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1. 发明申请

WO2010111070A1 NUTRITIONAL COMPOSITION COMPRISING CURCUMINOIDS AND METHODS OF MANUFACTURE 审中-公开
标题翻译：包含曲霉素的营养组合物及其制造方法
公开(公告)号：WO2010111070A1
公开(公告)日：2010-09-30
申请号：PCT/US2010/027477
申请日：2010-03-16
申请人： ABBOTT LABORATORIES , JOHNS, Paul, W. , MAZER, Terrence, B.
发明人： JOHNS, Paul, W. , MAZER, Terrence, B.
IPC分类号： A23L1/015 , A23L1/221 , A23L1/27 , A23L2/58
CPC分类号： A23L2/52 , A23L33/105 , A23L33/40 , A23V2002/00 , A23V2250/54246 , A23V2250/5114 , A23V2250/5424 , A23V2250/5046 , A23V2250/1578 , A23V2250/708 , A23V2250/0644 , A23V2250/71 , A23V2250/712 , A23V2250/714 , A23V2250/702 , A23V2250/156 , A23V2250/0612 , A23V2250/2112
摘要： Disclosed are nutritional compositions and methods for preparing the compositions, comprising fat, protein, and carbohydrate, including a combination of curcumin, demethoxycurcumin, and bisdemethoxycurcumin, which combination is solubilized in a polar oil having an HLB value of from about 0.7 to about 14 wherein the weight ratio of the bisdemethoxycurcumin to the curcumin is from about 1:1 to about 1:7 and the weight ratio of the bisdemethoxycurcumin to the demethoxycurcumin is from about 1:1 to about 1:2.5. The composition provides a selected ratio of curcuminoids having improved biological activity, bioavailability, and reduced color impact.
摘要翻译：公开了用于制备包含脂肪，蛋白质和碳水化合物的组合物的营养组合物和方法，包括姜黄素，去甲氧基姜黄素和双二甲氧基姜黄素的组合，该组合溶解在HLB值为约0.7至约14的极性油中，其中双二甲氧基姜黄素与姜黄素的重量比为约1:1至约1:7，双甲氧基姜黄素与去甲氧基姜黄素的重量比为约1:1至约1:2.5。组合物提供具有改善的生物活性，生物利用度和降低的颜色影响的选择的姜黄素比例。

2. 发明申请

WO2005051088A3 IRON-CONTAINING HUMAN MILK FORTIFIER WITH IMPROVED ANTIMICROBIAL PROPERTIES 审中-公开
公开(公告)号：WO2005051088A3
公开(公告)日：2005-06-09
申请号：PCT/US2004/035505
申请日：2004-10-26
申请人： ABBOTT LABORATORIES , JOHNS, Paul, W. , BARRETT-REIS, Bridget , MAZER, Terrence, B.
发明人： JOHNS, Paul, W. , BARRETT-REIS, Bridget , MAZER, Terrence, B.
IPC分类号： A23C9/20
摘要： Disclosed are human milk fortifier compositions, in either powder or liquid forms, comprising nutrients and selected iron-containing materials, wherein the fortifiers when added to human milk do not significantly inhibit or otherwise eliminate the inherent, in-vitro antimicrobial properties of the milk. This is accomplished by formulating the compositions with iron-containing insoluble iron, soluble bound iron, or combinations thereof, with little or no soluble unbound iron. Also disclosed are methods of providing nutrition to infants, especially preterm infants, by adding the human milk fortifier described herein with human milk to form a fortified human milk, and then administering the fortified human milk to the infant. The fortifier can also be used to fortify other infant formulas.

3. 发明申请

WO1997023190A1 ORAL ADMINISTRATION OF BENEFICIAL AGENTS 审中-公开
标题翻译：受益人的口头管理
公开(公告)号：WO1997023190A1
公开(公告)日：1997-07-03
申请号：PCT/US1996019942
申请日：1996-12-12
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , MAZER, Terrence, B. , WALTON, Joseph, E. , GECKLE, Ronita, K. , PIONTEK, Joseph
IPC分类号： A61J07/00
CPC分类号： A61J9/006 , A47G21/183 , A61J7/00 , A61J7/0038 , A61J7/0046 , A61J9/00
摘要： Apparatus for adding a beneficial agent to a liquid for drinking during oral administration includes a support structure that defines a retention pocket with liquid penetrable walls. At least one beneficial agent is contained in the retention pocket. The support structure is constructed to be placed in an imperforate walled zone through which a liquid for drinking passes before oral ingestion thereof. In the novel method a support structure with a retention pocket containing at least one beneficial agent is provided and placed in a vessel containing a liquid for drinking such that the at least one beneficial agent is in contact with the liquid for drinking.
摘要翻译：用于在口服给药期间将有益剂添加到用于饮用的液体中的装置包括限定具有液体可穿透壁的保留袋的支撑结构。保留口袋中含有至少一种有益剂。支撑结构被构造成放置在无孔的围壁区域中，用于饮用的液体在其口服摄取之前通过。在新颖方法中，提供了具有包含至少一种有益剂的保留袋的支撑结构，并将其置于含有用于饮用的液体的容器中，使得至少一种有益剂与用于饮用的液体接触。

4. 发明申请

WO1993012661A1 METHOD FOR REMOVING PHOSPHORUS FROM MILK AND WHEY PROTEIN 审中-公开
标题翻译：从牛奶和蛋白质中去除磷的方法
公开(公告)号：WO1993012661A1
公开(公告)日：1993-07-08
申请号：PCT/US1992010935
申请日：1992-12-17
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , NARDELLI, Christy, A. , HOGARTH, Arthur, J., C., L., , SIMPSON, James, M. , DAAB-KRZYKOWSKI, Andre , MAZER, Terrence, B.
IPC分类号： A23C09/00
CPC分类号： A23C7/043 , A23C9/1465 , A23J3/08
摘要： A method of separating phosphorus from condensed skim milk and from whey protein involves exposing the respective starting material to alumina particle while the starting material has a pH in the range of about 6.0 to 6.5. The alumina particles may be conditioned prior to use by exposing the particles to a solution containing a sulfate moiety. Both batch and continuous methods are disclosed. The figure is a graph showing the effect of alumina treatment on the calcium to phosphorus ratio in condensed skim milk.

5. 发明申请

WO1993012771A1 PROLAMINE COATINGS FOR TASTE-MASKING ORALLY-ADMINISTRABLE MEDICAMENTS 审中-公开
标题翻译：用于口服掩蔽的口服涂层口服药物
公开(公告)号：WO1993012771A1
公开(公告)日：1993-07-08
申请号：PCT/US1992011011
申请日：1992-12-18
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , MEYER, Glenn, A. , MAZER, Terrence, B.
IPC分类号： A61K09/38
CPC分类号： A61K9/0095 , A61K9/5052
摘要： Prolamine fractions of grain proteins, applied in weight ratios of 5 to 100 % relative to the active agent being coated, effectively prevent the partitioning of water-soluble or water-insoluble drugs at neutral pH's in the mouth and thereby mask the taste of orally-administered drugs, which normally have a bitter taste, without sacrificing bioavailability. Zein, gliadin or a mixture thereof, particularly in combination with between 2.5 and 15 % of water-insoluble vegetable source oil or wax capable of plasticizing the prolamine fraction, when applied to particles, granules, tablets or other forms of drugs or nutritionals, to an effective thickness of about 1 to about 35 micrometers, in order to encapsulate and prevent release of an orally-administered pharmaceutical or nutritional in a suspension or chewable dosage form until such medicament reaches the stomach.
摘要翻译：颗粒蛋白质的相对于所涂覆的活性剂的重量比为5〜100％的颗粒蛋白质成分有效地防止了水溶性或水不溶性药物在口腔中性pH下的分配，从而掩盖口服的味道，施用的药物，其通常具有苦味，而不牺牲生物利用度。玉米蛋白，麦醇溶蛋白或其混合物，特别是当施用于颗粒，颗粒，片剂或其它形式的药物或营养物时，特别是与2.5至15％的水不溶性植物来源油或能够增塑醇溶蛋白成分的蜡相结合，有效厚度为约1至约35微米，以便包封并防止口服药物或营养物在悬浮液或咀嚼剂型中的释放，直到该药物到达胃。

6. 发明申请

WO1993012668A1 SEPARATION OF PHYTATE AND MANGANESE FROM PLANT PROTEIN AND DIETARY FIBER USING ALUMINA 审中-公开
标题翻译：使用氧化铝从植物蛋白质和膳食纤维中分离植物和锰
公开(公告)号：WO1993012668A1
公开(公告)日：1993-07-08
申请号：PCT/US1992011020
申请日：1992-12-17
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , MAZER, Terrence, B. , NARDELLI, Christy, A. , HOGARTH, Arthur, J., C., L. , DAAB-KRZYKOWSKI, Andre
IPC分类号： A23J01/14
CPC分类号： A23J1/14 , A23L11/34 , A23L33/21
摘要： A method for separating phytate and manganese from protein and dietary fiber involves treatment of an aqueous slurry of phytate-containing material at a low pH with insoluble alumina. In a batch treatment process the pH of the solution is increased, leaving phytate units attached to the alumina while freeing the protein and dietary fiber. In a column treatment process, the column containing alumina is rinsed, after the low pH treatment, with dilute acid and water to recover the protein and/or dietary fiber. This method may be employed either during the manufacture of protein and fiber isolates from flour or flakes, or for removing phytate from commercially available protein and fiber commodities. The spent alumina may be readily regenerated and reused. The method of separating manganese from rice protein using this same technology is also discussed.

7. 发明申请

WO1998010665A1 PROCESS FOR TREATING PLANT PROTEINS AND NUTRITIONAL PRODUCTS MADE THEREFROM 审中-公开
标题翻译：用于处理植物蛋白质和营养产品的方法
公开(公告)号：WO1998010665A1
公开(公告)日：1998-03-19
申请号：PCT/US1997016081
申请日：1997-09-11
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , SUH, John, D. , OSTROM, Karin, M. , NDIFE, Louis, I. , ANLOAGUE, Paul, S. , CHURMA, James, N. , DAAB-KRZYKOWSKI, Andre , JOHNS, Paul, W. , GARCIA, Diane, M. , MAZER, Terrence, B. , MEI, Fu-I
IPC分类号： A23J03/14
CPC分类号： A23J3/16 , A23J3/14 , A23L5/273 , A23L11/34
摘要： The present invention relates generally to a process of isolating isoflavones/phytoestrogens from a plant protein and producing plant proteins for use in nutritional products that have reduced levels of phytoestrogens, manganese and/or nucleotides. More specifically, this invention is directed to a process of using ion exchange technology to remove phytoestrogens, manganese or nucleotides from plant proteins. Either the removed phytoestrogens or the treated plant protein may be retained for further processing. The phytoestrogens have utility as pharmaceuticals. The treated plant protein has utility in nutritional products. This invention is also directed to isoflavones prepared by the process, to plant protein products resulting from the inventive process, and to nutritional products that use the plant protein product as a source of amino nitrogen.
摘要翻译：本发明一般涉及从植物蛋白中分离异黄酮/植物雌激素并产生植物蛋白的方法，所述植物蛋白用于具有降低的植物雌激素，锰和/或核苷酸水平的营养产品。更具体地，本发明涉及使用离子交换技术从植物蛋白中去除植物雌激素，锰或核苷酸的方法。被去除的植物雌激素或经处理的植物蛋白质可被保留用于进一步处理。植物雌激素作为药物具有实用性。经处理的植物蛋白质可用于营养产品。本发明还涉及通过该方法制备的异黄酮，用于植入由本发明方法产生的蛋白质产物，以及使用植物蛋白产物作为氨基氮源的营养产品。

8. 发明授权

EP0869760B1 ORAL ADMINISTRATION OF BENEFICIAL AGENTS 失效
标题翻译：有效的药物口服给药
公开(公告)号：EP0869760B1
公开(公告)日：2004-03-31
申请号：EP96942969.5
申请日：1996-12-12
申请人： Abbott Laboratories
发明人： MAZER, Terrence, B. , WALTON, Joseph, E. , GECKLE, Ronita, K. , PIONTEK, Joseph
IPC分类号： A61J7/00 , A47G21/18
CPC分类号： A61J9/006 , A47G21/183 , A61J7/00 , A61J7/0038 , A61J7/0046 , A61J9/00
摘要： Apparatus for adding a beneficial agent to a liquid for drinking during oral administration includes a support structure that defines a retention pocket with liquid penetrable walls. At least one beneficial agent is contained in the retention pocket. The support structure is constructed to be placed in an imperforate walled zone through which a liquid for drinking passes before oral ingestion thereof. In the novel method a support structure with a retention pocket containing at least one beneficial agent is provided and placed in a vessel containing a liquid for drinking such that the at least one beneficial agent is in contact with the liquid for drinking.

9. 发明授权

EP1056492B1 APPARATUS FOR ALTERING COMPOSITION OF NUTRITIONAL PRODUCT DURING ENTERAL TUBE FEEDING 有权
标题翻译：设备，用于食品的肠内营养成分的变化
公开(公告)号：EP1056492B1
公开(公告)日：2004-09-01
申请号：EP99908525.1
申请日：1999-02-26
申请人： ABBOTT LABORATORIES
发明人： COLE, Rhonda, L. , GECKLE, Ronita, K. , MAZER, Terrence, B. , MURAWSKI, Frank, A. , PIONTEK, Carl, J. , STEPHENS, Gregory, J. , WALTON, Joseph, E.
IPC分类号： A61M5/14
CPC分类号： A61M5/007 , A61J15/00 , A61J15/0026 , A61J15/0069 , A61M5/1407 , A61M5/1409 , A61M31/002
摘要： An apparatus for modifying a liquid enteral nutritional product. The apparatus includes a chamber having an inlet and an outlet. The inlet of the chamber is constructed to be fluidly connected to a supply container containing a liquid enteral nutritional. The chamber defines an interior space. The apparatus further includes a retainer disposed in the interior space defined by the chamber. The retainer is constructed to receive one or more dosage form units of beneficial agent therein. The apparatus further includes at least one dosage form unit of beneficial agent retained by the retainer.

10. 发明公开

EP1102549A2 NUTRITIONALLY COMPLETE LOW pH ENTERAL FORMULA 无效
标题翻译：具有低PH NUTRITIOUS总肠组合物
公开(公告)号：EP1102549A2
公开(公告)日：2001-05-30
申请号：EP99920265.8
申请日：1999-04-30
申请人： Abbott Laboratories
发明人： DeWILLE, Normanella, T. , MORRIS, Jeffrey, G. , MAZER, Terrence, B. , ANLOAGUE, Paul, S. , SMELLER, Amanda, L. , CHANDLER, Michael, A. , GARCIA, Diane, M. , NDIFE, Louis, I.
IPC分类号： A23L1/29
CPC分类号： A23L2/66 , A23L2/38 , A23L33/115 , A23L33/15 , A23L33/16 , A23L33/19 , A23L33/40 , A23V2002/00 , A23V2250/628 , A23V2250/5114 , A23V2250/5424 , A23V2250/188 , A23V2250/032 , A23V2250/5072 , A23V2250/0616 , A23V2250/1944 , A23V2250/02 , A23V2250/156 , A23V2250/51084 , A23V2250/54246 , A23V2250/5108 , A23V2250/708 , A23V2250/704 , A23V2250/702 , A23V2250/712 , A23V2250/71 , A23V2250/5118 , A23V2250/54252
摘要： This invention is directed to a low pH nutritional formula that contains high levels of macronutrients, vitamins and minerals. The pH of the enteral formula is from about 3.0-4.6 and delivers at least 25 % of the RDI for selected vitamins and minerals in a 237 ml. serving. The enteral formula uses a stabilizing system comprising a high methoxy pectin to stabilize the protein and a unique process to produce the formula.

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