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1. 发明申请

WO2004037983A2 CAGED LIGANDS AND USES THEREOF 审中-公开
标题翻译： CAGED配偶及其用途
公开(公告)号：WO2004037983A2
公开(公告)日：2004-05-06
申请号：PCT/US2003/033438
申请日：2003-10-22
申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY , LAWRENCE, David , PESTELL, Richard , ALBANESE, Christopher
发明人： LAWRENCE, David , PESTELL, Richard , ALBANESE, Christopher
IPC分类号： C12N
CPC分类号： B82Y5/00 , A61K31/56 , A61K41/0042 , A61K47/554 , A61K47/6949 , A61K48/005 , A61K48/0058 , C12N15/67
摘要： Provided are caged compounds comprising a ligand that specifically reacts with a receptor not naturally present in mammals. The cage is released from the ligand upon illumination of the compound with light. Also provided are cells transfected with a gene of interest and a gene encoding a receptor, the gene of interest operably linked to a genetic element capable of being induced by the receptor when bound to a ligand, and the receptor not naturally present in the species of the cell. The cells also comprise a caged ligand of the receptor. Additionally provided are methods of inducing a gene of interest in the above cells. Also provided are methods of repressing a gene of interest in a cell using caged ligands of receptors. Methods are additionally provided for inducing elimination of a target sequence in a cell of a species, using a caged ligand and a recombinase.
摘要翻译：提供了包含与哺乳动物中天然存在的受体特异性反应的配体的笼养化合物。在用光照射化合物时，笼从配体释放出来。还提供了用感兴趣的基因转染的细胞和编码受体的基因，该靶基因可操作地连接到当与配体结合时能够被受体诱导的遗传元件，以及不是天然存在于细胞。细胞还包含受体的笼状配体。另外提供了在上述细胞中诱导目的基因的方法。还提供了使用笼式受体配体抑制细胞中目的基因的方法。另外提供了使用笼式配体和重组酶诱导物种细胞中靶序列的消除的方法。

2. 发明申请

WO2004046989A1 PRODUCT AND SERVICE RISK MANAGEMENT CLEARINGHOUSE 审中-公开
标题翻译：产品与服务风险管理清理室
公开(公告)号：WO2004046989A1
公开(公告)日：2004-06-03
申请号：PCT/US2003/013169
申请日：2003-04-30
申请人： GOLDMAN, SACHS & CO. , LAWRENCE, David
发明人： LAWRENCE, David
IPC分类号： G06F17/60
CPC分类号： G06Q40/08 , G06Q30/02 , G06Q40/00
摘要： A method and system for managing risk associated with a product or service is provided (Figure 3). Data relevant to risk variables associated with a product or service can be gathered (310) from multiple sources and aggregated according to risk variables (312). An inquiry relating to a risk subject can be received and portions of the aggregated data can be associated with the risk subject (313). A risk subject can include for example, a product, manufacturer, marketer or other related entity. The associated portions of the aggregated data can be transmitted (315), to a subscriber that submitted the risk subject. Risks related to products or services included in invoices, proposals and the like can also be input for risk management clearing. In addition, an inquiry can include a system to system inquiry involving an individual request or batch screening requests received electronically. Requests can also include a voice communication or a facsimile.
摘要翻译：提供了一种用于管理与产品或服务相关的风险的方法和系统（图3）。与产品或服务相关的风险变量相关的数据可以从多个来源收集（310），并根据风险变量进行汇总（312）。可以接收与风险主题相关的查询，并且可以将部分综合数据与风险对象相关联（313）。风险主体可以包括例如产品，制造商，营销商或其他相关实体。聚合数据的相关部分可以传送（315）到提交风险对象的用户。也可以输入与发票，提案等中包含的产品或服务相关的风险，以进行风险管理清算。此外，查询可以包括涉及到以电子方式收到的单独请求或批量筛选请求的系统查询系统。请求还可以包括语音通信或传真。

3. 发明申请

WO2004021102A2 GAMING INDUSTRY RISK MANAGEMENT CLEARINGHOUSE 审中-公开
标题翻译：游戏行业风险管理清算室
公开(公告)号：WO2004021102A2
公开(公告)日：2004-03-11
申请号：PCT/US2003/023310
申请日：2003-07-24
申请人： GOLDMAN, SACHS & CO. , LAWRENCE, David
发明人： LAWRENCE, David
IPC分类号： G06F
CPC分类号： G06Q40/04
摘要： Systems, methods, apparatus, computer program code and means for gathering, organizing and presenting on a real time basis information pertinent to Risks associated with subjects related to the Gaming Industry. Risks associated with the Gaming Industry can be managed by gathering data relevant to the Gaming Industry from multiple sources and aggregating the gathered data according to one or more risk variables. An inquiry relating to a risk subject can be received and portions of the aggregated data can be associated with the risk subject. The associated portions of the aggregated data can be transmitted to an entity placing the inquiry or other designated destination.
摘要翻译：系统，方法，设备，计算机程序代码和用于实时收集，组织和呈现与与博彩业相关的主题相关的风险的信息的手段。可以通过从多个来源收集与游戏行业相关的数据，并根据一个或多个风险变量聚合收集的数据来管理与游戏行业相关的风险。可以接收与风险主题有关的查询，并且可以将部分汇总数据与风险对象相关联。聚合数据的相关部分可以被发送到放置查询或其他指定目的地的实体。

4. 发明申请

WO2004010262A2 LONG TERM CARE RISK MANAGEMENT CLEARINGHOUSE 审中-公开
标题翻译：长期护理风险管理清洁室
公开(公告)号：WO2004010262A2
公开(公告)日：2004-01-29
申请号：PCT/US2003/023033
申请日：2003-07-21
申请人： GOLDMAN, SACHS & CO. , LAWRENCE, David
发明人： LAWRENCE, David
IPC分类号： G06F
CPC分类号： G06Q40/08
摘要： Systems, methods, apparatus, computer program code and means for gathering, organizing and presenting on a real time basis information pertinent to Risks associated with long term care related subjects. Risks associated with long term care can be managed by gathering data relevant to long term care from multiple sources and aggregating the gathered data according to one or more risk variables. An inquiry relating to a risk subject can be received and portions of the aggregated data can be associated with the risk subject. The associated portions of the aggregated data can be transmitted to an entity placing the inquiry or other designated destination.
摘要翻译：系统，方法，设备，计算机程序代码和用于实时收集，组织和呈现与长期护理相关主题相关的风险的信息的手段。与长期护理相关的风险可以通过从多个来源收集与长期护理相关的数据来管理，并根据一个或多个风险变量聚集收集的数据。可以接收与风险主题有关的查询，并且可以将部分汇总数据与风险对象相关联。聚合数据的相关部分可以被发送到放置查询或其他指定目的地的实体。

5. 发明申请

WO2004084028A3 LINK ANALYSIS MAPPING PROGRAM RISK MANAGEMENT 审中-公开
公开(公告)号：WO2004084028A3
公开(公告)日：2004-09-30
申请号：PCT/US2004/007928
申请日：2004-03-15
申请人： GOLDMAN, SACHS & CO. , CHILDERS, Gilmore, J. , LAWRENCE, David
发明人： CHILDERS, Gilmore, J. , LAWRENCE, David
IPC分类号： G06F17/60
摘要： A method and system for managing risk by indicating links between one or more persons or entities which can include a process that gathers information about individuals and organizations into a computerized system where it can be analyzed to associate one or more individuals or organizations (210) with links to other individuals or organizations (211). A user can designate a person or entity and the system will provide an indication of linkages associated with the designated person (214). Some embodiments can include a user specifying a particular type of link or limit links to a specified degree of separation between the designated person and any other person or entity (212, 213).

6. 发明申请

WO2004017529A2 METHOD AND SYSTEM FOR MAXIMIZING DATA THROUGHPUT RATE IN A POWER LINE COMMUNICATIONS SYSTEM BY MODIFYING PAYLOAD SYMBOL LENGTH 审中-公开
标题翻译：通过修改PAYLOAD符号长度在电力线通信系统中最大化数据通过速率的方法和系统
公开(公告)号：WO2004017529A2
公开(公告)日：2004-02-26
申请号：PCT/US2003/025866
申请日：2003-08-19
申请人： ENIKIA LLC , LOGVINOV, Oleg , WALVIS, Dick , EBERT, Brion , LAWRENCE, David
发明人： LOGVINOV, Oleg , WALVIS, Dick , EBERT, Brion , LAWRENCE, David
IPC分类号： H04B
CPC分类号： H04B3/54 , H04B3/542 , H04B2203/5408 , H04B2203/5416 , H04L1/0007 , H04L1/0017 , H04L27/2608
摘要： Data throughput rate in a power line communications ("PLC") system is controlled by generating PLC carrier signals in accordance with a PLC signal frame structure containing payload symbols where the payload symbol length is selected based on at least one of a PLC system channel quality and node configuration data. The selected payload symbol length determines the processing operations that a source PLC transceiver performs for generating PLC signals or that a destination PLC transceiver performs for extracting information content from received PLC signals. The payload symbol lengths can be selected to maximize the data throughput rate while maintaining compatibility with prior art PLC system protocols and standards that require a PLC signal frame structure and its payload portion to have fixed, predetermined lengths.
摘要翻译：电力线通信（“PLC”）系统中的数据吞吐率通过根据包含有效载荷符号的PLC信号帧结构生成PLC载波信号来控制，其中有效载荷符号长度被选择为基于PLC系统信道质量和节点配置数据。所选择的有效载荷符号长度确定源PLC收发器执行用于产生PLC信号的处理操作或目的地PLC收发器执行用于从接收到的PLC信号中提取信息内容的处理操作。可以选择有效载荷符号长度以最大化数据吞吐率，同时保持与现有技术的PLC系统协议和标准的兼容性，这些PLC系统协议和标准需要PLC信号帧结构，并且其有效载荷部分具有固定的预定长度。

7. 发明申请

WO2004001538A3 HEDGE FUND RISK MANAGEMENT 审中-公开
公开(公告)号：WO2004001538A3
公开(公告)日：2003-12-31
申请号：PCT/US2003/019219
申请日：2003-06-17
申请人： GOLDMAN, SACHS & CO. , LAWRENCE, David
发明人： LAWRENCE, David
IPC分类号： G06F17/60
摘要： A computerized method and system for managing risk associated with a Hedge Fund is gathered and stored as data in preparation for a risk inquiry search relating to a Hedge Fund. Documents and sources of Hedge Fund descriptor for which a risk inquiry search can be performed. The risk assessment or inquiry search can include data retrieved resultant to augmented retrieval methods. Scrubbed data as well as augmented data can be transmitted from a risk management clearinghouse (106) to a subscriber (111), or to a proprietary risk system (112) utilized by a subscriber (111), such as a risk management system maintained in-house. Risk inquiry searches can be automated and made a part of standard operating procedure for any transaction conducted by the subscriber in which a Hedge Fund is involved.

8. 发明申请

WO2003104944A2 SYSTEMS AND METHODS FOR MANAGING RISK ASSOCIATED WITH A GEO-POLITICAL AREA 审中-公开
标题翻译：用于管理与地理政治领域相关风险的系统和方法
公开(公告)号：WO2003104944A2
公开(公告)日：2003-12-18
申请号：PCT/US2003/018430
申请日：2003-06-11
申请人： GOLDMAN, SACHS & CO. , LAWRENCE, David
发明人： LAWRENCE, David
IPC分类号： G06F
CPC分类号： G06Q40/08
摘要： Methods and systems are presented for managing Risks, including regulatory and reputational risk. The methods can be implemented in a computer and include receiving data descriptive of informational artifacts with content related to at least one of reputational and regulatory risk into the computer system. The computer system can have one or more geopolitical areas defined within it. The computer system can also receive data descriptive of details of a financial transaction, wherein the details include an indication of at least one geopolitical area associated with the financial transaction. At least one informational artifact related to at least one of reputational and regulatory risk can be associated with the at least one geopolitical area associated with the financial transaction and the computer system can generate a report comprising data descriptive of the informational artifacts associated with the at least one geopolitical area associated with the financial transaction.
摘要翻译：提出了管理风险的方法和系统，包括监管和声誉风险。这些方法可以在计算机中实现，并且包括将与信息和监管风险中的至少一个有关的内容的信息文物描述到计算机系统中。计算机系统可以在其中定义一个或多个地理政治区域。计算机系统还可以接收描述金融交易的细节的数据，其中细节包括与金融交易相关联的至少一个地缘政治区域的指示。与声誉和管理风险中的至少一个有关的至少一个信息工件可以与与金融交易相关联的至少一个地缘政治区域相关联，并且计算机系统可以生成包括描述与至少与该金融交易相关联的信息工件的数据的报告与金融交易相关的一个地缘政治区域。

9. 发明申请

WO2006110121A1 CONSTRUCTION INDUSTRY RISK MANAGEMENT CLEARINGHOUSE 审中-公开
标题翻译：建筑业风险管理清理室
公开(公告)号：WO2006110121A1
公开(公告)日：2006-10-19
申请号：PCT/US2003/024373
申请日：2003-08-01
申请人： GOLDMAN, SACHS & CO. , LAWRENCE, David
发明人： LAWRENCE, David
IPC分类号： G06F17/60
CPC分类号： G06Q40/06
摘要： Systems, methods, apparatus, computer program code and means for gathering, organizing and presenting on a real time basis information pertinent to risks associated with subjects related to the Construction Industry (Figure 3). Risks associated with the Construction Industry can be managed by gathering data (310) relevant to the Construction Industry from multiple sources and aggregating (312) the gathered data according to one or more risk variables. An inquiry (313) relating to a Risk subject can be received and portions of the aggregated data can be associated (314) with the Risk subject. The associated portions of the aggregated data can be transmitted (317) to an entity placing the inquiry or other designated destination.
摘要翻译：系统，方法，设备，计算机程序代码和用于实时收集，组织和呈现与建筑行业相关的风险相关的信息的信息的方法（图3）。可以通过从多个来源收集与建筑行业相关的数据（310）来管理与建筑行业相关的风险，并根据一个或多个风险变量聚合（312）收集的数据。可以接收与风险主题相关的查询（313），并且可以将风险主题的一部分合并数据相关联（314）。聚合数据的相关部分可以发送（317）到放置查询或其他指定目的地的实体。

10. 发明申请

WO2004047082A2 INDEPENDENT RESEARCH CONSENSUS EARNINGS ESTIMATES AND METHODS OF DETERMINING SUCH 审中-公开
标题翻译：独立研究共识收益估算及确定方法
公开(公告)号：WO2004047082A2
公开(公告)日：2004-06-03
申请号：PCT/US2003/036562
申请日：2003-11-14
申请人： GOLDMAN, SACHS & CO. , LAWRENCE, David
发明人： LAWRENCE, David
IPC分类号： G11B
CPC分类号： G06Q40/02 , G06Q40/00 , G06Q40/025 , G06Q40/04 , G06Q40/12
摘要： Apparatus and methods are described for correlating business relationships and issuing earnings estimates. According to the present invention, an earnings estimate can be generated for a company as it compares to a consensus estimate, or other rating aggregate, along with an indication of an investment banking relationship or other business relationship that the entity providing the estimate has had with the company. In addition to a consensus estimate that may be based upon current and previous analyst earnings estimates, operating actuals, expected reporting dates, footnotes and company-issued guidelines, indications of investment banking relationships and a consensus estimate is provided that excludes input from banks conducting business with the company. The present invention can also include suggested actions that can be taken based upon data relating to an investment banking relationship, an earnings estimate and/or a consensus earnings estimate that excludes input from banks with substantial business relationships with the company.
摘要翻译：描述了用于关联业务关系和发布盈余估计的装置和方法。根据本发明，对于公司而言，可以产生对一个公司的收益估计，因为它与一个一致的估计或其他评级的总和相比较，以及提供估计的实体与投资银行关系或其他业务关系的指示公司。除了可能根据当前和之前的分析师盈利预测，经营实际情况，预期报告日期，脚注和公司发布的指引，投资银行业务关系的迹象以及协商一致的预测的协商一致的估计，不包括进行业务的银行的投入与公司。本发明还可以包括可以基于与投资银行关系，收益估计和/或共同收入估计相关的数据而采取的建议行动，该估计不包括与公司具有实质性业务关系的银行的投入。

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