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1. 发明专利

JP2007238636A Novel formulation for transdermal delivery of pergolide 审中-公开
标题翻译：用于透皮递送的新型配方
公开(公告)号：JP2007238636A
公开(公告)日：2007-09-20
申请号：JP2007168802
申请日：2007-06-27
申请人： Alza Corp , アルザコーポレイション
发明人： YUM SU II , NELSON MELINDA K , CAMPBELL PATRICIA S
IPC分类号： A61K31/4745 , A61M37/00 , A61K9/70 , A61K31/48 , A61K47/06 , A61K47/14 , A61K47/16 , A61K47/18 , A61K47/32 , A61K47/34 , A61P25/16
CPC分类号： A61K9/7053 , A61K9/0014 , A61K9/7084 , A61K31/48 , A61K47/14 , A61K47/18 , Y10S514/947
摘要： PROBLEM TO BE SOLVED: To provide a novel formulation for safe and effective transdermal administration of pergolide for treating Parkinson's disease. SOLUTION: The composition for releasing the pergolide to an individual requiring the pergolide therapy by the permeation through a body surface or membrane at a therapeutically effective rate contains pergolide mesylate in an amount effective for enabling successive release of the pergolide at least at 1 μg/cm 2 ×hr flow rate over the administration period to obtain the therapeutic plasma level of the pergolide, in a carrier. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种新颖的配方，用于安全有效的透皮给药pergolide治疗帕金森病。解决方案：将治疗有效率通过身体表面或膜渗透所需要的pergolide治疗的个体释放出高利格苷的组合物含有有效量使格列封醚甲磺酸盐至少能够在1 μg/ cm 2 / SP>×hr流量，以获得载体中的百里高剂的治疗血浆水平。版权所有（C）2007，JPO＆INPIT

2. 发明专利

DE69637061T2 未知
公开(公告)号：DE69637061T2
公开(公告)日：2008-01-10
申请号：DE69637061
申请日：1996-06-07
申请人： ALZA CORP
发明人： YUM SU II , NELSON MELINDA K , CAMPBELL PATRICIA S
IPC分类号： A61K31/48 , A61M37/00 , A61K9/70 , A61K47/06 , A61K47/14 , A61K47/18 , A61P25/16
摘要： Composition of matter for application to a body surface or membrane to administer pergolide by permeation through the body surface or membrane, the composition comprising pergolide to be administered, at a therapeutically effective rate, alone or in combination with a permeation enhancer or mixture. Also disclosed are drug delivery devices containing the pergolide or pergolide and enhancer composition and methods for the transdermal administration of the pergolide and pergolide/enhancer composition.

3. 发明专利

ES2275803T3 PROCEDIMIENTOS PARA FACILITAR LA MONITORIZACION NO INVASIVA DEL OXIGENO. 未知
公开(公告)号：ES2275803T3
公开(公告)日：2007-06-16
申请号：ES02075747
申请日：1993-02-19
申请人： ALZA CORP
发明人： WARRING JESSICA A , YUM SU II , SWEDLOW DAVID B , TASKOVICH LINA T , CORMIER MICHAEL J N , OLLERDESSEN ALBERT
IPC分类号： A61M35/00 , A61B5/00 , A61B5/024 , A61N1/30
摘要： Procedimiento para la monitorización no invasiva de una característica de la sangre de un paciente, que comprende: (i) proporcionar un dispositivo de administración transdérmica (10) que comprende: (a) un elemento de soporte (20) sustancialmente impermeable a un agente vasodilatador; (b) una primera capa adhesiva (26) adyacente a una superficie del elemento de soporte; (c) un depósito (22) adyacente a otra superficie del elemento de soporte, comprendiendo el depósito una cantidad suficiente de agente vasodilatador como para inducir una vasodilatación local en la piel del paciente al que pudiera fijarse el dispositivo; (d) una membrana de control de la velocidad (24) adyacente a una superficie distal de la capa de soporte del depósito, (ii) fijar una superficie expuesta del dispositivo de administración a un lugar predeterminado de la piel del paciente; (iii) unir un sensor electroóptico (40) a la primera capa adhesiva (26) del dispositivo de administración transdérmica, bien sea antes o bien después de la etapa (ii); (iv) permitir a continuación la administración transdérmica del agente vasodilatador a través del lugar de la piel a una velocidad dependiente de la composición y con un espesor de la membrana de control de la velocidad (24) y del coeficiente de difusión del agente vasodilatador dentro de la membrana de control de la velocidad (24); y (v) monitorizar al mismo tiempo una característica de la sangre del paciente con el uso del sensor.

4. 发明专利

DE69637061D1 未知
公开(公告)号：DE69637061D1
公开(公告)日：2007-06-14
申请号：DE69637061
申请日：1996-06-07
申请人： ALZA CORP
发明人： YUM SU II , NELSON MELINDA K , CAMPBELL PATRICIA S
IPC分类号： A61K31/48 , A61M37/00 , A61K9/70 , A61K47/06 , A61K47/14 , A61K47/18 , A61P25/16
摘要： Composition of matter for application to a body surface or membrane to administer pergolide by permeation through the body surface or membrane, the composition comprising pergolide to be administered, at a therapeutically effective rate, alone or in combination with a permeation enhancer or mixture. Also disclosed are drug delivery devices containing the pergolide or pergolide and enhancer composition and methods for the transdermal administration of the pergolide and pergolide/enhancer composition.

5. 发明专利

DE19681435T1 未知
公开(公告)号：DE19681435T1
公开(公告)日：1998-07-23
申请号：DE19681435
申请日：1996-06-07
申请人： ALZA CORP
发明人： YUM SU II , NELSON MELINDA K , CAMPBELL PATRICIA S
IPC分类号： A61M37/00 , A61K9/70 , A61K31/48 , A61K47/06 , A61K47/14 , A61K47/18 , A61P25/16
摘要： Composition of matter for application to a body surface or membrane to administer pergolide by permeation through the body surface or membrane, the composition comprising pergolide to be administered, at a therapeutically effective rate, alone or in combination with a permeation enhancer or mixture. Also disclosed are drug delivery devices containing the pergolide or pergolide and enhancer composition and methods for the transdermal administration of the pergolide and pergolide/enhancer composition.

6. 发明专利

MX9709162A COMPOSICIONES MEJORADAS DE LA PERMEACION EN LA PIEL QUE USAN LACTILATOS DE ACILO. 未知
公开(公告)号：MX9709162A
公开(公告)日：1998-03-31
申请号：MX9709162
申请日：1996-05-13
申请人： ALZA CORP
发明人： LEE EUN SOO , YUM SU II
IPC分类号： A61K9/00 , A61K9/70 , A61K47/14 , A61L15/44
摘要： La presente invencion está dirigida a la administracion transdérmica de un fármaco junto con una cantidad adecuada de un realzador de la permeacion de lactilato de acilo; la invencion incluye un dispositivo para el suministro transdérmico de fármaco que comprende una matriz adaptada a ser colocada en una relacion de transmision del fármaco y del realzador de la permeacion con un sitio de la piel; la matriz contiene cantidades suficientes de un realzador de la permeacion de lactilato de acilo y un fármaco, en combinacion, para administrar fármaco continuamente a la circulacion sistémica de un paciente a una velocidad terapéuticamente eficaz; la invencion está dirigida también a composiciones y métodos para la administracion transdérmica de un fármaco junto con un realzador de la permeacion de lactilato de acilo, solo o en combinacion con otros realzadores.

7. 发明专利

AU5792896A Skin permeation enhancer compositions using acyl lactylates 未知
公开(公告)号：AU5792896A
公开(公告)日：1996-12-11
申请号：AU5792896
申请日：1996-05-13
申请人： ALZA CORP
发明人： LEE EUN SOO , YUM SU II
IPC分类号： A61K9/00 , A61K9/70 , A61K47/14 , A61L15/44
摘要： The present invention is directed to the transdermal administration of a drug together with a suitable amount of an acyl lactylate permeation enhancer. The invention includes a transdermal drug delivery device comprising a matrix adapted to be placed in drug- and- permeation enhancer-transmitting relation with a skin site. The matrix contains sufficient amounts of an acyl lactylate permeation enhancer and drug, in combination, to continuously administer drug to the systemic circulation of a patient at a therapeutically effective rate. The invention is also directed to compositions and methods for transdermal administration of a drug together with an acyl lactylate permeation enhancer, alone or in combination with other enhancers.

8. 发明专利

CA2217029A1 SKIN PERMEATION ENHANCER COMPOSITIONS USING ACYL LACTYLATES 未知
公开(公告)号：CA2217029A1
公开(公告)日：1996-11-28
申请号：CA2217029
申请日：1996-05-13
申请人： ALZA CORP
发明人： LEE EUN SOO , YUM SU II
IPC分类号： A61K9/00 , A61K9/70 , A61K47/14 , A61K47/16 , A61K31/565 , A61K31/57
摘要： The present invention is directed to the transdermal administration of a drug together with a suitable amount of an acyl lactylate permeation enhancer. The invention includes a transdermal drug delivery device comprising a matrix adapted to be placed in drug-and permeation enhancer-transmitting relation with a skin site. The matrix contains sufficient amounts of an acyl lactylate permeation enhancer and drug, in combination, to continuously administer drug to the systemic circulation of a patient at a therapeutically effective rate. The invention is also directed to compositions and methods for transdermal administration of a drug together with an acyl lactylate permeation enhancer, alone or in combination with other enhancers.

9. 发明专利

ZA9407700B Monoglyceride/lactate ester permeation enhancer 未知
公开(公告)号：ZA9407700B
公开(公告)日：1995-11-21
申请号：ZA9407700
申请日：1994-10-03
申请人： ALZA CORP
发明人： TASKOVICH LINA TORMEN , YUM SU II , LEE EUN SOO , CRISOLOGO NIEVES MARZAN
IPC分类号： A61K20060101 , A61K

10. 发明专利

PT1213037E MÉTODO PARA MONITORIZAÇÃO FACILITADA NÃO INVASIVA DE OXIGÉNIO 未知
公开(公告)号：PT1213037E
公开(公告)日：2007-01-31
申请号：PT02075747
申请日：1993-02-19
申请人： ALZA CORP
发明人： TASKOVICH LINA T , CORMIER MICHAEL J N , WARRING JESSICA A , SWEDLOW DAVID B , OLLERDESSEN ALBERT , YUM SU II
IPC分类号： A61M35/00 , A61B5/00 , A61B5/024 , A61N1/30

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