专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2014039429A1 METHODS OF TISSUE GENERATION 审中-公开
标题翻译：组织生成方法
公开(公告)号：WO2014039429A1
公开(公告)日：2014-03-13
申请号：PCT/US2013/057806
申请日：2013-09-03
申请人： ANTHROGENESIS CORPORATION
发明人： BHATIA, Mohit B. , HARIRI, Robert J. , HOFGARTNER, Wolfgang , WANG, Jia-Lun , YE, Qian
IPC分类号： A61L27/38
CPC分类号： A61K35/12 , A61L27/18 , A61L27/3633 , A61L27/38 , A61L27/56 , C08L67/04
摘要： Provided herein are methods for forming three-dimensional tissues in vivo. In one embodiment, provided herein is a method for forming a three-dimensional tissue in vivo, comprising depositing on a surface that is in or on a subject at least one composition that comprises cells. In another embodiment, provided herein is a method for forming a three-dimensional tissue in vivo, comprising depositing on a surface that is in or on a subject at least one composition that comprises cells and at least one composition that comprises an extracellular matrix (ECM). In another embodiment, provided herein is a method for forming a three-dimensional tissue in vivo, comprising depositing on a surface that is in or on a subject at least one composition that comprises cells, at least one composition that comprises an extracellular matrix (ECM), and at least one other additional components.
摘要翻译：本文提供了在体内形成三维组织的方法。在一个实施方案中，本文提供了一种用于在体内形成三维组织的方法，其包括在至少一种包含细胞的组合物上沉积在受试者或受试者的表面上。在另一个实施方案中，本文提供了一种用于在体内形成三维组织的方法，其包括沉积在受试者或受试者的表面上，所述表面包含至少一种包含细胞的组合物和至少一种包含细胞外基质（ECM ）。在另一个实施方案中，本文提供了一种用于在体内形成三维组织的方法，其包括在至少一种包含细胞的组合物的至少一种包含细胞外基质（ECM））和至少一个其它附加组件。

2. 发明公开

EP3103462A1 TREATMENT OF INFLAMMATORY DISEASES USING PLACENTAL STEM CELLS 无效转让
标题翻译：白炽灯INFEKTIONSKRANKHEITEN MITHILFE VON PLAZENTA-STAMMZELLEN
公开(公告)号：EP3103462A1
公开(公告)日：2016-12-14
申请号：EP16166462.8
申请日：2008-02-12
申请人： Anthrogenesis Corporation
发明人： HARIRI, Robert J. , Edinger, James , WANG, Jia-Lun , Ye, Qian , Faleck, Herbert
IPC分类号： A61K35/44 , A61K35/50 , A61K35/64 , A61K35/644 , A61K38/21 , A61P37/06 , A61K45/06 , A61K35/12 , A61P1/00 , A61P1/12 , C12N5/073
CPC分类号： A61K35/50 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N2500/25 , C12N2500/36 , C12N2501/11 , C12N2501/135 , C12N2501/39 , A61K2300/00
摘要： The invention provides a composition comprising a matrix or a hydrogel and CD10 + , CD34 - , CD105 + , CD200 + placental stem cells for use in a method for treatment of inflammatory bowel disease, wherein the method comprises administering said composition in a therapeutically effective amount that is sufficient to cause a detectable improvement in one or more symptoms of said inflammatory bowel disease.
摘要翻译：本发明提供一种组合物，其包含用于治疗炎症性肠病的方法的基质或水凝胶和CD10 +，CD34 - ，CD105 +，CD200 +胎盘干细胞，其中所述方法包括以治疗有效量施用所述组合物这足以引起所述炎症性肠病的一种或多种症状的可检测的改善。

3. 发明公开

EP3068432A2 COMPOSITIONS COMPRISING HUMAN PLACENTAL PERFUSATE CELLS, SUBPOPULATIONS THEREOF, AND THEIR USES 审中-实审转让
标题翻译：与人群PLAZENTAPERFUSATZELLEN组合物，亚群体和其用途
公开(公告)号：EP3068432A2
公开(公告)日：2016-09-21
申请号：EP14862931.4
申请日：2014-11-14
申请人： Anthrogenesis Corporation
发明人： GURNEY, Jodi P. , ZHANG, Xiaokui , HERB, Stacy , HARIRI, Robert J.
IPC分类号： A61K45/00
CPC分类号： A61K35/50 , A61K35/28 , A61K2035/124
摘要： Provided herein are compositions comprising mononuclear cells from human placental perfusate and methods of using such cells, including using the cells together with hematopoietic cells, for example to establish chimerism, reduce the severity or duration of graft versus host disease, treat or ameliorate symptoms of sarcopenia, metabolic disorders and hematologic disorders, such as hematologic malignancies, and treat or ameliorate symptoms of ischemic encephalopathy (e.g., hypoxic ischemic encephalopathy) and other central nervous system injuries.

4. 发明授权

EP1349918B1 METHOD OF COLLECTING PLACENTAL STEM CELLS 有权
标题翻译：回收方法PLAZENTÄRER干细胞
公开(公告)号：EP1349918B1
公开(公告)日：2014-08-06
申请号：EP01999637.0
申请日：2001-12-05
申请人： Anthrogenesis Corporation
发明人： HARIRI, Robert J.
IPC分类号： C12N5/0775 , C12N5/073
CPC分类号： C12N5/0605 , A01N1/021 , A61K35/12 , A61K35/50 , A61K48/00 , A61K2035/124 , A61M1/02 , A61M2202/0462 , A61M2210/1458 , A61M2210/1466 , C12M29/10 , C12M47/04 , C12N5/0603 , C12N5/0647 , C12N5/0668 , C12N2509/00 , C12N2510/02 , C12N2533/90
摘要： A method of collecting embryonic-like stem cells from a placenta which has been treated to remove residual cord blood by perfusing the drained placenta with an anticoagulant solution to flush out residual cells, collecting the residual cells and perfusion liquid from the drained placenta, and separating the embryonic-like cells from the residual cells and perfusion liquid. Exogenous cells can be propagated in the placental bioreactor and bioactive molecules collected therefrom.

5. 发明公开

EP2084268A2 METHODS AND COMPOSITIONS FOR TREATMENT OF BONE DEFECTS WITH PLACENTAL CELL POPULATIONS 有权转让
标题翻译：方法和组合物的骨缺损胎盘细胞群治疗
公开(公告)号：EP2084268A2
公开(公告)日：2009-08-05
申请号：EP07867275.5
申请日：2007-10-23
申请人： Anthrogenesis Corporation
发明人： EDINGER, James W. , HARIRI, Robert J. , WANG, Jia-Lun , YE, Qian , LABAZZO, Kristen S. , PEREIRA, Marian , ABRAMSON, Sascha Dawn
IPC分类号： C12N5/08 , A61K35/50 , A61L27/38 , A61F2/28 , A61P19/00
CPC分类号： A61K35/50 , A61K9/0019 , A61K35/12 , A61K47/36 , A61K47/42 , A61L27/3834 , A61L27/3847 , C12N5/0605 , C12N5/0654 , C12N5/0668 , C12N2500/38 , C12N2500/42 , C12N2501/39 , C12N2506/025 , C12N2506/03 , C12N2533/18 , C12N2533/54
摘要： Provided herein are methods of using adherent placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. Also provided herein are methods of differentiating the placental stem cells. Further provided herein are methods of using the placental stem cells to formulate implantable or injectable compositions suitable for administration to a subject. Still further provided herein are provides methods for treating bone defects with stem cells and compositions comprising stem cells.
摘要翻译：提供在使用胎盘粘附干细胞和胎盘干细胞群，培养和方法，增殖和扩展的方法。因此，在鉴别是提供的胎盘干细胞的方法。进一步提供了使用所述胎盘干细胞配制的可植入或可注射的组合物适合于施用于受试者的方法。仍然进一步提供的是在提供了用于治疗骨缺损的干细胞和组合物，包含干细胞的方法。

6. 发明授权

EP2892577B1 METHODS OF TISSUE GENERATION 有权
公开(公告)号：EP2892577B1
公开(公告)日：2019-01-30
申请号：EP13835980.7
申请日：2013-09-03
申请人： Anthrogenesis Corporation
发明人： BHATIA, Mohit B. , HARIRI, Robert J. , HOFGARTNER, Wolfgang , WANG, Jia-Lun , YE, Qian
IPC分类号： A61L27/38

7. 发明公开

EP3299452A1 METHOD OF COLLECTING PLACENTAL STEM CELLS 审中-公开
标题翻译：收集胎盘干细胞的方法
公开(公告)号：EP3299452A1
公开(公告)日：2018-03-28
申请号：EP17185781.6
申请日：2001-12-05
申请人： Anthrogenesis Corporation
发明人： HARIRI, Robert J.
IPC分类号： C12N5/077
CPC分类号： C12N5/0605 , A01N1/021 , A61K35/12 , A61K35/50 , A61K48/00 , A61K2035/124 , A61M1/02 , A61M2202/0462 , A61M2210/1458 , A61M2210/1466 , C12M29/10 , C12M47/04 , C12N5/0603 , C12N5/0647 , C12N5/0668 , C12N2509/00 , C12N2510/02 , C12N2533/90
摘要： The invention provides methods of collecting embryonic-like stem cells from a placenta which has been treated to remove residual cord blood. The methods comprise perfusing a placenta which has been drained of cord blood with an anticoagulant perfusion solution to flush out residual cells and embryonic-like stem cells from said drained placenta, and collecting said residual cells and embryonic-like stem cells and perfusion solution from the drained placenta.
摘要翻译：本发明提供了从胎盘中收集胚胎样干细胞的方法，该胎盘已经被处理以除去残留的脐带血。所述方法包括用抗凝灌注液灌注已经排出脐带血的胎盘以从所述排出的胎盘中冲走残余细胞和胚胎样干细胞，并从所述残留细胞和胚胎样干细胞中收集所述残余细胞和灌注溶液排水胎盘。

8. 发明公开

EP3104865A1 MICRO-ORGANOIDS, AND METHODS OF MAKING AND USING THE SAME 无效转让
标题翻译： MICRO类器官和方法进行生产及其用途
公开(公告)号：EP3104865A1
公开(公告)日：2016-12-21
申请号：EP15749333.9
申请日：2015-02-10
申请人： Anthrogenesis Corporation
发明人： WANG, Jia-Lun , BHATIA, Mohit B. , HARIRI, Robert J. , HOFGARTNER, Wolfgang , YE, Qian
IPC分类号： A61K35/12 , C12N5/00
CPC分类号： A61K35/17 , A61K35/28 , A61K35/30 , A61K35/32 , A61K35/36 , A61K35/39 , A61K35/407 , A61K35/44 , A61K35/50 , C12N5/0062 , A61K2300/00
摘要： Provided herein are micro-organoids, referred to herein as Functional Physiological Units (FPUs), that are capable of replacing or augmenting one or more physiological functions in an individual, which are useful in the treatment of individuals lacking, or suffering a deficit in, said physiological function.

9. 发明公开

EP2892577A1 METHODS OF TISSUE GENERATION 审中-公开
标题翻译：方法的组织生成
公开(公告)号：EP2892577A1
公开(公告)日：2015-07-15
申请号：EP13835980.7
申请日：2013-09-03
申请人： Anthrogenesis Corporation
发明人： BHATIA, Mohit B. , HARIRI, Robert J. , HOFGARTNER, Wolfgang , WANG, Jia-Lun , YE, Qian
IPC分类号： A61L27/38
CPC分类号： A61K35/12 , A61L27/18 , A61L27/3633 , A61L27/38 , A61L27/56 , C08L67/04
摘要： Provided herein are methods for forming three-dimensional tissues in vivo. In one embodiment, provided herein is a method for forming a three-dimensional tissue in vivo, comprising depositing on a surface that is in or on a subject at least one composition that comprises cells. In another embodiment, provided herein is a method for forming a three-dimensional tissue in vivo, comprising depositing on a surface that is in or on a subject at least one composition that comprises cells and at least one composition that comprises an extracellular matrix (ECM). In another embodiment, provided herein is a method for forming a three-dimensional tissue in vivo, comprising depositing on a surface that is in or on a subject at least one composition that comprises cells, at least one composition that comprises an extracellular matrix (ECM), and at least one other additional components.

10. 发明授权

EP1362095B1 POST-PARTUM MAMMALIAN PLACENTA, ITS USE AND PLACENTAL STEM CELLS THEREFROM 有权
标题翻译：产后哺乳动物胎盘，其使用并获得干细胞
公开(公告)号：EP1362095B1
公开(公告)日：2015-05-27
申请号：EP02720974.1
申请日：2002-02-13
申请人： Anthrogenesis Corporation
发明人： HARIRI, Robert J.
IPC分类号： C12N5/071 , C12N5/0789
CPC分类号： C12N5/0605 , A61K35/12 , A61K48/00 , A61M1/02 , A61M2202/0462 , A61M2210/1458 , A61M2210/1466 , C12N5/0068 , C12N2500/90 , C12N2509/00 , C12N2533/90
摘要： The present invention provides a method of extracting and recovering embryonic like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to move residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method of utilizing the isolated and perfused placenta as a bioreactor in which to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagation of exogenous cells in a placental bioreactor and collecting the propagated exogenous cells and bioactive molecules therefrom.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式