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1. 发明申请

WO2014190222A2 MECHANICAL SYRINGE ACCESSORY 审中-公开
标题翻译：机械式注射附件
公开(公告)号：WO2014190222A2
公开(公告)日：2014-11-27
申请号：PCT/US2014/039263
申请日：2014-05-23
申请人： ALLERGAN, INC.
发明人： SCHWAB, Justin J. , KAYDA, Edwin J. , DOMINGUEZ, Zachary P. , MUDD, Christopher S.
IPC分类号： A61M5/315
CPC分类号： A61M5/31551 , A61M5/31501 , A61M5/31526 , A61M5/31535 , A61M5/31578 , A61M5/31595 , A61M2005/3126 , A61M2205/581 , A61M2205/582 , A61M2205/583
摘要： Described herein are syringe accessories that can be attached to standard syringes. These accessories utilize one or more mechanisms that can provide at least one additional sensory feedback to the user when performing an aliquot or dosed injection. In other embodiments, the accessories can prevent overdosing.
摘要翻译：这里描述的是可附接到标准注射器的注射器附件。这些附件利用一个或多个机构，当执行等分试样或剂量注射时，可以向使用者提供至少一种额外的感官反馈。在其他实施例中，附件可以防止过量。

2. 发明申请

WO2012054293A1 ARTICULATED GASTRIC IMPLANT CLIP 审中-公开
标题翻译：有条纹的植入物夹
公开(公告)号：WO2012054293A1
公开(公告)日：2012-04-26
申请号：PCT/US2011/056121
申请日：2011-10-13
申请人： ALLERGAN, INC. , DOMINGUEZ, Zachary P.
发明人： DOMINGUEZ, Zachary P.
IPC分类号： A61F5/00 , A61B17/08
CPC分类号： A61F5/0036 , A61F5/0003 , A61F5/0013 , A61F5/003 , A61F5/0033 , A61F5/0073 , A61F5/0076 , A61F5/0079 , A61F5/0086 , A61F5/0089 , Y10T24/44342 , Y10T24/4453 , Y10T24/44564
摘要： Intragastric implant devices for obesity treatment are disclosed. The device is passive and does not autonomously change shape, but instead reacts to movement of the stomach to induce satiety. The device includes a series of connected, articulated clips that plicate the stomach wall nondestructively (no puncturing through the gastric wall) such that the overall volume of the stomach is reduced. Cam-shaped clamping surfaces prevent slippage of the stomach tissue from within the clips. Methods of implant are disclosed including delivering the device through a transoral delivery tube and advancing the device through the esophagus to be deployed within the stomach. Removal of the device occurs in the reverse.
摘要翻译：公开了用于肥胖症治疗的胃内植入装置。该装置是被动的，并且不自主地改变形状，而是反应胃的运动以诱发饱腹感。该装置包括一系列连接的铰接的夹子，其非破坏性地使胃壁（不穿刺穿过胃壁），使得胃的总体积减小。凸轮形夹紧表面防止夹子内的胃组织滑动。公开了植入物的方法，包括通过经腹输送管递送装置并推进装置通过食道以部署在胃内。相反地，发生设备的移除。

3. 发明申请

WO2012054519A2 REACTIVE INTRAGASTRIC IMPLANT DEVICES 审中-公开
标题翻译：反应性入口植入装置
公开(公告)号：WO2012054519A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/056761
申请日：2011-10-18
申请人： ALLERGAN, INC. , DOMINGUEZ, Zachary P. , SCHWAB, Justin J. , BABKES, Mitchell H.
发明人： DOMINGUEZ, Zachary P. , SCHWAB, Justin J. , BABKES, Mitchell H.
IPC分类号： A61F5/00
CPC分类号： A61F5/0033 , A61F5/0036
摘要： Transoral three-dimensionally orthogonal intragastric spring systems, devices, methods of operation and manufacture are provided. A transoral three-dimensionally orthogonal intragastric spring system and/or device (and related methods of manufacture and operation) may reduce obesity or weight by stimulating the stomach walls of the patient. The three- dimensionally orthogonal intragastric spring device may be a purely mechanical device comprising a flexible body which in response to an input force in one direction, may deform and cause a resultant displacement in an orthogonal direction, thereby exerting a pressure on the inner stomach walls of the patient. Alternatively, a three-dimensionally orthogonal intragastric spring device may include a variable size balloon configured to occupy volume in the patient's stomach, thereby reducing the amount of space in the patient's stomach.
摘要翻译：提供经口三维正交的胃内弹簧系统，装置，操作和制造方法。经口三维正交的胃内弹簧系统和/或装置（以及相关的制造和手术方法）可以通过刺激患者的胃壁来减轻肥胖或体重。三维正交的胃内弹簧装置可以是纯粹的机械装置，其包括柔性体，其响应于一个方向上的输入力而变形并导致在正交方向上的合成位移，从而对内壁壁施加压力的病人。或者，三维正交的胃内弹簧装置可以包括构造成占据患者胃中的体积的可变大小的气囊，从而减少患者胃中的空间量。

4. 发明申请

WO2012054514A2 INTRAGASTRIC IMPLANTS WITH DUODENAL ANCHORS 审中-公开
标题翻译：带有DUODENAL锚杆的INTRAGASTRIC植入物
公开(公告)号：WO2012054514A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/056753
申请日：2011-10-18
申请人： ALLERGAN, INC. , DOMINGUEZ, Zachary P. , RAVEN, Joseph S. , BABKES, Mitchell H.
发明人： DOMINGUEZ, Zachary P. , RAVEN, Joseph S. , BABKES, Mitchell H.
IPC分类号： A61F5/00
CPC分类号： A61F5/0033 , A61F5/0036 , A61F5/0079
摘要： Intragastric fluid transfer devices and related methods for operation thereof are disclosed. The intragastric fluid transfer devices and related methods are intended to assist a patient in maintaining a healthy body weight by stimulating the inner stomach walls and/or the inner duodenum walls. Features of the intragastric fluid transfer device include insertion of the devices transorally and without invasive surgery, without associated patient risks of invasive surgery, and without substantial patient discomfort. The life span of these intragastric fluid transfer devices may be material-dependent upon long-term survivability within an acidic stomach, but is intended to last one year or longer.
摘要翻译：公开了胃内液体输送装置及其操作方法。胃内液体输送装置和相关方法旨在通过刺激内部胃壁和/或十二指肠内壁来帮助患者维持健康体重。胃内液体输送装置的特征包括经皮和无侵入性手术的装置插入，无相关患者的侵入性手术风险，并且没有实质的患者不适。这些胃内液体输送装置的使用寿命可以依赖于在酸性胃内的长期生存性，但是持续一年或更长时间。

5. 发明申请

WO2012054413A3 SPACE-FILLING INTRAGASTRIC IMPLANTS WITH FLUID FLOW 审中-公开
公开(公告)号：WO2012054413A3
公开(公告)日：2012-04-26
申请号：PCT/US2011/056608
申请日：2011-10-18
申请人： ALLERGAN, INC. , BABKES, Mitchell H. , DOMINGUEZ, Zachary P. , SCHWAB, Justin J.
发明人： BABKES, Mitchell H. , DOMINGUEZ, Zachary P. , SCHWAB, Justin J.
IPC分类号： A61F5/00
摘要： A variety of passive intragastric implant devices for obesity treatment are disclosed. Such passive devices do not autonomously change shape, but instead react within the stomach to induce satiety. The devices may take up volume within the stomach, thus reducing the intake capacity. Additionally, the devices may contact areas within the stomach, such as the cardia surrounding the esophageal sphincter, to stimulate satiety-inducing nerves. Also, certain devices slow gastric emptying by blocking or otherwise impeding flow through the pyloric sphincter. A number of devices combine two or more of these satiety-inducing features. Methods of implant are disclosed including compressing the devices within a delivery tube and transorally advancing the devices through the esophagus to be deployed within the stomach. Removal of the devices occurs in the reverse.

6. 发明申请

WO2013112442A1 GASTRIC BANDS FOR REDUCING OBSTRUCTIONS 审中-公开
标题翻译：用于减少阻碍的气体管
公开(公告)号：WO2013112442A1
公开(公告)日：2013-08-01
申请号：PCT/US2013/022478
申请日：2013-01-22
申请人： ALLERGAN, INC.
发明人： HOOVER, Jason , DOMINGUEZ, Zachary P. , SCHWAB, Justin J. , HONARYAR, Babak
IPC分类号： A61F5/00
CPC分类号： A61F5/0056 , A61F5/0033 , A61F5/0059
摘要： Generally described herein are apparatus, systems and methods related to gastric bands which provide increased compliance to reduce food obstructions and/or reduces over restriction causing symptoms such as gastric enlargement and pouch dilatation. In one embodiment, a dual ringed reservoir band or inflatable portion is provided. In one embodiment, an additional ring or a middle pouch may be added to the dual ringed reservoir band. The addition of an additional ring or middle pouch may further increase band compliance resulting in even fewer food obstructions. In another embodiment, one or more funnels can also be implemented into a gastric banding system to induce satiety and/or for guiding a bolus through the gastric band.
摘要翻译：本文通常描述的是与胃带相关的装置，系统和方法，其提供增加的顺应性以减少食物障碍物和/或减少超过限制，引起诸如胃增大和袋扩张的症状。在一个实施例中，提供双环储存带或可充气部分。在一个实施例中，可以将另外的环或中间袋添加到双环储存带中。添加额外的环或中间袋可能进一步增加带的依从性，导致更少的食物障碍。在另一个实施方案中，还可以将一个或多个漏斗实施到胃束带系统中以诱导饱腹感和/或引导通过胃束带的推注。

7. 发明申请

WO2013059419A2 IMPLANTABLE INJECTION PORT 审中-公开
标题翻译：可注射口
公开(公告)号：WO2013059419A2
公开(公告)日：2013-04-25
申请号：PCT/US2012/060760
申请日：2012-10-18
申请人： ALLERGAN, INC. , FRANKLIN, Ethan , SCHWAB, Justin J. , DOMINGUEZ, Zachary P.
发明人： FRANKLIN, Ethan , SCHWAB, Justin J. , DOMINGUEZ, Zachary P.
IPC分类号： A61M39/02 , A61F5/00
CPC分类号： A61M39/0208 , A61F5/0056 , A61M2039/0063 , A61M2039/0072 , Y10T156/1005
摘要： Injection ports are disclosed for use with a gastric band for the treatment of obesity. An injection port may include a septum having a top surface, a bottom surface, and a side wall connecting the top surface to the bottom surface. The injection port may also include a housing including a first inner side wall being tapered inwards such that an opening defined at a first end is larger than an opening defined at a second end, the tapering of the first inner side wall being used to secure the septum within the housing. The housing may further include a second inner side wall having a first end and a second end, the first end of the second inner side wall joined to the second end of the first inner side wall, and a bottom surface joined to the second end of the second inner side wall.
摘要翻译：公开了与胃带一起用于治疗肥胖症的注射口。注射口可以包括具有顶表面，底表面和连接顶表面和底表面的侧壁的隔膜。注入口还可以包括壳体，其包括向内锥形的第一内侧壁，使得限定在第一端处的开口大于限定在第二端处的开口，第一内侧壁的锥形用于固定房屋内的隔膜壳体还可以包括具有第一端和第二端的第二内侧壁，第二内侧壁的与第一内侧壁的第二端相连接的第一端和与第一内侧壁的第二端连接的底表面第二内侧壁。

8. 发明申请

WO2012125700A2 SELF-ADJUSTING GASTRIC BAND 审中-公开
标题翻译：自我调节胃带
公开(公告)号：WO2012125700A2
公开(公告)日：2012-09-20
申请号：PCT/US2012/029041
申请日：2012-03-14
申请人： ALLERGAN, INC. , SNOW, Sean , BABKES, Mitchell H. , BORRELL, Marcos , DEUEL, Christopher R. , DOMINGUEZ, Zachary P. , FRANKLIN, Ethan , HONARYAR, Babak , TORJESEN, Erik
发明人： SNOW, Sean , BABKES, Mitchell H. , BORRELL, Marcos , DEUEL, Christopher R. , DOMINGUEZ, Zachary P. , FRANKLIN, Ethan , HONARYAR, Babak , TORJESEN, Erik
IPC分类号： A61F5/00 , A61B5/00
CPC分类号： A61F5/0056
摘要： Generally described herein are automatic, self-adjusting, gastric banding systems and improvements thereof, that are capable of automatically relaxing and contracting in response to a large bolus passing through the area of a patient's stomach constricted by a gastric band. Alternatively, and/or in addition in one or more embodiments, the gastric banding systems described herein may also help prevent pouch dilatation and/or erosion. The apparatus and systems described herein aid in facilitating obesity control and/or treating obesity-related diseases while generally being non-invasive once implanted. Furthermore, certain embodiments of the self-adjusting gastric banding systems disclosed herein are automatically adjustable without complicated fluid control mechanisms, flow rate limiting devices, and/or valves. The automatic adjustments may also be made in response to other changes in the patient's esophageal-gastric junction, for example, in response to size, shape, and or location changes.
摘要翻译：这里一般描述的是自动的，自我调节的胃束带系统及其改进，其能够响应于大丸通过患者胃的区域而自动松弛和收缩，所述胃受到胃带。可替代地和/或另外在一个或多个实施例中，本文所述的胃束带系统还可以帮助防止囊扩张和/或侵蚀。本文所述的装置和系统有助于促进肥胖控制和/或治疗肥胖相关疾病，而一旦植入则通常是非侵入性的。此外，本文公开的自调节胃束带系统的某些实施例可自动调节而无需复杂的流体控制机构，流量限制装置和/或阀。例如，响应于患者的食管 - 胃交界处的其他变化，响应于尺寸，形状和/或位置变化，也可以进行自动调整。

9. 发明申请

WO2012054522A2 ANCHORED NON-PIERCING DUODENAL SLEEVE AND DELIVERY SYSTEMS 审中-公开
标题翻译：锚定式非连接套管和输送系统
公开(公告)号：WO2012054522A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/056765
申请日：2011-10-18
申请人： ALLERGAN, INC. , BABKES, Mitchell H. , DOMINGUEZ, Zachary P. , MUDD, Christopher S.
发明人： BABKES, Mitchell H. , DOMINGUEZ, Zachary P. , MUDD, Christopher S.
IPC分类号： A61F5/00
CPC分类号： A61F5/0079 , A61F5/0076
摘要： An intragastric implant for obesity treatment is disclosed. The device delays digestion by providing a duodenal sleeve, and may also slows gastric emptying by limiting flow through the pyloric sphincter. The implant includes an elongated axially-compressible duodenal sleeve having a non-tissue-piercing anchor on a proximal end sized to lodge within the duodenal bulb. The anchor may have oppositely-directed anchoring flanges to resists migration in both directions. The sleeve may also have barbed ribs to resist proximal movement back up into the stomach. A method of implant includes collapsing/compressing the device and transorally advancing it through the esophagus to be deployed within the duodenum. A dissolvable jacket may constrain the implant for delivery and naturally dissolve upon implant. Removal of the implant may occur in the reverse.
摘要翻译：公开了一种用于肥胖症治疗的胃内植入物。该装置通过提供十二指肠套管来延缓消化，并且还可以通过限制通过幽门括约肌的流动来减缓胃排空。植入物包括细长的可轴向压缩的十二指肠套管，其具有在近端上的非组织刺穿锚固件，其大小设置在十二指肠球囊内。锚固件可以具有相反方向的锚固凸缘以抵抗两个方向的迁移。套筒还可以具有倒钩肋，以抵抗近端移动回到胃中。一种植入物的方法包括塌缩/压缩装置，并将其经过食道通过其前端部署在十二指肠内。可溶解的护套可以限制植入物用于递送，并且在植入时自然地溶解。相反，可能会发生植入物的移除。

10. 发明申请

WO2014190223A3 INJECTION DEVICE WITH STRESS PROTECTION 审中-公开
公开(公告)号：WO2014190223A3
公开(公告)日：2014-11-27
申请号：PCT/US2014/039265
申请日：2014-05-23
申请人： ALLERGAN, INC.
发明人： DOMINGUEZ, Zachary P. , BERTOLOTE, Tiago , FRANKLIN, Ethan W. , SCHWAB, Justin J. , AUGARTEN, Mike , METZNER, Jason S.
IPC分类号： A61M5/48 , A61M5/31
摘要： Described are devices and systems for protection of injectable substances such as adipose cells from excessive stress or pressure during injection procedures. Further described are stress control mechanisms for detecting and/or controlling stress or pressure within injection devices.

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