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1. 发明专利

AU2010200087A1 Transdermal Vaccine Delivery Device Having Coated Microprotrusions 未知
公开(公告)号：AU2010200087A1
公开(公告)日：2010-01-28
申请号：AU2010200087
申请日：2010-01-08
申请人： ALZA CORP
发明人： MATRIANO JAMES , LIN WEIQI , CORMIER MICHAEL J N , MAA YUH-FUN
IPC分类号： A61K9/00 , A61B17/20 , A61K9/28 , A61K39/00 , A61K39/145 , A61K47/10 , A61K47/18 , A61K47/20 , A61K47/26 , A61M37/00
摘要： A device and method are provided for percutaneous transdermal delivery of a immunologically active agent. The agent is mixed with appropriate surfactants and dissolved in water to form an aqueous coating solution having the appropriate concentration for coating extremely tiny skin piercing elements. The coating solution is applied to the skin piercing elements using known coating techniques and then dried. The device is applied to the skin of a living animal, causing the microprotrusions to pierce the stratum corneum and deliver a immunologically effective dose of the immunologically active agent to the animal.

2. 发明专利

PT1213037E MÉTODO PARA MONITORIZAÇÃO FACILITADA NÃO INVASIVA DE OXIGÉNIO 未知
公开(公告)号：PT1213037E
公开(公告)日：2007-01-31
申请号：PT02075747
申请日：1993-02-19
申请人： ALZA CORP
发明人： TASKOVICH LINA T , CORMIER MICHAEL J N , WARRING JESSICA A , SWEDLOW DAVID B , OLLERDESSEN ALBERT , YUM SU II
IPC分类号： A61M35/00 , A61B5/00 , A61B5/024 , A61N1/30

3. 发明专利

AT346643T 未知
公开(公告)号：AT346643T
公开(公告)日：2006-12-15
申请号：AT02075747
申请日：1993-02-19
申请人： ALZA CORP
发明人： WARRING JESSICA A , YUM SU II , SWEDLOW DAVID B , TASKOVICH LINA T , CORMIER MICHAEL J N , OLLERDESSEN ALBERT
IPC分类号： A61B5/00 , A61B5/024 , A61N1/30 , A61M35/00
摘要： A method for non-invasive monitoring of a characteristic of the blood of a patient, comprising: (i) providing a transdermal delivery device (10) comprising: (a) a backing member (20) that is substantially impermeable to a vaso-dilating agent; (b) a first adhesive layer (26) adjacent to one surface of the backing member; (c) a reservoir (22) adjacent to another surface of the backing member, the reservoir comprising sufficient vaso-dilating agent to induce local vaso-dilation in the skin of the patient to which the device may be attached; (d) a rate-controlling membrane (24) adjacent to a backing layer distal surface of the reservoir, (ii) attaching one exposed surface of the delivery device to a predetermined site on the patient's skin; (iii) mating an electro-optical sensor (40) to the first adhesive layer (26) of the transdermal delivery device, either before or after step (ii); (iv) thereafter permitting transdermal delivery of the vaso-dilating agent through the skin site at a rate dependent on the composition and thickness of the rate-controlling membrane (24) and on the diffusion co-efficient of the vaso-dilating agent within the rate-controlling membrane (24); and (v) concurrently monitoring a characteristic of the patient's blood with the sensor.

4. 发明专利

NZ511464A Electrotransport device including a compatible antimicrobial agent 未知
公开(公告)号：NZ511464A
公开(公告)日：2003-07-25
申请号：NZ51146499
申请日：1999-10-29
申请人： ALZA CORP
发明人： CHIN IVAN W , MURDOCK THOMAS O , CORMIER MICHAEL J N
IPC分类号： A61N1/30
摘要： A transdermal electrotransport drug delivery device (10) having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. The cathode includes a cathodic electrode (24) and a cathodic reservoir (28) comprised of a housing composed of a polymeric material and an aqueous medium in contact with the housing. The aqueous medium includes i) a drug or an electrolyte salt or a mixture thereof and ii) a cetylpyridinium salt in an amount sufficient to inhibit microbial growth in the aqueous medium. The polymeric material is compatible with the cetylpyridinium salt. A process is also provided wherein when electric current flows from the source of electrical power so that the drug is transdermally delivered to the patient by electrotransport from the anodic reservoir, the cetylpyridinium salt is not transdermally delivered to the patient by electrotransport from the cathodic reservoir.

5. 发明专利

DK0717645T3 未知
公开(公告)号：DK0717645T3
公开(公告)日：1999-01-25
申请号：DK94929146
申请日：1994-08-31
申请人： ALZA CORP
发明人： CORMIER MICHAEL J N , LEDGER PHILIP W , JOHNSON JUANITA , PHIPPS JOSEPH B , CHAO STELLA
IPC分类号： A61N1/30
摘要： An electrotransport delivery device utilizing reservoir buffering at a select pH ranges in order to reduce skin irritation and skin resistance is provided. Cathodic reservoirs are buffered to a pH of less than about 4, preferably to a pH in the range of about 2 to 4, while anodic reservoirs are buffered to a pH above about 4, preferably to a pH in the range of about 4 to 10. Another electrotransport delivery device utilizes a potassium sensor to monitor potassium efflux from the skin. Potassium efflux above a certain predetermined level has been found to be a precursor to skin irritation/erythema. Operation of the device is modified (eg, terminated) when the predetermined potassium efflux level is sensed.

6. 发明专利

CA2257217A1 DEVICE FOR ENHANCING TRANSDERMAL AGENT DELIVERY OR SAMPLING 未知
公开(公告)号：CA2257217A1
公开(公告)日：1997-12-24
申请号：CA2257217
申请日：1997-06-18
申请人： ALZA CORP
发明人： NAT AVTAR S , BLOCK BARRY , NEUKERMANS ARMAND P , CORMIER MICHAEL J N
IPC分类号： A61B5/15 , A61B5/145 , A61B5/1473 , A61B5/157 , A61B10/00 , A61B17/20 , A61M37/00 , A61N1/30
摘要： A percutaneous agent delivery or sampling device (10) comprising a sheet (6) having at least one opening (8) therethrough and a plurality of microblades (4) for piercing the skin for increasing transdermal flux of an agent. The microblades (4) having a relatively sharp angled leading edge (11, 11') which transitions to a relatively gradually angled blade edge (13, 13').

7. 发明专利

ES2275803T3 PROCEDIMIENTOS PARA FACILITAR LA MONITORIZACION NO INVASIVA DEL OXIGENO. 未知
公开(公告)号：ES2275803T3
公开(公告)日：2007-06-16
申请号：ES02075747
申请日：1993-02-19
申请人： ALZA CORP
发明人： WARRING JESSICA A , YUM SU II , SWEDLOW DAVID B , TASKOVICH LINA T , CORMIER MICHAEL J N , OLLERDESSEN ALBERT
IPC分类号： A61M35/00 , A61B5/00 , A61B5/024 , A61N1/30
摘要： Procedimiento para la monitorización no invasiva de una característica de la sangre de un paciente, que comprende: (i) proporcionar un dispositivo de administración transdérmica (10) que comprende: (a) un elemento de soporte (20) sustancialmente impermeable a un agente vasodilatador; (b) una primera capa adhesiva (26) adyacente a una superficie del elemento de soporte; (c) un depósito (22) adyacente a otra superficie del elemento de soporte, comprendiendo el depósito una cantidad suficiente de agente vasodilatador como para inducir una vasodilatación local en la piel del paciente al que pudiera fijarse el dispositivo; (d) una membrana de control de la velocidad (24) adyacente a una superficie distal de la capa de soporte del depósito, (ii) fijar una superficie expuesta del dispositivo de administración a un lugar predeterminado de la piel del paciente; (iii) unir un sensor electroóptico (40) a la primera capa adhesiva (26) del dispositivo de administración transdérmica, bien sea antes o bien después de la etapa (ii); (iv) permitir a continuación la administración transdérmica del agente vasodilatador a través del lugar de la piel a una velocidad dependiente de la composición y con un espesor de la membrana de control de la velocidad (24) y del coeficiente de difusión del agente vasodilatador dentro de la membrana de control de la velocidad (24); y (v) monitorizar al mismo tiempo una característica de la sangre del paciente con el uso del sensor.

8. 发明专利

AT322272T 未知
公开(公告)号：AT322272T
公开(公告)日：2006-04-15
申请号：AT03022248
申请日：1997-07-15
申请人： ALZA CORP
发明人： GALE ROBERT M , NELSON MELINDA K , CORMIER MICHAEL J N , GUPTA SUNEEL K , CAMPBELL PATRICIA S
IPC分类号： A61K9/70 , A61K31/138 , A61K31/57 , A61K31/70 , A61K31/135

9. 发明专利

PT917484E 未知
公开(公告)号：PT917484E
公开(公告)日：2004-12-31
申请号：PT97932206
申请日：1997-06-18
申请人： ALZA CORP
发明人： THEEUWES FELIX T , CORMIER MICHAEL J N
IPC分类号： A61B5/15 , A61B5/145 , A61B5/1473 , A61B5/157 , A61B10/00 , A61B17/20 , A61M37/00 , A61N1/30

10. 发明专利

CZ2003687A3 Inhibition methods for reducing transdermal penetration of a medicament through inhibition of transdermal path closure 未知
公开(公告)号：CZ2003687A3
公开(公告)日：2004-01-14
申请号：CZ2003687
申请日：2001-09-06
申请人： ALZA CORP
发明人： LIN WEIQI , CORMIER MICHAEL J N , DADDONA PETER E , JOHNSON JUANITA A , MATRIANO JAMES A
IPC分类号： A61K9/70 , A61K31/662 , A61K31/721 , A61K31/726 , A61K31/727 , A61K45/00 , A61M35/00 , A61M37/00 , A61M31/00
摘要： This invention relates to a method for inhibiting a decrease in the transdermal flux of an agent that is being transdermally delivered or sampled over a prolonged period of time wherein the delivery or sampling involves disrupting at least the stratum corneum layer of the skin to form pathways through which the agent passes. The desired result is achieved by co-delivering or co-sampling the agent with an amount of at least one anti-healing agent wherein the amount of the anti-healing agent is effective in inhibiting a decrease in the agent transdermal flux compared to when the delivery or sampling of the agent is done under substantially identical conditions except in the absence of the anti-healing agent(s).

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