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1. 发明公开

EP1553184A4 PROCESS FOR PRODUCING TRIPEPTIDE OR HIGHER PEPTIDE 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG EINES TRIPEPTIDS ODERHÖHERENPEPTIDS
公开(公告)号：EP1553184A4
公开(公告)日：2005-11-30
申请号：EP03771346
申请日：2003-07-25
申请人： AJINOMOTO KK
发明人： YOKOZEKI KENZO , SUZUKI SONOKO , HARA SEIICHI , ABE ISAO
IPC分类号： C07K5/06 , C12N9/16 , C12N9/52 , C12N9/80 , C12N15/57 , C12P21/02
CPC分类号： C07K5/06 , C12N9/16 , C12N9/52 , C12N9/80 , C12P21/02
摘要： It is aimed at providing a method whereby a tripeptide or a higher peptide can be conveniently and less expensively produced at a high yield without resort to any complicated synthesis process. A novel enzyme capable of efficiently producing a peptide is found out from a bacterium belonging to the genus Endobacter or Sphingobacterium. By treating a carboxy component and an amine component with the above enzyme, a tripeptide or a higher peptide is produced.
摘要翻译：其目的在于提供一种方法，其中三肽或更高级的肽可以方便并且以较高的产率较便宜地生产，而无需采用任何复杂的合成方法。从属于Endobacter或Sphingobacterium的细菌中发现了一种能有效生产肽的新型酶。通过用上述酶处理羧基组分和胺组分，产生三肽或更高级的肽。

2. 发明公开

EP1658375A4 METHOD FOR PRODUCING DIPEPTIDES 审中-公开
标题翻译：用于生产二肽
公开(公告)号：EP1658375A4
公开(公告)日：2009-03-18
申请号：EP04748149
申请日：2004-07-26
申请人： AJINOMOTO KK
发明人： YOKOZEKI KENZO , ABE ISAO , HARA SEIICHI
IPC分类号： C12P21/02 , C12N1/20
CPC分类号： C12P21/02

3. 发明公开

EP1829968A4 MUTANT PROTEIN HAVING PEPTIDE-PRODUCTION ACTIVITY 审中-公开
标题翻译：用肽生产活动蛋白突变体
公开(公告)号：EP1829968A4
公开(公告)日：2008-09-10
申请号：EP05820283
申请日：2005-12-20
申请人： AJINOMOTO KK
发明人： ABE ISAO , TAKESHITA RIE , HARA SEIICHI , SUZUKI SONOKO , YOKOZEKI KENZO , SUGIYAMA MASAKAZU , SUZUKI SHUNICHI , WATANABE KUNIHIKO , SHIMBA NOBUHISA , NAKAMURA TAKEFUMI , TAGAMI UNO , KODAMA YUYA , ONOYE HIROMI , YUUJI REIKO , SUZUKI EIICHIRO , KASHIWAGI TATSUKI , XU NINGCHUN , KAI YUKO
IPC分类号： C12N15/09 , C12N9/00 , C12P13/00 , C12P21/02
CPC分类号： C07K14/00 , C07K14/195 , C12N9/93
摘要： Disclosed is an excellent peptide-producing protein. Also disclosed is a process for producing a peptide with high efficiency, or the like. The process comprises reacting an amine component with a carboxy component in the presence of at least one of the following proteins (I) and (II) to produce a peptide: (I) a mutant protein comprising an amino acid sequence having one or more of the mutations shown in mutation types 1 to 68, 239 to 290 and 324 to 377 in the amino acid sequence depicted in SEQ ID NO: 2; and (II) a mutant protein comprising an amino acid sequence having one or more of the mutations shown in mutation types L1 to L335 and M1 to M642 in the amino acid sequence depicted in SEQ ID NO: 208.

4. 发明公开

EP1553171A4 NOVEL ENZYME FORMING PEPTIDE, MICROORGANISM PRODUCING THE SAME AND PROCESS FOR PRODUCING DIPEPTIDE USING THEM 审中-公开
标题翻译：新型酶肽生成此生产微生物及其制造方法二肽使用它们的
公开(公告)号：EP1553171A4
公开(公告)日：2005-09-21
申请号：EP03794067
申请日：2003-07-25
申请人： AJINOMOTO KK
发明人： YOKOZEKI KENZO , SUZUKI SONOKO , HARA SEIICHI , KATAYAMA SATOSHI
IPC分类号： C07K5/06 , C07K5/068 , C07K5/072 , C07K5/078 , C07K5/083 , C07K5/103 , C07K7/06 , C12N1/21 , C12N9/00 , C12N9/18 , C12N9/48 , C12P21/02 , C12R1/01
CPC分类号： C07K5/06026 , C07K5/06034 , C07K5/06043 , C07K5/06052 , C07K5/0606 , C07K5/06069 , C07K5/06078 , C07K5/06086 , C07K5/06095 , C07K5/06104 , C07K5/06113 , C07K5/06147 , C07K5/06156 , C07K5/06165 , C07K5/06191 , C07K5/0806 , C07K5/081 , C07K5/1008 , C07K7/06 , C12N9/18 , C12N9/48 , C12N9/93 , C12P21/02 , C12R1/01
摘要： A novel enzyme by which a peptide can be conveniently and economically produced at a high yield without employing any complicated synthesis method. More specifically speaking, it is intended to provide a novel enzyme catalyzing a reaction of forming a peptide from a carboxy component and an amine component; a microorganism producing this enzyme; and a process for economically producing a peptide with the use of the above enzyme or the above microorganism. A novel enzyme capable of efficiently forming a peptide is found out in a bacterium belonging to the genus Empedobacter, which is newly found out, and thus a process for economically and conveniently producing a peptide is found out.

5. 发明专利

CA2495482C NOVEL PEPTIDE-FORMING ENZYME GENE 未知
公开(公告)号：CA2495482C
公开(公告)日：2011-02-22
申请号：CA2495482
申请日：2003-07-25
申请人： AJINOMOTO KK
发明人： HARA SEIICHI , YOKOZEKI KENZO , ABE ISAO , TONOUCHI NAOTO , JOJIMA YASUKO
IPC分类号： C12N15/57 , C12N1/21 , C12N9/00 , C12N9/48 , C12P21/02
摘要： The present invention relates to a novel enzyme capable of producing peptides easily, inexpensively and at high yield without going through a complex synthesis method. More particularly, the present invention provides a novel enzyme that catalyzes a peptide synthesis reaction from a carboxy component and an amine component, a microbe that produces this enzyme, and an inexpensive dipeptide production method that uses this enzyme or this microbe. A novel enzyme was found that efficiently synthesizes peptide from newly discovered bacteria belonging to the genus Empedobacter, and a method for producing dipeptide both easily and inexpensively was found.

6. 发明专利

DE60331336D1 未知
公开(公告)号：DE60331336D1
公开(公告)日：2010-04-01
申请号：DE60331336
申请日：2003-07-25
申请人： AJINOMOTO KK
发明人： YOKOZEKI KENZO , SUZUKI SONOKO , HARA SEIICHI , ABE ISAO
IPC分类号： C12N15/57 , C07K5/06 , C12N9/16 , C12N9/52 , C12N9/80 , C12P21/02
摘要： It is an object of the present invention to provide a method that allows the production of peptides that are equal to or longer than tripeptides easily, inexpensively and at high yield without going through a complex synthesis method. The inventors of the present invention have found a novel enzyme that efficiently produces a peptide from bacteria belonging to the genus Empedobacter or the genus Sphingobacterium. In the present invention, this enzyme is allowed to act on a carboxy component and an amine component to produce peptides that are equal to or longer than tripeptides.

7. 发明专利

PL374192A1 NOVEL ENZYME FORMING PEPTIDE, MICROORGANISM PRODUCING THE SAME AND PROCESS FOR PRODUCING DIPEPTIDE USING THEM 未知
公开(公告)号：PL374192A1
公开(公告)日：2005-10-03
申请号：PL37419203
申请日：2003-07-25
申请人： AJINOMOTO KK
发明人： YOKOZEKI KENZO , SUZUKI SONOKO , HARA SEIICHI , KATAYAMA SATOSHI , SAKAI HIROAKI
IPC分类号： C07K5/06 , C07K5/068 , C07K5/072 , C07K5/078 , C07K5/083 , C07K5/103 , C07K7/06 , C12N1/21 , C12N9/00 , C12N9/18 , C12N9/48 , C12P21/02 , C12R1/01
摘要： The present invention relates to a novel enzyme that allows peptide to be produced easily, inexpensively and at high yield without going through a complex synthesis method. More particularly, the present invention provides a novel enzyme that catalyzes a peptide-producing reaction from a carboxy component and an amine component, a microbe that produces the enzyme, and a method for inexpensive production of peptides using this enzyme or microbe. The novel enzyme that efficiently produces peptide was discovered from a newly discovered microbe belonging to the genus Empedobacter, and a method was found that allows peptides to be produced inexpensively and easily.

8. 发明专利

BR0305638A 未知
公开(公告)号：BR0305638A
公开(公告)日：2004-09-08
申请号：BR0305638
申请日：2003-07-25
申请人： AJINOMOTO KK
发明人： YOKOZEKI KENZO , SUZUKI SONOKO , HARA SEIICHI , KATAYANA SATOSHI
IPC分类号： C07K5/06 , C07K5/068 , C07K5/072 , C07K5/078 , C07K5/083 , C07K5/103 , C07K7/06 , C12N1/21 , C12N9/00 , C12N9/18 , C12N9/48 , C12P21/02 , C12R1/01
摘要： The present invention relates to a novel enzyme that allows peptide to be produced easily, inexpensively and at high yield without going through a complex synthesis method. More particularly, the present invention provides a novel enzyme that catalyzes a peptide-producing reaction from a carboxy component and an amine component, a microbe that produces the enzyme, and a method for inexpensive production of peptides using this enzyme or microbe. The novel enzyme that efficiently produces peptide was discovered from a newly discovered microbe belonging to the genus Empedobacter, and a method was found that allows peptides to be produced inexpensively and easily.

9. 发明公开

EP1587941A4 METHOD FOR PRODUCING ALPHA-L-ASPARTYL-L-PHENYLALANINE-BETA-ESTER AND METHOD FOR PRODUCING ALPHA-L-ASPARTYL-L-PHENYLALANINE-ALPHA-METHYL ESTER 有权
标题翻译：用于生产ALPHA-L-天冬氨酰-L-苯丙氨酸-β-酯及其制造方法ALPHA-L-天冬氨酰-L-苯丙氨酸-α-甲基酯
公开(公告)号：EP1587941A4
公开(公告)日：2006-06-21
申请号：EP04704772
申请日：2004-01-23
申请人： AJINOMOTO KK
发明人： YOKOZEKI KENZO , OHNO AYAKO , HARA SEIICHI , ABE ISAO
IPC分类号： C12P21/02 , A23L27/30 , C07K5/072 , C07K5/075 , C12N9/48 , C12N15/57 , C12P21/06
CPC分类号： C07K5/0613 , A23L27/32 , C07K5/06113 , C12P21/02 , C12P21/06
摘要： A method for producing an α-L-aspartyl-L-phenylalanine-β-ester (also named α-L-(β-o-substituted aspartyl)-L-phenylalanine), which is an intermediate of an α-L-aspartyl-L-phenylalanine-α-methyl ester (also named α-L-aspartyl-L-phenylalanine methyl ester; product name: aspartame), easily, at high yield and inexpensively without going through a complex synthesis method is provided. Further, an easy, inexpensive and high-yield production method for an α-L-aspartyl-L-phenylalanine-α-methyl ester is provided. α-L-aspartyl-L-phenylalanine-α-methyl ester is produced from a L-aspartic acid-α,β-diester and L-phenylalanine using an enzyme or enzyme-containing substance that has an ability to catalyze a reaction in which L-phenylalanine performs no nucleophilic attack on a β-ester site of L-aspartic acid-α,β-diester but performs a nucleophilic attack on an α-ester site thereof.
摘要翻译：一种用于在±L-天冬氨酰-L-苯丙氨酸-SQ-酯制备（即命名为±-L（²邻substituiertem天冬氨酰）-L-苯丙氨酸）的方法，所有这是在中间的在±L-天冬氨 -L-苯丙氨酸²甲酯（因而命名±-L天冬氨酰-L-苯丙氨酸甲基酯，商品名：阿司帕坦），容易地以高收率且廉价地，而无需通过复杂的合成方法要被提供。此外，对于在±提供L-天冬氨-L-苯丙氨酸±甲酯一种简单，廉价且高收率的制造方法。 ±-L天冬氨酰基-L-苯丙氨酸甲基酯±从L-天冬氨酸 - ±²二酯和L-苯丙氨酸在使用酶或含酶物质已做了以催化在哪一个反应能力产生 L-苯丙氨酸执行对L-天冬氨酸 - ±，²二酯的²酯站点没有亲核攻击，但执行对在其±酯位点的亲核攻击。

10. 发明公开

EP1541688A4 NOVEL PEPTIDE SYNTHASE GENE 有权
标题翻译： NEUARTIGES PEPTIDSYNTHASEGEN
公开(公告)号：EP1541688A4
公开(公告)日：2005-12-14
申请号：EP03771347
申请日：2003-07-25
申请人： AJINOMOTO KK
发明人： HARA SEIICHI , YOKOZEKI KENZO , ABE ISAO , TONOUCHI NAOTO , JOJIMA YASUKO
IPC分类号： C12N1/21 , C12N9/00 , C12N15/57 , C12P21/02 , C12N9/48 , C12R1/19 , C12R1/20
CPC分类号： C12N9/00 , C12N9/93 , C12P21/00 , C12P21/02
摘要： A novel enzyme by which a peptide can be conveniently and economically produced at a high yield without via a complicated synthesis process. More specifically, it is intended to provide a novel enzyme catalyzing a peptide synthesis reaction from a carboxy component and an amine component, a microorganism producing this enzyme, and a process for economically producing a peptide with the use of the enzyme or the microorganism. From a newly found bacterium belonging to the genus Empedobacter, a novel enzyme efficiently synthesizing a peptide is found out. Also, a process for economically and conveniently producing a peptide is found out.
摘要翻译：一种新的酶，通过该酶可以方便而经济地以高产率生产肽而无需经过复杂的合成过程。更具体地，旨在提供催化来自羧基组分和胺组分的肽合成反应的新型酶，产生该酶的微生物以及使用酶或微生物经济地生产肽的方法。从属于Empedobacter属的新发现的细菌中，发现了有效合成肽的新型酶。此外，还找到了经济方便地生产肽的方法。

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