 , A61L27/3839 , A61L27/56 , A61L2430/36 , C08J9/28 , C08J2201/0446 , C08J2201/0544 , C08J2207/10 , C12N15/88
摘要： Provided herein are bimodal porous polymer microspheres comprising macropores and micropores. Also provided herein are methods and apparatus for fabrication such microspheres. Further provided herein are methods of using bimodal porous polymer microspheres.
摘要翻译：本文提供了包含大孔和微孔的双峰多孔聚合物微球。本文还提供了用于制造这种微球的方法和装置。本文还提供了使用双峰多孔聚合物微球的方法。

5. 发明申请

WO2012040410A3 METHOD AND SYSTEM FOR LIVER LESION DETECTION 审中-公开
标题翻译：肝脏检测方法与系统
公开(公告)号：WO2012040410A3
公开(公告)日：2012-04-19
申请号：PCT/US2011052675
申请日：2011-09-22
申请人： SIEMENS CORP , SIEMENS AG , LIU DAVID , WU DIJIA , ZHOU SHAOHUA KEVIN , COSTA MARIA JIMENA , SUEHLING MICHAEL , TIETJEN CHRISTIAN
发明人： LIU DAVID , WU DIJIA , ZHOU SHAOHUA KEVIN , COSTA MARIA JIMENA , SUEHLING MICHAEL , TIETJEN CHRISTIAN
IPC分类号： G06T7/00
CPC分类号： G06T7/0016 , G06T7/41 , G06T2207/10072 , G06T2207/20012 , G06T2207/20041 , G06T2207/20081 , G06T2207/20104 , G06T2207/30056
摘要： A method and system for automatically detecting liver lesions in medical image data, such as 3D CT images, is disclosed. A liver region is segmented in a 3D image. Liver lesion center candidates are detected in the segmented liver region. Lesion candidates are segmented corresponding to the liver lesion center candidates, and lesions are detected from the segmented lesion candidates using learning based verification.
摘要翻译：公开了一种用于自动检测医学图像数据中肝脏病变的方法和系统，如3D CT图像。肝脏区域被分割成3D图像。肝脏病变中心候选人在分段肝脏区域检测到。病变候选者对应于肝脏病变中心候选物，并且使用基于学习的验证从分割的病变候选物检测病变。

6. 发明申请

WO2007075438A2 POLYPEPTIDES COMPRISING UNNATURAL AMINO ACIDS, METHODS FOR THEIR PRODUCTION AND USES THEREFOR 审中-公开
标题翻译：包含非天然氨基酸的多肽及其制备方法和用途
公开(公告)号：WO2007075438A2
公开(公告)日：2007-07-05
申请号：PCT/US2006047949
申请日：2006-12-15
申请人： CODON DEVICES INC , CHURCH GEORGE , LIU DAVID
发明人： CHURCH GEORGE , LIU DAVID
IPC分类号： C12P21/02 , C12N9/00 , C12P13/00
CPC分类号： C12N9/93 , C12P21/02
摘要： Certain aspects of the present invention provide artificial polypeptides containing ; one or more unnatural amino acids and methods for producing and using the artificial polypeptides.
摘要翻译：本发明的某些方面提供了人造多肽，其含有; 一种或多种非天然氨基酸以及生产和使用人造多肽的方法。

7. 发明申请

WO2012040410A2 METHOD AND SYSTEM FOR LIVER LESION DETECTION 审中-公开
标题翻译：肝细胞检测方法和系统
公开(公告)号：WO2012040410A2
公开(公告)日：2012-03-29
申请号：PCT/US2011052675
申请日：2011-09-22
申请人： SIEMENS CORP , SIEMENS AG , LIU DAVID , WU DIJIA , ZHOU SHAOHUA KEVIN , COSTA MARIA JIMENA , SUEHLING MICHAEL , TIETJEN CHRISTIAN
发明人： LIU DAVID , WU DIJIA , ZHOU SHAOHUA KEVIN , COSTA MARIA JIMENA , SUEHLING MICHAEL , TIETJEN CHRISTIAN
IPC分类号： G06T7/00
CPC分类号： G06T7/0016 , G06T7/41 , G06T2207/10072 , G06T2207/20012 , G06T2207/20041 , G06T2207/20081 , G06T2207/20104 , G06T2207/30056
摘要： A method and system for automatically detecting liver lesions in medical image data, such as 3D CT images, is disclosed. A liver region is segmented in a 3D image. Liver lesion center candidates are detected in the segmented liver region. Lesion candidates are segmented corresponding to the liver lesion center candidates, and lesions are detected from the segmented lesion candidates using learning based verification.
摘要翻译：公开了一种用于自动检测医学图像数据（例如3D CT图像）中的肝脏病变的方法和系统。肝脏区域在3D图像中被分割。在分段的肝脏区域中检测到肝脏病变中心候选者。根据肝脏病变中心候选者对病变候选者进行分段，并且使用基于学习的验证从分段病变候选者中检测病变。

8. 发明申请

WO2006079061A3 FREE REACTANT USE IN NUCLEIC ACID-TEMPLATED SYNTHESIS 审中-公开
标题翻译：免费的反应物用于核酸模板合成
公开(公告)号：WO2006079061A3
公开(公告)日：2006-09-28
申请号：PCT/US2006002420
申请日：2006-01-20
申请人： HARVARD COLLEGE , LIU DAVID , SAKURAI KAORI
发明人： LIU DAVID , SAKURAI KAORI
IPC分类号： C12N15/10 , C12Q1/68
CPC分类号： C07H21/00 , C12N15/1068
摘要： The present invention provides methods and compositions for expanding the scope of chemical reactions that can be performed during nucleic acid-templated organic syntheses. In particular, nucleic acid-templated chemistries are used to produce reaction intermediates attached to an oligonucleotide that can be used to identify the reaction intermediates and/or the resulting reaction products. The reaction intermediates then are reacted with free reactants (for example, reactants that are difficult or impractical to couple to an oligonucleotide) to produce a reaction product. This approach expands the scope of reagents useful in nucleic acid-templated syntheses to reagents that do not need to be or cannot be tethered to an oligonucleotide. The reagents, however, still permit the synthesis of reaction products attached to oligonucleotides that can be used to identify the reaction products.
摘要翻译：本发明提供了用于扩大可在核酸模板化有机合成期间进行的化学反应的范围的方法和组合物。具体而言，使用核酸模板化学物质来生产连接至可用于鉴定反应中间体和/或所得反应产物的寡核苷酸的反应中间体。然后使反应中间体与游离反应物（例如难以或不实际耦合至寡核苷酸的反应物）反应以产生反应产物。该方法将用于核酸模板合成的试剂扩大到不需要或不能连接寡核苷酸的试剂。然而，这些试剂仍然允许合成与可用于鉴定反应产物的寡核苷酸相连的反应产物。

9. 发明申请

WO2005116213A3 DIRECTED EVOLUTION OF PROTEINS 审中-公开
标题翻译：蛋白质的指导性进化
公开(公告)号：WO2005116213A3
公开(公告)日：2006-11-09
申请号：PCT/US2005013051
申请日：2005-04-15
申请人： HARVARD COLLEGE , LIU DAVID , LIU JANE M , BITTKER JOSHUA A
发明人： LIU DAVID , LIU JANE M , BITTKER JOSHUA A
IPC分类号： C12N9/88 , C12N9/90 , C12N15/10 , C12N15/12 , C12Q1/68
CPC分类号： C12N15/1058 , C12N9/88 , C12N9/90 , C12N15/1027
摘要： Disclosed is a method of altering a nucleic acid such as RNA or DNA. The method comprises fragmenting a parent nucleic acid strand to generate nucleic acid fragments. At least a subset of the fragments are ligated to generate shuffled nucleic acid strands. A selected strand is identified from the shuffled nucleic acid strands for a criterion. The methods of the invention can also be used to diversify proteins.
摘要翻译：公开了一种改变核酸如RNA或DNA的方法。该方法包括将母体核酸链断裂以产生核酸片段。连接片段的至少一个子集以产生洗牌的核酸链。从洗牌的核酸链中鉴定出选择的链，用于标准。本发明的方法也可用于使蛋白多样化。

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