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1. 发明申请

WO2005118885A3 METHODS AND APPARATUS FOR DETECTION OF VIRAL INFECTION 审中-公开
公开(公告)号：WO2005118885A3
公开(公告)日：2005-12-15
申请号：PCT/US2005/012019
申请日：2005-04-12
申请人： ALLIED BIOTECH, INC. , YU, Yong, Yi , LI, Lina , LI, Zhuangwu , BAO, Jun
发明人： YU, Yong, Yi , LI, Lina , LI, Zhuangwu , BAO, Jun
IPC分类号： C12Q1/00
摘要： This invention generally relates to apparatus and methods for high-throughput, reproducible and inexpensive detection of virus infection using multiplexing technologies such as slide-based, microtiter plate-based and membrane-based microarrays and beads technologies. The apparatus and methods allow simultaneous detection of multiple viral infections in a plurality of test samples.

2. 发明申请

WO2004044246A2 METHODS AND COMPOSITIONS FOR DETECTING TELOMERASE ACTIVITY 审中-公开
标题翻译：检测TELOMERASE活性的方法和组合物
公开(公告)号：WO2004044246A2
公开(公告)日：2004-05-27
申请号：PCT/US2003/035919
申请日：2003-11-12
申请人： ALLIED BIOTECH, INC. , LI, Zhuangwu , BAO, Jun , MAO, Hua , MA, Wenbin , LI, Lina
发明人： LI, Zhuangwu , BAO, Jun , MAO, Hua , MA, Wenbin , LI, Lina
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/68 , C12Q1/6841 , C12Q1/6851 , C12Q1/686 , C12Q2561/113 , C12Q2547/107 , C12Q2521/113 , C12Q2547/101 , C12Q2545/113
摘要： A method for determining telomerase activity using primer extension followed with real time PCR quantification is disclosed. The method of the present invention provides a rapid, sensitive and accurate measurement for telomerase activity in a biological sample. In one embodiment, the method includes the steps of: adding the biological sample to a reaction tube containing a first reaction mixture having a first primer and nucleoside triphosphates, a second reaction mixture having a second primer and a DNA polymerase, and a wax layer that separates the first reaction mixture from the second reaction mixture; incubating the biological sample with the first reaction mixture; admixing the extension product with the second reaction mixture; amplifying and quantifying the extension product using real-time PCR and a control template. In another embodiment, the detection method includes an in situ primer extension step that allows the production of the extension product within an intact cell. In this embodiment, the extension product can be preserved under appropriate conditions for an extended time before the completion of the quantification step.
摘要翻译：公开了使用引物延伸测定端粒酶活性的方法，随后进行实时PCR定量。本发明的方法提供对生物样品中端粒酶活性的快速，灵敏和准确的测量。在一个实施方案中，该方法包括以下步骤：将生物样品加入到含有具有第一引物和核苷三磷酸的第一反应混合物的反应管中，具有第二引物和DNA聚合酶的第二反应混合物和蜡层，将第一反应混合物与第二反应混合物分离; 用第一反应混合物孵育生物样品; 将延伸产物与第二反应混合物混合; 使用实时PCR扩增和定量扩增产物和对照模板。在另一个实施方案中，检测方法包括原位引物延伸步骤，其允许在完整细胞内产生延伸产物。在本实施例中，扩展产品可以在适当的条件下在量化步骤完成之前延长一段时间。

3. 发明公开

EP1731530A1 A KIND OF FUSION PROTEIN, GENE ENCODING IT, EXPRESSION METHOD AND USE THEREOF 审中-公开
标题翻译： EINE ART FUSIONSPROTEIN，GEN，DAS DIESES CODIERT，EXPRESSIONSVERFAHREN UND ANWENDUNG DAVON
公开(公告)号：EP1731530A1
公开(公告)日：2006-12-13
申请号：EP04731810.0
申请日：2004-05-08
申请人： Wu, Xianggui , Chen, Haiming , Gao, Junyu , Bao, Jun
发明人： CHEN, Haiming , GAO, Junyu , BAO, Jun
IPC分类号： C07K16/46 , C12N15/62 , A61K39/395 , A61P37/08
CPC分类号： C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2319/30 , Y10S530/862 , Y10S530/868
摘要： This invention provides a fusion protein (FP4) and the code gene, expression method, and clinical application; its goal is to provide a fusion protein, the code gene, and the expression method as well as to take this fusion protein as the active constituent anti-allergic medicine. In addition, the invention provides the sequence of fusion protein attached on SEQ ID 2 and any derivation protein of the fusion protein (FP4) which includes adding or deleting several amino acids of SEQ ID2 as well as increasing or deducing nuclear tides of SEQ ID 1. We designed to cross-link IgE active receptor and an IgG inhibitory receptor by endogens hinge without any extraneous chemical link. This invention fusion protein has function to block the IgE acceptor, moreover fragment of fusion protein has ability to specifically bind to a native IgG inhibitory receptor containing immunoreceptor tyrosine-based inhibitory motif, thereby inhibiting the IgE-driven mediator release from mast cells and basophils. It will play important role in the allergic disease treatment.
摘要翻译：本发明提供融合蛋白（FP4）及其代码基因，表达方法和临床应用; 其目标是提供融合蛋白，代码基因和表达方法，并将该融合蛋白作为活性成分抗过敏药物。此外，本发明提供了连接在SEQ ID 2上的融合蛋白的序列和融合蛋白（FP4）的任何衍生蛋白，其包括添加或缺失SEQ ID2的几个氨基酸，以及增加或推导出SEQ ID No.1 我们设计通过内源性铰链交联IgE活性受体和IgG抑制受体，而没有任何外来化学连接。本发明融合蛋白具有阻断IgE受体的功能，此外，融合蛋白的片段具有与含有免疫受体酪氨酸的抑制基序的天然IgG抑制受体特异性结合的能力，从而抑制IgE驱动的介体从肥大细胞和嗜碱性粒细胞释放。它将在过敏性疾病治疗中发挥重要作用。

4. 发明公开

EP1743032A2 METHODS AND APPARATUS FOR DETECTION OF VIRAL INFECTION 审中-公开
标题翻译：用于检测病毒感染的方法和设备
公开(公告)号：EP1743032A2
公开(公告)日：2007-01-17
申请号：EP05804762.2
申请日：2005-04-12
申请人： Allied Biotech, Inc.
发明人： YU, Yong, Yi , LI, Lina , LI, Zhuangwu , BAO, Jun
IPC分类号： C12Q1/00
CPC分类号： G01N33/543 , B01J2219/00315 , B01J2219/00367 , B01J2219/00378 , B01J2219/00387 , B01J2219/00432 , B01J2219/00497 , B01J2219/005 , B01J2219/00511 , B01J2219/00527 , B01J2219/00545 , B01J2219/00547 , B01J2219/00574 , B01J2219/00576 , B01J2219/00578 , B01J2219/00641 , B01J2219/00662 , B01J2219/00677 , B01J2219/00691 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , G01N33/56983 , G01N2469/20
摘要： This invention generally relates to apparatus and methods for high-throughput, reproducible and inexpensive detection of virus infection using multiplexing technologies such as slide-based, microtiter plate-based and membrane-based microarrays and beads technologies. The apparatus and methods allow simultaneous detection of multiple viral infections in a plurality of test samples.
摘要翻译：本发明一般涉及使用多路技术如基于载玻片，基于微量滴定板和基于膜的微阵列和珠技术用于高通量，可重复和廉价检测病毒感染的装置和方法。该设备和方法允许同时检测多个测试样品中的多种病毒感染。

5. 发明申请

WO2012045275A1 MOESIN FRAGMENTS ASSOCIATED WITH APLASTIC ANEMIA 审中-公开
标题翻译：与APLASTIC ANEMIA相关的MOESIN片段
公开(公告)号：WO2012045275A1
公开(公告)日：2012-04-12
申请号：PCT/CN2011/080523
申请日：2011-10-08
申请人： SHANGHAI KEXIN BIOTECH CO., LTD. , ZHANG, Yue , BAO, Jun , MAO, Hua , XIANG, Fei , SUN, Hongbin , QIAN, Jie , HAN, Yongjun , SITU, Weina
发明人： ZHANG, Yue , BAO, Jun , MAO, Hua , XIANG, Fei , SUN, Hongbin , QIAN, Jie , HAN, Yongjun , SITU, Weina
IPC分类号： A61K38/16 , C07K2/00
CPC分类号： G01N33/6893 , A61K38/19 , C07K14/52 , G01N33/564 , G01N2800/22
摘要： The present application provides compositions and methods useful for detecting and monitoring acquired aplastic anemia.
摘要翻译：本申请提供了用于检测和监测获得性再生障碍性贫血的组合物和方法。

6. 发明公开

EP1563096A2 METHODS AND COMPOSITIONS FOR DETECTING TELOMERASE ACTIVITY 审中-公开
标题翻译：方法和组合物端粒酶活性检测
公开(公告)号：EP1563096A2
公开(公告)日：2005-08-17
申请号：EP03783305.0
申请日：2003-11-12
申请人： Allied Biotech, Inc.
发明人： LI, Zhuangwu , BAO, Jun , MAO, Hua , MA, Wenbin , LI, Lina
IPC分类号： C12Q1/68 , C12Q1/48
CPC分类号： C12Q1/6886 , C12Q1/68 , C12Q1/6841 , C12Q1/6851 , C12Q1/686 , C12Q2561/113 , C12Q2547/107 , C12Q2521/113 , C12Q2547/101 , C12Q2545/113
摘要： A method for determining telomerase activity using primer extension followed with real time PCR quantification is disclosed. The method of the present invention provides a rapid, sensitive and accurate measurement for telomerase activity in a biological sample. In one embodiment, the method includes the steps of: adding the biological sample to a reaction tube containing a first reaction mixture having a first primer and nucleoside triphosphates, a second reaction mixture having a second primer and a DNA polymerase, and a wax layer that separates the first reaction mixture from the second reaction mixture; incubating the biological sample with the first reaction mixture; admixing the extension product with the second reaction mixture; amplifying and quantifying the extension product using real-time PCR and a control template. In another embodiment, the detection method includes an in situ primer extension step that allows the production of the extension product within an intact cell. In this embodiment, the extension product can be preserved under appropriate conditions for an extended time before the completion of the quantification step.

7. 发明申请

WO2012045279A1 MOESIN FRAGMENTS ASSOCIATED WITH IMMUNE THROMBOCYTOPENIA 审中-公开
标题翻译：与免疫性血栓形成相关的MOESIN片段
公开(公告)号：WO2012045279A1
公开(公告)日：2012-04-12
申请号：PCT/CN2011/080532
申请日：2011-10-08
申请人： SHANGHAI KEXIN BIOTECH CO., LTD. , ZHANG, Yue , BAO, Jun
发明人： ZHANG, Yue , BAO, Jun
IPC分类号： A61K38/16 , C07K2/00
CPC分类号： G01N33/6854 , C07K14/52 , C07K2319/02 , C07K2319/50 , G01N33/564 , G01N2800/222 , G01N2800/52
摘要： The present application provides compositions and methods useful for detecting and monitoring immune thrombocytopenia.
摘要翻译：本申请提供了用于检测和监测免疫血小板减少症的组合物和方法。

8. 发明申请

WO2010075575A1 COMPOSITIONS AND METHODS FOR RE-PROGRAMMING CELLS WITHOUT GENETIC MODIFICATION 审中-公开
标题翻译：用于重新编程细胞的组合物和方法，无遗传修饰
公开(公告)号：WO2010075575A1
公开(公告)日：2010-07-01
申请号：PCT/US2009/069518
申请日：2009-12-23
申请人： BIOPIPS, INC. , ZHU, Yong , WU, Shili , BAO, Jun
发明人： ZHU, Yong , WU, Shili , BAO, Jun
IPC分类号： C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： C12N5/0696 , A61K2035/122 , C12N5/0637 , C12N5/0676 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606
摘要： The present inventions are directed to compositions and methods regarding the reprogramming of biological samples (such as cells) without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof.
摘要翻译：本发明涉及关于生物样品（例如细胞）的重新编程而不向样品中引入外源基因的组合物和方法。特别地，本发明涉及能够转导到生物样品但不是基因或引起遗传修饰的可导纳材料。本发明还涉及使用其可转导组合物重新编程生物样品的路径或治疗疾病的方法。

9. 发明申请

WO2012045281A1 DIAGNOSTIC AND THERAPEUTIC USES OF MOESIN FRAGMENTS 审中-公开
标题翻译：糖蛋白片的诊断和治疗用途
公开(公告)号：WO2012045281A1
公开(公告)日：2012-04-12
申请号：PCT/CN2011/080538
申请日：2011-10-08
申请人： SHANGHAI KEXIN BIOTECH CO., LTD. , ZHANG, Yue , BAO, Jun
发明人： ZHANG, Yue , BAO, Jun
IPC分类号： A61K38/02 , A61K39/395 , G01N33/564 , A61P7/00
CPC分类号： A61K39/3955 , A61K38/1703 , A61K38/1709 , C07K16/18 , C07K2317/76 , G01N33/564 , G01N33/6854 , G01N2800/10 , G01N2800/52
摘要： The present application provides compositions and methods for modulating the activity and quantity of platelets and preventing and treating disorders or diseases associated with abnormal activity and quantity of platelets.
摘要翻译：本申请提供调节血小板的活性和量的组合物和方法，并预防和治疗与血小板的异常活性和数量相关的疾病或疾病。

10. 发明申请

WO2011163531A2 COMPOSITIONS AND METHODS FOR RE-PROGRAMMING CELLS WITHOUT GENETIC MODIFICATION FOR TREATMENT OF CARDIOVASCULAR DISEASES 审中-公开
标题翻译：用于重新编程细胞的组合物和方法，不进行遗传修饰以治疗心血管疾病
公开(公告)号：WO2011163531A2
公开(公告)日：2011-12-29
申请号：PCT/US2011/041709
申请日：2011-06-23
申请人： VIVOSCRIPT, INC. , ZHU, Yong , WU, Shili , BAO, Jun
发明人： ZHU, Yong , WU, Shili , BAO, Jun
IPC分类号： C12N15/01 , C12N5/07 , C12N15/12 , C07K14/47 , A61K38/17 , A61P9/00
CPC分类号： A61K38/16 , A61K38/00 , B82Y5/00 , C12N5/0637 , C12N5/0696 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , Y10S977/773
摘要： The present inventions are directed to compositions and methods regarding the reprogramming of other cells (such as fibroblast cells) into cardiomyocytes without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof.
摘要翻译：本发明涉及关于将其它细胞（例如成纤维细胞）重编程成心肌细胞而不向样品中引入外源基因的组合物和方法。特别地，本发明涉及能够转导到生物样品但不是基因或引起遗传修饰的可导纳材料。本发明还涉及使用其可转导组合物重新编程生物样品的路径或治疗疾病的方法。

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