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1. 发明申请

WO2004077012A3 METHODS AND SYSTEMS FOR CONTROLLING AND/OR INCREASING IONTOPHORETIC FLUX 审中-公开
标题翻译：用于控制和/或增加IOPOPHORETIC FLUX的方法和系统
公开(公告)号：WO2004077012A3
公开(公告)日：2006-09-08
申请号：PCT/US2004004126
申请日：2004-02-13
申请人： ACIONT INC , HIGUCHI WILLIAM I , MILLER DAVID J , LI KEVIN S
发明人： HIGUCHI WILLIAM I , MILLER DAVID J , LI KEVIN S
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/0428 , A61N1/0436 , A61N1/30 , A61N1/327
摘要： An iontophoretic method is provided to selectively transport a compound of interest through a localized region of an individual's body tissue that exhibits a low electrical resistance and/or a high permeability. The method involves placing a permselective material, typically having a resistance comparable or higher than the resistance of the localized region, in ion-conducting relation to the localized region. An electrical current is then applied through the permselective material to the localized region, thereby transporting the compound of interest iontophoretically through the localized region. When the permselective material is capable of hindering iontophoretic transport of a competing ion, the transference efficiency of the compound of interest is increased during iontophoresis. As a result, the compound of interest is delivered into or extracted from the localized region at an enhanced rate. As transport efficiencies approach unity, absolute predictivity of transport also becomes possible. Also provided are electrode assemblies and iontophoretic systems capable of carrying out the iontophoretic method.
摘要翻译：提供离子电渗疗法以选择性地将感兴趣的化合物输送通过显示低电阻和/或高渗透性的个体身体组织的局部区域。该方法包括将通常具有与局部区域的电阻相当或更高的电阻的选择性选择材料置于与局部区域的离子传导关系中。然后通过选择选择材料将电流施加到局部区域，从而通过局部区域输送离子电渗透的化合物。当选择选择性材料能够阻碍竞争离子的离子电渗转运时，在离子电渗中增加感兴趣的化合物的转移效率。结果，感兴趣的化合物以增强的速率被递送到局部区域或从局部区域提取。随着运输效率达到统一，运输的绝对预测也成为可能。还提供了能够进行离子电渗法的电极组件和离子电渗系统。

2. 发明申请

WO2007050645A3 INTRAOCULAR IONTOPHORETIC DEVICE AND ASSOCIATED METHODS 审中-公开
标题翻译：室内静电装置及相关方法
公开(公告)号：WO2007050645A3
公开(公告)日：2009-04-30
申请号：PCT/US2006041541
申请日：2006-10-24
申请人： ACIONT INC , HIGUCHI JOHN W , LI KEVIN S
发明人： HIGUCHI JOHN W , LI KEVIN S
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0448 , A61N1/306
摘要： The present invention includes methods and devices for delivering an active agent into the eye of a subject. One such device may include an anode assembly (14) having an anode housing and an anode configured to electrically couple to a power source (20), the anode assembly (14) being configured to contact and remain against a surface of the eye. The device may also include a cathode assembly (16) having a cathode housing and a cathode configured to electrically couple to the power source (20), the cathode assembly being configured to contact and remain against the surface of the eye. Additionally, the device may include at least one active agent reservoir (19) functionally associated with at least one of the anode assembly (14) and the cathode assembly (16).
摘要翻译：本发明包括用于将活性剂递送到受试者的眼睛中的方法和装置。一个这样的装置可以包括阳极组件（14），阳极组件（14）具有阳极壳体和被配置为电耦合到电源（20）的阳极，阳极组件（14）构造成接触并保持在眼睛的表面上。该装置还可以包括阴极组件（16），阴极组件（16）具有阴极壳体和配置成电耦合到电源（20）的阴极，阴极组件构造成接触并保持在眼睛的表面上。另外，该装置可以包括与阳极组件（14）和阴极组件（16）中的至少一个功能性相关联的至少一个活性剂储存器（19）。

3. 发明公开

EP1940507A4 INTRAOCULAR IONTOPHORETIC DEVICE AND ASSOCIATED METHODS 审中-公开
标题翻译：眼内电迁移设备和相关程序
公开(公告)号：EP1940507A4
公开(公告)日：2011-04-20
申请号：EP06826593
申请日：2006-10-24
申请人： ACIONT INC
发明人： HIGUCHI JOHN W , LI KEVIN S
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0448 , A61N1/306

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