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1. 发明申请

WO2010117457A3 SYSTEM COMPRISING DUAL-SIDED THERMAL CYCLER AND EMULSION PCR IN POUCH 审中-公开
标题翻译：系统包含双面热循环和乳液中的乳液PCR
公开(公告)号：WO2010117457A3
公开(公告)日：2011-03-24
申请号：PCT/US2010001053
申请日：2010-04-08
申请人： APPLIED BIOSYSTEMS LLC , LIU DAVID , YANG JOON MO , SHARIATI MARYAM , WOO SAM , COX DAVID M , LEHTO DENNIS
发明人： LIU DAVID , YANG JOON MO , SHARIATI MARYAM , WOO SAM , COX DAVID M , LEHTO DENNIS
IPC分类号： C12M1/38 , C12Q1/68
CPC分类号： B01F3/0807 , B01F7/161 , B01F7/22 , B01F2215/0422 , B01F2215/0431 , B01F2215/0481
摘要： A system and method are provided for large volume sample amplification adaptable for use with conventional PCR-based reactions as well as emulsion-based PCR reactions. A sample is retained in a pouch or flexible bag which permits bulk PCR amplification with efficient heat-transfer properties. For applications involving emulsion-based PCR amplification, the system and method provide improved uniformity in emulsion amplification and can be used to amplify large or small volume emulsions rapidly and reproducibly.
摘要翻译：提供适用于常规基于PCR的反应以及基于乳液的PCR反应的大体积样品扩增的系统和方法。将样品保留在袋或柔性袋中，其允许具有有效的热传递性质的大量PCR扩增。对于涉及基于乳液的PCR扩增的应用，该系统和方法提供了乳液扩增的改进的均匀性，并可用于快速和可重复地扩增大体积或小体积的乳液。

2. 发明申请

WO2007024800A3 DEVICE AND METHOD FOR MAKING DISCRETE VOLUMES OF A FIRST FLUID IN CONTACT WITH A SECOND FLUID, WHICH ARE IMMISCIBLE WITH EACH OTHER 审中-公开
标题翻译：用于制造与第二流体接触的第一流体的离散体积的装置和方法，其与任何其它物质不相容
公开(公告)号：WO2007024800A3
公开(公告)日：2007-12-13
申请号：PCT/US2006032640
申请日：2006-08-22
申请人： APPLERA CORP , COX DAVID M , WOO SAM L , REEL RICHARD T , LEHTO DENNIS A , LEE LINDA G , WIYATNO WILLY , OLDHAM MARK F , NURSE JAMES C , GREINER DOUGLAS P , WOJTOWICZ JANUSZ B
发明人： COX DAVID M , WOO SAM L , REEL RICHARD T , LEHTO DENNIS A , LEE LINDA G , WIYATNO WILLY , OLDHAM MARK F , NURSE JAMES C , GREINER DOUGLAS P , WOJTOWICZ JANUSZ B
IPC分类号： E03B1/00 , B01F7/00 , B01F9/00 , C02F1/00 , G01N1/14 , G01N1/28 , G01N35/00
CPC分类号： C12Q1/6869 , B01J2219/00353 , B01J2219/0036 , B01J2219/00364 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00657 , B01J2219/00659 , B01L3/0293 , B01L3/502715 , B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2200/10 , B01L2300/0864 , B01L2300/0867 , B01L2400/0421 , B01L2400/0487 , C12Q1/6806 , C12Q1/6874 , F15C5/00 , F16K99/0001 , F16K99/0011 , F16K99/0013 , F16K2099/0084 , G01N1/14 , G01N27/44743 , G01N27/44769 , G01N35/08 , Y10T137/0318 , Y10T137/4259 , Y10T137/85978 , Y10T137/85986 , Y10T137/86863 , Y10T436/2575 , C12Q2535/101
摘要： Various embodiments described in the application relate to an apparatus, system, and method for generating, within a conduit, discrete volumes of one or more fluids that are immiscible with a second fluid. The discrete volumes can be used for biochemical or molecular biology procedures involving small volumes, for example, microliter-sized volumes, nanoliter-sized volumes, or smaller. The system can comprise an apparatus comprising at least one conduit operatively connected to one or more pumps for providing discrete volumes separated from one another by a fluid that is immiscible with the fluid(s) of the discrete volumes, for example, aqueous immiscible-fiuid-discrete volumes separated by an oil.
摘要翻译：在本申请中描述的各种实施例涉及用于在管道内产生与第二流体不混溶的一种或多种流体的离散体积的装置，系统和方法。离散体积可用于涉及小体积的生物化学或分子生物学过程，例如微升体积，纳升级体积或更小体积。该系统可以包括一个装置，该装置包括至少一个管道，其可操作地连接到一个或多个泵，用于通过与离散体积的流体不混溶的流体彼此分开的离散体积，例如含水混溶液 - 油分离体积。

3. 发明申请

WO2007024914A2 DEVICE AND METHOD FOR MICROFLUIDIC CONTROL OF A FIRST FLUID IN CONTACT WITH A SECOND FLUID, WHEREIN THE FIRST AND SECOND FLUIDS ARE IMMISCIBLE 审中-公开
标题翻译：第一流体与第二流体接触的第一流体的微流控制的装置和方法，其中第一和第二流体是不容易的
公开(公告)号：WO2007024914A2
公开(公告)日：2007-03-01
申请号：PCT/US2006032861
申请日：2006-08-22
申请人： APPLERA CORP , COX DAVID M , WOO SAM LEE , BOEGE STEVEN J , OLDHAM MARK F , REEL RICHARD T , NORDMAN ERIC S , LEE LINDA G , WIYATNO WILLY , SAGATELYAN DMITRY M
发明人： COX DAVID M , WOO SAM LEE , BOEGE STEVEN J , OLDHAM MARK F , REEL RICHARD T , NORDMAN ERIC S , LEE LINDA G , WIYATNO WILLY , SAGATELYAN DMITRY M
IPC分类号： B01D24/00
CPC分类号： C12Q1/6869 , B01J2219/00353 , B01J2219/0036 , B01J2219/00364 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00657 , B01J2219/00659 , B01L3/0293 , B01L3/502715 , B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2200/10 , B01L2300/0864 , B01L2300/0867 , B01L2400/0421 , B01L2400/0487 , C12Q1/6806 , C12Q1/6874 , F15C5/00 , F16K99/0001 , F16K99/0011 , F16K99/0013 , F16K2099/0084 , G01N1/14 , G01N27/44743 , G01N27/44769 , G01N35/08 , Y10T137/0318 , Y10T137/4259 , Y10T137/85978 , Y10T137/85986 , Y10T137/86863 , Y10T436/2575 , C12Q2535/101
摘要： Various embodiments described in the application relate to an apparatus, system, and method for fluidically controlling, within a conduit, discrete volumes of one or more fluids that are immiscible with a second fluid. The discrete volumes can be used for biochemical or molecular biology procedures involving small volumes, for example, microliter-sized volumes, nanoliter-sized volumes, or smaller. The system can comprise combinations of detectors, controllers, valves, and fluid supply units to control the spatial size, location and/or fluidic composition of discrete volumes separated from one another by a fluid that is immiscible with the fluid(s) of the discrete volumes, for example, aqueous immiscible-fluid-discrete volumes separated by an oil.
摘要翻译：在本申请中描述的各种实施例涉及用于在管道内流体控制与第二流体不混溶的一种或多种流体的离散体积的装置，系统和方法。离散体积可用于涉及小体积的生物化学或分子生物学过程，例如微升体积，纳升级体积或更小体积。该系统可以包括检测器，控制器，阀和流体供应单元的组合，以控制通过与离散的流体不混溶的流体彼此分离的离散体积的空间尺寸，位置和/或流体组成体积，例如由油分离的含水不混溶流体离散体积。

4. 发明申请

WO2007024798A3 APPARATUS, SYSTEM, AND METHOD USING IMMISCIBLE-FLUID-DISCRETE-VOLUMES 审中-公开
标题翻译：装置，系统和使用可疑流体分离体积的方法
公开(公告)号：WO2007024798A3
公开(公告)日：2009-04-30
申请号：PCT/US2006032637
申请日：2006-08-22
申请人： APPLERA CORP , LEE LINDA G , WOO SAM L , MA CONGCONG , REEL RICHARD T , OLDHAM MARK F , COX DAVID M , SCHROEDER BENJAMIN G , SORENSON JON M , WIYATNO WILLY
发明人： LEE LINDA G , WOO SAM L , MA CONGCONG , REEL RICHARD T , OLDHAM MARK F , COX DAVID M , SCHROEDER BENJAMIN G , SORENSON JON M , WIYATNO WILLY
IPC分类号： C12P19/34
CPC分类号： C12Q1/6869 , B01J2219/00353 , B01J2219/0036 , B01J2219/00364 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00657 , B01J2219/00659 , B01L3/0293 , B01L3/502715 , B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2200/10 , B01L2300/0864 , B01L2300/0867 , B01L2400/0421 , B01L2400/0487 , C12Q1/6806 , C12Q1/6874 , F15C5/00 , F16K99/0001 , F16K99/0011 , F16K99/0013 , F16K2099/0084 , G01N1/14 , G01N27/44743 , G01N27/44769 , G01N35/08 , Y10T137/0318 , Y10T137/4259 , Y10T137/85978 , Y10T137/85986 , Y10T137/86863 , Y10T436/2575 , C12Q2535/101
摘要： Various embodiments of the teachings relate to a system or method for sample preparation or analysis in biochemical or molecular biology procedures. The sample preparation can involve small volume processed in discrete portions or segments or slugs, herein referred to as discrete volumes. A molecular biology procedure can be nucleic acid analysis. Nucleic acid analysis can be an integrated DNA amplification/DNA sequencing procedure.
摘要翻译：本发明的各种实施方案涉及生物化学或分子生物学程序中用于样品制备或分析的系统或方法。样品制备可以涉及在离散部分或段或块中的小体积处理，在本文中称为离散体积。分子生物学程序可以是核酸分析。核酸分析可以是一个综合的DNA扩增/ DNA测序程序。

5. 发明申请

WO2010009426A3 DEVICES AND METHODS FOR REAGENT DELIVERY 审中-公开
标题翻译：用于试剂递送的装置和方法
公开(公告)号：WO2010009426A3
公开(公告)日：2010-04-01
申请号：PCT/US2009051041
申请日：2009-07-17
申请人： LIFE TECHNOLOGIES CORP , LEE LINDA G , WOO SAM L , COX DAVID M , LAU ALDRICH N K , REEL RICHARD T , VATTA PAOLO , YUE MIN
发明人： LEE LINDA G , WOO SAM L , COX DAVID M , LAU ALDRICH N K , REEL RICHARD T , VATTA PAOLO , YUE MIN
IPC分类号： C12M1/38 , C12Q1/68
CPC分类号： B01L3/0293 , B01L7/52 , B01L2400/0442 , B01L2400/0478 , B01L2400/0481 , G01N35/1002
摘要： A method for delivering reagent during a thermal cycling reaction may include placing a delivery device containing a reagent proximate to a reaction site, initiating a first stage of the reaction, wherein the first stage includes a period of an elevated temperature, and after completing the first stage of the reaction, dispensing the reagent from the delivery device to the reaction site, wherein the dispensing includes automatically actuating the delivery device to deliver the reagent.
摘要翻译：用于在热循环反应期间递送试剂的方法可以包括将包含试剂的递送装置放置在靠近反应位点的位置，引发反应的第一阶段，其中第一阶段包括升高的温度，并且在完成第一反应阶段将试剂从递送装置分配到反应部位，其中分配包括自动致动递送装置以输送试剂。

6. 发明申请

WO2005098417A3 LIQUID PROCESSING DEVICE INCLUDING GAS TRAP, AND SYSTEM AND METHOD 审中-公开
标题翻译：包括气体捕获的液体加工装置，以及系统和方法
公开(公告)号：WO2005098417A3
公开(公告)日：2007-02-01
申请号：PCT/US2005009261
申请日：2005-03-21
申请人： APPLERA CORP , COX DAVID M
发明人： COX DAVID M
IPC分类号： G01N15/06 , B01L3/00 , G01N31/22
CPC分类号： B01L3/502738 , B01L2300/0803 , B01L2300/0864 , B01L2300/087 , B01L2400/0409 , B01L2400/0487 , B01L2400/0683 , Y10T436/11 , Y10T436/111666
摘要： A device is provided that can include at least one gas trap that can be arranged in fluid communication with a sample-containment feature formed in or on the device. The has trap can be arranged to trap gas or air displaced from the sample-containment feature as the sample-containment feature is loaded with a liquid. The trapped gas in the gas trap can assist in breaking-up and expelling the liquid from the sample-containment feature during a subsequent liquid transfer operation, for example, to an adjacent samplecontainment feature. Systems for processing such a device and methods using such a device are also provided.
摘要翻译：提供了一种装置，其可以包括至少一个气体捕集器，其可以被布置成与形成在装置中或装置上的样品容纳特征流体连通。具有捕集器可以布置成当样品容纳特征装载有液体时捕获从样品容纳特征中移位的气体或空气。在随后的液体转移操作期间，气阱中的被捕获的气体可以有助于分离和排出来自样品容纳特征的液体，例如到相邻的样品保持特征。还提供了用于处理这种设备的系统和使用这种设备的方法。

7. 发明申请

WO2007087239A3 MICROARRAY MICROCARD 审中-公开
公开(公告)号：WO2007087239A3
公开(公告)日：2007-12-06
申请号：PCT/US2007001573
申请日：2007-01-22
申请人： APPLERA CORP , COX DAVID M
发明人： COX DAVID M
IPC分类号： C12Q1/68
CPC分类号： B01L3/502738 , B01L7/52 , B01L2300/0636 , B01L2300/0803 , B01L2300/087 , B01L2400/0409 , B01L2400/0655
摘要： A fluid processing device is provided that comprises a substrate including a surface and a fluid processing pathway at least partially formed in or on the surface. The fluid processing pathway can comprise a channel, a reaction region in fluid communication with the channel, a microarray in fluid communication with the channel, and optionally a deformable valve. The microarray can comprise binding and/or detection sites, and each site can comprise a binding moiety. A method and a system using the fluid processing device, are also provided.
摘要翻译：提供了流体处理装置，其包括具有表面和至少部分地形成在表面中或表面上的流体处理通道的衬底。流体处理通路可以包括通道，与通道流体连通的反应区域，与通道流体连通的微阵列，以及可选的可变形阀。微阵列可以包含结合和/或检测位点，并且每个位点可以包含结合部分。还提供了使用流体处理装置的方法和系统。

8. 发明申请

WO2005097324A2 MICROFLUIDIC DEVICE INCLUDING DISPLACEABLE MATERIAL TRAP, AND SYSTEM 审中-公开
标题翻译：微流体装置，包括可摆放的材料夹和系统
公开(公告)号：WO2005097324A2
公开(公告)日：2005-10-20
申请号：PCT/US2005009260
申请日：2005-03-21
申请人： APPLERA CORP , COX DAVID M , DESMOND SEAN M
发明人： COX DAVID M , DESMOND SEAN M
IPC分类号： B01L3/00 , F16K99/00
CPC分类号： F16K99/0015 , B01L3/5025 , B01L3/502738 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/0684 , B01L2200/10 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0406 , B01L2400/0409 , B01L2400/0655 , B01L2400/0677 , B01L2400/0683 , B01L2400/086 , F16K99/0001 , Y10T137/1624 , Y10T137/8593
摘要： A microfluidic device is provided that can include at least one trap for receiving displaceable adhesion material displaced during a closing operation of a deformable valve. The trap can be formed as a recess or chamber in a substrate of the microfluidic device. A system including a deformer for opening such a valve is also provided as are methods of opening such a valve.
摘要翻译：提供了一种微流体装置，其可以包括至少一个捕集器，用于接收在可变形阀的关闭操作期间移动的可移位粘合材料。捕集器可以形成为微流体装置的衬底中的凹部或室。包括用于打开这种阀的变形器的系统也被设置为打开这种阀的方法。

9. 发明申请

WO2007024417A3 FLUID PROCESSING DEVICE, SYSTEM, KIT, AND METHOD 审中-公开
标题翻译：流体处理装置，系统，工具包和方法
公开(公告)号：WO2007024417A3
公开(公告)日：2007-11-22
申请号：PCT/US2006029689
申请日：2006-07-31
申请人： APPLERA CORP , COX DAVID M , VAN BUSKIRK DANIEL , LAKDAWALLA ABIZAR
发明人： COX DAVID M , VAN BUSKIRK DANIEL , LAKDAWALLA ABIZAR
IPC分类号： C12M1/14 , C12M3/04
CPC分类号： B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L7/52 , B01L2200/027 , B01L2200/0689 , B01L2300/044 , B01L2300/0672 , B01L2300/0816 , B01L2300/0887 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487
摘要： A fluid processing device, system, kit, and method, are provided, for processing a liquid sample. The device can comprise a substrate comprising one or more fluid processing pathways, wherein each pathway can comprise at least a first region, one or more outlet regions, and a channel connecting and in fluid communication with the respective first region and the respective one or more outlet regions, and a cover provided in communication with at least a portion of the top surface of the substrate. The cover can comprise one or more slits each slit respectively aligned with a different respective one of the one or more outlet regions. A removal seal can be applied to the cover to seal the one or more slits.
摘要翻译：提供流体处理装置，系统，试剂盒和方法，用于处理液体样品。该装置可以包括包括一个或多个流体处理路径的基底，其中每个通路可以包括至少第一区域，一个或多个出口区域和与相应的第一区域和相应的一个或多个流体连通并与其流体连通的通道出口区域，以及设置成与所述基板的顶表面的至少一部分连通的盖。盖可以包括一个或多个狭缝，每个狭缝分别与一个或多个出口区域中的不同相应的一个对齐。移除密封件可以施加到盖子上以密封一个或多个狭缝。

10. 发明申请

WO2006025929A3 THERMAL DEVICE, SYSTEM, AND METHOD, FOR FLUID PROCESSING DEVICE 审中-公开
标题翻译：用于流体加工装置的热装置，系统和方法
公开(公告)号：WO2006025929A3
公开(公告)日：2007-04-19
申请号：PCT/US2005022628
申请日：2005-06-23
申请人： APPLERA CORP , SHIGEURA JANICE S , DESMOND SEAN M , COX DAVID M
发明人： DESMOND SEAN M , COX DAVID M , SHIGEURA JOHN S
IPC分类号： G05D23/00
CPC分类号： G05D23/24 , G05D23/192 , G05D23/20 , G05D23/22 , Y02P20/129 , Y10S435/809
摘要： A device, system, and method are provided for thermally treating a fluid processing device. According to various embodiments, a system is provided that can include a thermal device and a fluid processing device holder. The thermal device can include a first block having a thermal conductivity greater than 0.5 Watt per centimeter Kelvin (W/cm K), a second block having a thermal conductivity greater than 0.5 W/cm K, and a heat-pump device disposed between the first block and the second block. The heat-pump device can transfer thermal energy from at least one of the first block and the second block to the other of the first block and the second block. The fluid processing device holder can hold a fluid processing device in a heat-transfer position with respect to the first block and the second block. The fluid processing device can be a microfluidic device.
摘要翻译：提供了用于热处理流体处理装置的装置，系统和方法。根据各种实施例，提供一种可以包括热装置和流体处理装置支架的系统。热装置可以包括具有大于0.5瓦/厘米开尔文（W / cm K）的热导率的第一块，具有大于0.5W / cm K的热导率的第二块，以及设置在第一块和第二块。热泵装置可以将热能从第一块和第二块中的至少一个传递到第一块和第二块中的另一个块。流体处理装置保持器可以将流体处理装置保持在相对于第一块和第二块的热传递位置。流体处理装置可以是微流体装置。

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