专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO0003035A9 EVACUATED SENSOR DEVICE FOR DETECTING MICROORGANISMS IN BLOOD SAMPLES, AND METHOD THEREFOR 审中-公开
标题翻译：用于检测血液样本中的微生物的消除传感器装置及其方法
公开(公告)号：WO0003035A9
公开(公告)日：2000-10-05
申请号：PCT/US9915599
申请日：1999-07-12
申请人： AKZO NOBEL NV , MARESCH MARTIN J , MATSUMURA PAUL M , JEFFREY SCOTT R , HYMAN JONES M , THORPE THURMAN C
发明人： MARESCH MARTIN J , MATSUMURA PAUL M , JEFFREY SCOTT R , HYMAN JONES M , THORPE THURMAN C
IPC分类号： C12M1/00 , C12M1/28 , C12M1/34 , C12Q1/02 , C12Q1/04 , C12Q1/24 , C12Q1/00
CPC分类号： C12M23/04 , C12M23/22 , C12M23/24 , C12M25/06 , C12M25/14 , C12M41/36 , C12Q1/04 , C12Q1/045 , C12Q1/24
摘要： A device and method allow for collection of a blood specimen and for detecting the presence of microorganisms in the blood specimen. The device is a sensor plate under vacuum which provides an environment to culture microbial organism colonies from a blood sample and a means to facilitate microbial detection and quantification manually or with an instrument. The vacuum sensor plate has a microorganism immobilisation matrix layer and a sensor layer. Detected microbial colonies are immediately available for further testing. A kit is provided having a needle assembly for direct draw of blood from a patient onto the immobilisation layer within the vacuum sensor plate. The sensor plate provides an area for accepting a blood sample, a mechanism to immobilize the blood sample on an interior surface of the plate, nutrients to facilitate growth of microorganisms in the sample, and a sensor layer for allowing the detection and/or enumeration of microorganism colonies within the blood sample. The Figure is an illustration of sensor plate (1) which can be in the form of a flat, shallow container with at least one side being transparent or lucent.
摘要翻译：装置和方法允许收集血液样本并检测血液样本中微生物的存在。该装置是真空下的传感器板，其提供从血液样品中培养微生物菌落的环境，以及手动或用仪器促进微生物检测和量化的手段。真空传感器板具有微生物固定基质层和传感器层。检测到的微生物菌落立即可用于进一步测试。提供了一种套件，其具有用于将血液从患者直接抽取到真空传感器板内的固定层上的针组件。传感器板提供用于接受血液样本的区域，将血液样本固定在板的内表面上的机制，营养物质以促进样品中微生物的生长，以及传感器层，用于允许检测和/或计数血液样品中的微生物菌落。该图是传感器板（1）的图示，其可以是平坦的浅容器的形式，其中至少一侧是透明的或透明的。

2. 发明申请

WO0159060A2 APPARATUS AND METHOD FOR SURFACE CULTURE OF MICROORGANISMS FROM BULK FLUIDS 审中-公开
标题翻译：来自大流行体的微生物表面培养的装置和方法
公开(公告)号：WO0159060A2
公开(公告)日：2001-08-16
申请号：PCT/US0103812
申请日：2001-02-06
申请人： AKZO NOBEL NV , HYMAN JONES M , MATSUMURA PAUL M , JEFFREY SCOTT R , MARESCH MARTIN J , THORPE THURMAN C
发明人： HYMAN JONES M , MATSUMURA PAUL M , JEFFREY SCOTT R , MARESCH MARTIN J , THORPE THURMAN C
IPC分类号： C12M1/16 , C12M1/34 , C12Q1/04 , C12Q1/24
CPC分类号： C12M25/14 , C12Q1/04 , C12Q1/045 , C12Q1/24
摘要： Devices for culturing microorganisms include a container and within the container an immobilization layer made of an interconnected network of polymer chains. The interstitial spaces between the interconnected polymer chains are of a size on average less than an average size of microorganisms to be cultured such that substantially all of the microorganisms in a sample during culturing are immobilized on the surface of the immobilization lawyer. Related methods for detecting microorganisms include providing a device as described above and adding a fluid sample to the device. The fluid sample potentially contains microorganisms and is of a volume of at least .04 ml per each square centimeter of surface area of the immobilization layer. The method then allows the fluid sample to be completely absorbed and immobilized within the immobilization layer, while substantially all microorganisms present within the fluid sample are immobilized on a top surface of the immobilization layer. The device with the fluid sample can be incubated for a period of time so as to allow for growth of any microorganisms present. The method then can detect any microorganisms present on the immobilization layer.
摘要翻译：用于培养微生物的装置包括容器，并且在容器内由聚合物链的互连网络制成的固定层。互连聚合物链之间的间隙空间的平均尺寸小于待培养的微生物的平均尺寸，使得培养期间样品中的基本上所有的微生物固定在固定律师的表面上。用于检测微生物的相关方法包括提供如上所述的装置并将流体样品添加到装置中。流体样品潜在地含有微生物，并且其体积为固定化层每平方厘米表面积至少为0.04ml。该方法然后允许流体样品被完全吸收并固定在固定层内，而流体样品中存在的基本上所有的微生物都固定在固定化层的顶表面上。具有流体样品的装置可以孵育一段时间，以便允许任何存在的微生物的生长。该方法然后可以检测固定层上存在的任何微生物。

3. 发明申请

WO02064086A2 METHOD FOR THE SEPARATION OF ADSORBENTS FROM MICROBIOLOGICAL GROWTH MEDIA 审中-公开
标题翻译：从微生物生长介质中分离吸附物的方法
公开(公告)号：WO02064086A2
公开(公告)日：2002-08-22
申请号：PCT/US0203637
申请日：2002-02-08
申请人： BIO MERIEUX INC , MARESCH MARTIN J , JEFFREY SCOTT R
发明人： MARESCH MARTIN J , JEFFREY SCOTT R
IPC分类号： C12N1/20 , C12N11/02 , C12N11/08 , C12Q1/04 , A61K
CPC分类号： C12N1/20 , C12N11/02 , C12N11/08 , C12Q1/045 , G01N2333/21 , G01N2333/22 , G01N2333/245 , G01N2333/285 , G01N2333/305 , G01N2333/31 , G01N2333/40
摘要： The present invention relates to a method for the separation of adsorbents from growth media, utilizing polymeric dispersants. These dispersants or flocculating agents have been found to efficiently separate beneficial adsorbents without significantly changing the viable microorganisms for further testing.
摘要翻译：本发明涉及利用聚合物分散剂从吸附剂分离吸附剂的方法。已经发现这些分散剂或絮凝剂有效分离有益的吸附剂，而不显着改变活的微生物用于进一步的测试。

4. 发明公开

EP1163362A4 DEVICE AND METHOD FOR MICROBIAL SUSCEPTIBILITY TESTING 有权
标题翻译：设备和检验方法微生物学敏
公开(公告)号：EP1163362A4
公开(公告)日：2004-12-29
申请号：EP00917807
申请日：2000-03-09
申请人： AKZO NOBEL NV
发明人： MATSUMURA PAUL M , HYMAN JONES M , JEFFREY SCOTT R , MARESCH MARTIN J , THORPE THURMAN C , BARRON WILLIAM G
IPC分类号： C12M1/34 , C12Q1/18 , C12Q1/20 , C12R1/01 , G01N21/25 , C12N1/00 , C12Q1/02 , C12Q1/22 , G01N33/53
CPC分类号： G01N21/253 , C12Q1/18
摘要： A method and apparatus for performing microbial antibiotic susceptibility testing include disposable, multi-chambered susceptibility plates and an automated plate handler and image acquisition and processing instrument the susceptibility plates are inoculated with a microorganism (any suitable organism such as bacteria, fungi, protozoa, algae and viruses) and anti-microbial agent(s) are applied such that the microorganism is exposed to a variety of concentrations, or a gradient of each anti-microbial agent. The plates are then placed in the instrument, which monitors and measures the growth (or lack thereof) of the microorganisms. This data is used to determine the susceptibility of the microorganism to the antibiotics. Such a system automates antimicrobial susceptibility testing using solid media and Kirby-Bauer standardized result reporting. The system provides a level of automation previously associated only with broth microdilution testing, while retaining the advantages of the manual disk diffusion test. Figure (1) shows an illustration of agar plate for performing a disk diffusion antibiotic susceptibility test.

5. 发明专利

CA2380027A1 APPARATUS AND METHOD FOR DETECTING, QUANTIFYING AND CHARACTERIZING MICROORGANISMS 未知
公开(公告)号：CA2380027A1
公开(公告)日：2001-02-08
申请号：CA2380027
申请日：2000-06-15
申请人： AKZO NOBEL NV
发明人： JEFFREY SCOTT R , BARRON WILLIAM G , MARESCH MARTIN J , THORPE THUMAN C , HYMAN JONES M , MATSUMURA PAUL M
IPC分类号： G01N33/48 , C12M1/00 , C12M1/34 , C12Q1/00 , C12Q1/02 , C12Q1/04 , C12Q1/06 , C12Q1/18 , G01N21/25 , G01N33/483 , G01N33/493 , G01N35/04
摘要： A method is disclosed for performing a plurality of microbiological tests in any order or at the same time, and within the same instrument. The method includes performing microbiological detection and/or enumeration testing, wherein one or more test samples are added to respective detection plates, each of the plates are placed on or within a holder of the instrument and incubated in the instrument, and during and/or after incubation, each plate is imaged by an imaging device in the instrument in order to determine whether and/or how many microorganism colonies are present. The method also includes performing susceptibility and/or identification testing of microorganisms, wherein if susceptibility testing is performed, one or more samples containi ng microorganisms are added to respective susceptibility plates before or after one or more antibiotics are added to the plate, each of the plates is placed on or within a holder of the instrument and incubated in the instrument, and each plate is imaged by an imaging device the same as or different as the imaging device of step (a) to determine whether and/or the extent of microorganism growth inhibition, and if identification testing is performed, one or more samples containing microorganisms are added to respective identification plates containing substrates for microorganisms, each of said plates is placed on or within a holder of the instrument and incubated in th e instrument, and each plate is imaged by an imaging device the same as or different as the imaging devices in steps (a) and/or (b) to classify and/or identify the microorganism(s) on each plate. The figure shows a block diagra m of the main components of the multifunctional instrument.

6. 发明专利

AU3485901A Apparatus and method for surface culture of microorganisms from bulk fluids 未知
公开(公告)号：AU3485901A
公开(公告)日：2001-08-20
申请号：AU3485901
申请日：2001-02-06
申请人： AKZO NOBEL NV
发明人： HYMAN JONES M , MATSUMURA PAUL M , JEFFREY SCOTT R , MARESCH MARTIN J , THORPE THURMAN C
IPC分类号： C12M1/16 , C12M1/34 , C12Q1/04 , C12Q1/24
摘要： A device and method are provided for isolating and culturing microorganisms from a bulk fluid sample. The device comprises a container having therein a polymeric immobilization layer having interstitial spaces between polymer chains such as a gel matrix. The interstitial spaces are of an average size less than an average size of microorganisms to be separated from the sample and cultured. A bulk fluid sample is applied to the immobilization layer where fluid is absorbed by the layer and microorganisms remain on the surface of the layer. After culturing, microorganism colonies are readily accessible on the surface of the layer for harvest and testing. The immobilization layer may contain one or more of nutrients for microorganisms growth, lytic agents, lytic enzymes, antibiotics, antibiotic neutralizers, indicators, detergents and selective agents. An adjacent support layer may be above and/or below the immobilization layer. The immobilization layer may be in combination with a sensor layer that changes color in areas corresponding to portions of the layer having microorganisms thereon. A membrane may be embedded in the immobilization layer for enhancing microorganism visibility and facilitating microorganism harvest.

7. 发明专利

AU705576B2 Device and method for detecting microorganisms 未知
公开(公告)号：AU705576B2
公开(公告)日：1999-05-27
申请号：AU6038696
申请日：1996-06-04
申请人： AKZO NOBEL NV
发明人： READ KAREN A , TROGDON DAVID E , THORPE THURMAN C , RONSICK CHRISTOPHER S , JEFFREY SCOTT R
IPC分类号： C12M1/24 , C12M1/34 , C12Q1/04 , C12Q1/22 , G01N21/25 , C12M1/04
摘要： A method and a sealable, sterilizable vessel for detecting the presence of microorganisms in a specimen, the vessel containing a liquid culture medium and a sensor with an indicator medium therein. A gas permeable membrane with a gas impermeable removable seal thereon are provided in a wall of the vessel. If the microorganism to be detected is an anaerobic organism, then the gas impermeable seal is left in place. If the microorganism to be detected is an aerobic organism, then the gas impermeable seal is removed so as to allow the passage of oxygen into the vessel. In a preferred embodiment, the gas permeable membrane allows the passage of oxygen into the vessel while at least partly restricting the passage of carbon dioxide to outside of the vessel. Changes in the indicator medium resulting from a change in gas production (CO2, NH2, H2S, etc.), volatile acid production or pH concentration in the medium, are detected from outside the vessel.

8. 发明专利

CA2220968C DEVICE AND METHOD FOR DETECTING MICROORGANISMS 未知
公开(公告)号：CA2220968C
公开(公告)日：2008-01-29
申请号：CA2220968
申请日：1996-06-04
申请人： AKZO NOBEL NV
发明人： TROGDON DAVID E , THORPE THURMAN C , READ KAREN A , RONSICK CHRISTOPHER S , JEFFREY SCOTT R
IPC分类号： C12Q1/04 , C12M1/24 , C12M1/34 , C12Q1/22 , G01N21/25
摘要： A method and a sealable, sterilizable vessel (36) for detecting the presence of microorganisms in a specimen, the vessel contain-ing a liquid culture medium and a sensor (37) with an indicator medium therein. A gas permeable membrane (31) with a gas im-permeable removable seal (32) thereon are provided in a wall of the vessel. If the microorganism to be detected is an anaerobic organism, then the gas impermeable seal (32) is left in place. If the microorganism to be detected is an aerobic organism, then the gas impermeable seal (32) is removed so as to allow the passage of oxygen into the vessel. In a preferred embodiment, the gas perme-able membrane (31) allows the passage of oxygen into the vessel while at least partly restricting the passage of carbon dioxide to outside of the vessel. Changes in the indicator medium resulting from a change in gas production (CO2, NH2, H2S, etc.), volatile acid production or pH concentration in the medium, are detected from outside the vessel.

9. 发明专利

CA2365232A1 DEVICE AND METHOD FOR MICROBIAL SUSCEPTIBILITY TESTING 未知
公开(公告)号：CA2365232A1
公开(公告)日：2000-09-21
申请号：CA2365232
申请日：2000-03-09
申请人： AKZO NOBEL NV
发明人： JEFFREY SCOTT R , MATSUMURA PAUL M , HYMAN JONES M , THORPE THURMAN C , BARRON WILLIAM G , MARESCH MARTIN J
IPC分类号： C12M1/34 , C12Q1/18 , C12Q1/20 , C12R1/01 , G01N21/25 , C12N1/00 , C12Q1/02 , C12Q1/22 , G01N33/53
摘要： A method and apparatus for performing microbial antibiotic susceptibility testing include disposable, multi-chambered susceptibility plates and an automated plate handler and image acquisition and processing instrument the susceptibility plates are inoculated with a microorganism (any suitable organism such as bacteria, fungi, protozoa, algae and viruses) and anti- microbial agent(s) are applied such that the microorganism is exposed to a variety of concentrations, or a gradient of each anti-microbial agent. The plates are then placed in the instrument, which monitors and measures the growth (or lack thereof) of the microorganisms. This data is used to determi ne the susceptibility of the microorganism to the antibiotics. Such a system automates antimicrobial susceptibility testing using solid media and Kirby- Bauer standardized result reporting. The system provides a level of automati on previously associated only with broth microdilution testing, while retaining the advantages of the manual disk diffusion test. Figure (1) shows an illustration of agar plate for performing a disk diffusion antibiotic susceptibility test.

10. 发明专利

CA2337208A1 EVACUATED SENSOR DEVICE FOR DETECTING MICROORGANISMS IN BLOOD SAMPLES, AND METHOD THEREFOR 未知
公开(公告)号：CA2337208A1
公开(公告)日：2000-01-20
申请号：CA2337208
申请日：1999-07-12
申请人： AKZO NOBEL NV
发明人： MARESCH MARTIN J , JEFFREY SCOTT R , MATSUMURA PAUL M , HYMAN JONES M , THORPE THURMAN C
IPC分类号： C12M1/00 , C12M1/28 , C12M1/34 , C12Q1/02 , C12Q1/04 , C12Q1/24 , C12Q1/00
摘要： A device and method allow for collection of a blood specimen and for detecti ng the presence of microorganisms in the blood specimen. The device is a sensor plate under vacuum which provides an environment to culture microbial organi sm colonies from a blood sample and a means to facilitate microbial detection a nd quantification manually or with an instrument. The vacuum sensor plate has a microorganism immobilisation matrix layer and a sensor layer. Detected microbial colonies are immediately available for further testing. A kit is provided having a needle assembly for direct draw of blood from a patient on to the immobilisation layer within the vacuum sensor plate. The sensor plate provides an area for accepting a blood sample, a mechanism to immobilize the blood sample on an interior surface of the plate, nutrients to facilitate growth of microorganisms in the sample, and a sensor layer for allowing the detection and/or enumeration of microorganism colonies within the blood sample. The Figure is an illustration of sensor plate (1) which can be in th e form of a flat, shallow container with at least one side being transparent o r lucent.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式