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1. 发明公开

EP1404336A1 COMPOSITIONS COMPRISING CGMPPDE5 INHIBITOR FOR TRANSDERMAL DELIVERY TO THE ERECTILE TISSUE OF THE PENIS 审中-公开
标题翻译：含成分PDE5 CGMP为HEMMAR经皮给予阴茎EREKTILGEWEBE
公开(公告)号：EP1404336A1
公开(公告)日：2004-04-07
申请号：EP01274318.3
申请日：2001-11-27
申请人： Bhattacharya, Sampad
发明人： BHATTACHARYA, Sampad , TUMBALAM, Kiran Kumar
IPC分类号： A61K31/505 , A61K9/00 , A61K9/06 , A61P15/10
CPC分类号： A61K9/0034 , A61K9/0014 , A61K31/519
摘要： The invention relates to a pharmaceutical composition comprising cyclic guanosine monophosphate phosphodiesterase type 5 (cGMP PDE5) inhibitor, sildenafil citrate, pharmaceutically acceptable solubilisers and penetration enhancers, along with thickening agents, buffers, emulsifiers and pharmaceutically acceptable surfactants and preservatives, for transdermal delivery to the erectile tissue of the penis, a process of preparing the said composition and method for treatment of erectile dysfunction / vasculogenic impotence by direct/topical application of the transdermal composition to the tissues covering the corpus cavernosum and to the glans penis. The transdermal delivery vehicle for topical application of the composition according to this invention may be in various forms such as gels, ointments, creams, lotions, emulsions and sprays.

2. 发明专利

AU2003264859A8 Intranasal pharmaceutical compositions comprising an antihistamine and a leukotriene inhibitor 未知
公开(公告)号：AU2003264859A8
公开(公告)日：2003-12-19
申请号：AU2003264859
申请日：2003-05-30
申请人： BHATTACHARYA SAMPAD
发明人： BHATTACHARYA SAMPAD , LAGU KIRAN , CHHABADA SANGEETA
IPC分类号： A61K9/00 , A61K31/00 , A61K31/4545 , A61K45/06 , A61K31/47

3. 发明专利

AU2003264859A1 INTRANASAL PHARMACEUTICAL COMPOSITIONS COMPRISING AN ANTIHISTAMINE AND A LEUKOTRIENE INHIBITOR 未知
公开(公告)号：AU2003264859A1
公开(公告)日：2003-12-19
申请号：AU2003264859
申请日：2003-05-30
申请人： BHATTACHARYA SAMPAD
发明人： BHATTACHARYA SAMPAD , LAGU KIRAN , CHHABADA SANGEETA
IPC分类号： A61K9/00 , A61K31/00 , A61K31/4545 , A61K45/06

4. 发明申请

WO2003101434A2 INTRANASAL PHARMACEUTICAL COMPOSITIONS COMPRISING AN ANTIHISTAMINE AND A LEUKOTRIENE INHIBITOR 审中-公开
标题翻译：包含抗菌素和白藜芦醇抑制剂的内用药物组合物
公开(公告)号：WO2003101434A2
公开(公告)日：2003-12-11
申请号：PCT/IN2003/000205
申请日：2003-05-30
申请人： BHATTACHARYA, Sampad , LAGU, Kiran , CHHABADA, Sangeeta
发明人： BHATTACHARYA, Sampad , LAGU, Kiran , CHHABADA, Sangeeta
IPC分类号： A61K31/00
CPC分类号： A61K45/06 , A61K9/0043 , A61K31/00 , A61K31/4545 , A61K2300/00
摘要： A pharmaceutical composition in the intranasal delivery to the nasal mucosa for prevention and treatment of symptoms of allergic rhiities and problems like nasal polyps comprising of Loratadine or Desloratadine which are potent antihistamine and solubilised at pharmaceutically acceptable pH of 4 to 8 which does not cause any irritation in the nose and permits the application of potent antihistamine at the site of action the nasal mucosa in lesser doses and without any side effect with immediate onset of action. Montelukast Sodium in combination with Loratadine would be very effective and gives some effect as intranasal steroids that without any side effects. Addition of pharmaceutical acceptable delivery vehicle help in forming intranasal application dosage units for applying the composition at nasal mucosa.
摘要翻译：鼻内输送到鼻粘膜中的药物组合物，用于预防和治疗过敏性症状的症状，以及诸如包含有效抗组胺药的氯雷他定或去氯雷他定的鼻息肉等问题，并且在药学上可接受的4至8的pH下溶解，这不引起任何刺激在鼻子中，允许在作用部位施用有效的抗组胺药，鼻粘膜以较小剂量施用，并且没有任何副作用，立即起作用。孟鲁司特钠与氯雷他定组合将非常有效，并且作为没有任何副作用的鼻内类固醇产生一些作用。添加药物可接受的输送载体有助于形成用于在鼻粘膜上施用组合物的鼻内施用剂量单位。

5. 发明申请

WO2004108117A2 EXTENDED RELEASE OSMO-MICROSEALED FORMULATION 审中-公开
标题翻译：扩展发布OSMO-MICROSEALD公式
公开(公告)号：WO2004108117A2
公开(公告)日：2004-12-16
申请号：PCT/IN2004000133
申请日：2004-05-14
申请人： ALEMBIC LTD , BHATTACHARYA SAMPAD , GUMMUDAVELLI SRIDHAR , JOSHI MAYANK
发明人： BHATTACHARYA SAMPAD , GUMMUDAVELLI SRIDHAR , JOSHI MAYANK
IPC分类号： A61K9/00 , A61K9/20 , A61K9/28 , A61K9/32 , A61K9/50
CPC分类号： A61K9/2846 , A61K9/0004 , A61K9/2077 , A61K9/2081 , A61K9/5042 , A61K9/5047
摘要： Extended Release Osmo-microsealed Formulation comprising 1hree controlled release systems associated in series, first an inner solid particulate phase containing Venlafaxine Hydrochloride (Active), and one or more hydrophobic polymers-, one or more diluents required to increase the bulk one or more osmogen (agents which can generate osmotic pressure across the hydrophobic coating) and one or more binder polymers essentially to provide strength/hardness to the particle, second, an outer solid continuous phase including one or more hydrophilic polymers, it is further compressed into tablet and third is an optional functional coat surrounding the tablet, this invention also provides process/method for forming the described osmo-microsealed extended release delivery system and using such system for treating human ailment/depression are also provided.
摘要翻译：延长释放的Osmo-microsaled制剂包含1个串联的控制释放系统，首先是含有盐酸文拉法辛（活性）的内部固体颗粒相和一种或多种疏水性聚合物，一种或多种增加体积一种或多种渗透剂所需的稀释剂（可以产生穿过疏水涂层的渗透压的试剂）和一种或多种粘合剂聚合物基本上为颗粒提供强度/硬度，其次为包括一种或多种亲水性聚合物的外部固体连续相，进一步压制成片剂，第三种是本发明还提供了形成所述渗透微密封延长释放递送系统的方法/方法，并且还提供了用于治疗人类疾病/抑郁症的系统。

6. 发明申请

WO2002102385A1 COMPOSITIONS COMPRISING CGMPPDE5 INHIBITOR FOR TRANSDERMAL DELIVERY TO THE ERECTILE TISSUE OF THE PENIS 审中-公开
标题翻译：包含CGMPPDE5抑制剂的组合物，用于转导性递送至PENIS的组织组织
公开(公告)号：WO2002102385A1
公开(公告)日：2002-12-27
申请号：PCT/IN2001/000210
申请日：2001-11-27
申请人： BHATTACHARYA, Sampad , TUMBALAM, Kiran Kumar
发明人： BHATTACHARYA, Sampad , TUMBALAM, Kiran Kumar
IPC分类号： A61K31/505
CPC分类号： A61K9/0034 , A61K9/0014 , A61K31/519
摘要： The invention relates to a pharmaceutical composition comprising cyclic guanosine monophosphate phosphodiesterase type 5 (cGMP PDE5) inhibitor, sildenafil citrate, pharmaceutically acceptable solubilisers and penetration enhancers, along with thickening agents, buffers, emulsifiers and pharmaceutically acceptable surfactants and preservatives, for transdermal delivery to the erectile tissue of the penis, a process of preparing the said composition and method for treatment of erectile dysfunction / vasculogenic impotence by direct/topical application of the transdermal composition to the tissues covering the corpus cavernosum and to the glans penis. The transdermal delivery vehicle for topical application of the composition according to this invention may be in various forms such as gels, ointments, creams, lotions, emulsions and sprays.
摘要翻译：本发明涉及包含环状鸟苷酸磷酸二酯酶5（cGMP PDE5）抑制剂，柠檬酸西地那非，药学上可接受的增溶剂和渗透促进剂以及增稠剂，缓冲剂，乳化剂和药学上可接受的表面活性剂和防腐剂的药物组合物，用于经皮递送至阴茎的勃起组织，制备所述组合物的方法和通过将透皮组合物直接/局部施用于覆盖海绵体海绵体和阴茎阴茎的组织来治疗勃起功能障碍/血管性阳and的方法。用于局部施用根据本发明的组合物的透皮递送载体可以是各种形式，例如凝胶，软膏，乳膏，洗剂，乳剂和喷雾剂。

7. 发明申请

WO2005074895A1 EXTENDED RELEASE COATED MICROTABLETS OF VENLAFAXINE HYDROCHLORIDE 审中-公开
标题翻译：延长释放的氯化铝盐酸盐包衣微胶囊
公开(公告)号：WO2005074895A1
公开(公告)日：2005-08-18
申请号：PCT/IN2004/000340
申请日：2004-10-27
申请人： ALEMBIC LIMITED , BHATTACHARYA, Sampad , KSHIRSAGAR, Rajesh , JOSHI, Mayank , PANDITA, Sandeep
发明人： BHATTACHARYA, Sampad , KSHIRSAGAR, Rajesh , JOSHI, Mayank , PANDITA, Sandeep
IPC分类号： A61K9/48
CPC分类号： A61K9/4808 , A61K9/2866 , A61K31/137
摘要： The present invention relates to an extended release once daily pharmaceutical formulation comprising venlafaxine hydrochloride and pharmaceutically acceptable excipients. More particularly, the present invention relates to an extended release composition in the form of mini-tablets which are incorporated in hard gelatin capsules.
摘要翻译：本发明涉及包含盐酸文拉法辛和药学上可接受的赋形剂的每日一次药物制剂。更具体地说，本发明涉及一种微胶囊形式的延缓释放组合物，其被并入硬明胶胶囊中。

8. 发明申请

WO2004108117A3 EXTENDED RELEASE OSMO-MICROSEALED FORMULATION COMPRISING VENLAFAXINE 审中-公开
公开(公告)号：WO2004108117A3
公开(公告)日：2004-12-16
申请号：PCT/IN2004/000133
申请日：2004-05-14
申请人： ALEMBIC LIMITED , BHATTACHARYA, Sampad , GUMMUDAVELLI, Sridhar , JOSHI, Mayank
发明人： BHATTACHARYA, Sampad , GUMMUDAVELLI, Sridhar , JOSHI, Mayank
IPC分类号： A61K9/32
摘要： Extended Release Osmo-microsealed Formulation comprising 1hree controlled release systems associated in series, first an inner solid particulate phase containing Venlafaxine Hydrochloride (Active), and one or more hydrophobic polymers-, one or more diluents required to increase the bulk one or more osmogen (agents which can generate osmotic pressure across the hydrophobic coating) and one or more binder polymers essentially to provide strength/hardness to the particle, second, an outer solid continuous phase including one or more hydrophilic polymers, it is further compressed into tablet and third is an optional functional coat surrounding the tablet, this invention also provides process/method for forming the described osmo-microsealed extended release delivery system and using such system for treating human ailment/depression are also provided.

9. 发明申请

WO2003101434A3 INTRANASAL PHARMACEUTICAL COMPOSITIONS COMPRISING AN ANTIHISTAMINE AND A LEUKOTRIENE INHIBITOR 审中-公开
公开(公告)号：WO2003101434A3
公开(公告)日：2003-12-11
申请号：PCT/IN2003/000205
申请日：2003-05-30
申请人： BHATTACHARYA, Sampad , LAGU, Kiran , CHHABADA, Sangeeta
发明人： BHATTACHARYA, Sampad , LAGU, Kiran , CHHABADA, Sangeeta
IPC分类号： A61K31/4545
摘要： A pharmaceutical composition in the intranasal delivery to the nasal mucosa for prevention and treatment of symptoms of allergic rhiities and problems like nasal polyps comprising of Loratadine or Desloratadine which are potent antihistamine and solubilised at pharmaceutically acceptable pH of 4 to 8 which does not cause any irritation in the nose and permits the application of potent antihistamine at the site of action the nasal mucosa in lesser doses and without any side effect with immediate onset of action. Montelukast Sodium in combination with Loratadine would be very effective and gives some effect as intranasal steroids that without any side effects. Addition of pharmaceutical acceptable delivery vehicle help in forming intranasal application dosage units for applying the composition at nasal mucosa.

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