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    • 2. 发明申请
    • REACTIVE INTRAGASTRIC IMPLANT DEVICES
    • 反应性入口植入装置
    • WO2012054519A2
    • 2012-04-26
    • PCT/US2011/056761
    • 2011-10-18
    • ALLERGAN, INC.DOMINGUEZ, Zachary P.SCHWAB, Justin J.BABKES, Mitchell H.
    • DOMINGUEZ, Zachary P.SCHWAB, Justin J.BABKES, Mitchell H.
    • A61F5/00
    • A61F5/0033A61F5/0036
    • Transoral three-dimensionally orthogonal intragastric spring systems, devices, methods of operation and manufacture are provided. A transoral three-dimensionally orthogonal intragastric spring system and/or device (and related methods of manufacture and operation) may reduce obesity or weight by stimulating the stomach walls of the patient. The three- dimensionally orthogonal intragastric spring device may be a purely mechanical device comprising a flexible body which in response to an input force in one direction, may deform and cause a resultant displacement in an orthogonal direction, thereby exerting a pressure on the inner stomach walls of the patient. Alternatively, a three-dimensionally orthogonal intragastric spring device may include a variable size balloon configured to occupy volume in the patient's stomach, thereby reducing the amount of space in the patient's stomach.
    • 提供经口三维正交的胃内弹簧系统,装置,操作和制造方法。 经口三维正交的胃内弹簧系统和/或装置(以及相关的制造和手术方法)可以通过刺激患者的胃壁来减轻肥胖或体重。 三维正交的胃内弹簧装置可以是纯粹的机械装置,其包括柔性体,其响应于一个方向上的输入力而变形并导致在正交方向上的合成位移,从而对内壁壁施加压力 的病人。 或者,三维正交的胃内弹簧装置可以包括构造成占据患者胃中的体积的可变大小的气囊,从而减少患者胃中的空间量。
    • 5. 发明申请
    • RE-SHAPING INTRAGASTRIC IMPLANTS
    • 重新形成的INTRAGASTRIC植入
    • WO2012051108A2
    • 2012-04-19
    • PCT/US2011/055598
    • 2011-10-10
    • ALLERGAN, INC.BABKES, Mitchell H.DOMINGUEZ, Zachary P.MUDD, Christopher S.RAVEN, Joseph S.
    • BABKES, Mitchell H.DOMINGUEZ, Zachary P.MUDD, Christopher S.RAVEN, Joseph S.
    • A61F5/00
    • A61F5/0036
    • The present application provides implantable intragastric devices for the treatment of obesity. The intragastric devices advantageously act as a volume-occupying device, and is able to survive implantation in a patient's stomach for a year or longer. In addition, the intragastric devices may be configured to stimulate an inner stomach wall and/or temporarily block the pylorus to slow gastric emptying and/or be rotationally variant, thereby encouraging different stimulation points on the inner wall of the stomach and limiting the stomach's ability to adapt over long term implantation. The intragastric devices may reshape the stomach cavity, such as by pushing on opposite sides so as to "planarize" the stomach. For instance, the device may be an inflated disk, or an implantable loop or a springy coil that may be straightened for delivery/extraction yet assume the loop or coil shape upon implant.
    • 本申请提供了用于治疗肥胖症的可植入胃内装置。 胃内装置有利地用作体积占用装置,并且能够在患者的胃中植入一年或更长时间。 此外,胃内装置可构造成刺激胃内壁和/或暂时阻塞幽门以减缓胃排空和/或旋转变化,从而促进胃内壁上的不同刺激点并限制胃的能力 以适应长期植入。 胃内装置可以重塑胃腔,例如通过推动相对侧以便“平面化” 胃。 例如,该装置可以是充气盘,或者可植入环或弹性线圈,其可以被拉直以用于递送/提取,但是在植入时呈现环或线圈形状。
    • 7. 发明申请
    • ANCHORED NON-PIERCING DUODENAL SLEEVE AND DELIVERY SYSTEMS
    • 锚定式非连接套管和输送系统
    • WO2012054522A2
    • 2012-04-26
    • PCT/US2011/056765
    • 2011-10-18
    • ALLERGAN, INC.BABKES, Mitchell H.DOMINGUEZ, Zachary P.MUDD, Christopher S.
    • BABKES, Mitchell H.DOMINGUEZ, Zachary P.MUDD, Christopher S.
    • A61F5/00
    • A61F5/0079A61F5/0076
    • An intragastric implant for obesity treatment is disclosed. The device delays digestion by providing a duodenal sleeve, and may also slows gastric emptying by limiting flow through the pyloric sphincter. The implant includes an elongated axially-compressible duodenal sleeve having a non-tissue-piercing anchor on a proximal end sized to lodge within the duodenal bulb. The anchor may have oppositely-directed anchoring flanges to resists migration in both directions. The sleeve may also have barbed ribs to resist proximal movement back up into the stomach. A method of implant includes collapsing/compressing the device and transorally advancing it through the esophagus to be deployed within the duodenum. A dissolvable jacket may constrain the implant for delivery and naturally dissolve upon implant. Removal of the implant may occur in the reverse.
    • 公开了一种用于肥胖症治疗的胃内植入物。 该装置通过提供十二指肠套管来延缓消化,并且还可以通过限制通过幽门括约肌的流动来减缓胃排空。 植入物包括细长的可轴向压缩的十二指肠套管,其具有在近端上的非组织刺穿锚固件,其大小设置在十二指肠球囊内。 锚固件可以具有相反方向的锚固凸缘以抵抗两个方向的迁移。 套筒还可以具有倒钩肋,以抵抗近端移动回到胃中。 一种植入物的方法包括塌缩/压缩装置,并将其经过食道通过其前端部署在十二指肠内。 可溶解的护套可以限制植入物用于递送,并且在植入时自然地溶解。 相反,可能会发生植入物的移除。
    • 9. 发明申请
    • UPPER STOMACH GASTRIC IMPLANTS
    • 上部胃癌植入物
    • WO2012054411A2
    • 2012-04-26
    • PCT/US2011/056606
    • 2011-10-18
    • ALLERGAN, INC.BABKES, Mitchell H.DOMINGUEZ, Zachary P.
    • BABKES, Mitchell H.DOMINGUEZ, Zachary P.
    • A61F5/00
    • A61F5/0036A61F5/0033A61F5/0079
    • A variety of passive intragastric implant devices for obesity treatment are disclosed. Such passive devices do not autonomously change shape, but instead react within the stomach to induce satiety. The devices may provide slowed entry into the stomach, thus reducing the intake capacity. Additionally, the devices may contact areas within the stomach, such as the cardia surrounding the esophageal sphincter, to stimulate satiety-inducing nerves. Some devices combine two or more of these satiety-inducing features. Methods of implant are disclosed including compressing the devices within a delivery tube and transorally advancing the devices through the esophagus to be deployed within the stomach. Removal of the devices occurs in the reverse. The implants are formed of materials that permit the implant to be compressed into a substantially linear transoral delivery configuration and that will resist degradation over a period of at least six months within the stomach.
    • 公开了用于肥胖治疗的各种被动胃内植入装置。 这种被动装置不会自动改变形状,而是在胃内反应以引起饱腹感。 这些装置可能会减缓进入胃部的速度,从而降低进气量。 另外,装置可以接触胃内的区域,例如围绕食道括约肌的贲门,以刺激引起饱腹感的神经。 一些装置结合了两种或更多种这些引起饱腹感的特征。 公开了植入方法,包括压缩输送管内的装置并且经由食道经口腔推进装置以部署在胃内。 反过来拆除设备。 植入物由允许植入物被压缩成基本上线性的经口输送构造并且在胃内至少六个月内抵抗降解的材料形成。