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1. 发明申请

WO2015191934A3 BLOOD-BRAIN BARRIER (BBB) PENETRATING DUAL SPECIFIC BINDING PROTEINS FOR TREATING BRAIN AND NEUROLOGICAL DISEASES 审中-公开
标题翻译：血脑屏障（BBB）穿刺双重特异性结合蛋白治疗脑和神经疾病
公开(公告)号：WO2015191934A3
公开(公告)日：2016-02-04
申请号：PCT/US2015035441
申请日：2015-06-11
申请人： ABBVIE INC , HANZATIAN DENISE KARAOGLU , GOODEARL ANDREW D , MUELLER BERNHARD KLAUSE , MUELLER REINHOLD , KLEIN CORINNA
发明人： HANZATIAN DENISE KARAOGLU , GOODEARL ANDREW D , MUELLER BERNHARD KLAUSE , MUELLER REINHOLD , KLEIN CORINNA
IPC分类号： C07K16/24 , A61K39/00 , A61P25/00 , A61P25/04 , A61P25/10 , A61P25/28 , A61P35/00 , C07K16/28 , C07K16/42
CPC分类号： C07K16/2881 , A61K2039/505 , C07K16/18 , C07K16/22 , C07K16/241 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/64 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2319/00
摘要： Engineered agents or multivalent and multispecific binding proteins capable of penetrating the cells or tissue of the blood-brain barrier (BBB) are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
摘要翻译：提供能够穿透血脑屏障（BBB）的细胞或组织的工程化剂或多价和多特异性结合蛋白，以及制备和用于预防，诊断和/或治疗疾病的方法。

2. 发明申请

WO0157038A9 HETEROCYCLIC COMPOUNDS AND THEIR USE AS PARP INHIBITORS 审中-公开
标题翻译：杂环化合物和它们作为PARP抑制剂
公开(公告)号：WO0157038A9
公开(公告)日：2001-09-20
申请号：PCT/EP0100790
申请日：2001-01-25
申请人： BASF AG , LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , GRANDEL ROLAND , MUELLER REINHOLD , SCHULT SABINE
发明人： LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , GRANDEL ROLAND , MUELLER REINHOLD , SCHULT SABINE
IPC分类号： C07D471/04 , A61K31/437 , A61P25/00
CPC分类号： C07D471/04
摘要： The invention relates to compounds of formula (I), wherein; either A or A represents CONH2, and the other radical A or A represents hydrogen, chlorine, fluorine, bromine, iodine C1-C6 alkyl, OH, nitro, CF3, CN, NR R , NH-CO-R , O-C1-C4 alkyl; X can represent N and C-R ; X , independent of X , can represent N and C-R ; R can represent hydrogen, C1-C6 alkyl, C1-C4 alkyl-phenyl, phenyl; B can represent an unsaturated, saturated or partially unsaturated monocyclic, bicyclic or tricyclic ring having a maximum of 15 carbon atoms, an unsaturated, saturated or partially unsaturated monocyclic, bicyclic or tricyclic ring having a maximum of 14 carbon atoms and 0 to 5 nitrogen atoms, 0 to 2 oxygen atoms or 0 to 2 sulfur atoms, which can each still be substituted with an R and a maximum of 3 of the same or different radicals R , and; R , R , R , R -R have the meanings as cited in Claim No. 1. The invention also relates to the tautomeric forms, and possible enantiomeric and diastereomeric forms of said compounds, to the prodrugs thereof and to their use as PARP inhibitors.
摘要翻译：本发明涉及式（I）化合物式中A <1>或A <2>是CONH 2，另一基团A <2>或A <1>为氢，氯，氟，溴，碘，C1-C6 烷基，OH，硝基，CF 3，CN，NR <11> - [R <12>，NH-CO-R <13>，O-C 1 -C 4烷基，并且X <1>可以是N和CR <2> 和X <2>可以是独立的X <1>，N和CR <2>和C 1 -C 4 - 烷基 - 苯基，R <2>是氢，C1-C6烷基的苯基，和B是不饱和，饱和或部分不饱和的单 - ，最多15个碳原子，不饱和的二环或三环的环，饱和或部分不饱和的单 - ，具有最大14个碳原子和0至5个氮原子，0〜2个氧原子和0〜二环或三环环可以指2个硫原子，每个的又带有R <4>和最多3组相同或不同的基团R <5>可以被取代，并且R <1>，R <4>，R <5>，R <11> - [R <13>的含义如权利要求1和互变异构形式在指示物，可能的对映体和非对映形式，以及它们的前体药物，以及它们作为PARP抑制剂的用途。

3. 发明授权

US962236A Fur-beating machine. 失效
公开(公告)号：US962236A
公开(公告)日：1910-06-21
申请号：US1909470958
申请日：1909-01-06
申请人： MUELLER REINHOLD
发明人： MUELLER REINHOLD
CPC分类号： A47L11/36

4. 发明申请

WO2007039256A3 BINDING DOMAINS OF PROTEINS OF THE REPULSIVE GUIDANCE MOLECULE (RGM) PROTEIN FAMILY AND FUNCTIONAL FRAGMENTS THEREOF, AND THEIR USE 审中-公开
标题翻译：装订排斥性引导分子（RGM）蛋白质家族蛋白质的和域的功能片段，以及它们的用途
公开(公告)号：WO2007039256A3
公开(公告)日：2007-07-05
申请号：PCT/EP2006009497
申请日：2006-09-29
申请人： ABBOTT GMBH & CO KG , MUELLER BERNHARD K , SCHAFFAR GREGOR , MUELLER REINHOLD
发明人： MUELLER BERNHARD K , SCHAFFAR GREGOR , MUELLER REINHOLD
IPC分类号： C07K14/475 , A61K39/395 , A61P25/00 , C07K14/71 , C07K16/28
CPC分类号： C07K14/705 , A61K38/00 , C07K16/28 , C07K2317/34
摘要： The invention concerns the identification and use of neogenin receptor-binding domains of members of the repulsive guidance molecule (RGM) protein family as well as polypeptide fragments derived therefrom. The inventive domains, i.e. peptide fragments are suited as agents for the active or passive immunization of individuals as well as diagnostic and therapeutic agents for use with diseases or pathological conditions in whose origin or progression, a member of the RGM family and a cellular receptor assigned to this molecule are involved. The invention also concerns monoclonal and polyclonal antibodies directed against the inventive binding domains and against the polypeptides derived therefrom, and to method for producing the inventive domains, polypeptides and antibodies.
摘要翻译：本发明涉及狂犬病指导分子（RGM）蛋白家族的成员的Neogenin受体结合结构域的鉴定和用途以及由其衍生的多肽片段。本发明的结构域或肽片段是作为个人的主动或被动免疫，以及用于在疾病或疾病状态，其发展或过程中RGM家族的成员和所分配的该分子的细胞受体的参与使用的诊断剂和治疗剂的一种手段是有用的。本发明还涉及针对根据本发明的结合结构域并针对由其衍生的多肽的单克隆和多克隆抗体以及用于生产根据本发明的结构域，多肽和抗体的方法。

5. 发明申请

WO0123390A3 AZEPINOINDOLE DERIVATIVES, THE PRODUCTION AND USE THEREOF 审中-公开
标题翻译： AZEPINOINDOL衍生物及其制备和应用
公开(公告)号：WO0123390A3
公开(公告)日：2001-12-27
申请号：PCT/EP0009024
申请日：2000-09-15
申请人： BASF AG , LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , GRANDEL ROLAND , MUELLER REINHOLD , SCHULT SABINE
发明人： LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , GRANDEL ROLAND , MUELLER REINHOLD , SCHULT SABINE
IPC分类号： A61K31/55 , A61P3/10 , A61P9/10 , A61P11/00 , A61P13/12 , A61P19/02 , A61P25/00 , A61P25/08 , A61P25/10 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , C07D487/06
CPC分类号： C07D487/06
摘要： The invention relates to compounds of formula (I) as well as to the tautomeric forms thereof, possible enantiomeric and diastereomeric forms and the prodrugs thereof, the production and use thereof, whereby the values have the meaning as given in the description.
摘要翻译：本发明涉及式（I）化合物及其互变异构形式，可能的对映体和非对映体形式，及其前药，其制备和用途，其值具有说明书中给出的含义。

6. 发明申请

WO2006020933A2 DUAL LABELED FLUORESCENT PROBES 审中-公开
标题翻译：双标签荧光探针
公开(公告)号：WO2006020933A2
公开(公告)日：2006-02-23
申请号：PCT/US2005028859
申请日：2005-08-12
申请人： STRATAGENE CALIFORNIA , SORGE JOSEPH , MUELLER REINHOLD , PADMABANDU GOTHAMI
发明人： SORGE JOSEPH , MUELLER REINHOLD , PADMABANDU GOTHAMI
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6818 , C12Q1/686 , C12Q2525/301 , C12Q2521/301 , C12Q2565/101
摘要： The present invention relates to probes useful for the detection and measurement of target nucleic acids, as well as compositions and kits containing such probes. The probes of the present invention include an interactive pair of labels, as well as a hairpin sequence that does not hybridize to a target nucleic acid. According to the present invention, the probe generates a detectable signal indicative of a presence of a target nucleic acid. The detectable signal emitted by one of the pair of labels is substantially constant upon binding of the probe to target nucleic acid, and the detectable signal increases by at least (2) fold upon cleavage of the probe between the pair of labels.
摘要翻译：本发明涉及可用于检测和测量靶核酸的探针，以及含有这种探针的组合物和试剂盒。本发明的探针包括互补的标记物对，以及不与靶核酸杂交的发夹序列。根据本发明，探针产生指示靶核酸存在的可检测信号。在将该探针与靶核酸结合后，由该对标记中的一个发射的可检测信号基本上是恒定的，并且当探针在该对标记之间切割时，可检测信号增加至少（2）倍。

7. 发明申请

WO0123386A3 BENZODIAZEPIN DERIVATIVES, THE PRODUCTION AND USE THEREOF 审中-公开
标题翻译：苯二氮类衍生物，生产和使用
公开(公告)号：WO0123386A3
公开(公告)日：2002-05-10
申请号：PCT/EP0009023
申请日：2000-09-15
申请人： BASF AG , LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , GRANDEL ROLAND , MUELLER REINHOLD , SCHULT SABINE
发明人： LUBISCH WILFRIED , KOCK MICHAEL , HOEGER THOMAS , GRANDEL ROLAND , MUELLER REINHOLD , SCHULT SABINE
IPC分类号： A61K31/5517 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/14 , A61P11/00 , A61P13/12 , A61P17/02 , A61P19/02 , A61P25/00 , A61P25/08 , A61P25/10 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/04 , A61P37/02 , A61P43/00 , C07D487/06 , C07D519/00 , A61K31/519 , C07D243/14
CPC分类号： C07D487/06
摘要： The invention relates to compounds of formula (I) as well as to the tautomeric forms thereof, possible enantiomeric and diastereomeric forms and the prodrugs thereof, the production and use thereof, whereby the values have the meaning as given in the description.
摘要翻译：本发明涉及式（I）和它们的互变异构形式，对映异构体可能与非对映异构形式，以及它们的前药，其制备和用途的化合物，其中的值具有说明书中给出的含义。

8. 发明申请

WO2009136382A2 ANTIBODIES TO RECEPTOR OF ADVANCED GLYCATION END PRODUCTS (RAGE) AND USES THEREOF 审中-公开
标题翻译：高级糖果终产品（RAGE）及其用途的受体抗体
公开(公告)号：WO2009136382A2
公开(公告)日：2009-11-12
申请号：PCT/IB2009051915
申请日：2009-05-08
申请人： ABBOTT GMBH & CO KG , ABBOTT LAB , GU JIJIE , HSIEH CHUNG-MING , WU ZHEN , DIGIAMMARINO ENRICO L , LUO FENG , FOX GERARD B , HARLAN JOHN E , SCHMIDT MARTIN , LOEBBERT RALF , MUELLER REINHOLD , EBERT ULRICH , NIMMRICH VOLKER
发明人： GU JIJIE , HSIEH CHUNG-MING , WU ZHEN , DIGIAMMARINO ENRICO L , LUO FENG , FOX GERARD B , HARLAN JOHN E , SCHMIDT MARTIN , LOEBBERT RALF , MUELLER REINHOLD , EBERT ULRICH , NIMMRICH VOLKER
IPC分类号： C12N15/12 , C12N5/00 , C12N7/00
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/28 , C07K16/464 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C12P21/005
摘要： The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE protein. Specifically, these antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application are useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example missfolded proteins like amyloid ß and advanced glycation-end-products.
摘要翻译：本申请涉及分离的蛋白质，特别是单克隆抗体，特别是结合RAGE蛋白质的CDR-移植的人源化抗体。具体地说，这些抗体具有抑制RAGE与其各种配体结合的能力。本申请中描述的抗体或其部分可用于治疗由RAGE的病理生理学配体表征或诱导的疾病或病症，例如错折叠蛋白，如淀粉样蛋白β和晚期糖基化终产物。

9. 发明申请

WO2008064292A2 NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST THE NOGO-66 RECEPTOR (NGR) AND USES THEREOF 审中-公开
标题翻译：中和抗NOGO-66受体（NGR）的单克隆抗体及其用途
公开(公告)号：WO2008064292A2
公开(公告)日：2008-05-29
申请号：PCT/US2007085349
申请日：2007-11-21
申请人： ABBOTT LAB , MEZLER MARIO , MOELLER ACHIM , MUELLER REINHOLD , MUELLER BERNHARD K , GHAYUR TARIQ , BARLOW EVE H , SCHMIDT MARTIN , MEYER AXEL , TEUSCH NICOLE
发明人： MEZLER MARIO , MOELLER ACHIM , MUELLER REINHOLD , MUELLER BERNHARD K , GHAYUR TARIQ , BARLOW EVE H , SCHMIDT MARTIN , MEYER AXEL , TEUSCH NICOLE
IPC分类号： A61K39/395
CPC分类号： C07K16/28 , A61K39/3955 , A61K2039/505 , C07H21/00 , C07K16/2863 , C07K2317/14 , C07K2317/34 , C07K2317/41 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
摘要翻译：本发明涉及结合Nogo-66受体的分离的蛋白质，特别是单克隆抗体。具体地说，这些抗体具有抑制Nogo-66受体的天然配体结合并中和Nogo-66受体的能力。本发明的这些抗体或其部分可用于检测NgR和抑制NgR活性，例如在患有NgR或Nogo-66活性有害的病症的人中。

10. 发明专利

DE102007019355A1 Patient`s tumor tissue irradiating device, has beam guide formed as symmetrical polygon around isocenter guiding electron beam in supporting structure and on radiation heads, where deflection magnets are arranged for deflecting beam 未知
公开(公告)号：DE102007019355A1
公开(公告)日：2008-01-03
申请号：DE102007019355
申请日：2007-04-23
申请人： FORSTER JAN , FORSTER RENATE , MUELLER REINHOLD G , ACHTERBERG NILS
发明人： FORSTER JAN , MUELLER REINHOLD , ACHTERBERG NILS
IPC分类号： A61N5/10
摘要： The device has an electron source (3) for producing electron beam (8). A set of radiation heads (7) is arranged around an isocenter (2) in a supporting structure (5) and provides radiation in a direction of the isocenter. The electron beam is guided in the supporting structure and on the radiation heads by a beam guide. The beam guide is formed as a symmetrical polygon (10) around the isocenter. Deflection magnets (9) are arranged for deflecting the electron beam. The magnets have a kick device for deflecting the electron beam on the radiation heads.

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