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1. 发明申请

WO2006080029A1 EXTENDED RELEASE FORMULATION OF LEVETIRACETAM 审中-公开
标题翻译：延长释放配方的利多卡因
公开(公告)号：WO2006080029A1
公开(公告)日：2006-08-03
申请号：PCT/IN2005/000275
申请日：2005-08-12
申请人： ALEMBIC LIMITED , KSHIRSAGAR, Rajesh , JOSHI, Mayank , RAICHANDANI, Yogesh
发明人： KSHIRSAGAR, Rajesh , JOSHI, Mayank , RAICHANDANI, Yogesh
IPC分类号： A61K31/4015 , A61K9/30
CPC分类号： A61K31/4015 , A61K9/1635 , A61K9/2054 , A61K9/2077 , A61K9/2866
摘要： An extended release pharmaceutical composition of Levetiracetam with once a day dosage regime and the process of preparing it. The extended release tablet of Levetiracetam with the core comprising of Levetiracetam and water dispersible rate controlling polymer, and the tablet core optionally functional coated comprising a combination of water non-dispersible and/or water dispersible polymer. It provides extended therapeutically effective plasma levels over a twenty four hour period with diminished incidences of neuropsychiatric adverse events by eliminating the troughs and peaks of drug concentration in a patients blood plasma, which comprises administering orally to a patient in need thereof, an extended release tablet that provides a peak blood plasma level of Levetiracetam in from about eight to about Sixteen hours. The core is prepared by Wet granulation, Dry granulation or Direct compression and optionally the tablet core is coated either in a coating pan or in a Fluidized bed system.
摘要翻译：延长释放的左乙拉西坦药物组合物，每日一次剂量方案及其制备方法。左乙拉西坦的延长释放片剂，其核心包含左乙拉西坦和水分散速率控制聚合物，并且片芯任选地功能性包衣，其包含水不可分散和/或水分散性聚合物的组合。它通过消除患者血浆中药物浓度的波谷和峰值，在二十四小时内提供延长的治疗有效血浆水平，减少神经精神不良事件的发生率，其包括向有需要的患者口服延长释放片剂其提供左乙拉西坦的血浆血浆水平高达约8至16小时。核心通过湿法制粒，干法制粒或直接压片制备，并且任选地，片芯包被在涂布盘或流化床系统中。

2. 发明申请

WO2006137079A1 PROCESS AND COMPOSITION OF PREPARING GRANULAR SUCRALOS FOR EMULATING TABLE SUGAR 审中-公开
标题翻译：制备用于模拟表糖的颗粒状SUCRALOS的方法和组合
公开(公告)号：WO2006137079A1
公开(公告)日：2006-12-28
申请号：PCT/IN2005/000336
申请日：2005-12-10
申请人： ALEMBIC LIMITED , KSHIRSAGAR, Rajesh , JOSHI, Mayank , KUMAR, Amresh
发明人： KSHIRSAGAR, Rajesh , JOSHI, Mayank , KUMAR, Amresh
IPC分类号： A23L1/236
CPC分类号： A23L27/37 , A23V2002/00 , A23V2200/132 , A23V2250/264
摘要： A low-calorie solid, pourable composition for emulating sugar, the composition comprising an intense sweetener and at least one low-calorie bulking agent selected from maltodextrin, magnesium oxide, magnesium carbonate, calcium stearate, colloidal silicon dioxide and starch or combinations thereof, and a process for the preparation of said composition.
摘要翻译：一种用于模拟糖的低热量固体可倾倒组合物，该组合物包含强甜味剂和至少一种选自麦芽糖糊精，氧化镁，碳酸镁，硬脂酸钙，胶体二氧化硅和淀粉或其组合的低热量填充剂，以及一种制备所述组合物的方法。

3. 发明申请

WO2006046256A1 EXTENDED RELEASE FORMULATION OF PRAMIPEXOLE DIHYDROCHLORIDE 审中-公开
标题翻译：扩展释放配方的二氯二氯化物
公开(公告)号：WO2006046256A1
公开(公告)日：2006-05-04
申请号：PCT/IN2005/000347
申请日：2005-10-20
申请人： ALEMBIC LIMITED , KSHIRSAGAR, Rajesh , JOSHI, Mayank , KUMAR, Amresh
发明人： KSHIRSAGAR, Rajesh , JOSHI, Mayank , KUMAR, Amresh
IPC分类号： A61K9/52 , A61K9/26 , A61K31/428
CPC分类号： A61K9/5078 , A61K9/2081 , A61K9/5047 , A61K31/428
摘要： An extended release composition of Pramipexole or a pharmaceutical acceptable salt thereof, wherein the active agent is coated on a non pareil inert core, the drug loaded core is further coated with a polymeric layer which enables the release of the active agent over an extended period and optionally the extended release pellets being further blended with suitable excipients and compressed into a multi unit tablet and processes for the preparation of the said composition.
摘要翻译：普拉克索或其药学上可接受的盐的延长释放组合物，其中活性剂涂覆在非帕拉尔惰性核心上，药物负载核心进一步涂覆聚合物层，其能够在延长的时间内释放活性剂，任选地，延长释放丸粒进一步与合适的赋形剂混合并压制成多单位片剂并制备所述组合物。

4. 发明申请

WO2005074895A1 EXTENDED RELEASE COATED MICROTABLETS OF VENLAFAXINE HYDROCHLORIDE 审中-公开
标题翻译：延长释放的氯化铝盐酸盐包衣微胶囊
公开(公告)号：WO2005074895A1
公开(公告)日：2005-08-18
申请号：PCT/IN2004/000340
申请日：2004-10-27
申请人： ALEMBIC LIMITED , BHATTACHARYA, Sampad , KSHIRSAGAR, Rajesh , JOSHI, Mayank , PANDITA, Sandeep
发明人： BHATTACHARYA, Sampad , KSHIRSAGAR, Rajesh , JOSHI, Mayank , PANDITA, Sandeep
IPC分类号： A61K9/48
CPC分类号： A61K9/4808 , A61K9/2866 , A61K31/137
摘要： The present invention relates to an extended release once daily pharmaceutical formulation comprising venlafaxine hydrochloride and pharmaceutically acceptable excipients. More particularly, the present invention relates to an extended release composition in the form of mini-tablets which are incorporated in hard gelatin capsules.
摘要翻译：本发明涉及包含盐酸文拉法辛和药学上可接受的赋形剂的每日一次药物制剂。更具体地说，本发明涉及一种微胶囊形式的延缓释放组合物，其被并入硬明胶胶囊中。

5. 发明申请

WO2004108117A3 EXTENDED RELEASE OSMO-MICROSEALED FORMULATION COMPRISING VENLAFAXINE 审中-公开
公开(公告)号：WO2004108117A3
公开(公告)日：2004-12-16
申请号：PCT/IN2004/000133
申请日：2004-05-14
申请人： ALEMBIC LIMITED , BHATTACHARYA, Sampad , GUMMUDAVELLI, Sridhar , JOSHI, Mayank
发明人： BHATTACHARYA, Sampad , GUMMUDAVELLI, Sridhar , JOSHI, Mayank
IPC分类号： A61K9/32
摘要： Extended Release Osmo-microsealed Formulation comprising 1hree controlled release systems associated in series, first an inner solid particulate phase containing Venlafaxine Hydrochloride (Active), and one or more hydrophobic polymers-, one or more diluents required to increase the bulk one or more osmogen (agents which can generate osmotic pressure across the hydrophobic coating) and one or more binder polymers essentially to provide strength/hardness to the particle, second, an outer solid continuous phase including one or more hydrophilic polymers, it is further compressed into tablet and third is an optional functional coat surrounding the tablet, this invention also provides process/method for forming the described osmo-microsealed extended release delivery system and using such system for treating human ailment/depression are also provided.

6. 发明授权

EP1843761B1 EXTENDED RELEASE FORMULATION OF LEVETIRACETAM 有权
标题翻译： LEVETIRACETAM的扩大释放制剂
公开(公告)号：EP1843761B1
公开(公告)日：2018-01-31
申请号：EP05815688.6
申请日：2005-08-12
申请人： Alembic Limited
发明人： KSHIRSAGAR, Rajesh , JOSHI, Mayank , RAICHANDANI, Yogesh
IPC分类号： A61K31/4015 , A61K9/30
CPC分类号： A61K31/4015 , A61K9/1635 , A61K9/2054 , A61K9/2077 , A61K9/2866
摘要： An extended release pharmaceutical composition of Levetiracetam with once a day dosage regime and the process of preparing it. The extended release tablet of Levetiracetam is with the core comprising of Levetiracetam and water dispersible rate controlling polymer, and the tablet core is optionally functional coated comprising a combination of water non-dispersible and/or water dispersible polymer. It provides extended therapeutically effective plasma levels over a twenty four hour period with diminished incidences of neuropsychiatric adverse events by eliminating the troughs and peaks of drug concentration in a patients blood plasma, which comprises administering orally to a patient in need thereof, an extended release tablet that provides a peak blood plasma level of Levetiracetam in from about eight to about Sixteen hours. The core is prepared by Wet granulation, Dry granulation or Direct compression and optionally the tablet core is coated either in an coating pan or in and Fluidized bed system.

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