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1. 发明申请

WO2006088823A2 METHOD FOR DETECTING MISFOLDED PROTEINS AND PRIONS 审中-公开
标题翻译：检测蛋白质和蛋白质的方法
公开(公告)号：WO2006088823A2
公开(公告)日：2006-08-24
申请号：PCT/US2006/005095
申请日：2006-02-14
申请人： ADLYFE, INC. , ORSER, Cindy, S. , PAN, Tao , SETHI, Jasmeet
发明人： ORSER, Cindy, S. , PAN, Tao , SETHI, Jasmeet
IPC分类号： G01N33/53
CPC分类号： G01N33/54333 , G01N2800/2828
摘要： The invention provides methods and kits for detecting conformationally altered proteins, such as prions or other proteins associated with disease states, in a sample. The methods comprise selectively capturing and separating complexes of peptide and conformationally altered protein from substances that interfere with detection of such complexes, and preferably amplification of the detection signal b addition of a second double-labeled peptide.
摘要翻译：本发明提供了用于检测样品中构象改变的蛋白质（例如与疾病状态相关的其他蛋白质）的方法和试剂盒。所述方法包括选择性捕获和分离肽和构象改变的蛋白质的复合物与干扰这种复合物检测的物质，优选扩增第二双标记肽的检测信号b的添加。

2. 发明申请

WO2006031644A2 IMMOBILIZED PROBES AND METHODS OF DETECTING CONFORMATIONALLY ALTERED PRION PROTEINS 审中-公开
标题翻译：固定化探针和检测连续的重叠蛋白质的方法
公开(公告)号：WO2006031644A2
公开(公告)日：2006-03-23
申请号：PCT/US2005/032135
申请日：2005-09-09
申请人： ADLYFE, INC. , ORSER, Cindy, S. , PAN, Tao
发明人： ORSER, Cindy, S. , PAN, Tao
IPC分类号： C12Q1/68 , C12P21/06
CPC分类号： G01N33/6896 , G01N33/54393 , G01N2800/2828
摘要： The present invention provides methods of making immobilized probes that are specific for prion proteins, methods of using such probes to bind, detect, and remove prion proteins from samples, and kits for practicing the invention. The invention discloses immobilized probes that are locked into a particular, pre-determined configuration and that retain their activity and specificity even when exposed to conditions that would typically alter their activity and specificity.
摘要翻译：本发明提供了制备对朊病毒蛋白特异的固定化探针的方法，使用这些探针结合，检测和从样品中除去朊病毒蛋白的方法，以及用于实施本发明的试剂盒。本发明公开了固定化的探针，其被锁定在特定的预定构型中，并且即使当暴露于通常会改变其活性和特异性的条件时也保持其活性和特异性。

3. 发明申请

WO2010108319A1 OPTICAL IMAGING SYSTEM WITH AN ANTI-SHAKING OPTICAL ELEMENT 审中-公开
标题翻译：具有防滑光学元件的光学成像系统
公开(公告)号：WO2010108319A1
公开(公告)日：2010-09-30
申请号：PCT/CN2009/071007
申请日：2009-03-25
申请人： HONG KONG APPLIED SCIENCE & TECHNOLOGY RESEARCH INSTITUTE CO., LTD , KWAN, Kai Cheong , PAN, Tao , LAM, Sio Kuan
发明人： KWAN, Kai Cheong , PAN, Tao , LAM, Sio Kuan
IPC分类号： G02B27/64 , G02B17/08 , G02B15/00
CPC分类号： G02B27/646 , G02B13/001 , G02B13/0055 , G02B17/08
摘要： An optical imaging system (1) comprises at least one lens group (2,3,4) for projecting an image on an image sensing means (5), an optical path being defined between a light entrance of the optical system (1) and the image sensing means (5), a reflective optical element (6) having convergent or divergent optical power and being located in the optical path, and a means for moving the reflective optical element (6) in response to unwanted movement to eliminate or mitigate the negative imaging effect of the unwanted movement.
摘要翻译：光学成像系统（1）包括用于在图像感测装置（5）上投影图像的至少一个透镜组（2,3,4），光学系统定义在光学系统（1）的光入射与图像感测装置（5），具有会聚或发散的光功率并位于光路中的反射光学元件（6），以及用于响应于不期望的移动来移动反射光学元件（6）以消除或减轻的装置负面影像效果的不必要的运动。

4. 发明申请

WO2009129645A1 INTEGRATED ENHANCED CHEMILUMINESCENCE BIOSENSORS 审中-公开
标题翻译：集成增强型荧光生物传感器
公开(公告)号：WO2009129645A1
公开(公告)日：2009-10-29
申请号：PCT/CN2008/000810
申请日：2008-04-21
申请人： HONEYWELL INERNATIONAL INC. , PAN, Tao , SUN, Zhenhong , WANG, Wendy , LIU, Xuanbin
发明人： PAN, Tao , SUN, Zhenhong , WANG, Wendy , LIU, Xuanbin
IPC分类号： G01N27/447 , G01N27/26 , G01N21/76 , G01N30/00
CPC分类号： G01N21/76 , G01N27/44726 , Y10T436/143333
摘要： A method and apparatus for determining the concentration of an analyte in a sample is provided. This method involves combining enhanced chemiluminescence with microchip capillary electrophoresis or microchip liquid chromatography.
摘要翻译：提供了用于确定样品中分析物浓度的方法和装置。该方法涉及将增强的化学发光与微芯片毛细管电泳或微芯片液相色谱相结合。

5. 发明申请

WO2009129646A1 LUCIFERIN-LUCIFERASE BASED MICRODEVICE FOR BIOSENSING 审中-公开
标题翻译： LUCIFERIN-LUCIFERASE基于微生物鉴定的MICRODEVICE
公开(公告)号：WO2009129646A1
公开(公告)日：2009-10-29
申请号：PCT/CN2008/000811
申请日：2008-04-21
申请人： HONEYWELL INTERNATIONAL INC. , PAN, Tao , SUN, Zhenhong , WANG, Wendy , LIU, Xuanbin
发明人： PAN, Tao , SUN, Zhenhong , WANG, Wendy , LIU, Xuanbin
IPC分类号： G01N21/76
CPC分类号： G01N21/763
摘要： A method and apparatus for determining the concentration of one or more microbes in a sample is provided. This method involves filtering a sample through a filter inside a sample tube to retain the one or more microbes on the filter. The resulting filtrate, which contains or produces adenosine triphosphate, is passed through the sample tube and enters the reporter region. In the reporter region, the adenosine triphosphate in the filtrate comes in contact with a transparent porous matrix, which includes a luciferin-luciferase complex. The adenosine triphosphate interacts with the luciferin-luciferase complex to provide light response, which is measured by a detector. The light response is compared with a calibration curve to determine the total concentration of one or more microbes in a sample.
摘要翻译：提供了用于确定样品中一种或多种微生物浓度的方法和装置。该方法包括通过样品管内的过滤器过滤样品以将一种或多种微生物保留在过滤器上。将含有或产生三磷酸腺苷的所得滤液通过样品管并进入报道区。在报道区域中，滤液中的三磷酸腺苷与透明的多孔基质接触，其包括荧光素 - 荧光素酶复合物。三磷酸腺苷与荧光素 - 荧光素酶复合物相互作用以提供光响应，其由检测器测量。将光响应与校准曲线进行比较，以确定样品中一种或多种微生物的总浓度。

6. 发明申请

WO2015089778A1 HEAT DISSIPATION MATERIAL AND METHOD OF MAKING THE SAME 审中-公开
标题翻译：散热材料及其制备方法
公开(公告)号：WO2015089778A1
公开(公告)日：2015-06-25
申请号：PCT/CN2013/089927
申请日：2013-12-19
申请人： HONEYWELL INTERNATIONAL INC. , LIU, Xuanbin , PAN, Tao , WANG, Jinlong , MAO, Xinhui , XU, Honglu
发明人： LIU, Xuanbin , PAN, Tao , WANG, Jinlong , MAO, Xinhui , XU, Honglu
IPC分类号： C01B3/08 , H05K7/20
CPC分类号： C23C22/66 , C23F1/36 , F21V29/89 , F21Y2115/10 , Y02E60/36
摘要： A heat dissipation material (30, 42) and a method (10) of making the same are provided. The method (10) includes the step (12) of preparing an aqueous solution (62, 72) of sodium hydroxide and the step (14) of reacting at least one aluminum plate (22, 64, 76, 78) with the aqueous solution (62, 72). The method (10) can allow at least one aluminum plate (22, 64, 76, 78) to react with the aqueous solution (62, 72) until a micro-porous surface (38) forms on at least one aluminum plate (22, 64, 76, 78) or aluminum heat-sink, and a layer (24) of a reaction product forms on a surface (26) of at least one aluminum plate (22, 64, 76, 78).
摘要翻译：提供散热材料（30,42）及其制造方法（10）。方法（10）包括制备氢氧化钠水溶液（62,72）的步骤（12），和使至少一个铝板（22,64,76,78）与水溶液（62,72）。方法（10）可允许至少一个铝板（22,64,76,78）与水溶液（62,72）反应，直到在至少一个铝板（22）上形成微孔表面（38），64,76,78）或铝散热器，并且在至少一个铝板（22,64,76,78）的表面（26）上形成反应产物层（24）。

7. 发明申请

WO2011143791A1 MICROARRAY READER BASED ON EVANESCENT WAVE DETECTION 审中-公开
标题翻译：基于历史波检测的微型读取器
公开(公告)号：WO2011143791A1
公开(公告)日：2011-11-24
申请号：PCT/CN2010/000709
申请日：2010-05-20
申请人： HONEYWELL INTERNATIONAL INC. , LIU, Xuanbin , PAN, Tao , SUN, Zhenhong
发明人： LIU, Xuanbin , PAN, Tao , SUN, Zhenhong
IPC分类号： G01N21/64 , G01N33/53 , C12Q1/68
CPC分类号： G01N21/64 , C12Q1/686 , G01N21/6452 , G01N21/648
摘要： A microarray reader (500) includes a light source (501) which emits light and beam shaping elements (502) positioned near the light source (501) to direct the light. The microarray reader (500) further includes a microarray (504) that is at least formed of an optical substrate (505) and a reaction chamber (506) in contact with the optical substrate (505). A buffer solution (507) is encapsulated by the optical substrate (505) and the reaction chamber (506) and a holder (508) aligns the microarray (504) relative to the light source (501) such that when light hits the buffer solution (507) molecules in the buffer solution (507) are excited to emit fluorescent light. A temperature control component (509) is thermally engaged with the holder (508) such that the temperature control component (509) adjusts the temperature of the buffer solution (507). The microarray reader (500) further includes a sensor (510) that receives the fluorescent light emitted by the excited molecules in the buffer solution (507) to generate a signal. The microarray reader (500) provides a simple and low-cost solution to overcome the drawback of improper alignment of the microarray (504) on the temperature control component (509).
摘要翻译：微阵列读取器（500）包括发射光的光源（501）和位于光源（501）附近的引导光的光束成形元件（502）。微阵列读取器（500）还包括微阵列（504），其至少由与光学基板（505）接触的光学基板（505）和反应室（506）形成。缓冲溶液（507）由光学基底（505）和反应室（506）封装，并且保持器（508）相对于光源（501）对准微阵列（504），使得当光照射缓冲溶液缓冲溶液（507）中的（507）分子被激发以发射荧光。温度控制部件（509）与保持器（508）热接合，使得温度控制部件（509）调节缓冲溶液（507）的温度。微阵列读取器（500）还包括传感器（510），其接收由缓冲溶液（507）中的激发分子发射的荧光以产生信号。微阵列读取器（500）提供了简单且低成本的解决方案，以克服微阵列（504）在温度控制部件（509）上的不正确对准的缺点。

8. 发明申请

WO2011088588A1 REACTOR FOR QUANTITATIVE ANALYSIS OF NUCLEIC ACIDS 审中-公开
标题翻译：核酸定量分析反应器
公开(公告)号：WO2011088588A1
公开(公告)日：2011-07-28
申请号：PCT/CN2010/000083
申请日：2010-01-20
申请人： HONEYWELL INTERNATIONAL, INC. , SUN, Zhenhong , PAN, Tao , LIU, Xuanbin
发明人： SUN, Zhenhong , PAN, Tao , LIU, Xuanbin
IPC分类号： C12Q1/68 , B01L3/00
CPC分类号： B01L3/5027 , B01L3/502707 , B01L7/52 , B01L2200/0689 , B01L2200/12 , B01L2300/0636 , B01L2300/0816
摘要： A reactor for the quantitative analysis of target nucleic acids using an evanescent wave detection technique and a method for the quantitative analysis of target nucleic acids are provided. The reactor includes a substrate with a cavity, a buffer layer arranged over the substrate, a quartz cover plate arranged over the buffer layer, and inlet and outlet ports. The reactor is thermally and chemically stable for PCR processing and suitable for an evanescent wave detection technique.
摘要翻译：提供了使用ev逝波检测技术定量分析靶核酸的反应器和用于定量分析靶核酸的方法。反应器包括具有空腔的衬底，布置在衬底上的缓冲层，布置在缓冲层上的石英盖板以及入口和出口。反应器对于PCR处理是热和化学稳定的并且适用于ev逝波检测技术。

9. 发明申请

WO2006033974A2 DETECTION OF PROTEIN AGGREGATES BY HOMOLOGOUS ELISA 审中-公开
标题翻译：通过同源ELISA检测蛋白质聚集体
公开(公告)号：WO2006033974A2
公开(公告)日：2006-03-30
申请号：PCT/US2005/032985
申请日：2005-09-16
申请人： CASE WESTERN RESERVE UNIVERSITY , SY, Man-Sun , PAN, Tao , LI, Ruliang
发明人： SY, Man-Sun , PAN, Tao , LI, Ruliang
CPC分类号： G01N33/53 , G01N33/6896 , G01N2800/2828
摘要： A method of detecting disease related protein aggregate in a sample comprises using a capture monoclonal antibody and detecting-monoclonal antibody. The capture monoclonal antibody and the detecting monoclonal antibody are identical.
摘要翻译：检测样品中疾病相关蛋白聚集体的方法包括使用捕获单克隆抗体和检测单克隆抗体。捕获单克隆抗体和检测单克隆抗体是相同的。

10. 发明授权

EP1853915B1 METHOD FOR DETECTING MISFOLDED PROTEINS AND PRIONS 有权转让
标题翻译：检测方法的假折叠的蛋白和朊病毒
公开(公告)号：EP1853915B1
公开(公告)日：2011-10-12
申请号：EP06720716.7
申请日：2006-02-14
申请人： Adlyfe, Inc.
发明人： ORSER, Cindy, S. , PAN, Tao , SETHI, Jasmeet
IPC分类号： G01N33/53 , G01N33/566 , C07K17/00 , B01L3/00
CPC分类号： G01N33/54333 , G01N2800/2828
摘要： The invention provides methods and kits for detecting conformationally altered proteins, such as prions or other proteins associated with disease states, in a sample. The methods comprise selectively capturing and separating complexes of peptide and conformationally altered protein from substances that interfere with detection of such complexes, and preferably amplification of the detection signal b addition of a second double-labeled peptide.

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