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1. 发明申请

WO2008153893A3 METHODS AND SPECIES-SPECIFIC PRIMERS FOR DETECTION AND QUANTIFICATION OF STREPTOCOCCUS MUTANS AND STREPTOCOCCUS SANGUINIS IN MIXED BACTERIAL SAMPLES 审中-公开
标题翻译：用于检测和定量混合细菌样品中的杆菌和杆菌的方法和物种特异性引物
公开(公告)号：WO2008153893A3
公开(公告)日：2009-02-12
申请号：PCT/US2008007066
申请日：2008-06-04
申请人： UNIV NEW YORK SCHOOL MEDICINE , LI YIHONG , CAUFIELD PAGE W , SAXENA DEEPAK , ZHOU CHEN
发明人： LI YIHONG , CAUFIELD PAGE W , SAXENA DEEPAK , ZHOU CHEN
IPC分类号： C12Q1/68 , C12Q1/14
CPC分类号： C12Q1/689 , C12Q2600/16
摘要： Dental caries is a polymicrobial infectious disease. Of the hundreds of bacteria present in the biofilms coating teeth, the Streptococcus mutans (S. mutans) remain strongly linked to caries and dental disease. Streptococcus sanguinis (S. sanguinis) may serve a protective or antagonistic role against the cariogenic bacterium S. mutans. In the present invention, exemplary sets of species-specific PCR primers are provided for the identification and quantification of S. mutans and of S. sanguinis in clinical samples, including the simultaneous and sensitive analysis of both bacterial species. Assays, kits and methods for determining the presence and amount of S. mutans and/or S. sanguinis are provided. Oligonucleotide probes and primers for use in the assays, kits and methods are described. Assays and methods for determining and evaluating an individual's oral bacteria, risk for caries, and effects of prevention and treatment modalities, are provided.
摘要翻译：牙龋是一种多微生物感染性疾病。在生物膜涂覆牙齿中存在的数百种细菌中，变形链球菌（变形链球菌）与龋齿和牙齿疾病密切相关。血清链球菌（S.sanguinis）可能对致龋菌细菌变形链球菌起保护作用或拮抗作用。在本发明中，提供了典型的物种特异性PCR引物组用于在临床样品中鉴定和定量变形链球菌和血清芽孢杆菌，包括对这两种细菌物种的同时和敏感的分析。提供了用于确定变形链球菌和/或血清血友病的存在和量的测定，试剂盒和方法。描述了用于测定，试剂盒和方法的寡核苷酸探针和引物。提供了确定和评估个人口腔细菌，龋风险和预防和治疗方式的影响的方法和方法。

3. 发明申请

WO2005005596A2 CHARACTERIZATION OF THE EARLIEST STAGES OF THE SEVERE ACUTE RESPIRATORY SYNDROME (SARS) VIRUS AND USES THEREOF 审中-公开
标题翻译：严重急性呼吸系统综合症（SARS）病毒的最佳阶段的特征及其用途
公开(公告)号：WO2005005596A2
公开(公告)日：2005-01-20
申请号：PCT/IB2004002237
申请日：2004-07-09
申请人： CHINESE NAT HUMAN GENOME CT SH , GUANGDONG CT FOR DISEASE CONTR , GUANGZHOU CT FOR DISEASE CONTR , CHANGCHUN UNVERSITY OF AGRICUL , RUIJIN HOSPITAL AFFILIATED TO , SHANGHAI INST BIOL SCIENCES , NANFANG HOSPITAL FIRST MEDICAL , GUANGDONG J TECH SCIENCE DEV C , 2ND AF HOSP SUN YAT SEN UNIV , ZHAO GUOPING , XU RUI HENG , WU XINYAN , TU CHENG , SONG HUAI-DONG , LI YIHONG , HOU JINLIN , XU JUN , MIN JUN
发明人： ZHAO GUOPING , XU RUI HENG , WU XINYAN , TU CHENG , SONG HUAI-DONG , LI YIHONG , HOU JINLIN , XU JUN , MIN JUN
IPC分类号： A61K39/12 , A61K39/215 , C07K14/165 , C12N20060101 , C12N7/00 , C12Q1/68 , C12Q1/70 , C12N
CPC分类号： C12N7/00 , A61K2039/5252 , A61K2039/5254 , C07K14/005 , C12N2770/20021 , C12N2770/20022 , C12Q1/702
摘要： Severe Acute Respiratory Syndrome ("SARS") is a human respiratory disease of recent origin, widespread infectivity, recurring incidence, and significant mortality. Although there is abundant evidence suggesting that the coronavirus responsible for the disease ("SARS-CoV") evolves during an outbreak, there is currently little data on the earliest strains of this coronavirus. The present invention is directed to the characterization of the genomic RNA sequences of these earliest SARS coronaviruses, to the identification of nucleotide positions within the SARS-CoV genomic RNA that are characteristic of the different evolutionary stages of the coronavirus, to kits based on these positions for use in diagnosis of the disease in patients, and for the development of vaccines to the disease based on the lowered virulence and contagiousness of these earliest strains of SARS-CoV.
摘要翻译：严重急性呼吸系统综合症（“SARS”）是近来起源的人类呼吸道疾病，传染性广泛，发生率高，死亡率高。尽管有大量证据表明，在疫情爆发期间，负责该疾病的冠状病毒（“SARS-CoV”）也会发生变化，但目前关于这种冠状病毒最早发病的数据很少。本发明涉及这些最早的SARS冠状病毒的基因组RNA序列的鉴定，以鉴定冠状病毒不同进化阶段特征的SARS-CoV基因组RNA内的核苷酸位置，基于这些位置的试剂盒用于诊断患者疾病，并根据这些最早的SARS-CoV毒株的毒力和感染性降低疫苗开发疫苗。

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