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    • 1. 发明申请
    • TRIAZOLE PHOSPHONATE PESTICIDES
    • 三唑磷酸酯类农药
    • WO1995014385A1
    • 1995-06-01
    • PCT/GB1994002568
    • 1994-11-23
    • AGREVO UK LIMITEDWRIGHT, Gillian +hfLINDELL, Stephen, DavidFOSTER, Stephen, GeorgeMILLING, Richard, James
    • AGREVO UK LIMITEDWRIGHT, Gillian +hfWRIGHT, Brian, John +di
    • A01N57/24
    • C12Q1/18A01N57/24A01N61/00C07F9/6518
    • Compounds of formula (I), where Tr is optionally substituted 1,2,4-triazol-1-yl or 1.2.4-triazol-3-yl; A is a) Q, where Q is an optionally substituted chain containing 3 to 6 atoms, and in which (i) when the chain is of 3 atoms, at least one of the chain atoms is a hetero atom, (ii) when the chain comprises 4 carbon atoms, then the second carbon from the triazole is not substituted by optionally substituted hydroxy, and (iii) when the chain is of 3 to 5 atoms, the phospho group is not attached directly to an oxygen atom; or b) an optionally substituted three membered carbon chain or ring, in which two optional substituents can together with the chain atoms form a carbocyclic ring; and in which when A is a chain, various proviso apply, can be used for combating fungi. The compounds have been shown to be inhibitors of imidazole glycerol phosphate dehydratase. Many of the compounds are novel and these also have other pesticidal activity.
    • 式(I)化合物,其中Tr是任选取代的1,2,4-三唑-1-基或1.2,4-三唑-3-基; A是a)Q,其中Q是含有3至6个原子的任选取代的链,并且其中(i)当链为3原子时,至少一个链原子为杂原子,(ii)当 链包含4个碳原子,则来自三唑的第二碳不被任选取代的羟基取代,和(iii)当链为3至5个原子时,磷基不直接附着在氧原子上; 或b)任选取代的三元碳链或环,其中两个任选的取代基与链原子一起形成碳环; 并且当A是链时,各种附带条件适用,可用于对抗真菌。 这些化合物已被证明是咪唑甘油磷酸酯脱水酶的抑制剂。 许多化合物是新颖的,并且也具有其他杀虫活性。
    • 2. 发明申请
    • CHROMONES USEFUL AS FUNGICIDES
    • CHROMONES有用作为防腐剂
    • WO1998027080A1
    • 1998-06-25
    • PCT/GB1997003368
    • 1997-12-18
    • AGREVO UK LIMITEDMACRITCHIE, Jacqueline, AnneO'MAHONY, Mary, JosephineLINDELL, Stephen, David
    • AGREVO UK LIMITED
    • C07D311/22
    • C07D215/22A01N43/14A01N43/42A01N43/50A01N43/653C07D311/22C07D311/30C07D335/06
    • Compounds of formula (I) in which Z is O, S(O)n or NR, and a) P is WR ; and Q is R or W R or b) P is R and Q is R ; and when Z is S(O)n or NR, and Q is W R ; P can be R ; W and W , which may be the same or different, are O, S(O)n, N(R ), N(R )N(R ), N(R )O or ON(R ); R is hydrogen, or an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, phenyl or heterocyclyl group; R, R , R , R , R and R , which may be the same or different, have the same meaning as R , or are acyl, or any two adjacent R groups together with the atoms to which they are attached form an optionally substituted ring which may contain other heteroatoms; R and R , which may be the same or different, have the same meaning as R (heterocyclyl groups being carbon linked) or are cyano, nitro, COOR or COR , each X, which may be the same as or different from any other X, is halogen, CN, NO2, SF5, B(OH)2, trialkylsilyl or a group E, OE or SE where E is a group as defined hereinbefore for R or is optionally substituted amino; or two adjacent groups X together with the atoms to which they are attached form an optionally substituted carbocyclic or heterocyclic ring; n is 0, 1 or 2; and p is 0 to 4 have fungicidal activity.
    • 其中Z为O,S(O)n或NR的式(I)化合物,和a)P为WR 2; 且Q为R 1或W 2 R 2a或b)P为R a且Q为R b; 当Z为S(O)n或NR时,Q为W 2 R 2a; P可以是R 1; W和W 2可以相同或不同,是O,S(O)n,N(R 3),N(R 3)N(R 4),N(R 3)O或ON(R 3); R 1是氢或任选取代的烷基,烯基,炔基,环烷基,环烯基,环炔基,苯基或杂环基; R 1,R 2,R 2a,R 2b,R 3和R 4可以相同或不同,具有与R 1相同的含义,或是酰基,或 任何两个相邻的R基团与它们所连接的原子一起形成可以含有其它杂原子的任选取代的环; R a和R b可以相同或不同,具有与R 1(杂环基是碳连接的)相同的含义或氰基,硝基,COOR 1或COR 1, 每个X可以与任何其它X相同或不同,是卤素,CN,NO2,SF5,B(OH)2,三烷基甲硅烷基或基团E,OE或SE,其中E是R定义的基团 或是任选取代的氨基; 或两个相邻基团X与它们所连接的原子一起形成任选取代的碳环或杂环; n为0,1或2; p为0〜4具有杀菌活性。
    • 3. 发明申请
    • HETEROCYCLIC FUNGICIDES
    • 杂环类杀真菌剂
    • WO1997013762A1
    • 1997-04-17
    • PCT/GB1996002491
    • 1996-10-11
    • AGREVO UK LIMITEDO'MAHONY, Mary, JosephineWEST, Peter, JohnMACRITCHIE, Jacqueline, AnneLINDELL, Stephen, DavidMILLWARD, Peter
    • AGREVO UK LIMITED
    • C07D311/22
    • C07D311/18A01N43/16C07D311/22C07D311/54C07D311/56
    • Compounds of forumla (I) where one of Z and Y is CO and the other is C-W-R and the dotted line indicates a double bond is present where necessary to meet valency requirements, W is O, S(O)n, N(R ), N(R )N(R ), N(R )O or ON(R ); R is hydrogen, or an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, phenyl or heterocyclyl group; R , R and R , which may be the same or different, are as defined above for R , or are acyl, or R and R or R and R or R and R together with the nitrogen or oxygen to which they are attached form an optionally substituted ring which may contain other hetero atoms; each X, which may be the same as or different from any other X, is halogen, CN, NO2, SF5, B(OH)2, trialkylsilyl or a group E, OE or S(O)nE where E is a group as defined hereinbefore for R or is optionally substituted amino; or two adjacent groups X together with the atoms to which they are attached form an optionally substituted carbocyclic or heterocyclic ring; n is 0, 1 or 2; and p is 0 to 4 have fungicidal activity. Many of the compounds are novel.
    • 其中Z和Y中的一个是CO并且另一个是CWR 2的forumla(I)的化合物,并且虚线表示在必要时存在满足价态要求的双键,W是O,S(O)n,N (R 3),N(R 3)N(R 4),N(R 3)O或ON(R 3); R 1是氢或任选取代的烷基,烯基,炔基,环烷基,苯基或杂环基; R 2,R 3和R 4可以相同或不同,如上文对R 1所定义,或是酰基,或R 2和R 3或R“ 2>和R 4或R 3和R 4与它们所连接的氮或氧一起形成可以含有其它杂原子的任选取代的环; 每个X可以与任何其它X相同或不同,是卤素,CN,NO2,SF5,B(OH)2,三烷基甲硅烷基或基团E,OE或S(O)nE,其中E是基团 R 2所定义,或任选被取代的氨基; 或两个相邻基团X与它们所连接的原子一起形成任选取代的碳环或杂环; n为0,1或2; p为0〜4具有杀菌活性。 许多化合物是新颖的。
    • 9. 发明申请
    • ANILIDE DERIVATIVES AS FUNGICIDES
    • 抗生素衍生物作为防腐剂
    • WO1995025723A1
    • 1995-09-28
    • PCT/GB1995000570
    • 1995-03-16
    • AGREVO UK LIMITEDRIORDAN, Peter, DominicBODDY, Ian, KennethOSBOURN, Susan, Elisabeth
    • AGREVO UK LIMITED
    • C07D213/82
    • C07D213/81A01N43/10A01N43/40A01N43/50A01N43/52A01N43/54A01N43/60A01N43/713A01N43/82A01N43/84A01N43/90A01N47/12A01N47/20A01N59/20C07D213/82C07D231/12C07D233/56C07D239/28C07D239/30C07D239/34C07D239/38C07D239/42C07D239/52C07D239/56C07D241/24C07D249/08C07D333/38C07D401/12C07D413/12C07D417/12
    • Compounds of formula (I), wherein: X is O or S; A is a 6 membered heteroaryl group comprising at least one nitrogen atom, which is optionally substituted by one or more of the group R ; R is alkyl, cycloalkyl, cycloalkenyl, alkenyl, alkynyl or amino, (each of which is optionally substituted), Y -X-, halogen, cyano, nitro, acyl, acyloxy, optionally substituted heterocyclyl or optionally substituted phenyl; or two adjacent groups together with the carbon atoms to which they are attached can form an optionally substituted benzo ring; R has the same meaning as R or two adjacent groups together with the carbon atoms to which they are attached can form an optionally substituted heterocyclic ring; Y is alkyl, cycloalkyl, cycloalkenyl, alkenyl or alkynyl, each of which is optionally substituted, hydrogen or acyl; Y has the same meaning as Y or is optionally substituted phenyl or optionally substituted heterocyclyl; Z is C(=X )-X -R , cyano, nitro, amino, acyl, optionally substituted heterocyclyl, -C(R )=N-OR or -C(R )=N-NR R ; R is alkyl, cycloalkyl, cycloalkenyl, alkenyl, alkynyl, phenyl or heterocyclyl, each of which is optionally substituted, hydrogen or an inorganic or organic cationic group ; X and X , which may be the same or different, are O or S , R , R and R , which may be the same or different, are alkyl, cycloalkyl, cycloalkenyl, alkenyl, alkynyl, phenyl or heterocyclyl, each of which is optionally substituted or hydrogen or R and R together with the atom(s) to which they are attached can form a ring; n is 0 to 4, together with complexes with metal salts, as well as salts with bases of compounds which are acids and salts with acids of compounds which are bases, have fungidal activity.
    • 式(I)化合物,其中:X为O或S; A是包含至少一个氮原子的6元杂芳基,其任选被一个或多个R 2基团取代; R 1是烷基,环烷基,环烯基,烯基,炔基或氨基(各自任选被取代),Y 1 -X - ,卤素,氰基,硝基,酰基,酰氧基,任选取代的杂环基或任选取代 苯基; 或两个相邻基团与它们所连接的碳原子一起形成任选取代的苯并环; R 2具有与R 1相同的含义或两个相邻基团与它们所连接的碳原子一起形成任选取代的杂环; Y是烷基,环烷基,环烯基,烯基或炔基,其各自任选被取代,氢或酰基; Y 1具有与Y相同的含义或任选取代的苯基或任选取代的杂环基; Z是C(= X 1)-X 2 -R 3,氰基,硝基,氨基,酰基,任选取代的杂环基,-C(R 5)= N-OR 6或 - C(R <5>)= N-NR <6> - [R <7>; R 3是烷基,环烷基,环烯基,烯基,炔基,苯基或杂环基,其各自任选被取代,氢或无机或有机阳离子基团; X 1和X 2可以相同或不同,是O或S,R 5,R 6和R 7可以相同或不同,是烷基,环烷基 ,环烯基,烯基,炔基,苯基或杂环基,其各自为任选取代的或氢或R 6和R 7与它们所连接的原子一起形成环; n为0至4,以及与金属盐的络合物,以及与作为碱的化合物的酸的化合物的碱的盐,与具有杀真菌活性的化合物的酸形成的盐。
    • 10. 发明申请
    • FUNGICIDAL N-ARYL FIVE-MEMBERED CYCLIC IMIDES
    • 杀真菌N-ARYL五分钟循环
    • WO1998004525A1
    • 1998-02-05
    • PCT/GB1997002012
    • 1997-07-28
    • AGREVO UK LIMITEDWEST, Peter, JohnCORNELL, Clive, Leonard
    • AGREVO UK LIMITED
    • C07D207/40
    • C07D207/408A01N43/36A01N43/50A01N43/78A01N43/82A01N55/00C07D233/72C07D271/07C07D277/34
    • Compounds of general formula (I) wherein A is O, S or NR ; B is CR R , CR , NR , or N; D is CR R , CR , NR , N, O or S; E is O, S or NR ; provided that when B is NR , then D is CR , O or S; and when B is N, then D is CR ; where the dotted line signifies that a single or a double bond can be present as appropriate; K is -O-, -S(O)n-, -CHR -, -CHR CHR -, -CR =CR -, -C=C-, -CHR O-, -OCHR -, -CHR S(O)n-, -S(O)nCHR -, -CH(R )O-N=C(R )-, -C(R )=N-OCH(R )-, -C(R )=N-O-, -O-N=C(R )-, -CHR OC(=O)N(R ), -CH(R )N(R )N=C(R )- or a direct bond; where the moiety depicted on the rigt side of the linkage is attached to L; L is optionally substituted alkyl; optionally substituted alkenyl; optionally substituted alkynyl; optionally substituted cycloalkyl; optionally substituted cycloalkenyl; optionally substituted heterocyclyl; optionally substituted phenyl; or Si(R )3; or R , K, and L together with the phenyl ring M, can form an optionally substituted fused ring system. These compounds have pesticidal, especially fungicidal, insecticidal and acaricidal activity.
    • 其中A为O,S或NR 1的通式(I)的化合物; B是CR 2 R 3,CR 2,NR 2或N; D是CR 4 R 5,CR 4,NR 4,N,O或S; E是O,S或NR 6; 条件是当B为NR 2时,则D为CR 45,O或S; 当B为N时,则D为CR 4。 其中虚线表示可以适当地存在单键或双键; K是-O - , - S(O)n - , - CHR 13 - , - CHR 13 CHR 14 - ,-CR 13 = CR 14 - , - C = -CHR 13,-OCHR 13 - , - CHR 13 S(O)n - , - S(O)n CHR 13 - , - CH(R 13) R 15) - , - C(R 15)= N-OCH(R 13) - , - C(R 15)= NO-,-ON = C(R 15) ,-CHR 15 OC(= O)N(R 20),-CH(R 13)N(R 21)N = C(R 15) - 或直接键; 其中所述连接件的所述部分上所示的部分连接到L; L是任选取代的烷基; 任选取代的烯基; 任选取代的炔基; 任选取代的环烷基; 任选取代的环烯基; 任选取代的杂环基; 任选取代的苯基; 或Si(R 22)3; 或R 9,K和L与苯环M一起可以形成任选取代的稠环体系。 这些化合物具有杀虫,特别是杀真菌,杀虫和杀螨活性。