专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009111056A1 CONFORMATIONALLY CONSTRAINED CARBOXYLIC ACID DERIVATIVES USEFUL FOR TREATING METABOLIC DISORDERS 审中-公开
标题翻译：适用于治疗代谢障碍的有约束力的羧酸衍生物
公开(公告)号：WO2009111056A1
公开(公告)日：2009-09-11
申请号：PCT/US2009/001435
申请日：2009-03-04
申请人： AMGEN INC. , BROWN, Sean, P. , DRANSFIELD, Paul, J. , HOUZE, Jonathan , KOHN, Todd, J. , LIU, Jiwen , MEDINA, Julio , PATTAROPONG, Vatee , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , YU, Ming , ZHU, Liusheng
发明人： BROWN, Sean, P. , DRANSFIELD, Paul, J. , HOUZE, Jonathan , KOHN, Todd, J. , LIU, Jiwen , MEDINA, Julio , PATTAROPONG, Vatee , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , YU, Ming , ZHU, Liusheng
IPC分类号： C07C59/72 , C07D213/64 , A61K31/192 , A61P3/10 , A61P9/00 , A61K31/435
CPC分类号： C07C59/72
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I or the general formula III: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式I或通式III：其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

2. 发明申请

WO2009048527A1 SUBSTITUTED BIPHENYL GPR40 MODULATORS 审中-公开
标题翻译：取代的BIPHENYL GPR40调节器
公开(公告)号：WO2009048527A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/011422
申请日：2008-10-03
申请人： AMGEN INC. , KIM, Yong-Jae , BROWN, Sean, P. , CAO, Qiong , DRANSFIELD, Paul, J. , DU, Xiaohui , HOUZE, Jonathan , JIAO, Xian Yun , KOHN, Todd, J. , LAI, Sujen , LI, An-Rong , LIN, Daniel , LUO, Jian , MEDINA, Julio, C. , REAGAN, Jeffrey, D. , PATTAROPONG, Vatee , SCHWARZ, Margrit , SHEN, Wang , SU, Yongli , SWAMINATH, Gayathri , VIMOLRATANA, Marc , WANG, Xiang , XIONG, Yumei , YANG, Li , YU, Ming , ZHANG, Jie , ZHU, Liusheng
发明人： KIM, Yong-Jae , BROWN, Sean, P. , CAO, Qiong , DRANSFIELD, Paul, J. , DU, Xiaohui , HOUZE, Jonathan , JIAO, Xian Yun , KOHN, Todd, J. , LAI, Sujen , LI, An-Rong , LIN, Daniel , LUO, Jian , MEDINA, Julio, C. , REAGAN, Jeffrey, D. , PATTAROPONG, Vatee , SCHWARZ, Margrit , SHEN, Wang , SU, Yongli , SWAMINATH, Gayathri , VIMOLRATANA, Marc , WANG, Xiang , XIONG, Yumei , YANG, Li , YU, Ming , ZHANG, Jie , ZHU, Liusheng
IPC分类号： C07C59/68 , C07C217/54 , C07C323/19 , C07D213/64 , A61K31/192 , A61K31/4415 , A61P3/10
CPC分类号： C07C323/62 , C07C59/68 , C07C59/72 , C07C217/54 , C07C217/62 , C07C317/22 , C07C323/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D213/64 , C07D309/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式I：其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

3. 发明申请

WO2010045258A2 SPIROCYCLIC GPR40 MODULATORS 审中-公开
标题翻译：螺旋GPR40调制器
公开(公告)号：WO2010045258A2
公开(公告)日：2010-04-22
申请号：PCT/US2009/060549
申请日：2009-10-13
申请人： AMGEN INC. , BROWN, Sean P. , DRANSFIELD, Paul , DU, Xiaohui , FU, Zice , HOUZE, Jonathan , JIAO, XianYun , LAI, SuJen , LI, An-Rong , LIU, Jiwen , MA, Zhihua , MEDINA, Julio C. , PATTAROPONG, Vatee , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , WANG, Zhongyu , YU, Ming , ZHU, Liusheng
发明人： BROWN, Sean P. , DRANSFIELD, Paul , DU, Xiaohui , FU, Zice , HOUZE, Jonathan , JIAO, XianYun , LAI, SuJen , LI, An-Rong , LIU, Jiwen , MA, Zhihua , MEDINA, Julio C. , PATTAROPONG, Vatee , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , WANG, Zhongyu , YU, Ming , ZHU, Liusheng
IPC分类号： C07C62/34 , C07D249/00 , C07D277/00 , C07D311/00 , C07D231/00 , C07D271/00 , C07D221/00
CPC分类号： C07C62/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/643 , C07D217/24 , C07D253/065 , C07D277/22 , C07D311/04 , C07D401/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I'A or I'B, where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式IA，IB，I'A或I'B，其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

4. 发明申请

WO2008030618A1 BENZO-FUSED COMPOUNDS FOR USE IN TREATING METABOLIC DISORDERS 审中-公开
标题翻译：用于治疗代谢性疾病的苯并呋喃化合物
公开(公告)号：WO2008030618A1
公开(公告)日：2008-03-13
申请号：PCT/US2007/019662
申请日：2007-09-06
申请人： AMGEN INC. , BROWN, Sean P. , DRANSFIELD, Paul , HOUZE, Jonathan B. , LIU, Jinqian , LIU, Jiwen , MA, Zhihua , MEDINA, Julio C. , PATTAROPONG, Vatee , SCHMITT, Michael J. , SHARMA, Rajiv , WANG, Yingcai
发明人： BROWN, Sean P. , DRANSFIELD, Paul , HOUZE, Jonathan B. , LIU, Jinqian , LIU, Jiwen , MA, Zhihua , MEDINA, Julio C. , PATTAROPONG, Vatee , SCHMITT, Michael J. , SHARMA, Rajiv , WANG, Yingcai
IPC分类号： C07D213/55 , C07D231/12 , C07D233/64 , C07D239/26 , C07D249/10 , C07D257/04 , C07D261/08 , C07D263/32 , C07D285/12 , C07D333/24 , C07D207/327 , C07D277/587 , C07C59/72 , C07C233/65 , A61K31/192 , A61K31/40
CPC分类号： C07D233/64 , C07C51/09 , C07C51/367 , C07C51/47 , C07C235/34 , C07C2602/10 , C07D207/327 , C07D213/55 , C07D231/12 , C07D239/26 , C07D249/10 , C07D257/04 , C07D261/08 , C07D263/32 , C07D277/587 , C07D285/12 , C07D333/24 , C07C59/72
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables Q, L 1 , ℗, L 2 , M, X, L 3 , and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式I：其中变量Q，L 1，...，L 2，M，X，L 3，...的定义 >和A。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

5. 发明申请

WO2008130514A1 SUBSTITUTED BIPHENYL PHENOXY-, THIOPHENYL- AND AMINOPHENYLPROPANOIC ACID GPR40 MODULATORS 审中-公开
标题翻译：取代二苯基苯氧基 - ，十二烯基和氨基亚氨基丙酸GPR40调节剂
公开(公告)号：WO2008130514A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/004701
申请日：2008-04-10
申请人： AMGEN INC. , BROWN, Sean, P. , DRANSFIELD, Paul , FU, Zice , HOUZE, Jonathan , JIAO, Xian, Yun , KOHN, Todd, J. , PATTAROPONG, Vatee , VIMOLRATANA, Marc , SCHMITT, Michael, J.
发明人： BROWN, Sean, P. , DRANSFIELD, Paul , FU, Zice , HOUZE, Jonathan , JIAO, Xian, Yun , KOHN, Todd, J. , PATTAROPONG, Vatee , VIMOLRATANA, Marc , SCHMITT, Michael, J.
IPC分类号： C07C59/68 , C07C59/72 , C07D261/08 , A61K31/41 , A61K31/19 , A61P3/00
CPC分类号： C07C59/68 , C07C59/72 , C07D261/08
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula (I) where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式（I），其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

6. 发明申请

WO2010151737A2 HETEROCYCLIC COMPOUNDS AND THEIR USES 审中-公开
公开(公告)号：WO2010151737A2
公开(公告)日：2010-12-29
申请号：PCT/US2010/039937
申请日：2010-06-25
申请人： AMGEN INC. , BROWN, Matthew , CHEN, Yi , CUSHING, Timothy D. , GONZALEZ LOPEZ DE TURISO, Felix , HE, Xiao , KOHN, Todd J. , LOHMAN, Julia Winslow , PATTAROPONG, Vatee , SEGANISH, Jennifer , SHIN, Youngsook , SIMARD, Jillian L.
发明人： BROWN, Matthew , CHEN, Yi , CUSHING, Timothy D. , GONZALEZ LOPEZ DE TURISO, Felix , HE, Xiao , KOHN, Todd J. , LOHMAN, Julia Winslow , PATTAROPONG, Vatee , SEGANISH, Jennifer , SHIN, Youngsook , SIMARD, Jillian L.
IPC分类号： C07D401/14
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D491/107 , C07D491/113 , C07D491/20 , C07D495/10 , C07D513/04
摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

7. 发明申请

WO2012003283A1 HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY 审中-公开
标题翻译：杂环化合物及其作为PI3K活性抑制剂的用途
公开(公告)号：WO2012003283A1
公开(公告)日：2012-01-05
申请号：PCT/US2011/042539
申请日：2011-06-30
申请人： AMGEN INC. , DRANSFIELD, Paul, John , GONZALEZ LOPEZ DE TURISO, Felix , KOHN, Todd, J. , PATTAROPONG, Vatee , SIMARD, Jillian, L.
发明人： DRANSFIELD, Paul, John , GONZALEZ LOPEZ DE TURISO, Felix , KOHN, Todd, J. , PATTAROPONG, Vatee , SIMARD, Jillian, L.
IPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D491/107 , A61K31/4709 , A61K31/4375 , A61P35/00 , A61P29/00
CPC分类号： C07D471/04 , A61K31/4375 , A61K31/4709 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/107
摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
摘要翻译：取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎性病症不限于自身免疫疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏症状包括但不限于白血病，如急性骨髓性白血病（AML）骨髓增生异常综合征（MDS）骨髓增殖性疾病（MPD）慢性骨髓性白血病（MPD），慢性骨髓性白血病 C ML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

8. 发明申请

WO2012003264A1 NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS AS PIK3 -DELTA INHIBITORS 审中-公开
标题翻译：含有杂环化合物的硝酸盐作为PIK3-抑制剂
公开(公告)号：WO2012003264A1
公开(公告)日：2012-01-05
申请号：PCT/US2011/042506
申请日：2011-06-30
申请人： AMGEN INC. , DRANSFIELD, Paul John , GONZALEZ LOPEZ DE TURISO, Felix , PATTAROPONG, Vatee , SIMARD, Jillian L.
发明人： DRANSFIELD, Paul John , GONZALEZ LOPEZ DE TURISO, Felix , PATTAROPONG, Vatee , SIMARD, Jillian L.
IPC分类号： C07D401/14 , C07D473/16 , A61K31/506 , A61K31/497 , A61K31/4709 , A61P35/00 , A61P37/00 , A61P29/00 , A61P19/00
CPC分类号： C07D413/14 , C07D401/14 , C07D473/16
摘要： Substituted bicyclic heteroaryls of the following formulae and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
摘要翻译：下列配方的取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎症包括但不限于自身免疫疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏性疾病，本发明还使得能够治疗依赖于p110活性或与p110活性相关的癌症的方法，所述癌症包括但不限于白血病，例如急性骨髓性白血病（AML）Myelo-dysplastic综合征（MDS）骨髓增殖性疾病（MPD） C 慢性骨髓性白血病（CML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞性白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

9. 发明申请

WO2009158011A1 ALKYNYL ALCOHOLS AS KINASE INHIBITORS 审中-公开
标题翻译：亚苄基醇作为激酶抑制剂
公开(公告)号：WO2009158011A1
公开(公告)日：2009-12-30
申请号：PCT/US2009/003803
申请日：2009-06-26
申请人： AMGEN INC. , CHEN, Guoqing , CUSHING, Timothy, D. , FISHER, Benjamin , HE, Xiao , LI, Kexue , LI, Zhihong , MCGEE, Lawrence, R. , PATTAROPONG, Vatee , FAULDER, Paul , SEGANISH, Jennifer, L. , SHIN, Youngsook
发明人： CHEN, Guoqing , CUSHING, Timothy, D. , FISHER, Benjamin , HE, Xiao , LI, Kexue , LI, Zhihong , MCGEE, Lawrence, R. , PATTAROPONG, Vatee , FAULDER, Paul , SEGANISH, Jennifer, L. , SHIN, Youngsook
IPC分类号： C07D213/82 , C07D233/88 , C07D407/08 , C07D413/12 , C07D417/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/06 , C07D487/10 , C07D487/16 , C07D491/10 , C07D495/10 , A61K31/506 , A61K31/404
CPC分类号： C07D413/14 , C07D213/82 , C07D233/88 , C07D401/14 , C07D403/04 , C07D403/14 , C07D407/08 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/06 , C07D487/10 , C07D487/16 , C07D491/10 , C07D495/10
摘要： Selected compounds are effective for prophylaxis and treatment of inflammation and inflammatory disorders, such as NIK-mediated disorders. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, inflammation and the like.
摘要翻译：选择的化合物对于预防和治疗炎症和炎症性疾病如NIK介导的病症是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及炎症等的病症的药物组合物和方法。

10. 发明申请

WO2005004818A2 HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTICANCER AGENTS 审中-公开
标题翻译：杂环化合物及其作为反应剂的用途
公开(公告)号：WO2005004818A2
公开(公告)日：2005-01-20
申请号：PCT/US2004/022226
申请日：2004-07-09
申请人： IMCLONE SYSTEMS INCORPORATED , OUYANG, Xiaohu , KISELYOV, Alexander , CHEN, Xiaoling , HE, Hai-Ying , KAWAKAMI, Joel , PATTAROPONG, Vatee , PIATNITSKI, Evgueni , TUMA, Maria, Carolina , KINCAID, John
发明人： OUYANG, Xiaohu , KISELYOV, Alexander , CHEN, Xiaoling , HE, Hai-Ying , KAWAKAMI, Joel , PATTAROPONG, Vatee , PIATNITSKI, Evgueni , TUMA, Maria, Carolina , KINCAID, John
IPC分类号： A61K
CPC分类号： C07D401/04 , C07D249/14 , C07D263/48 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14
摘要： The present invention relates to heterocyclic compounds that have anticancer activity, and pharmaceutical compositions that contain such compounds, methods of treating diseases and conditions in mammals using such compounds and composition and methods for their manufacture.
摘要翻译：本发明涉及具有抗癌活性的杂环化合物和含有这些化合物的药物组合物，使用这些化合物治疗哺乳动物疾病和病症的方法及其制备方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式