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1. 发明申请

WO2010018950A3 PROTEIN SCAFFOLD LIBRARY BASED ON KRINGLE DOMAIN STRUCTURE AND USES THEREOF 审中-公开
标题翻译：基于KRINGLE域结构的蛋白质支架库及其应用
公开(公告)号：WO2010018950A3
公开(公告)日：2010-06-03
申请号：PCT/KR2009004423
申请日：2009-08-07
申请人： AJOU UNIV IND ACAD COOP FOUND , KIM YONG-SUNG , KWON MYUNG-HEE , LEE CHANG-HAN
发明人： KIM YONG-SUNG , KWON MYUNG-HEE , LEE CHANG-HAN
IPC分类号： C40B40/10
CPC分类号： C12N15/1044 , C40B40/10
摘要： There are provided a Kringle domain structure, comprising: inducing artificial mutations at amino acid residues except for conserved amino acid residues that are important to maintain the structural scaffold of a Kringle domain; and protein scaffold variants, based on the Kringle domain structure, which modulate the biological activities of a variety of target molecules derived from the protein scaffold library by specifically binding to the target molecules. Also, there is provided a method for constructing homo-/hetero-oligomers which allow multi-specificity binding to multiple targets by the tandem assembly monomeric Kringle domain variants using a linker. Additionally, there is provided a method for preparing multispecific monomers and multivalent monomers by grafting target-binding loops of a Kringle domain variant into non-binding loops of another Kringle domain variant with the same or different target binding specificity. Furthermore, a protein scaffold variant based on the Kringle domain structure that specifically binds to target molecules, DNA encoding the protein scaffold variant, or a method and composition for prevention, detection, diagnosis, treatment or relieving of diseases or disorders, particularly cancers and other immune-related diseases, comprising: administering an effective amount of the related molecule to animals, preferably human.
摘要翻译：提供了Kringle结构域结构，其包括：在保留Kringle结构域的结构支架很重要的保守氨基酸残基之外的氨基酸残基处诱导人工突变; 以及基于Kringle域结构的蛋白质支架变体，其通过特异性结合靶分子来调节源自蛋白质支架文库的多种靶分子的生物活性。此外，提供了一种构建同型/异型寡聚体的方法，其允许使用接头通过串联组装单体Kringle域变体多特异性结合多个靶标。另外，提供了通过将Kringle结构域变体的靶结合环移植到具有相同或不同靶标结合特异性的另一Kringle结构域变体的非结合环中来制备多特异性单体和多价单体的方法。此外，基于特异性结合靶分子的Kringle结构域结构的蛋白质骨架变体，编码蛋白质骨架变体的DNA或用于预防，检测，诊断，治疗或缓解疾病或病症，特别是癌症和其他疾病的方法和组合物包括：将有效量的相关分子给予动物，优选人类。

2. 发明申请

WO2009134027A3 ANTI-NUCLEIC ACID ANTIBODY INDUCING CELL DEATH OF CANCER CELLS AND COMPOSITION FOR PREVENTING OR TREATING CANCERS COMPRISING THE SAME 审中-公开
标题翻译：抗核酸抗体诱导癌细胞细胞死亡和组合物，用于预防或治疗包括其的癌症
公开(公告)号：WO2009134027A3
公开(公告)日：2010-01-21
申请号：PCT/KR2009001973
申请日：2009-04-16
申请人： AJOU UNIV IND ACAD COOP FOUND , KWON MYUNG-HEE , KIM YONG-SUNG , JANG JI-YOUNG
发明人： KWON MYUNG-HEE , KIM YONG-SUNG , JANG JI-YOUNG
IPC分类号： A61K39/395 , A61K36/48 , C12N9/12 , C12P21/04
CPC分类号： C07K16/44 , A61K2039/505 , C07K16/30 , C07K2317/622 , C07K2317/73 , C07K2317/77 , C07K2317/82 , C12N9/0002 , C12N9/22
摘要： There are provided an anti-nucleic acid antibody inducing cell death of cancer cells by invading normal cells; and a composition for preventing or treating cancers comprising the anti-nucleic acid antibody, which shows anticancer effect of an anti-nucleic acid antibody that shows cytotoxicity by damaging nucleic acid strands, that is, genetic information of a cancer cell when the anti-nucleic acid antibody, which has binding activity and degrading activity to the nucleic acid strands in cells at the same time, is overexpressed in the cancer cell, or flows in the cancer cell. Therefore, the composition for treating cancers may be useful to induce the selective cell death in cancer cells than in normal cells since the anti-nucleic acid antibody very easily permeates into the cancer cells due to the excellent selectivity, compared to the normal cells.
摘要翻译：提供通过侵入正常细胞诱导癌细胞的细胞死亡的抗核酸抗体; 以及用于预防或治疗包含抗核酸抗体的癌症的组合物，其显示通过损伤核酸链显示细胞毒性的抗核酸抗体的抗癌作用，即抗核酸抗体的抗核酸抗体，即抗核酸抗体的遗传信息同时对细胞中的核酸链具有结合活性和降解活性的酸抗体在癌细胞中过表达，或在癌细胞中流动。因此，与正常细胞相比，用于治疗癌症的组合物可以用于诱导癌细胞中的选择性细胞死亡，因为与正常细胞相比，抗核酸抗体由于优异的选择性而非常容易地渗入癌细胞。

3. 发明公开

EP2310559A4 PROTEIN SCAFFOLD LIBRARY BASED ON KRINGLE DOMAIN STRUCTURE AND USES THEREOF 审中-公开
标题翻译：蛋白质骨架库上的三环结构域结构的综合及其用途
公开(公告)号：EP2310559A4
公开(公告)日：2012-06-06
申请号：EP09806812
申请日：2009-08-07
申请人： AJOU UNIV IND ACAD COOP FOUND
发明人： KIM YONG-SUNG , KWON MYUNG-HEE , LEE CHANG-HAN
IPC分类号： C40B40/10
CPC分类号： C12N15/1044 , C40B40/10

4. 发明公开

EP2279002A4 ANTI-NUCLEIC ACID ANTIBODY INDUCING CELL DEATH OF CANCER CELLS AND COMPOSITION FOR PREVENTING OR TREATING CANCERS COMPRISING THE SAME 有权
标题翻译：癌细胞的细胞死亡的抗核酸抗体诱导以及预防那些含有成分和治疗癌症
公开(公告)号：EP2279002A4
公开(公告)日：2011-09-14
申请号：EP09738933
申请日：2009-04-16
申请人： AJOU UNIV IND ACAD COOP FOUND
发明人： KWON MYUNG-HEE , KIM YONG-SUNG , JANG JI-YOUNG
IPC分类号： C07K16/30 , A61K36/48 , A61K39/395 , C07K16/44 , C12N9/00 , C12N9/12 , C12P21/04
CPC分类号： C07K16/44 , A61K2039/505 , C07K16/30 , C07K2317/622 , C07K2317/73 , C07K2317/77 , C07K2317/82 , C12N9/0002 , C12N9/22

5. 发明公开

EP2068906A4 ANTIVIRAL AGENT AGAINST ANIMAL VIRUSES 有权转让
标题翻译：抗病毒药物对动物病毒
公开(公告)号：EP2068906A4
公开(公告)日：2010-02-03
申请号：EP07808288
申请日：2007-09-18
申请人： UNIV SUNGKYUNKWAN FOUND , AJOU UNIV IND ACAD COOP FOUND , INVITROPLANT CO LTD , MINISTRY FOR FOOD AGRICULTURE
发明人： LEE SUK-CHAN , KIM YONG-SUNG , KWON MYUNG-HEE , KIM TAI-HYUN , KIM JEONG-SUN , LEE GUN-SUP , SHIM HYE-KYUNG , PARK EUL-YONG , JUNG YU-CHUL , KIM KI-YOON , JUNG YI-JUNG , LEE WOO-RAM , KIM YOUNG-RIM , SOHN JONG-NAM , LEE SEUNG-HYUN
IPC分类号： A61K38/16
CPC分类号： C07K16/10 , A61K39/00 , A61K39/395 , A61K2039/505 , A61K2300/00 , C07K14/47 , C07K16/44 , C07K2317/622 , C07K2317/76 , C07K2317/92

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