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1. 发明申请

WO9640259A3 SKIN PERMEATION ENHANCER COMPOSITIONS COMPRISING GLYCEROL MONOLAURATE AND LAURYL ACETATE 审中-公开
标题翻译：包含甘油单酯和乙酸铝的皮肤渗透增强剂组合物
公开(公告)号：WO9640259A3
公开(公告)日：1997-02-27
申请号：PCT/US9608105
申请日：1996-05-30
申请人： ALZA CORP , BURKOTH TERRY L , TASKOVICH LINA T , CRISOLOGO NIEVES MARZAN , BESTE RUSSELL , HAMLIN RICHARD D , GALE ROBERT M , LEE EUN SOO , YUM SU IL
发明人： BURKOTH TERRY L , TASKOVICH LINA T , CRISOLOGO NIEVES MARZAN , BESTE RUSSELL , HAMLIN RICHARD D , GALE ROBERT M , LEE EUN SOO , YUM SU IL
IPC分类号： A61K9/00 , A61K9/70 , A61K47/14
CPC分类号： A61K9/7053 , A61K9/0014 , A61K9/7069 , A61K9/7084 , A61K47/14 , Y10S514/946 , Y10S514/947
摘要： Compositions, devices, and methods for transdermal administration of an active agent are disclosed using a novel dual permeation enhancer mixture comprising lauryl acetate and a monoglyceride, preferably glycerol monolaurate. The dual permeation enhancer mixture comprising lauryl acetate is a potent permeation enhancer and provides stable systems which are more readily characterized.

2. 发明申请

WO2006081497A3 HYDROPHILIC BIOCOMPATIBLE ADHESIVE FORMULATIONS AND USES 审中-公开
标题翻译：水解生物降解胶粘剂配方及用途
公开(公告)号：WO2006081497A3
公开(公告)日：2006-11-30
申请号：PCT/US2006003091
申请日：2006-01-27
申请人： CORIUM INT INC , AV TOPCHIEV INST PETROCHEMICAL , SINGH PARMINDER , LEE EUN SOO , SAGI APPALA , FELDSTEIN MIKHAIL M , BAIRAMOV DANIR F
发明人： SINGH PARMINDER , LEE EUN SOO , SAGI APPALA , FELDSTEIN MIKHAIL M , BAIRAMOV DANIR F
IPC分类号： A61L15/44 , A61L15/58
CPC分类号： A61L15/44 , A61B5/04087 , A61K9/7061 , A61K47/32 , A61L15/585 , A61L2300/402 , A61L2300/404 , A61L2300/412 , A61L2300/602 , A61N1/0428 , A61N1/0444 , A61N1/0448 , A61N1/0456 , A61N1/0468 , A61N1/0496 , Y10T442/2525 , C08L33/06
摘要： This invention relates to the use of hydrophilic, biocompatible adhesives in drug delivery systems, wound dressings, bioelectrodes, and other systems in which hydrophilic, biocompatible adhesives are desirable. In particular, the invention relates to water-swellable, water-insoluble polymers that in combination render a composition adhesive upon contact with moisture, wherein a first water-swellable, water-insoluble polymer is cationic, a second water-swellable, water-insoluble polymer is anionic, and the polymers are ionically associated with each other to form a polymer matrix.
摘要翻译：本发明涉及在药物递送系统，伤口敷料，生物电极和其中需要亲水性，生物相容性粘合剂的其它系统中使用亲水性，生物相容性粘合剂。特别地，本发明涉及水溶胀性水不溶性聚合物，其在与水分接触时组合使组合物粘合，其中第一水溶胀性水不溶性聚合物为阳离子，第二水溶胀性，水不溶性聚合物是阴离子的，并且聚合物彼此离子键合以形成聚合物基质。

3. 发明申请

WO2006069236A3 SUSTAINED RELEASE TOOTH WHITENING FORMULATIONS AND SYSTEMS 审中-公开
标题翻译：持续发布牙膏配方和系统
公开(公告)号：WO2006069236A3
公开(公告)日：2006-09-08
申请号：PCT/US2005046577
申请日：2005-12-21
申请人： CORIUM INT INC , AV TOPCHIEV INST PETROCHEMICAL , SINGH PARMINDER , LEE EUN SOO , SAGI APPALA , FELDSTEIN MIKHAIL M , BAIRAMOV DANIR F
发明人： SINGH PARMINDER , LEE EUN SOO , SAGI APPALA , FELDSTEIN MIKHAIL M , BAIRAMOV DANIR F
IPC分类号： A61K8/22 , A61K8/42 , A61K8/73 , A61K8/81 , A61K8/86 , A61Q11/00
CPC分类号： A61K8/0208 , A61K8/22 , A61K8/42 , A61K8/731 , A61K8/8147 , A61K8/8152 , A61K8/817 , A61K8/8176 , A61K8/86 , A61Q11/00
摘要： A tooth whitening composition comprises a mixture of tooth whitening agents, with a first whitening agent selected so as to release peroxide gradually upon contact with moisture and produce an alkaline pH, and a second whitening agent selected so as to release peroxide rapidly upon contact with moisture, and a water-swellable, water-insoluble polymer.
摘要翻译：牙齿美白组合物包含牙齿增白剂的混合物，其中选择第一增白剂以便在与水分接触时逐渐释放过氧化物并产生碱性pH，并且选择第二增白剂，以便在与水分接触时快速释放过氧化物，和水溶胀性水不溶性聚合物。

4. 发明申请

WO2010083035A2 TRANSDERMAL ADMINISTRATION OF TAMSULOSIN 审中-公开
标题翻译：透皮给药TAMSULOSIN
公开(公告)号：WO2010083035A2
公开(公告)日：2010-07-22
申请号：PCT/US2010000081
申请日：2010-01-14
申请人： CORIUM INT INC , SINGH PARMINDER , LEE EUN SOO , JAIN AMIT K
发明人： SINGH PARMINDER , LEE EUN SOO , JAIN AMIT K
IPC分类号： A61K9/70 , A61K31/137 , A61K31/18 , A61K47/06
CPC分类号： A61K9/70 , A61K9/0014 , A61K9/7023 , A61K9/7053 , A61K31/137 , A61K31/18 , A61K47/02 , A61K47/12 , A61K47/14
摘要： In an aspect of the invention, a composition for making a patch for the transdermal delivery of tamsulosin is provided. The composition comprises (a) at least about 1 wt% tamsulosin or a pharmaceutically acceptable salt of tamsulosin, (b) at least about 40 wt% polyisobutylene adhesive or hydrophobic synthetic rubber adhesive, (c) about 1 -20 wt% of an aprotic solvent in which tamsulosin dissolves readily, (d) about 1-20 wt% of an unsaturated fatty acid or an alpha-hydroxy acid or a mixture of unsaturated fatty acids or alpha-hydroxy acids or of both unsaturated fatty acids and alpha-hydroxy acids, (e) a lipophilic permeation enhancer, and (f) a matrix modifier.
摘要翻译：在本发明的一个方面，提供了一种用于制造透皮递送坦洛新的贴剂的组合物。该组合物包含（a）至少约1重量％的坦洛新或坦洛新的药学上可接受的盐，（b）至少约40wt％的聚异丁烯粘合剂或疏水性合成橡胶粘合剂，（c）约1-20wt％的非质子（d）约1-20重量％的不饱和脂肪酸或α-羟基酸或不饱和脂肪酸或α-羟基酸或不饱和脂肪酸和α-羟基酸的混合物，（e）亲脂性渗透促进剂，和（f）基质改性剂。

5. 发明专利

JP2006117688A Monoglyceride/lactate ester permeation enhancer for oxybutynin 审中-公开
标题翻译：氧化丁烯的单一/酸乳化剂渗透增强剂
公开(公告)号：JP2006117688A
公开(公告)日：2006-05-11
申请号：JP2005350255
申请日：2005-12-05
申请人： Alza Corp , アルザ・コーポレーション
发明人： LEE EUN SOO , WATANABE TYLER , GALE ROBERT M , BURKOTH TERRY L
IPC分类号： A61K31/216 , A61K9/00 , A61K9/70 , A61K31/215 , A61K31/57 , A61K47/14 , A61K47/32 , A61P13/02 , A61P15/00 , A61P17/00 , A61P21/00
CPC分类号： A61K9/7053 , A61K9/0014 , A61K9/7084 , A61K31/215 , A61K31/216 , A61K31/57 , A61K47/14 , Y10S514/946 , Y10S514/947 , A61K31/565 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide a composition of matter for application to a body surface or membrane to administer oxybutynin by permeation through the body surface or membrane.
SOLUTION: This composition comprising, in combination, the oxybutynin to be administered, in a therapeutically effective amount; and a permeation enhancing mixture comprising a monoglyceride or a mixture of monoglycerides, and a lactic ester or a mixture of lactic esters, present in specific concentrations.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供用于施用于身体表面或膜的物质组合物，以通过穿过身体表面或膜的方式施用奥昔布宁。解决方案：该组合物组合包含治疗有效量的待施用的奥昔布宁; 以及包含单酸甘油酯或单酸甘油酯的混合物和以特定浓度存在的乳酸酯或乳酸酯混合物的渗透增强混合物。版权所有（C）2006，JPO＆NCIPI

6. 发明申请

WO9817315A3 PERMEATION ENHANCERS FOR TRANSDERMAL DRUG DELIVERY COMPOSITIONS, DEVICES, AND METHODS 审中-公开
标题翻译：透皮药物输送组合物的渗透增强剂，装置和方法
公开(公告)号：WO9817315A3
公开(公告)日：1998-07-02
申请号：PCT/US9718956
申请日：1997-10-23
申请人： ALZA CORP
发明人： LEE EUN SOO , YUM SU IL
IPC分类号： A61K9/00 , A61K9/70 , A61K31/216 , A61K31/4045 , A61K31/407 , A61K31/5517 , A61K31/565 , A61K31/568 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/00
CPC分类号： A61K9/7053 , A61K9/0014 , A61K9/7084 , A61K47/10 , A61K47/12 , A61K47/14 , Y10S514/946 , Y10S514/947
摘要： The present invention is directed to the transdermal administration of at least one drug together with a suitable amount of a permeation enhancer comprising monoalkyl ethers of polyethyleneglycol and their alkyl or aryl carboxylic acid esters and carboxymethyl ethers. The invention includes a transdermal drug delivery device comprising a matrix adapted to be placed in drug-and-permeation enhancer-transmitting relation with a skin site. The matrix contains sufficient amounts of the permeation enhancer and drug, in combination, to continuously administer drug to the systemic circulation of a patient at a therapeutically effective rate. The invention is also directed to compositions and methods for transdermal administration of at least one drug together with a permeation enhancer of this invention, alone or in combination with other enhancers.

7. 发明申请

WO9610429A2 IMPROVED TRANSDERMAL DEVICE HAVING DECREASED DELAMINATION 审中-公开
标题翻译：改进的具有减少分层的变形装置
公开(公告)号：WO9610429A2
公开(公告)日：1996-04-11
申请号：PCT/US9511732
申请日：1995-09-15
申请人： ALZA CORP
发明人： GALE ROBERT M , LEE EUN SOO
IPC分类号： A61M37/00 , A61K9/70 , A61M35/00
CPC分类号： A61K9/7084
摘要： A device for the transdermal administration of a drug comprising a microporous tie layer located between the drug reservoir and the contact adhesive. The tie layer eliminates blooming and delamination and has no appreciable adverse effect on either the drug flux or release rate from the device.
摘要翻译：用于经皮给药的药物的装置，其包含位于药物储存器和接触粘合剂之间的微孔连接层。连接层消除了起霜和分层，并且对药物通量或来自装置的释放速率没有明显的不利影响。

8. 发明专利

JP2006143750A Improved transdermal device having decreased delamination 审中-公开
标题翻译：改进的具有减少分层的变形装置
公开(公告)号：JP2006143750A
公开(公告)日：2006-06-08
申请号：JP2006054798
申请日：2006-03-01
申请人： Alza Corp , アルザ・コーポレーション
发明人： GALE ROBERT M , LEE EUN SOO
IPC分类号： A61K9/70 , A61M37/00 , A61K31/568 , A61K47/12 , A61K47/14 , A61P15/00
CPC分类号： A61K9/7084
摘要： PROBLEM TO BE SOLVED: To provide a medical device for eliminating blooming and delamination in an interface between the medicine reservoir and the contact adhesive without giving no appreciable adverse effect on the drug flux or release rate from the therapeutic transdermal system.
SOLUTION: This device for the transdermal administration of a medicine at a therapeutically effective rate, comprising: (a) a non-aqueous reservoir comprising a therapeutically effective amount of the medicine and a skin permeation-enhancing amount of a permeation enhancer mixture comprising a non-ionic surfactant and a cosolvent; (b) a microporous tie layer on the skin-proximal surface of the reservoir; (c) a backing on or adjacent the skin-distal surface of the reservoir; and (d) means for maintaining the reservoir in medicine- and permeation enhancer mixture-transmitting relation with the skin on the skin-proximal surface of the tie layer.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种用于消除药物贮存器和接触粘合剂之间的界面中的起皱和分层的医疗装置，而不会对来自治疗性透皮系统的药物通量或释放速率没有明显的不利影响。解决方案：用于以治疗有效速率透皮施用药物的该装置，包括：（a）非水储存器，其包含治疗有效量的药物和皮肤渗透增强量的渗透促进剂混合物包括非离子表面活性剂和助溶剂; （b）在所述储存器的皮肤近端表面上的微孔粘结层; （c）在所述储存器的所述皮肤远侧表面上或附近的背衬; 和（d）用于将所述储存器保持在与所述粘结层的皮肤近端表面上的皮肤的药物和渗透增强剂混合物传递关系中的装置。版权所有（C）2006，JPO＆NCIPI

9. 发明专利

JPS63119421A IMPROVED TRANSDERMAL ADMINISTRATION DEVICE WITH SPEED CONTROL ADHESIVE 失效
公开(公告)号：JPS63119421A
公开(公告)日：1988-05-24
申请号：JP22007287
申请日：1987-09-02
申请人： ALZA CORP
发明人： ENSCORE DAVID J , LEE EUN SOO , YUM SUN IL
IPC分类号： A61F13/00 , A61K9/70 , A61L15/16 , A61L15/64 , A61M37/00

10. 发明专利

AT214946T 未知
公开(公告)号：AT214946T
公开(公告)日：2002-04-15
申请号：AT96914625
申请日：1996-05-13
申请人： ALZA CORP
发明人： LEE EUN SOO , YUM SU II
IPC分类号： A61K9/00 , A61K9/70 , A61K47/14 , A61L15/44
摘要： The present invention is directed to the transdermal administration of a drug together with a suitable amount of an acyl lactylate permeation enhancer. The invention includes a transdermal drug delivery device comprising a matrix adapted to be placed in drug- and- permeation enhancer-transmitting relation with a skin site. The matrix contains sufficient amounts of an acyl lactylate permeation enhancer and drug, in combination, to continuously administer drug to the systemic circulation of a patient at a therapeutically effective rate. The invention is also directed to compositions and methods for transdermal administration of a drug together with an acyl lactylate permeation enhancer, alone or in combination with other enhancers.

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