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1. 发明专利

NZ605486A Spiro-cyclic amine derivatives as s1p modulators 未知
公开(公告)号：NZ605486A
公开(公告)日：2014-08-29
申请号：NZ60548611
申请日：2011-07-08
申请人： ABBVIE BV , ABBVIE INC
发明人： IWEMA BAKKER WOUTER I , COOLEN HEIN K A C , VAN DONGEN MARIA J P , STOIT AXEL , LEFLEMME NICOLAS J-L D , ADRIAN D HOBSON
IPC分类号： C07D265/36 , A61K31/407 , A61K31/4355 , A61K31/5386 , A61P25/00 , C07D491/107 , C07D491/20
摘要： ABSTRACT - 605486 The disclosure relates to spiro-benzofuran-piperidine derivatives of the formula (I) wherein R1; R2; R3; Q; -W-T-; R5; Z; and A have the definitions provided in the specification; or a pharmaceutically acceptable salt, a solvate or hydrate thereof or one or more N-oxides thereof. These compounds have affinity to sphingosine-1-phosphate (S1P) receptors and may be used in the treatment, alleviation or prevention of diseases and conditions in which an S1P receptor is involved, wherein the disease is a CNS disorder, such as a neurodegenerative disorder, in particular selected from a cognitive disorder, Alzheimer’s disease, (vascular) dementia, Nieman’s Pick disease, and cognitive deficits in schizophrenia, obsessive-compulsive behaviour, major depression, autism, multiple sclerosis and pain, and specifically a cognitive disorder, such as age-related cognitive decline.

2. 发明专利

PT2590955T DERIVADOS DE AMINA ESPIROCÍCLICA COMO MODULADORES DE S1P 未知
公开(公告)号：PT2590955T
公开(公告)日：2016-11-17
申请号：PT11730314
申请日：2011-07-08
申请人： ABBVIE INC , ABBVIE BV
发明人： AXEL STOIT , WOUTER I IWEMA BAKKER , HEIN K A C COOLEN , MARIA J P VAN DONGEN , NICOLAS J -L D LEFLEMME , ADRIAN D HOBSON
IPC分类号： C07D265/36 , A61K31/407 , A61K31/4355 , A61K31/5386 , A61P25/00 , C07D491/107 , C07D491/20

3. 发明专利

NZ605491A Fused heterocyclic derivatives as s1p modulators 未知
公开(公告)号：NZ605491A
公开(公告)日：2014-08-29
申请号：NZ60549111
申请日：2011-07-08
申请人： ABBVIE BV , ABBVIE INC
发明人： IWEMA BAKKER WOUTER I , COOLEN HEIN K A C , VAN DONGEN MARIA J P , SMID PIETER , SLIEDREGT LEONARDUS A J M , DEN HARTOG JACOBUS A J , ADRIAN D HOBSON
IPC分类号： C07D487/04 , A61K31/429 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/55 , A61P25/28 , C07D491/04 , C07D498/04 , C07D513/04
摘要： The disclosure relates to a fused heterocyclic derivative of the formula (I), wherein the variables R1-R4, z, A, Q, X and Y are as defined in the specification. 4-{ 2-[4-(2-Fluoro-benzyloxy)-phenyl]-6,7-dihydro-4H-furo[3,2-c]pyridine-5-yl} -butyric acid is a typical example of said fused heterocyclic derivative. These compounds of formula (I) are modulators of the S1P receptor (Sphingosine-1-phosphate receptor). More specifically, they are agonists of S1P5. The compounds have therapeutic use in treatment of neurodegenerative disorder, in particular selected from a cognitive disorder, Alzheimer’s disease, (vascular) dementia, Nieman’s Pick disease, and cognitive deficits in schizophrenia, obsessive-compulsive behaviour, major depression, autism, multiple sclerosis and pain, and specifically a cognitive disorder, such as age-related cognitive decline.

4. 发明专利

MY161229A FUSED HETEROCYCLIC DERIVATIVES AS S1P MODULATORS 未知
公开(公告)号：MY161229A
公开(公告)日：2017-04-14
申请号：MYPI2013000055
申请日：2011-07-08
申请人： ABBVIE BV , ABBVIE INC
发明人： SMID PIETER , IWEMA BAKKER WOUTER I , COOLEN HEIN K A C , SLIEDREGT LEONARDUS A J M , VAN DONGEN MARIA J P , DEN HARTOG JACOBUS A J , ADRIAN D HOBSON
IPC分类号： C07D487/04 , A61K31/429 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/55 , A61P25/28 , C07D491/04 , C07D498/04 , C07D513/04
摘要： THE PRESENT INVENTION RELATES TO A FUSE HETEREOCYCLIC DERIVATIVE OF THE FORMULA(I) WHERE IN R1 IS SELECTED FROM CYANO, (2-4C)ALKENYL, (2-4C)ALKYNYL, (1-4C)ALKYL, EACH OPTIONALLY SUBSTITUTED WITH CN OR ONE OR MORE FLUORO ATOMS, (3-6C)CYCLOALKYL, (4-6C)CYCLOALKENYL OR A (8- 10C)BICYCLIC GROUP, EACH OPTIONALLY SUBSTITUTED WITH HALOGEN OR (1-4C)ALKYL OPTIONALLY SUBSTITUTED WITH ONE OR MORE FLUORO ATOMS, PHENYL, BIPHENYL, NAPHTHYL, EACH OPTIONALLY SUBSTITUTED WITH ONE OR MORE SUBSTITUENTS INDEPENDENTLY SELECTED FROM HALOGEN, CYANO, (1-4C)ALKYL OPTIONALLY SUBSTITUTED WITH ONE OR MORE FLUORO ATOMS, (1-4C)ALKOXY OPTIONALLY SUBSTITUTED WITH ONE OR MORE FLUORO ATOMS, AMINO, DIMETHYLAMINO, AND (3-6C)CYCLOALKYL OPTIONALLY SUBSTITUTED WITH PHENYL WHICH MAY BE SUBSTITUTED WITH (1-4C)ALKYL OR HALOGEN, AND PHENYL SUBSTITUTED WITH PHENOXY, BENZYL, BENZYLOXY, PHENYLETHYL OR MONOCYCLIC HETEROCYCLE, EACH OPTIONALLY SUBSTITUTED WITH (1-4C)ALKYL, Z IS A LINKING GROUP –W-(CN-ALKYLENE)-T- WHEREIN W IS ATTACHED TO R1 AND SELECTED FROM A BOND, -O-, CO –S- -SO-, -S02-NH-, -CH=CH, C(CF3)=CH-, -C=C-, CH2-O-, -O-C0-, -C0-0- CO-NH, -NH-C0- AND TRANS-CYCLOPROPYLENE; N IS AN INTEGER FROM 0 TO 10; AND T IS ATTACHED TO THE PHENYLENE/PYRIDYL MOIETY AND SELECTED FROM A BOND, 0- -S- S0, -SO2-, -NH-, -C0, -C= C-, AND TRANS-CYCLOPROPYLENE; N IS AN INTEGER FROM 0 TO 10; AND T I ATTACHED TO THE PHENYLENE/PYRIDYL MOIETY AND SELECTED FROM ABOND, -O-, -S-, -SO-, -SO2-,- NH-,-CO-,-C=C-, -C=C-, AND TRANS-CYCLOPROPYLENE; R2 IS H OR ONE OR MORE SUBSTITUENTS INDEPENDENTLY SELECTED FROM CYANI, HALOGEN, (1-4C)ALKYL OPTIONALLY SUBSTITUTED WITH ONE OR MORE SUBSTITUENTS INDEPENDENTLY SELECTED FROM CYANO, HALOGEN, (1-4C)ALKYL OPTIONALLY SUBSTITUTED WITH ONE OR MORE HALOGEN ATOMS, OR (1-4C) ALKOXY OPTIONALLY SUBSTITUED WITH ONE OR MORE HALOGEN ATOMS; RING STRUCTURE A MAY CONTAIN ONE NITROGEN ATOM; X IS SELECTED FROM C OR N; IF X IS C, R3 IS SELECTED FROM H AND (1-4C)ALKYL, OTHERWISE R3 IS NOT PRESENT; Y IS SELECTED

5. 发明专利

DOP2017000289A MODULADORES DE RECEPTOR NUCLEAR 未知
公开(公告)号：DOP2017000289A
公开(公告)日：2017-12-31
申请号：DO2017000289
申请日：2017-12-07
申请人： ABBVIE INC
发明人： ERIC C BREINLINGER , KEVIN P CUSACK , MICHAEL E KORT , ADRIAN D HOBSON , MARIA A ARGIRIADI , DOMINIQUE POTIN , MARTINE BARTH , OLIVIA POUPARDIN , LAURENT MOUNIER , JEROME AMAUDRUT
IPC分类号： A61K31/404 , A61K31/416 , A61P29/00 , A61P37/00 , C07D209/14 , C07D209/18 , C07D235/16 , C07D401/10 , C07D403/10 , C07D405/10 , C07D405/14 , C07D471/04 , C07D487/04 , C07D491/10
摘要： La invención proporciona compuestos de Fórmula (I) Fórmula (I) sales farmacéuticamente aceptables de los mismos, en la que la variable se define en el presente documento. Los compuestos de la invención son útiles para tratar afecciones inmunológicas.

6. 发明专利

BR112020010694A2 agonista de receptor de glicocorticoides e imunoconjugados do mesmo 未知
公开(公告)号：BR112020010694A2
公开(公告)日：2020-11-10
申请号：BR112020010694
申请日：2018-11-29
申请人： ABBVIE INC
发明人： ADRIAN D HOBSON , AXEL HERNANDEZ JR , CHRISTIAN GOESS , CHRISTOPHER C MARVIN , LING C SANTORA , LU WANG , LU WANG , MICHAEL J MCPHERSON , WENDY WAEGELL
IPC分类号： C07K16/24 , A61K47/68 , A61P19/02
摘要： trata-se de imunoconjugados de agonista de receptor de glicocorticoide, agonistas de receptor de glicocorticoide e métodos de uso dos mesmos.

7. 发明专利

BR112020010691A2 conjugados de fármaco-anticorpo anti-cd40 未知
公开(公告)号：BR112020010691A2
公开(公告)日：2020-11-10
申请号：BR112020010691
申请日：2018-11-29
申请人： ABBVIE INC
发明人： ADRIAN D HOBSON , AXEL HERNANDEZ JR , CHRISTOPHER C MARVIN , CLAIRE L IHLE , JASON Z OH , LING C SANTORA , LU WANG , LU WANG , MICHAEL J MCPHERSON , OLIVIA A PERNG , SHAUGHN H BRYANT , WENDY WAEGELL
IPC分类号： A61K31/585 , A61K39/395 , C07K16/28
摘要： trata-se de conjugados de fármaco-anticorpo anti-cd40 que compreendem um radical de fórmula (i), em que r1, r2 e r3 são como definidos neste documento. são ainda fornecidos conjugados de fármaco-anticorpo anti-cd40 de fórmula (ii), em que z, r, aa1, aa2, aa3, m, p, q, n, w, r1, r2 e r3 são como definidos neste documento. além disso, são fornecidas composições farmacêuticas e kits das mesmas, e métodos para usar as mesmas.

8. 发明专利

BR112018074922A2 agonista de receptores de glucocorticoides e seus imunoconjugados 未知
公开(公告)号：BR112018074922A2
公开(公告)日：2019-03-12
申请号：BR112018074922
申请日：2017-06-01
申请人： ABBVIE INC
发明人： ADRIAN D HOBSON , AXEL HERNANDEZ JR , CHRISTIAN GOESS , CHRISTOPHER C MARVIN , DIANA SCHMIDT , JASON Z OH , JOHN T RANDOLPH , MARTIN E HAYES , MICHAEL J MCPHERSON , WENDY WAEGELL
IPC分类号： A61K31/58 , A61K47/68 , A61P37/00 , C07J71/00 , C07K16/24
摘要： são proporcionados aqui imunoconjugados de agonistas de receptores de glucocorticoides, agonistas de receptores de glucocorticoides e métodos de uso dos mesmos, p.ex., para tratar doenças autoimunes ou inflamatórias.

9. 发明专利

BR112017026452A2 moduladores de receptores nucleares 未知
公开(公告)号：BR112017026452A2
公开(公告)日：2018-08-14
申请号：BR112017026452
申请日：2016-06-08
申请人： ABBVIE INC
发明人： ADRIAN D HOBSON , DOMINIQUE POTIN , ERIC C BREINLINGER , JÉRÔME AMAUDRUT , KEVIN P CUSACK , LAURENT MOUNIER , MARIA A ARGIRIADI , MARTINE BARTH , MICHAEL E KORT , OLIVIA POUPARDIN
IPC分类号： C07D209/14 , A61K31/404 , A61K31/416 , A61P29/00 , A61P37/00 , C07D209/18 , C07D235/16 , C07D401/10 , C07D403/10 , C07D405/10 , C07D405/14 , C07D471/04 , C07D487/04 , C07D491/10
摘要： a invenção proporciona compostos da fórmula (i), seus sais farmaceutica-mente aceitáveis, em que as variáveis são definidas aqui. os compostos da inven-ção são úteis para tratamento de condições imunológicas.

10. 发明专利

UY37269A AGONISTA DEL RECEPTOR DE GLUCOCORTICOIDES E INMUNOCONJUGADOS DEL MISMO 未知
公开(公告)号：UY37269A
公开(公告)日：2018-01-02
申请号：UY37269
申请日：2017-06-01
申请人： ABBVIE INC
发明人： CHRISTOPHER C MARVIN , SCHMIDT DIANA , GOESS CHRISTIAN , JASON Z OH , AXEL HERNANDEZ JR , MICHAEL J MCPHERSON , MARTIN E HAYES , ADRIAN D HOBSON , JOHN T RANDOLPH , WAEGELL WENDY
IPC分类号： A61P37/00 , A61K31/58 , A61K39/395 , C07J71/00 , C07K16/24
摘要： En la presente se proveen inmunoconjugados de agonistas de receptor de glucocorticoide, agonistas del receptor de glucocorticoides, y métodos para usar los mismos, por ejemplo, para tratar enfermedades autoinmunológicas e inflamatorias.

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