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1. 发明公开

EP2335692A1 Silicone liquid and fluorinated liquid for sequential use in the treatment of retinal tears and/or detachments 审中-公开
标题翻译：硅氧烷流体，以及用于在视网膜撕裂和/或视网膜脱离治疗顺序使用氟化液体
公开(公告)号：EP2335692A1
公开(公告)日：2011-06-22
申请号：EP10193173.1
申请日：2010-11-30
申请人： AL.CHI.MI.A. S.r.l.
发明人： Beccaro, Mauro , Bettini, Enrico , Signori, Paolo
IPC分类号： A61K31/02 , A61K31/075 , A61K31/695 , A61K31/80 , A61P27/02
CPC分类号： A61K31/695 , A61K31/02 , A61K31/075 , A61K31/80 , A61K2300/00
摘要： A first liquid having a density lower than 1.00 g/cm 3 and a second liquid having a density higher than 1.00 g/cm 3 for sequential use in the surgical treatment of tears and/or detachments of the retina, where the said liquids are injected separately into the vitreous cavity after removal of the vitreous humour. In particular, is silicone liquid and is injected first and kept within the vitreous cavity for a determined period of time. Subsequently, the second liquid is injected, which is a fluorinated liquid, which, being miscible with the first liquid, forms a homogenous solution with the latter, with no phase separation and a density higher than 1.00 g/cm 3 . This solution exerts a tamponing action also on the lower portion of the retina, replacing the aqueous phase where PVR would otherwise tend to develop.
摘要翻译：具有密度比1.00克下的第一液体/ cm 3以下，且具有比1.00克/ cm 3的较高的在手术治疗的视网膜，其中所述液体被注入的泪液和/或脱离顺序使用的密度的第二液体分别成去除玻璃体的后玻璃体腔。具体地讲，是硅酮液和第一次注射，并保持玻璃体腔内的时间确定的开采期。随后，第二液体被注入，所有这一切都为氟化液体，其中，与所述第一液体可混溶的，形成与后者均匀的溶液，没有相分离且比1.00克/立方厘米更高的密度。因此，该溶液施加在视网膜的下部的tamponing动作，替换wässrige阶段，其中PVR否则将倾向于发展。

2. 发明公开

EP2020245A1 Device for ophthalmic treatments and methods for making said device 有权
标题翻译： Methode zum Herstellen einer Vorrichtungfürophthalmische Behandlungen
公开(公告)号：EP2020245A1
公开(公告)日：2009-02-04
申请号：EP07425491.3
申请日：2007-07-31
申请人： AL.CHI.MI.A. S.r.l.
发明人： Beccaro, Mauro , Bettini, Enrico , Signori, Paolo
IPC分类号： A61L2/04 , A61F9/00 , A61M5/00 , A61K9/00
CPC分类号： A61M5/001 , A61F9/0017 , A61F9/00727 , A61K9/0019 , A61K9/0048 , A61L2/07 , A61M5/002 , A61M5/344 , A61M5/347 , A61M2005/3104 , A61M2209/06
摘要： A device for ophthalmic treatments comprises a package (9) forming a housing chamber (9a) inside it, and a syringe (2) inserted in the housing chamber (9a) and filled with a sterile liquid, of the type which can be injected into an eyeball. The liquid (4) is selected from amongst the family of perfluorocarbons. There are also two methods for making the device (1).
摘要翻译：用于眼科治疗的装置包括在其内形成容纳室（9a）的包装（9）和插入容纳室（9a）中并填充有无菌液体的注射器（2），其可以注入一个眼球。液体（4）选自全氟化碳族之一。还有两种制造设备的方法（1）。

3. 发明公开

EP3709016A1 METHOD FOR CARRYING OUT AN IN VITRO CYTOTOXICITY TEST ON RETINAL TISSUE 有权
公开(公告)号：EP3709016A1
公开(公告)日：2020-09-16
申请号：EP20158454.7
申请日：2020-02-20
申请人： AL.CHI.MI.A. S.r.l.
发明人： Beccaro, Mauro , Bettini, Enrico , Signori, Paolo , Gatto, Claudio
IPC分类号： G01N33/50 , C12Q1/02
摘要： Method for carrying out a cytotoxicity test in the ophthalmic sector, comprising a treatment step, in vitro, wherein a substance to be tested, in a concentration of interest, is put in contact with living human cells, and is kept in contact with the human cells, in predetermined incubating conditions for a predetermined incubating time interval, an evaluating step wherein the viability of the human cells subjected to the treatment step is evaluated, and a determining step wherein, based on the viability evaluated in that way, the cytotoxicity or non-cytotoxicity of the substance to be tested is determined, wherein for carrying out the method use is made of human cells constituted of one or more first pieces of a full thickness human retina, obtained from an eyeball explanted from a deceased subject, and wherein the treatment step starts within seventy-two hours of the death of the deceased subject.

4. 发明公开

EP3738949A1 HEAVY DYE PREPARATIONS, IN PARTICULAR FOR USE IN SURGICAL METHODS OF OPHTHALMIC SURGERY AND FOR DYEING PROTEINS 审中-实审
公开(公告)号：EP3738949A1
公开(公告)日：2020-11-18
申请号：EP20177573.1
申请日：2016-05-25
申请人： AL.CHI.MI.A. S.r.l.
发明人： Beccaro, Mauro , Bettini, Enrico , Signori, Paolo
IPC分类号： C07C309/49 , A61K49/00 , A61P41/00 , C09B11/12 , C09B11/20
摘要： A dye preparation having a density greater than 1.01 g/cm 3 and comprising at least one dye and at least one agent for increasing its density that is a polymer with the empirical formula (C 12 H 22 O 11 ·C 3 H 5 ClO)n, and the structure

The dye is selected from the group consisting of triphenylmethane dyes, azo dyes, cyanine dyes, natural dyes and/or mixtures of them.

5. 发明授权

EP2020245B1 Method for making a device for ophthalmic treatments 有权
标题翻译：一种制造用于眼科治疗的装置的方法
公开(公告)号：EP2020245B1
公开(公告)日：2011-11-30
申请号：EP07425491.3
申请日：2007-07-31
申请人： AL.CHI.MI.A. S.r.l.
发明人： Beccaro, Mauro , Bettini, Enrico , Signori, Paolo
IPC分类号： A61L2/04 , A61F9/00 , A61M5/00 , A61K9/00
CPC分类号： A61M5/001 , A61F9/0017 , A61F9/00727 , A61K9/0019 , A61K9/0048 , A61L2/07 , A61M5/002 , A61M5/344 , A61M5/347 , A61M2005/3104 , A61M2209/06

6. 发明公开

EP2292193A2 Device for injecting into an eyeball a sterile liquid selected from amongst perfluorocarbons 审中-公开
标题翻译：装置，用于从注入全氟化碳包含眼睛的无菌液体
公开(公告)号：EP2292193A2
公开(公告)日：2011-03-09
申请号：EP10175445.5
申请日：2010-09-06
申请人： AL.CHI.MI.A. S.r.l.
发明人： Beccaro, Mauro , Bettini, Enrico , Signori, Paolo
IPC分类号： A61F9/00 , A61F9/007 , A61M5/20 , A61M5/145 , A61M5/155 , A61M5/34
CPC分类号： A61F9/0017 , A61F9/00727 , A61M5/14526 , A61M5/155 , A61M5/2053 , A61M5/344 , A61M5/347 , A61M2005/3104
摘要： Device for injecting into an eyeball a sterile liquid selected from amongst perfluorocarbons, comprising a tubular container body (3) having a first dispensing end (5) and a second end (6), and an adapter (4) for connecting a thrust fluid feed tube (6) to the second end (6). A first stopper (17) is inserted into the container body (3) in a sealed fashion and sterile liquid (2) is fed between the first stopper (17) and the first end (5). The adapter (4) consists of first and second connecting means (21), (22) to attach the adapter (4) to a feed tube (20) and to the second end (6), as well as first and second seal means (23), (24) to guarantee the fluid seal between the adapter (4) and the feed tube (20) and the container body (3). A duct (25) for the passage of a thrust fluid extends through the adapter (4) from the feed tube (20) to the container body (3).
摘要翻译：设备，用于注入在眼球从之中的全氟化碳中选出的无菌液体，其包括管状容器主体（3），其具有一个第一分配端（5）和第二端（6），以及用于连接一个推力流体（4）适配器的进料管（6）到第二端（6）。第一止动件（17）以密封的方式插入到容器主体（3）和无菌液体（2）的第一止动件（17）和所述第一（5）端部之间供给。所述适配器（4）besteht第一和第二连接装置（21），（22）用于连接所述适配器（4）的进料管（20）和第二端（6），以及第一和第二密封手段（23）（24），以保证在适配器（4）和进料管（20）和容器主体之间的流体密封件（3）。一种用于推力流体的通道管道（25）通过从所述进料管（20）在容器主体（3）适配器（4）延伸。

7. 发明授权

EP1224864B1 A method for preserving explanted corneas 有权
标题翻译：一种用于保存移植的眼角膜方法
公开(公告)号：EP1224864B1
公开(公告)日：2003-04-02
申请号：EP01830028.5
申请日：2001-01-19
申请人： AL.CHI.MI.A. S.R.L.
发明人： Beccaro, Mauro , Bettini, Enrico
IPC分类号： A01N1/02
CPC分类号： A01N1/0226 , A01N1/02

8. 发明授权

EP2926794B1 Ready-to-use device and method for removing interfering factors from samples to be subjected to microbiological examination 有权
标题翻译：即用型设备和方法，用于从要进行微生物检查的样品中去除干扰因素
公开(公告)号：EP2926794B1
公开(公告)日：2017-09-06
申请号：EP15158113.9
申请日：2015-03-06
申请人： AL.CHI.MI.A. S.r.l.
发明人： Beccaro, Mauro , Bettini, Enrico , Signori, Paolo
IPC分类号： A61J1/20 , B01J47/00 , B01J47/04 , B01J47/012
CPC分类号： B01J47/04 , B01J47/012

9. 发明公开

EP2292193A3 Device for injecting into an eyeball a sterile liquid selected from amongst perfluorocarbons 审中-公开
标题翻译：装置，用于从注入全氟化碳包含眼睛的无菌液体
公开(公告)号：EP2292193A3
公开(公告)日：2012-10-31
申请号：EP10175445.5
申请日：2010-09-06
申请人： AL.CHI.MI.A. S.r.l.
发明人： Beccaro, Mauro , Bettini, Enrico , Signori, Paolo
IPC分类号： A61F9/00 , A61F9/007 , A61M5/20 , A61M5/145 , A61M5/155 , A61M5/34
CPC分类号： A61F9/0017 , A61F9/00727 , A61M5/14526 , A61M5/155 , A61M5/2053 , A61M5/344 , A61M5/347 , A61M2005/3104
摘要： Device for injecting into an eyeball a sterile liquid selected from amongst perfluorocarbons, comprising a tubular container body (3) having a first dispensing end (5) and a second end (6), and an adapter (4) for connecting a thrust fluid feed tube (6) to the second end (6). A first stopper (17) is inserted into the container body (3) in a sealed fashion and sterile liquid (2) is fed between the first stopper (17) and the first end (5). The adapter (4) consists of first and second connecting means (21), (22) to attach the adapter (4) to a feed tube (20) and to the second end (6), as well as first and second seal means (23), (24) to guarantee the fluid seal between the adapter (4) and the feed tube (20) and the container body (3). A duct (25) for the passage of a thrust fluid extends through the adapter (4) from the feed tube (20) to the container body (3).

10. 发明公开

EP1224864A1 A method for preserving explanted corneas 有权
标题翻译：维尔法赫恩·科尔维耶翁
公开(公告)号：EP1224864A1
公开(公告)日：2002-07-24
申请号：EP01830028.5
申请日：2001-01-19
申请人： AL.CHI.MI.A. S.R.L.
发明人： Beccaro, Mauro , Bettini, Enrico
IPC分类号： A01N1/02
CPC分类号： A01N1/0226 , A01N1/02
摘要： A method for preserving explanted corneas, comprising the operative phases of adding a hydrophilic substance to a bath of a preserving fluid, subsequently fully immersing a cornea in the preserving fluid bath and maintaining the fluid bath containing the cornea at a preservation temperature. The operating phase of adding a hydrophilic substance to the preserving fluid bath is conducted by diffusing the hydrophilic substance only in a delimited portion of the bath, and the cornea is immersed in the preserving fluid outside the delimited portion. The operative phase of maintaining the fluid bath at a preservation temperature is preferably conducted at a temperature ranging between 4°C and 31°C.
摘要翻译：一种保护外植角膜的方法，包括将亲水物质加入保存液的浴中的操作阶段，随后将角膜完全浸入保存液浴中，并将包含角膜的流体浴保持在保存温度。将亲水性物质添加到保存液体浴中的操作阶段是通过仅将亲水物质扩散到浴槽的界定部分进行的，角膜浸渍在定界部分外的保存流体中。将流体浴保持在保存温度的操作阶段优选在4℃至31℃的温度下进行。

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