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1. 发明申请

WO2007050645A3 INTRAOCULAR IONTOPHORETIC DEVICE AND ASSOCIATED METHODS 审中-公开
标题翻译：室内静电装置及相关方法
公开(公告)号：WO2007050645A3
公开(公告)日：2009-04-30
申请号：PCT/US2006041541
申请日：2006-10-24
申请人： ACIONT INC , HIGUCHI JOHN W , LI KEVIN S
发明人： HIGUCHI JOHN W , LI KEVIN S
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0448 , A61N1/306
摘要： The present invention includes methods and devices for delivering an active agent into the eye of a subject. One such device may include an anode assembly (14) having an anode housing and an anode configured to electrically couple to a power source (20), the anode assembly (14) being configured to contact and remain against a surface of the eye. The device may also include a cathode assembly (16) having a cathode housing and a cathode configured to electrically couple to the power source (20), the cathode assembly being configured to contact and remain against the surface of the eye. Additionally, the device may include at least one active agent reservoir (19) functionally associated with at least one of the anode assembly (14) and the cathode assembly (16).
摘要翻译：本发明包括用于将活性剂递送到受试者的眼睛中的方法和装置。一个这样的装置可以包括阳极组件（14），阳极组件（14）具有阳极壳体和被配置为电耦合到电源（20）的阳极，阳极组件（14）构造成接触并保持在眼睛的表面上。该装置还可以包括阴极组件（16），阴极组件（16）具有阴极壳体和配置成电耦合到电源（20）的阴极，阴极组件构造成接触并保持在眼睛的表面上。另外，该装置可以包括与阳极组件（14）和阴极组件（16）中的至少一个功能性相关联的至少一个活性剂储存器（19）。

2. 发明申请

WO2008013913A3 METHOD AND DEVICE FOR MINIMALLY INVASIVE SITE SPECIFIC OCULAR DRUG DELIVERY 审中-公开
标题翻译：用于最小入侵地点特异性药物输送的方法和装置
公开(公告)号：WO2008013913A3
公开(公告)日：2008-12-04
申请号：PCT/US2007016850
申请日：2007-07-26
申请人： ACIONT INC , HIGUCHI JOHN W , TUITUPOU ANTHONY
发明人： HIGUCHI JOHN W , TUITUPOU ANTHONY
IPC分类号： A61M31/00
CPC分类号： A61F9/0017 , A61K31/44 , A61K31/56 , A61N1/30
摘要： The present invention includes techniques for delivering an active agent into the eye of a subject. Accordingly, in one aspect a method may include delivering invasively an active agent into a peripheral tissue of the eye to form a drug reservoir, and applying an electric current to thus drive at least a portion of the active agent at least partially thorough the choroid. Numerous configurations are contemplated for the positioning of the electric current relative to the drug reservoir. For example, in one aspect the electric current may be applied to the drug reservoir from a non-invasively positioned electrode. In another aspect, the electric current may be applied to the drug reservoir from an invasively positioned electrode. In yet another aspect, delivering the active agent may further include implanting an invasive electrode having an associated drug reservoir containing the active agent into the peripheral tissue.
摘要翻译：本发明包括将活性剂递送到受试者的眼睛中的技术。因此，一方面，方法可以包括将活性剂侵入性输送到眼睛的外周组织中以形成药物储存器，并且施加电流从而至少部分地驱动至少一部分活性剂脉络膜。考虑到相对于药物储存器定位电流的许多构造。例如，在一个方面，电流可以从非侵入性定位的电极施加到药物储存器。另一方面，电流可以从入侵位置的电极施加到药物储存器。在另一方面，递送活性剂还可以包括将包含活性剂的相关药物储库的侵入性电极植入外周组织中。

3. 发明申请

WO2008013913A8 METHOD AND DEVICE FOR MINIMALLY INVASIVE SITE SPECIFIC OCULAR DRUG DELIVERY 审中-公开
标题翻译：最小侵入性特定眼部药物递送的方法和装置
公开(公告)号：WO2008013913A8
公开(公告)日：2008-08-14
申请号：PCT/US2007016850
申请日：2007-07-26
申请人： ACIONT INC , HIGUCHI JOHN W , TUITUPOU ANTHONY
发明人： HIGUCHI JOHN W , TUITUPOU ANTHONY
IPC分类号： A61F2/00 , A61K31/44 , A61K31/56 , A61N1/30
CPC分类号： A61F9/0017 , A61K31/44 , A61K31/56 , A61N1/30
摘要： The present invention includes techniques for delivering an active agent into the eye of a subject. Accordingly, in one aspect a method may include delivering invasively an active agent into a peripheral tissue of the eye to form a drug reservoir, and applying an electric current to the drug reservoir to thus drive at least a portion of the active agent at least partially through the choroid. Numerous configurations are contemplated for the positioning of the electric current relative to the drug reservoir. For example, in one aspect the electric current may be applied to the drug reservoir from a non-invasively positioned electrode. In another aspect, the electric current may be applied to the drug reservoir from an invasively positioned electrode. A variety of invasive positions are contemplated, including, for example, positioning the invasive electrode within the peripheral tissue. In yet another aspect, delivering the active agent may further include implanting an invasive electrode having an associated drug reservoir containing the active agent into the peripheral tissue.
摘要翻译：本发明包括用于将活性剂递送到受试者的眼睛中的技术。因此，在一个方面，一种方法可以包括：将活性剂侵入性地递送到眼睛的外周组织中以形成药物储存器，并且将电流施加到药物储存器，从而至少部分地驱动活性剂的至少一部分通过脉络膜。考虑到电流相对于药物储存器的定位的许多配置。例如，在一个方面，电流可以从非侵入定位的电极施加到药物储存器。另一方面，电流可以从侵入定位的电极施加到药物储存器。考虑了各种侵入位置，包括例如将侵入电极定位在外周组织内。在又一方面，递送活性剂可以进一步包括将具有含有活性剂的相关药物储库的侵入性电极植入周围组织中。

4. 发明公开

EP1940507A4 INTRAOCULAR IONTOPHORETIC DEVICE AND ASSOCIATED METHODS 审中-公开
标题翻译：眼内电迁移设备和相关程序
公开(公告)号：EP1940507A4
公开(公告)日：2011-04-20
申请号：EP06826593
申请日：2006-10-24
申请人： ACIONT INC
发明人： HIGUCHI JOHN W , LI KEVIN S
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0448 , A61N1/306

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