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1. 发明公开

US20240196882A1 PRESERVATION SOLUTION, PRESERVATION SYSTEM AND METHOD FOR PRESERVING BIOLOGICAL TISSUES IN VITRO, IN PARTICULAR CORNEAL TISSUES 审中-公开
公开(公告)号：US20240196882A1
公开(公告)日：2024-06-20
申请号：US18506225
申请日：2023-11-10
申请人： AL.CHI.MI.A. S.R.L.
发明人： Claudio GATTO , Jana D'AMATO TOTHOVA , Laura GIURGOLA
IPC分类号： A01N1/02
CPC分类号： A01N1/0226
摘要： A preservation solution for corneal tissues in vitro comprises

between approximately 0.05% and approximately 15% by weight/volume of a culture medium for biological tissues,
between approximately 0.05 and approximately 20% by weight/volume of at least one polymer compound having oncotic properties and a Mean molecular weight between 20000 and 550000 Dalton, preferably between 30000 and 200000 Dalton,
and between approximately 0.05% and approximately 5% by weight/volume of at least one nutrient protein, said at least one protein being of foetal or embryonic animal origin,
said preservation solution being suitable for preserving the corneal tissues at a temperature between approximately +2° C. and approximately +37° C. and for a preservation period up to 4 weeks, maintaining the vitality of the corneal cells in a substantially unchanged state and the corneal thickness in a substantially physiological state during the preservation period at a temperature between approximately +2° C. and approximately +37° C.

2. 发明公开

US20240172743A1 PRESERVATION SOLUTION, PRESERVATION SYSTEM AND METHOD FOR PRESERVING BIOLOGICAL TISSUES IN VITRO, IN PARTICULAR CORNEAL TISSUES 审中-公开
公开(公告)号：US20240172743A1
公开(公告)日：2024-05-30
申请号：US18506219
申请日：2023-11-10
申请人： AL.CHI.MI.A. S.R.L.
发明人： Claudio GATTO , Jana D'AMATO TOTHOVA , Laura GIURGOLA
IPC分类号： A01N1/02
CPC分类号： A01N1/0226 , A01N1/0215
摘要： A preservation solution for corneal tissues in vitro includes:

approximately 0.05%-15% by weight/volume of a culture medium for biological tissues,
approximately 0.05%-20% by weight/volume of at least one polymer compound having oncotic properties and a Mean molecular weight between 5000 and 550000 Dalton, and
approximately 0.05%-5% by weight/volume of at least one nutrient protein, which is a uniquely synthetic origin.

The preservation solution being suitable for preserving the corneal tissues at a temperature between approximately +2° C. and approximately +37° C. and for a preservation period up to 4 weeks, maintaining the vitality of the corneal cells in a substantially unchanged state and the corneal thickness in a substantially physiological state during the preservation period at temperatures between approximately +2° C. and approximately +37° C.

3. 发明申请

US20180104361A1 DYE MOLECULE AND DYE PREPARATIONS, IN PARTICULAR FOR USE IN SURGICAL METHODS OF OPHTHALMIC SURGERY AND FOR DYEING PROTEINS 审中-公开
公开(公告)号：US20180104361A1
公开(公告)日：2018-04-19
申请号：US15573069
申请日：2016-05-25
申请人： AL.CHI.MI.A. S.R.L.
发明人： MAURO BECCARO , ENRICO BETTINI , PAOLO SIGNORI
IPC分类号： A61K49/00 , C07C309/49
CPC分类号： A61K49/006 , C07C309/49 , C09B11/12 , C09B11/20
摘要： A dye molecule having the structure (I): where R1 is an SO3− group bound to a hydrogen H atom or to another atom or to an ammonium NH4 group or to a lysine salt or to an arginine salt or to a different monovalent cation, and R2 is an SO3− group, in particular for making dye preparations for use in methods for the treatment of the bodies of humans or animals, for example for dyeing the internal limiting membrane ILM and/or epiretinal membranes EPRM in a surgical method which involves subsequent removal respectively of the ILM and/or of the EPRM; as well as a dye preparation having a density higher than 1.01 g/cm3 and comprising at least one dye and at least one agent for increasing its density which is a polymer with the empirical formula (C12H22O11.C3H5ClO)n, and structure (II).

4. 发明申请

WO1997017944A1 COSMETIC FORMULATIONS CONTAINING BALANCED MIXTURES OF NATURAL-ORIGIN ANIONIC POLYMERS AND PROCESS FOR TOPICAL APPLICATION OF SAME 审中-公开
标题翻译：含有自然原始阴离子聚合物的平衡混合物的化妆品配方及其局部应用方法
公开(公告)号：WO1997017944A1
公开(公告)日：1997-05-22
申请号：PCT/IT1996000210
申请日：1996-11-13
申请人： AL.CHI.MI.A. S.R.L. , SCESA, Carla , CALDERINI, Gabriella
发明人： AL.CHI.MI.A. S.R.L.
IPC分类号： A61K07/48
CPC分类号： A61K8/733 , A61K8/73 , A61K2800/594 , A61Q19/00
摘要： Cosmetic formulations containing balanced mixtures of natural-origin anionic polymers, made up of a gel material consisting of a balanced mixture of anionic polysaccharides of natural origin containing 0.1 % to 5 % of a soluble alginate, 0.01 % to 0.5 % of agar, 0.01 % to 0.5 % of pectin and 0.05 % to 1 % of xanthan gum, the balance being water. The process for topical application of the gel material comprises the following operating steps: spreading a polysaccharide matrix of said gel material over a plate; levelling said polysaccharide matrix to a homogeneous layer of predetermined thickness; dipping said plate into a 1 % calcium salt solution for about 5 minutes; subsequently dipping said plate into a 2 % calcium salt solution for about 2 minutes; thereby obtaining a structured gel provided with a physical pattern of its own; separating said structured gel from said plate; subsequently washing said structured gel in distilled water.
摘要翻译：包含天然来源阴离子聚合物的平衡混合物的化妆品制剂由由含有0.1％至5％的可溶性藻酸盐的阴离子多糖的平衡混合物，0.01％至0.5％琼脂，0.01％至0.5％的果胶和0.05％至1％的黄原胶，其余为水。用于局部施用凝胶材料的方法包括以下操作步骤：将所述凝胶材料的多糖基质铺展在平板上; 将所述多糖基质平整成具有预定厚度的均匀层; 将所述板浸入1％钙盐溶液中约5分钟; 随后将所述板浸入2％钙盐溶液中约2分钟; 从而获得具有其自身的物理图案的结构化凝胶; 将所述结构化凝胶与所述板分离; 随后在蒸馏水中洗涤所述结构化凝胶。

5. 发明申请

WO2019102281A1 CHEMICAL PREPARATION AND METHOD FOR THE DETECTION OF A RADICAL ACTIVITY 审中-公开
公开(公告)号：WO2019102281A1
公开(公告)日：2019-05-31
申请号：PCT/IB2018/058497
申请日：2018-10-30
申请人： AL.CHI.MI.A. S.R.L.
发明人： BECCARO, Mauro , BETTINI, Enrico , SIGNORI, Paolo
IPC分类号： A61F2/32 , A61K31/04 , C07C291/02 , C07K14/82 , A61K31/506 , C12Q1/6886
CPC分类号： C07K14/78 , C07K14/47 , C12Q1/6886
摘要： A chemical preparation for use in a method for the treatment of the bodies of humans or animals, or for use in a diagnostic method applied to the bodies of humans or animals, such that it has a behaviour that means that when, in the presence of a predetermined quantity of crystalline lens proteins with a weight/volume concentration preferably equal to 0.15%, the chemical preparation is subjected to: - either in vivo to one or more steps of said method for the treatment of the bodies of humans or animals or of said diagnostic method applied to the bodies of humans or animals; - or in vitro or ex vivo to one or more steps that reproduce steps of said method for the treatment of the bodies of humans or animals or of said diagnostic method applied to the bodies of humans or animals; the quantity of crystalline lens proteins present is reduced at most by a reduction quantity that, as an absolute value by weight, is equal to 40% of the predetermined quantity of crystalline lens proteins.

6. 发明申请

WO2009133575A1 FLUOROALKYLOXY ALKANES, PROCESS FOR PRODUCTION AND USES THEREOF 审中-公开
标题翻译：氟烷基铝，其生产工艺及其用途
公开(公告)号：WO2009133575A1
公开(公告)日：2009-11-05
申请号：PCT/IT2008/000293
申请日：2008-04-28
申请人： AL.CHI.MI.A. S.r.l. , CONTE, Lino , ZAGGIA, Alessandro , BECCARO, Mauro , BETTINI, Enrico , SIGNORI, Paolo
发明人： CONTE, Lino , ZAGGIA, Alessandro , BECCARO, Mauro , BETTINI, Enrico , SIGNORI, Paolo
IPC分类号： C07C41/16 , C07C43/12
CPC分类号： C07C41/16 , C07C43/12
摘要： The present invention relates to fluoroalkyloxy alkanes having formula (I) : R F -R 1 -O-R 2 wherein: R F is a linear or branched perf luoroalkyl group, having from 1 to 12, preferably from 2 to 8, carbon atoms; R 1 is a linear or branched, non-fluorinated alkylene group, having from 1 to 6, preferably from 2 to 4, carbon atoms,- R 2 is a linear or branched, non-f luorinated alkyl group, having from 1 to 12, preferably from 2 to 8, carbon atoms, possibly containing at least one ether bond -O- along the chain. The present invention further relates to a process for preparation and use thereof, possibly in mixture with at least one silicone oil, as medicaments in ophthalmology, in particular as tamponade liquids in an operation for the treatment of retinal detachment.
摘要翻译：本发明涉及具有式（I）的氟代烷氧基烷烃：RF-R 1 -O-R 2其中：RF是具有1至12个，优选2至8个碳原子的直链或支链全氟烷基; R1是具有1至6个，优选2至4个碳原子的直链或支链的非氟化亚烷基，-R 2是直链或支链的非氟化烷基，其具有1至12个，优选 2至8个碳原子，可能含有沿该链的至少一个醚键-O-。本发明进一步涉及其制备和使用方法，可能与至少一种硅油混合，作为眼科药物，特别是作为治疗视网膜脱离手术的填塞液。

7. 发明申请

WO2016203381A1 VISCOELASTIC PREPARATION FOR USE IN SURGICAL METHODS OF OHPHTALMIC SURGERY 审中-公开
标题翻译：用于手术方法的粘弹性制剂用于OHPHTALMIC手术
公开(公告)号：WO2016203381A1
公开(公告)日：2016-12-22
申请号：PCT/IB2016/053518
申请日：2016-06-15
申请人： AL.CHI.MI.A. S.R.L.
发明人： BECCARO, Mauro , BETTINI, Enrico , SIGNORI, Paolo
IPC分类号： A61K9/00 , A61K9/08 , A61K47/36 , A61K47/38
CPC分类号： A61K9/0048 , A61K9/08 , A61K47/36 , A61K47/38
摘要： A viscoelastic preparation for use in methods for the treatment of the bodies of humans or animals, in particular for use as a hydrating and protective substance for the cornea during a surgical method of ophthalmic surgery, in which preparation forms a protective layer on the cornea and guarantees an optical enlargement effect of the visual field observable through the cornea; the preparation comprises a water-based phosphate buffer and, as a weight/volume percentage, at least: - at least one polymer for increasing the viscosity selected from the group comprising hydroxypropyl methylcellulose HPMC, carboxymethylcellulose, hydroxyethylcellulose, hyaluronic acid, sodium alginate, hydroxypropylguar polyvinylpyrrolidone, polyvinyl alcohol, polymethacrylic acid, copolymer with polyoxyethylene-polyoxypropylene and polyethylene glycol in a quantity of between 0.2% and 20%; - xanthan gum in a quantity of between 0.01 % and 1 %; - carrageenan in a quantity of between 0.005% and 0.5%.
摘要翻译：一种用于治疗人或动物体的方法的粘弹性制剂，特别是在眼科手术的手术方法期间用作角膜的水合和保护性物质，其中制剂在角膜上形成保护层，保证通过角膜可观察到的视野的光学放大效应; 所述制剂包含水基磷酸盐缓冲液，并且以重量/体积百分比计至少： - 至少一种用于增加粘度的聚合物，所述聚合物选自包含羟丙基甲基纤维素HPMC，羧甲基纤维素，羟乙基纤维素，透明质酸，藻酸钠，羟丙基瓜尔胶聚乙烯吡咯烷酮，聚乙烯醇，聚甲基丙烯酸，聚氧乙烯 - 聚氧丙烯和聚乙二醇的共聚物，其量为0.2％至20％; - 黄原胶，其量为0.01％至1％; - 角叉菜胶的量为0.005％至0.5％。

8. 发明申请

WO2016189475A1 DYE MOLECULE AND DYE PREPARATIONS, IN PARTICULAR FOR USE IN SURGICAL METHODS OF OPHTHALMIC SURGERY AND FOR DYEING PROTEINS 审中-公开
标题翻译： DYE分子和染料制剂，特别是用于手术方法的眼科手术和用于染色蛋白质
公开(公告)号：WO2016189475A1
公开(公告)日：2016-12-01
申请号：PCT/IB2016/053062
申请日：2016-05-25
申请人： AL.CHI.MI.A. S.R.L.
发明人： BECCARO, Mauro , BETTINI, Enrico , SIGNORI, Paolo
IPC分类号： A61K49/00
CPC分类号： A61K49/006 , C07C309/49 , C09B11/12 , C09B11/20
摘要： A dye molecule having the structure (I): where R 1 is an SO 3 - group bound to a hydrogen H atom or to another atom or to an ammonium NH4 group or to a lysine salt or to an arginine salt or to a different monovalent cation, and R 2 is an SO 3 - group, in particular for making dye preparations for use in methods for the treatment of the bodies of humans or animals, for example for dyeing the internal limiting membrane ILM and/or epiretinal membranes EPRM in a surgical method which involves subsequent removal respectively of the ILM and/or of the EPRM; as well as a dye preparation having a density higher than 1.01 g/cm 3 and comprising at least one dye and at least one agent for increasing its density which is a polymer with the empirical formula (C 12 H 22 O 11 ·C 3 H 5 ClO) n , and structure (II).
摘要翻译：具有结构（I）的染料分子：其中R1是与氢原子或另一个原子或铵NH 4基团或者赖氨酸盐或精氨酸盐或不同的一价阳离子结合的SO 3 - 基团，并且R2是SO3-基团，特别是用于制备用于治疗人或动物体的方法的染料制剂，例如用于以外科方法染色内部限制性膜ILM和/或视网膜EPRM，其涉及分别随后移除ILM和/或EPRM; 以及密度高于1.01g / cm 3的染料制剂，并且包含至少一种染料和至少一种用于增加其密度的试剂，其是具有经验式（C12H22O11·C3H5ClO）n的聚合物和结构（II）。

9. 发明申请

WO2009016547A2 DEVICE FOR OPHTALMIC TREATMENTS AND METHODS FOR MAKING SAID DEVICE 审中-公开
标题翻译：用于眼科治疗的装置和用于制造所述装置的方法
公开(公告)号：WO2009016547A2
公开(公告)日：2009-02-05
申请号：PCT/IB2008/052949
申请日：2008-07-23
申请人： AL.CHI.MI.A. S.R.L , BECCARO, Mauro , BETTINI, Enrico , SIGNORI, Paolo
发明人： BECCARO, Mauro , BETTINI, Enrico , SIGNORI, Paolo
IPC分类号： A61L2/04 , A61F9/00 , A61M5/00 , A61K9/00
CPC分类号： A61M5/001 , A61F9/0017 , A61F9/00727 , A61K9/0019 , A61K9/0048 , A61L2/07 , A61M5/002 , A61M5/344 , A61M5/347 , A61M2005/3104 , A61M2209/06
摘要： A device for ophthalmic treatments comprises a package (9) forming a housing chamber (9a) inside it, and a syringe (2) inserted in the housing chamber (9a) and filled with a sterile liquid, of the type which can be injected into an eyeball. The liquid (4) is selected from amongst the family of perfluorocarbons. There are also two methods for making the device (1).
摘要翻译：用于眼科治疗的装置包括在其内部形成容纳腔室（9a）的包装（9）和插入容纳腔室（9a）中且填充有无菌液体的注射器（2）可以注入眼球的类型。液体（4）选自全氟化碳族。还有两种制作设备的方法（1）。

10. 发明公开

EP4368021A1 PRESERVATION SOLUTION, PRESERVATION SYSTEM AND METHOD FOR PRESERVING BIOOLOGICAL TISSUES IN VITRO, IN PARTICULAR CORNEAL TISSUES 审中-公开
公开(公告)号：EP4368021A1
公开(公告)日：2024-05-15
申请号：EP23209199.1
申请日：2023-11-10
申请人： AL.CHI.MI.A. S.r.l.
发明人： GATTO, Claudio , D AMATO TOTHOVA, Jana , GIURGOLA, Laura
IPC分类号： A01N1/02
CPC分类号： A01N1/021 , A01N1/0226 , A01N1/0221
摘要： A preservation solution for corneal tissues in vitro comprises
- between approximately 0.05% and approximately 15% by weight/volume of a culture medium for biological tissues,
- between approximately 0.05 and approximately 20% by weight/volume of at least one polymer compound having oncotic properties and a Mean molecular weight between 20000 and 550000 Dalton, preferably between 30000 and 200000 Dalton,
- and between approximately 0.05% and approximately 5% by weight/volume of at least one nutrient protein, said at least one protein being of foetal or embryonic animal origin,
- said preservation solution being suitable for preserving the corneal tissues at a temperature between approximately +2°C and approximately +37°C and for a preservation period up to 4 weeks, maintaining the vitality of the corneal cells in a substantially unchanged state and the corneal thickness in a substantially physiological state during the preservation period at a temperature between approximately +2°C and approximately +37°C.

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