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1. 发明申请

WO2006034383A1 VISCOELASTIC SOLUTION OR GEL FORMULATION, AND METHODS OF TREATING A BODY SITE WITH THE SAME 审中-公开
标题翻译：粘弹性溶液或凝胶配方，以及与其相同处理体系的方法
公开(公告)号：WO2006034383A1
公开(公告)日：2006-03-30
申请号：PCT/US2005/033932
申请日：2005-09-21
申请人： ADVANCED MEDICAL OPTICS, INC. , TERWEE, Thom , NORRBY, Sverker , SHIMIZU, Robert , BERGMAN, Rolf
发明人： TERWEE, Thom , NORRBY, Sverker , SHIMIZU, Robert , BERGMAN, Rolf
IPC分类号： A61K9/08
CPC分类号： A61K9/0048
摘要： The invention relates to method of preparing a viscoelastic therapeutic liquid comprising a viscoelastic agent and a homogenously distributed therapeutically active agent, wherein the therapeutically active agent is distributed throughout the viscoelastic compound when the viscoelastic compound is in dry form. In one embodiment of the invention, the viscoelastic compound in dry form is mixed with an aqueous solution of the therapeutically active agent. The invention further relates to utilities of homogenous viscoelastic compositions in therapeutic applications including ophthalmic surgery.
摘要翻译：本发明涉及制备包含粘弹性剂和均匀分布的治疗活性剂的粘弹性治疗液的方法，其中当粘弹性化合物为干燥形式时，治疗活性剂分布在整个粘弹性化合物中。在本发明的一个实施方案中，将干燥形式的粘弹性化合物与治疗活性剂的水溶液混合。本发明还涉及均匀粘弹性组合物在治疗应用中的用途，包括眼科手术。

2. 发明申请

WO2003096875A3 KIT AND METHOD IN EYE SURGERY 审中-公开
公开(公告)号：WO2003096875A3
公开(公告)日：2003-11-27
申请号：PCT/SE2003/000794
申请日：2003-05-16
申请人： PHARMACIA GRONINGEN BV , NORRBY, Sverker , BERGMAN, Rolf , HILLBORN, Jöns
发明人： NORRBY, Sverker , BERGMAN, Rolf , HILLBORN, Jöns
IPC分类号： A61L27/24
摘要： A kit is provided, which comprises a) a collagen patch and b) an adhesive composition comprising (i) fibrin, fibrinogen or a combination thereof, and (ii) a biocompatible polymer capable of forming a viscous aqueous solution. Also provided is use of the kit for the preparation of a sealing device for use in ophthalmic surgery to replace a natural lens which has been removed, in which sealing device the collagen patch of the kit is adapted to seal an opening in a capsular bag of an eye while admitting the entrance of an injection device through the opening for injection of a lens-forming material into the capsule; and in which sealing device the adhesive composition of the kit is adapted to be applied to the collagen patch so as to enable adhesion of the collagen patch to the capsular bag. Also provided are methods for sealing an opening in a capsular bag of an eye, in which methods the kit is employed.

3. 发明申请

WO2010064150A2 SYSTEMS AND METHODS FOR DETERMING INTRAOCULAR LENS POWER 审中-公开
标题翻译：确定眼内镜片能量的系统和方法
公开(公告)号：WO2010064150A2
公开(公告)日：2010-06-10
申请号：PCT/IB2009/008074
申请日：2009-04-06
申请人： AMO REGIONAL HOLDINGS , NORRBY, Sverker , BERGMAN, Rolf
发明人： NORRBY, Sverker , BERGMAN, Rolf
IPC分类号： A61F2/16 , A61B3/10
CPC分类号： A61F2/1613 , A61B3/0025 , A61B3/103 , A61B3/107
摘要： A system for providing an intraocular lens includes a processor and a computer readable memory. The computer readable memory is configured to communicate with the processor, the memory having stored therein at least one of: one or more ocular dimensions, and at least one predetermined refractive outcome. The memory further includes a sequence of instructions which, when executed by the processor, cause the processor to select an intraocular lens, select a power of an intraocular lens, or provide an intraocular lens. The sequence of instructions includes determining one or more dimensions of an eye. The instructions also include calculating, based on a mathematical relationship, a distance from an apex of a cornea of the eye to an apex or plane of the intraocular lens after insertion into the eye. The instructions further calculating an optical power of the intraocular lens suitable for providing a predetermined refractive outcome. The mathematical relationship includes an axial length of the eye, an anterior chamber depth of the natural crystalline lens, and a corneal radius of the eye, but is independent of a thickness of the natural crystalline lens.
摘要翻译：用于提供人工晶状体的系统包括处理器和计算机可读存储器。计算机可读存储器被配置为与处理器通信，存储器中存储有以下中的至少一个：一个或多个眼部尺寸以及至少一个预定的屈光结果。存储器还包括一系列指令，所述指令序列在由处理器执行时使处理器选择眼内透镜，选择眼内透镜的光焦度或提供眼内透镜。指令序列包括确定眼睛的一个或多个维度。该说明书还包括基于数学关系计算在插入眼中之后从眼角膜的顶点到眼内晶状体的顶点或平面的距离。该指令进一步计算适合于提供预定屈光结果的眼内透镜的光焦度。数学关系包括眼睛的轴向长度，自然晶状体的前房深度和眼睛的角膜半径，但与天然晶状体的厚度无关。

4. 发明申请

WO2003096875A2 KIT AND METHOD IN EYE SURGERY 审中-公开
标题翻译：眼科手术中的包装和方法
公开(公告)号：WO2003096875A2
公开(公告)日：2003-11-27
申请号：PCT/SE2003/000794
申请日：2003-05-16
申请人： PHARMACIA GRONINGEN BV , NORRBY, Sverker , BERGMAN, Rolf , HILLBORN, Jöns
发明人： NORRBY, Sverker , BERGMAN, Rolf , HILLBORN, Jöns
IPC分类号： A61B
CPC分类号： A61F2/1616 , A61F9/00736 , A61L31/044 , A61L31/046 , C09J189/00
摘要： A kit is provided, which comprises a) a collagen patch and b) an adhesive composition comprising (i) fibrin, fibrinogen or a combination thereof, and (ii) a biocompatible polymer capable of forming a viscous aqueous solution. Also provided is use of the kit for the preparation of a sealing device for use in ophthalmic surgery to replace a natural lens which has been removed, in which sealing device the collagen patch of the kit is adapted to seal an opening in a capsular bag of an eye while admitting the entrance of an injection device through the opening for injection of a lens-forming material into the capsule; and in which sealing device the adhesive composition of the kit is adapted to be applied to the collagen patch so as to enable adhesion of the collagen patch to the capsular bag. Also provided are methods for sealing an opening in a capsular bag of an eye, in which methods the kit is employed.
摘要翻译：提供了一种试剂盒，其包括a）胶原蛋白片和b）包含（i）纤维蛋白，纤维蛋白原或其组合的粘合剂组合物，和（ii）能够形成粘性水溶液的生物相容性聚合物。还提供了该套件的用途，用于制备用于眼科手术中的密封装置，以取代已经去除的天然晶状体，其中，所述套件的胶原贴片适合于密封胶囊袋中的开口的密封装置眼睛同时通过用于将透镜形成材料注射到胶囊中的开口进入注射装置; 并且其中将所述试剂盒的粘合剂组合物适用于所述胶原蛋白贴片的密封装置，以便能够将所述胶原蛋白贴片粘附到所述胶囊袋上。还提供了用于密封眼睛囊袋中的开口的方法，其中采用该试剂盒的方法。

5. 发明申请

WO2007030623A2 BI-MODAL HYALURONATE SOLUTION 审中-公开
标题翻译：双模式透明质酸溶液
公开(公告)号：WO2007030623A2
公开(公告)日：2007-03-15
申请号：PCT/US2006/034864
申请日：2006-09-07
申请人： AMO REGIONAL HOLDINGS , BERGMAN, Rolf , LUNDQVIST, Maria , MANNBERG, Stig , LUNDGREN, Bjorn , SHIMIZU, Robert
发明人： BERGMAN, Rolf , LUNDQVIST, Maria , MANNBERG, Stig , LUNDGREN, Bjorn , SHIMIZU, Robert
IPC分类号： A61K47/36 , A61L31/04 , C08L5/08
CPC分类号： A61K9/0048 , A61K31/717 , A61K31/728 , A61K31/737 , A61K31/785 , A61K47/36
摘要： Formulations and methods for protecting cell layers and tissues exposed to trauma are disclosed. Different molecular mass fractions of the same polymer can be used to better control the physical and chemical properties of the formulation. In this manner the benefits of both fractions, and not just the benefits of the average of the fractions, can be seen in the formulation.
摘要翻译：公开了用于保护暴露于创伤的细胞层和组织的制剂和方法。可以使用相同聚合物的不同分子量级分来更好地控制制剂的物理和化学性质。以这种方式，可以在配方中看到两种馏分的益处，而不仅仅是馏分平均的益处。

6. 发明公开

EP1791523A1 VISCOELASTIC SOLUTION OR GEL FORMULATION, AND METHODS OF TREATING A BODY SITE WITH THE SAME 失效转让
标题翻译：一种用于生产粘弹性解决方案
公开(公告)号：EP1791523A1
公开(公告)日：2007-06-06
申请号：EP05799943.5
申请日：2005-09-21
申请人： Advanced Medical Optics, Inc.
发明人： TERWEE, Thom , NORRBY, Sverker , SHIMIZU, Robert , BERGMAN, Rolf
IPC分类号： A61K9/08
CPC分类号： A61K9/0048
摘要： The invention relates to method of preparing a viscoelastic therapeutic liquid comprising a viscoelastic agent and a homogenously distributed therapeutically active agent, wherein the therapeutically active agent is distributed throughout the viscoelastic compound when the viscoelastic compound is in dry form. In one embodiment of the invention, the viscoelastic compound in dry form is mixed with an aqueous solution of the therapeutically active agent. The invention further relates to utilities of homogenous viscoelastic compositions in therapeutic applications including ophthalmic surgery.

7. 发明申请

WO2007037743A1 NOVEL AZETIDINE COMPOUNDS USEFUL IN THE TREATMENT OF FUNCTIONAL GASTROINTESTINAL DISORDERS, IBS AND FUNCTIONAL DYSPEPSIA 审中-公开
标题翻译：用于治疗功能性胃肠疾病，IBS和功能性运动障碍的新AZETIDINE化合物
公开(公告)号：WO2007037743A1
公开(公告)日：2007-04-05
申请号：PCT/SE2006/001092
申请日：2006-09-27
申请人： ASTRAZENECA AB , BERGMAN, Rolf , HOLMQVIST, Sara , VON UNGE, Sverker
发明人： BERGMAN, Rolf , HOLMQVIST, Sara , VON UNGE, Sverker
IPC分类号： C07D487/04 , A61K31/397 , A61K31/4985 , A61K31/5383 , A61P1/00 , C07D205/04 , C07D405/12 , C07D471/04 , C07D498/04
CPC分类号： C07D205/04 , C07D405/12 , C07D471/04 , C07D487/04 , C07D498/04
摘要： The present invention relates to new azetidine compounds, to pharmaceutical compositions cotaining them and the use of said compounds in in the treatment of functional gastrointestinal disorders, IBS and functional dyspepsia. The compounds are neurokinin (NK) antagonists . The present invention further relates to processes for the preparation of the compounds.
摘要翻译：本发明涉及新的氮杂环丁烷化合物，与它们接合的药物组合物和所述化合物在治疗功能性胃肠道疾病，IBS和功能性消化不良中的用途。化合物是神经激肽（NK）拮抗剂。本发明还涉及制备化合物的方法。

8. 发明申请

WO2007142580A1 NOVEL METHOD FOR PREPARATION OF AMMONIUM SALTS OF ESOMEPRAZOLE 审中-公开
标题翻译：用于制备异辛胺的盐的新方法
公开(公告)号：WO2007142580A1
公开(公告)日：2007-12-13
申请号：PCT/SE2007/000548
申请日：2007-06-07
申请人： ASTRAZENECA AB , BERGMAN, Rolf , FREGLER, Christina , LINDBERG, Per
发明人： BERGMAN, Rolf , FREGLER, Christina , LINDBERG, Per
IPC分类号： C07D401/12 , A61K31/4439 , A61P1/04
CPC分类号： C07D401/12
摘要： The present invention relates to a process for the preparation of quartenary ammoniumsalts of esomeprazole. Further, the present invention also relates to the use quartenary ammoniumsalts of esomeprazole for the treatment of gastrointestinal disorders, pharmaceutical compositions containing them as well as the quartenary ammoniumsalts of esomeprazole, as such.
摘要翻译：本发明涉及一种用于制备艾美拉唑盐酸铵的方法。此外，本发明还涉及用于治疗胃肠道疾病的埃索美拉唑的季铵盐酸铵，以及含有它们的药物组合物以及埃索美拉唑的季铵盐铵盐。

9. 发明申请

WO2008115141A1 4, 5-DIHYDRO-1,3-THIAZOL-2-AMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF RESPIRATORY, CARDIOVASCULAR, NEUROLOGICAL OR GASTROINTESTINAL DISORDERS 审中-公开
标题翻译： 4,5-二氢-1,3-噻唑-2-胺衍生物及其在治疗呼吸道感染，心脏病，神经性或胃肠疾病中的应用
公开(公告)号：WO2008115141A1
公开(公告)日：2008-09-25
申请号：PCT/SE2008/050300
申请日：2008-03-18
申请人： ALBIREO AB , BERGMAN, Rolf , CALAZA-CABANAS, Isabel , JOHANSSON, Anders, M. , SVENSSON-HENRIKSSON, Anette, Marie , THORSTENSSON, Fredrik
发明人： BERGMAN, Rolf , CALAZA-CABANAS, Isabel , JOHANSSON, Anders, M. , SVENSSON-HENRIKSSON, Anette, Marie , THORSTENSSON, Fredrik
IPC分类号： C07D277/18 , A61K31/426 , A61K31/4439 , A61P1/00 , A61P1/14 , A61P11/00 , A61P25/00 , A61P3/10 , A61P9/00 , C07D401/12 , C07C211/42 , C07C215/46 , C07D209/40 , C07D233/50 , C07D403/12
CPC分类号： C07D209/40 , C07C211/42 , C07C2602/08 , C07D233/50 , C07D277/18 , C07D401/12 , C07D403/12
摘要： The present invention relates to compounds of formula (I), (XI) or (CI), to pharmaceutical compositions containing said compounds and to the use of said compounds in therapy. The present invention further relates to processes for the preparation of compounds of formula (I), (XI) or (CI) and to new intermediates used in the preparation thereof.
摘要翻译：本发明涉及含有所述化合物的药物组合物和所述化合物在治疗中的用途的式（I），（XI）或（C1）化合物。本发明还涉及式（I），（XI）或（C1）化合物的制备方法和用于制备其的新中间体。

10. 发明申请

WO2007073301A1 BENZOIMIDAZOLE DERIVATIVES AS PRODRUGS OF PROTON PUMP INHIBITORS 审中-公开
标题翻译：苯并咪唑衍生物作为原料泵抑制剂的原料
公开(公告)号：WO2007073301A1
公开(公告)日：2007-06-28
申请号：PCT/SE2006/001465
申请日：2006-12-21
申请人： ASTRAZENECA AB , BERGMAN, Rolf , LINDBERG, Per
发明人： BERGMAN, Rolf , LINDBERG, Per
IPC分类号： C07D401/12 , A61K31/4439 , A61P1/04
CPC分类号： C07D401/12
摘要： The present invention relates to new compounds, which are prodrugs of proton pump inhibitors and to pharmaceutical formulations and the use thereof. The present application is also related to a process for preparing said prodrugs.
摘要翻译：本发明涉及新化合物，其是质子泵抑制剂和药物制剂的前药及其用途。本申请还涉及制备所述前药的方法。

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