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1. 发明申请

WO2008002278A1 SHG QUANTIFICATION OF MATRIX-RELATED TISSUE DYNAMIC AND DISEASE 审中-公开
标题翻译：基质相关组织动态和疾病的SHG量化
公开(公告)号：WO2008002278A1
公开(公告)日：2008-01-03
申请号：PCT/SG2007/000194
申请日：2007-06-29
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , SUN, Wanxin , YU, Hanry
发明人： SUN, Wanxin , YU, Hanry
IPC分类号： G02F1/37 , G02B21/00
CPC分类号： G02B21/0024 , G01N21/6458 , G01N21/6486 , G02B21/086
摘要： A microscope (200) for optical imaging of high optical scattering coefficient biological tissue, comprising an optical excitation source (201) for irradiating a scan area of the sample (205) and generating optical emissions, wherein the sample has a first face facing away from the source and a second face facing the source. A two dimensional element (207) for scanning the light over the sample; a focussing element (209) having a numerical aperture NAi to focus the light onto the sample; a first optical condenser (213) to collect light from the first face, the collected light comprising source transmitted light and first optical emission generated in the sample, the condenser having a NA2 larger than NAi; an optical filter(215) to block the transmitted source light; an aperture with a size corresponding to the irradiated area of the sample, the aperture at the conjugate image position of the sample generated by the condenser; and an optical detector (217) collecting light from the first face for detecting the first optical emission from the scan area.
摘要翻译：一种用于高光学散射系数生物组织的光学成像的显微镜（200），包括用于照射样品（205）的扫描区域并产生光学发射的光学激发源（201），其中所述样品具有面向远离来源和面向源的第二面。用于扫描样品上的光的二维元件（207）; 具有数值孔径NAi以将光聚焦到样品上的聚焦元件（209）; 收集来自第一面的光的第一光学冷凝器（213），所收集的光包括源透射光和在样品中产生的第一光发射，冷凝器具有大于NAi的NA2; 滤光器（215），用于阻挡所发射的光源; 具有对应于样品的照射面积的尺寸的孔，由冷凝器产生的样品的共轭图像位置处的孔; 以及收集来自第一面的光的光学检测器（217），用于检测来自扫描区域的第一光发射。

2. 发明申请

WO2007081543A2 HIGH-THROUGHPUT CELL-BASED ASSAYS FABRICATED WITH INTEGRATED SILICON AND CELL CULTURE TECHNOLOGIES 审中-公开
标题翻译：一体化硅和细胞培养技术的高通量细胞测定
公开(公告)号：WO2007081543A2
公开(公告)日：2007-07-19
申请号：PCT/US2006/049082
申请日：2006-12-20
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , KAN, Shyi-herng , YING, Jackie, Y. , YU, Hanry , SCHUMACHER, Karl , NG, Susanne, San San , SUN, Wanxin
发明人： KAN, Shyi-herng , YING, Jackie, Y. , YU, Hanry , SCHUMACHER, Karl , NG, Susanne, San San , SUN, Wanxin
IPC分类号： C12M3/00 , C12M3/04 , G01N33/50 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0068 , B01L3/5085 , B01L2300/069 , B01L2300/0829 , B01L2300/0887 , C12M23/20 , C12M23/34 , C12M25/02 , C12N2533/10 , C12N2533/54 , C12N2535/10
摘要： The present invention relates to articles and methods involving porous materials (e.g., membranes) which may interact with species, such as biological molecules, cells, etc., whereby the species may adhere to or become immobilized with respect to a surface of the porous material or an adhesion layer coating the porous surface. The porous material may be capable of attaching species with control over the positioning and spatial distribution of the species across the surface of the material. Such articles and methods may be useful in, for example, biological assays, biological sensors, or in the culturing of biological cells.
摘要翻译：本发明涉及涉及可能与物种如生物分子，细胞等相互作用的多孔材料（例如膜）的制品和方法，由此物种可以相对于多孔材料的表面粘附或变得固定或涂覆多孔表面的粘附层。多孔材料可以能够连接物种，从而控制物种在材料表面上的定位和空间分布。这样的制品和方法可用于例如生物测定，生物传感器或生物细胞的培养。

3. 发明公开

EP1979466A2 HIGH-THROUGHPUT CELL-BASED ASSAYS FABRICATED WITH INTEGRATED SILICON AND CELL CULTURE TECHNOLOGIES 有权
标题翻译：生成的测试程序对电池的集成硅及细胞培养技术基于高通量
公开(公告)号：EP1979466A2
公开(公告)日：2008-10-15
申请号：EP06849257.8
申请日：2006-12-20
申请人： Agency for Science, Technology and Research
发明人： KAN, Shyi-herng , YING, Jackie, Y. , YU, Hanry , SCHUMACHER, Karl , NG, Susanne, San San , SUN, Wanxin
IPC分类号： C12M3/00 , C12M3/04 , G01N33/50 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0068 , B01L3/5085 , B01L2300/069 , B01L2300/0829 , B01L2300/0887 , C12M23/20 , C12M23/34 , C12M25/02 , C12N2533/10 , C12N2533/54 , C12N2535/10
摘要： The present invention relates to articles and methods involving porous materials (e.g., membranes) which may interact with species, such as biological molecules, cells, etc., whereby the species may adhere to or become immobilized with respect to a surface of the porous material or an adhesion layer coating the porous surface. The porous material may be capable of attaching species with control over the positioning and spatial distribution of the species across the surface of the material. Such articles and methods may be useful in, for example, biological assays, biological sensors, or in the culturing of biological cells.

4. 发明授权

EP2033047B1 SHG QUANTIFICATION OF MATRIX-RELATED TISSUE DYNAMIC AND DISEASE 有权
公开(公告)号：EP2033047B1
公开(公告)日：2020-02-19
申请号：EP07748739.5
申请日：2007-06-29
申请人： Agency for Science, Technology and Research
发明人： SUN, Wanxin , YU, Hanry
IPC分类号： G02F1/37 , G02B21/00 , G02B21/08 , G01N21/64

5. 发明授权

EP1979466B8 HIGH-THROUGHPUT CELL-BASED ASSAYS FABRICATED WITH INTEGRATED SILICON AND CELL CULTURE TECHNOLOGIES 有权
标题翻译：生成的测试程序对电池的集成硅及细胞培养技术基于高通量
公开(公告)号：EP1979466B8
公开(公告)日：2012-10-24
申请号：EP06849257.8
申请日：2006-12-20
申请人： Agency for Science, Technology and Research
发明人： KAN, Shyi-herng , YING, Jackie, Y. , YU, Hanry , SCHUMACHER, Karl , NG, Susanne, San San , SUN, Wanxin
IPC分类号： G01N33/50 , C12M3/04 , C12M3/00 , C12M1/12 , C12N5/00 , B01L3/00
CPC分类号： C12N5/0068 , B01L3/5085 , B01L2300/069 , B01L2300/0829 , B01L2300/0887 , C12M23/20 , C12M23/34 , C12M25/02 , C12N2533/10 , C12N2533/54 , C12N2535/10

6. 发明申请

WO2002068919A1 APERTURELESS NEAR-FIELD SCANNING RAMAN MICROSCOPY USING REFLECTION SCATTERING GEOMETRY 审中-公开
标题翻译：使用反射散射几何的无损扫描扫描拉曼显微镜
公开(公告)号：WO2002068919A1
公开(公告)日：2002-09-06
申请号：PCT/SG2002/000026
申请日：2002-02-22
申请人： NATIONAL UNIVERSITY OF SINGAPORE , SHEN, Ze, Xiang , SUN, Wanxin
发明人： SHEN, Ze, Xiang , SUN, Wanxin
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01N21/658 , G01N2021/656 , G01Q60/22
摘要： A laser beam (24) is focused to a small spot size onto a sample (14). A silver coated metal probe (16) has its tip positioned within the beam, close to or contacting the sample (14). A reflected Raman signal (28) is detected. The metal probe (16) enhances the Raman signal, and provides high resolution. It may be cantilevered, and scanned across the surface of the sample (14), with its position monitored via optical means (20, 22).
摘要翻译：将激光束（24）聚焦到样品（14）上的小斑点尺寸。金属探针或金属涂覆的探针（16）的尖端位于梁内，靠近或接触样品（14）。检测到反射的拉曼信号（28）。探头（16）增强拉曼信号，并提供高分辨率。探针可以是银涂层的; 其尖端和样品之间的距离可以通过悬臂或音叉的原理来控制; 并且其可以扫描穿过样品（14）的表面，其位置通过光学装置（20,22）监测。

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