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1. 发明公开

EP0864654A4 STRESS-TOLERANT MICROORGANISM AND METHOD OF THE PRODUCTION OF FERMENTATION PRODUCT 失效
标题翻译：压力容器MIKROORGANISMEN UND METHODS ZUR HERSTELLUNG EINES FERMENTATIONSPRODUKTS
公开(公告)号：EP0864654A4
公开(公告)日：1998-11-18
申请号：EP96901978
申请日：1996-02-09
申请人： AJINOMOTO KK
发明人： KIMURA EIICHIRO , KIKUCHI YOSHIMI , KAWAHARA YOSHIO , GOTO SHINYA , KURAHASHI OSAMU , NAKAMATSU TSUYOSHI
IPC分类号： C12P13/04 , C12P13/08 , C12P13/14 , C12P13/22
CPC分类号： C12P13/222 , C12P13/04 , C12P13/08 , C12P13/14
摘要： A method of the fermentative production of useful substances such as amino acids with the use of a microorganism comprising culturing the microorganism in a medium and recovering the fermentation product thus accumulated in the medium, wherein the microorganism is the one to which a tolerance to the stress suppressing its growth and/or the production of the fermentation product has been imparted by introducing at least either a gene encoding a heat shock protein or a gene encoding the sigma factor acting specifically on the heat shock protein gene thereinto to thereby elevate the expression level of the heat shock protein in the cells.
摘要翻译：使用微生物发酵生产有用物质如氨基酸的方法，包括在培养基中培养微生物并回收在培养基中积累的发酵产物，其中微生物是对应激的耐受性通过引入编码热休克蛋白的基因或编码特异性地作用于热休克蛋白基因的σ因子的基因中的至少一种来抑制其生长和/或发酵产物的生成，从而提高发酵产物的表达水平细胞中的热休克蛋白。

2. 发明公开

EP1219712A4 THERMOPHILIC AMINO ACID BIOSYNTHESIS SYSTEM ENZYME GENE OF THERMOTOLERANT CORYNEFORM BACTERIUM 有权
标题翻译： GEN FOR A嗜热酶氨基酸生物合成系统并和平THERMO棒状杆菌型细菌
公开(公告)号：EP1219712A4
公开(公告)日：2004-06-02
申请号：EP00964654
申请日：2000-10-04
申请人： AJINOMOTO KK
发明人： HIRANO SEIKO , NONAKA GEN , MATSUZAKI YUMI , AKIYOSHI NAOKI , NAKAMURA KANAE , KIMURA EIICHIRO , OSUMI TSUYOSHI , MATSUI KAZUHIKO , KAWAHARA YOSHIO , KURAHASHI OSAMU , NAKAMATSU TSUYOSHI , SUGIMOTO SHINICHI
IPC分类号： C07K14/34 , C12N9/02 , C12N9/04 , C12N9/12 , C12N9/26 , C12N9/88 , C12N15/31 , C12N15/53 , C12N15/54 , C12N15/56 , C12N15/60 , C12P13/04
CPC分类号： C12Y108/01004 , C07K14/34 , C12N9/0006 , C12N9/0008 , C12N9/0051 , C12N9/1205 , C12N9/2408 , C12N9/88 , C12Y101/01041 , C12Y102/01051 , C12Y102/04002 , C12Y104/01004 , C12Y203/03001 , C12Y207/01011 , C12Y302/01026 , C12Y401/01031 , C12Y401/03001 , C12Y402/01003 , C12Y604/01001 , C12Y604/01002
摘要： PCR is effected by using chromosomal DNA of Corynebacterium thermoaminogenes as a template with plural primer pairs designed on the basis of domains conserved at the amino acid level among known gene sequences of various microorganisms corresponding to genes encoding L-amino acid biosynthesis system enzymes originating in Corynebacterium thermoaminogenes (preferably enzymes acting at higher temperatures than Corynebacterium glutamicum does). By using primers providing amplified fragments as screening primers, clones containing the target DNA fragments are selected from a Corynebacterium thermoaminogenes chromosomal DNA plasmid library.

3. 发明公开

EP0877090A4 PROCESS FOR PRODUCING L-AMINO ACIDS 失效
标题翻译： Verfahren zur Herstellung von L-Aminosäuren
公开(公告)号：EP0877090A4
公开(公告)日：2001-04-18
申请号：EP96927917
申请日：1996-08-27
申请人： AJINOMOTO KK
发明人： KISHINO HIROKO , IZUI MASAKO , ONO YUKIKO , ITO HISAO , KURAHASHI OSAMU
IPC分类号： C12N15/09 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/22 , C12R1/19 , C12N15/54
CPC分类号： C12P13/04
摘要： A process for producing L-amino acids comprising incubating microorganisms which are capable of producing L-amino acids, in particular, L-phenylalanine, L-tryptophan, L-tyrosine, L-threonine or L-isoleucine and have an enhanced productivity of phosphoenolpyruvic acid in a medium and taking up the L-amino acids thus produced and accumulated in the medium.
摘要翻译：一种生产L-氨基酸的方法，包括培养能够产生L-氨基酸的微生物，特别是L-苯丙氨酸，L-色氨酸，L-酪氨酸，L-苏氨酸或L-异亮氨酸并且具有增强的磷酸烯醇式丙酮酸生产力在培养基中加入酸并摄入由此产生并在培养基中积累的L-氨基酸。

4. 发明公开

EP1004663A4 PROCESS FOR PRODUCING PURINE NUCLEOSIDES VIA FERMENTATION 失效
标题翻译：过程通过发酵嘌呤核苷的PRODUCING
公开(公告)号：EP1004663A4
公开(公告)日：2004-09-15
申请号：EP98932584
申请日：1998-07-17
申请人： AJINOMOTO KK
发明人： MATSUI HIROSHI , KAWASAKI HISASHI , SHIMAOKA MEGUMI , TAKENAKA YASUHIRO , KURAHASHI OSAMU
IPC分类号： C12N1/21 , C12N15/09 , C12P19/40 , C12P19/32 , C12R1/19
CPC分类号： C12N9/1077 , C12P19/38 , C12P19/40 , C12R1/19
摘要： A process for producing purine nucleosides which comprises breeding and culturing microorganisms having a gene encoding an enzyme wherein the feedback inhibition has been substantially relieved by substituting one or two amino acid residues in PRPP amidotransferase encoded by Escherichia coli purF, a gene encoding a protein wherein the repressor in the purine nucleotide biosynthesis system encoded by purR has been inactivated and a gene encoding an enzyme wherein purine nucleoside phosphorylase encoded by deoD has been inactivated, a gene encoding an enzyme wherein succinyl-AMP synthase encoded by purA has been inactivated, a gene encoding an enzyme wherein 6-phosphogluconate dehydratase encoded by edd has been inactivated and a gene encoding an enzyme wherein phosphoglucose isomerase encoded by pgi has been inactivated, or the like.

5. 发明公开

EP1197555A4 DNA ENCODING SUCROSE PTS ENZYME II 有权
标题翻译： FÜRDAS SACCHAROSE-PTS-ENZYM KODIERENDE DNA
公开(公告)号：EP1197555A4
公开(公告)日：2003-07-09
申请号：EP00940903
申请日：2000-06-30
申请人： AJINOMOTO KK
发明人： IZUI MASAKO , SUGIMOTO MASAKAZU , NAKAMATSU TSUYOSHI , KURAHASHI OSAMU
IPC分类号： C12N9/12 , C12N15/54
CPC分类号： C12N9/1205 , C12Y207/01069
摘要： A gene encoding a protein constituting sucrose PTS of a coryneform bacterium provided by amplifying the downstream domain of a coryneform bacterium sucrase gene by the cassette-ligation mediated PCR method and thus obtaining a DNA encoding sucrose PTS enzyme II which is the protein (A) or (B) described below: (A) a protein having the amino acid sequence represented by SEQ ID NO:2 in Sequence Listing; and (B) a protein having an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO:2 in Sequence Listing by substitution, deletion, insertion, addition or inversion of one or more amino acids and having an activity of binding to sucrose.
摘要翻译：通过盒式连接介导的PCR扩增棒状杆菌型细菌的蔗糖酶基因下游的区域，得到编码构成棒状细菌的蔗糖PTS的蛋白质的基因，得到编码下述定义的蛋白质的蔗糖PTS酶II的DNA（ A）或（B）：（A）序列表中具有SEQ ID NO：2的氨基酸序列的蛋白质。（B）序列表中具有SEQ ID NO：2的氨基酸序列的蛋白质，包括一个或几个氨基酸的取代，缺失，插入，添加或转化，以及与蔗糖结合的活性。

6. 发明公开

EP0771879A4 -g(a)-KETOGLUTARIC DEHYDROGENASE GENE 失效
标题翻译： -g（a）-KETOGLUTARSÄUREDEHYDROGENASEGEN
公开(公告)号：EP0771879A4
公开(公告)日：1997-12-17
申请号：EP95921119
申请日：1995-06-07
申请人： AJINOMOTO KK
发明人： ASAKURA YOKO , USUDA YOSHIHIRO , TSUJIMOTO NOBUHARU , KIMURA EIICHIRO , ABE CHIZU AJINOMOTO , KAWAHARA YOSHIO , NAKAMATSU TSUYOSHI , KURAHASHI OSAMU
IPC分类号： C12N1/21 , C12N9/02 , C12N15/53 , C12P13/08 , C12P13/14
CPC分类号： C12N9/0008 , C12P13/08 , C12P13/14
摘要： A coryneform L-glutamate producing bacterium deficient in α-ketoglutaric dehydrogenase activity; a process for producing L-glutamic acid by using the bacterium; a gene coding for an enzyme having an α-KGDH activity originating in the coryneform L-glutamate producing bacterium; a recombinant DNA containing the above gene; a coryneform bacterium holding the above DNA; and a process for producing L-lysine by using an L-lysine producing bacterium holding the recombinant DNA.
摘要翻译：缺乏α-酮戊二酸脱氢酶活性的L-谷氨酸棒状杆菌生产菌; 通过使用该细菌生产L-谷氨酸的方法; 编码源自L-谷氨酸棒状杆菌的细菌的具有α-KGDH活性的酶的基因; 含有上述基因的重组DNA; 含有上述DNA的棒状细菌; 以及使用含有重组DNA的L-赖氨酸生产菌生产L-赖氨酸的方法。

7. 发明公开

EP1033407A4 PROCESS FOR CONSTRUCTING AMINO ACID-PRODUCING BACTERIUM AND PROCESS FOR PRODUCING AMINO ACID BY FERMENTATION METHOD WITH THE USE OF THE THUS CONSTRUCTED AMINO ACID-PRODUCING BACTERIUM 有权
标题翻译：用于生产氨基酸生产菌和它们的用途用于产生氨基酸
公开(公告)号：EP1033407A4
公开(公告)日：2004-08-18
申请号：EP99944770
申请日：1999-09-22
申请人： AJINOMOTO KK
发明人： ASAKURA YOKO , NAKAMURA JUN , KANNO SOHEI , SUGA MIKIKO , KIMURA EIICHIRO , ITO HISAO , MATSUI KAZUHIKO , OHSUMI TSUYOSHI , NAKAMATSU TSUYOSHI , KURAHASHI OSAMU
IPC分类号： C12N15/37 , C12N1/21 , C12N15/67 , C12P13/04 , C12P13/14 , C12N9/02 , C12N9/10 , C12N15/52 , C12P19/38
CPC分类号： C12P13/14 , C12N15/67
摘要： A process for preparing a coryne bacterium having an improved amino acid- or nucleic acid-productivity which comprises constructing mutants of the coryne bacterium by mutating the promoter sequence of an amino acid or nucleic acid biosynthesis gene on the chromosome of the coryne bacterium so as to bring it close to the consensus sequence or by genetic recombination, culturing the resultant mutants and then taking up therefrom a mutant producing the amino acid or the nucleic acid at a high yield. By using this process, the expression dose of a target gene can be adequately strengthened and controlled without resort to any plasmid and a mutant capable of producing an amino acid at a high yield can be constructed by genetic recombination or mutation.

8. 发明公开

EP1241246A4 PROCESS FOR PRODUCING L-AMINO ACID AND NOVEL GENE 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG VON L-AMINOSÄUREUND NEUES GEN
公开(公告)号：EP1241246A4
公开(公告)日：2004-03-24
申请号：EP00985850
申请日：2000-12-22
申请人： AJINOMOTO KK
发明人： SUGIMOTO MASAKAZU , NAKAI YUTA , ITO HISAO , KURAHASHI OSAMU
IPC分类号： C12N1/21 , C12N9/12 , C12N15/54 , C12P13/08 , C12P13/14 , C12N1/20 , C12P13/04 , C12P13/06 , C12P13/18 , C12R1/13 , C12R1/15
CPC分类号： C12N9/1205 , C12P13/08 , C12P13/14
摘要： A gene encoding fructose phosphotransferase is transferred into a coryneform bacterium capable of producing an L-amino acid such as L-lysine or L-glutamic acid and thus the fructose phosphotransferase activity is potentiated, thereby improving the L-amino acid productivity.
摘要翻译：将编码果糖磷酸转移酶的基因导入具有产生L-赖氨酸或L-谷氨酸等L-氨基酸的能力的棒状细菌，以提高果糖磷酸转移酶活性，从而提高L-氨基酸产生能力。

9. 发明公开

EP0872547A4 PROCESS FOR PRODUCING L-VALINE AND L-LEUCINE 失效
标题翻译：工艺生产L-华菱和L-亮氨酸
公开(公告)号：EP0872547A4
公开(公告)日：2001-05-23
申请号：EP95930006
申请日：1995-08-30
申请人： AJINOMOTO KK
发明人： TOMITA FUSAO , YOKOTA ATSUSHI , HASHIGUCHI KENICHI , ISHIGOOKA MASAKO , KURAHASHI OSAMU
IPC分类号： C12N1/21 , C12N15/52 , C12N15/70 , C12P13/06 , C12P13/08 , C12N1/20
CPC分类号： C12N15/70 , C12N15/52 , C12P13/06 , C12P13/08
摘要： L-Valine is produced by culturing in a liquid medium a microorganism demanding lipoic acid for growth, a microorganism deficient in H -ATPase, or a microorganism demanding lipoic acid for growth and deficient in H -ATPase among L-valine- or L-leucine- producing microorganisms of the genus Escherichia , accumulating the L-valine produced in the medium, and harvesting the same.

10. 发明专利

AT501265T 未知
公开(公告)号：AT501265T
公开(公告)日：2011-03-15
申请号：AT09003058
申请日：2001-07-02
申请人： AJINOMOTO KK
发明人： NAKAI YUTA , NAKANISHI KAZUO , KAWAHARA YOSHIO , ITO HISAO , KURAHASHI OSAMU
IPC分类号： C12N15/09 , C12P13/08 , C12N1/21 , C12N9/02 , C12P1/04 , C12P13/04 , C12P13/22 , C12R1/19
摘要： In a method for producing a target substance utilizing a microorganism comprising culturing the microorganism in a medium to produce and accumulate the target substance in the medium and collecting the target substance, there is used, as the microorganism, a mutant strain or a genetic recombinant strain constructed from a parent strain of the microorganism having a respiratory chain pathway of high energy efficiency and a respiratory chain pathway of low energy efficiency as respiratory chain pathways in which the cytochrome bo type oxidase activity is enhanced in comparison to the unmodified strain.

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