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1. 发明申请

WO2008021124A3 COMPOSITIONS AND DRUG-DELIVERY SYSTEMS COMPRISING RAPAMYCIN ANALOGS AND PACLITAXEL 审中-公开
标题翻译：包含RAPAMYCIN类似物和PACLITAXEL的组合物和药物递送系统
公开(公告)号：WO2008021124A3
公开(公告)日：2008-04-03
申请号：PCT/US2007017619
申请日：2007-08-07
申请人： ABBOTT LAB , BURKE SANDRA E , CROMACK KEITH R , MACK MATTHEW , TONER JOHN L
发明人： BURKE SANDRA E , CROMACK KEITH R , MACK MATTHEW , TONER JOHN L
IPC分类号： A61K45/06 , A61K9/127 , A61L31/14 , A61L31/16 , A61P7/10
CPC分类号： A61K45/06 , A61K9/0019 , A61K9/0024 , A61K31/337 , A61K31/4745 , A61L31/16 , A61L2300/416 , A61L2300/45
摘要： The present invention provides for drug-delivery systems and compositions comprising zotarolimus and paclitaxel, or derivatives, prodrugs or salts thereof, as well as methods of treatment using such systems and compositions, wherein the drugs complement each other in effect and/or activity. Medical devices are disclosed which include supporting structures that include at least one pharmaceutically acceptable carrier or excipient, which carrier or excipient can include one or more therapeutic agents or substances, with the carrier including at least one coating on the surface thereof, and the coating associated with the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and drug-delivery systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.
摘要翻译：本发明提供药物递送系统和组合物，其包含唑他罗莫司和紫杉醇或其衍生物，前药或盐，以及使用这种系统和组合物的治疗方法，其中所述药物在有效和/或活性中相互补充。公开了包括至少一种药学上可接受的载体或赋形剂的载体结构的医疗装置，所述载体或赋形剂可以包括一种或多种治疗剂或物质，载体包括其表面上的至少一个涂层，并且涂层相关联与治疗物质，例如药物。适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统的药物递送球囊。这些组合物和药物递送系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物分化抑制剂，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。

2. 发明申请

WO2007109372A3 DELIVERY OF HIGHLY LIPOPHILIC AGENTS VIA MEDICAL DEVICES 审中-公开
公开(公告)号：WO2007109372A3
公开(公告)日：2008-10-23
申请号：PCT/US2007007357
申请日：2007-03-22
申请人： ABBOTT LAB , CROMACK KEITH R , TONER JOHN L , BURKE SANDRA E , KRASULA RICHARD W , SCHWARTZ LEWIS B
发明人： CROMACK KEITH R , TONER JOHN L , BURKE SANDRA E , KRASULA RICHARD W , SCHWARTZ LEWIS B
IPC分类号： A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/00 , A61L2300/22 , A61L2300/416 , A61L2300/45
摘要： An apparatus and system for delivering a lipophilic agent associated with a medical device including: a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, wherein the first lipophilic agent is associated with the medical device, wherein the first lipophilic agent/medical device is placed adjacent to said body lumen, and wherein a therapeutically effective amount of the first lipophilic agent is delivered to a desired area within a subject. Furthermore, the invention relates to a method for improving patency in a subject involving placement of a medical device in a body lumen for treating and/or preventing adjacent diseases or maintaining patency of the body lumen.

3. 发明申请

WO2008045961A3 COMPOSITIONS AND METHODS OF ADMINISTERING RAPAMYCIN ANALOGS WITH PACLITAXEL USING MEDICAL DEVICES 审中-公开
标题翻译：使用医疗设备管理吡虫啉类似物的组合物和方法
公开(公告)号：WO2008045961A3
公开(公告)日：2008-08-28
申请号：PCT/US2007080987
申请日：2007-10-10
申请人： ABBOTT LAB , TONER JOHN L , BURKE SANDRA E , CROMACK KEITH R , MACK MATTHEW
发明人： TONER JOHN L , BURKE SANDRA E , CROMACK KEITH R , MACK MATTHEW
IPC分类号： A61K31/37 , A61K31/436 , A61P9/00
CPC分类号： A61K31/337 , A61K9/0024 , A61K31/436 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/45 , C07D498/18
摘要： Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices comprising supporting structures capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.
摘要翻译：公开了包含紫杉醇和第二药物如雷帕霉素，类似物，衍生物，盐和酯的系统和组合物，以及其中药物具有互补作用的递送方法。包含能够包含或支持药学上可接受的载体或赋形剂的支持结构的医疗装置，所述载体或赋形剂可以含有一种或多种治疗剂或物质，所述载体优选在其表面上包括涂层，所述包衣包括治疗物质，例如药物。适用于本发明的医疗装置的支撑结构包括冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。

4. 发明申请

WO2007111925A3 ZOTAROLIMUS-CONTAINING DRUG DELIVERY SYSTEMS FOR IMPLANTATION INTO A BODY LUMEN OF A SUBJECT 审中-公开
标题翻译：含ZOTAROLIMUS的药物输送系统，用于植入身体的身体
公开(公告)号：WO2007111925A3
公开(公告)日：2007-11-15
申请号：PCT/US2007007090
申请日：2007-03-21
申请人： ABBOTT LAB , TONER JOHN L , BURKE SANDRA E , CROMACK KEITH R
发明人： TONER JOHN L , BURKE SANDRA E , CROMACK KEITH R
IPC分类号： A61K9/00 , A61F2/06 , A61K31/00 , A61L27/00 , A61L29/00 , A61L31/16
CPC分类号： A61K9/0019 , A61F2/91 , A61K31/192 , A61K31/4745 , A61L31/10 , A61L31/16 , A61L2300/256 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/45 , A61L2300/602
摘要： Systems and compositions comprising zotarolimus that are safer, more effective and produce less inflammation than rapamycin and paclitaxel systems are disclosed. Medical devices comprising supporting structures capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier including a coating on the surface thereof, and the coating having the therapeutic compounds, including, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.
摘要翻译：公开了包含佐他莫司的系统和组合物，其比雷帕霉素和紫杉醇系统更安全，更有效并且产生较少的炎症。医疗装置包括能够包含或支持药学上可接受的载体或赋形剂的载体结构的载体或赋形剂，所述载体或赋形剂可以包含一种或多种治疗剂或物质，载体包括其表面上的涂层，以及具有治疗化合物的涂层，包括例如药物。适用于本发明的医疗装置的支撑结构包括冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。

5. 发明申请

WO2008063319A3 METHODS OF ADMINISTERING RAPAMYCIN ANALOGS WITH ANTI-INFLAMMATORIES USING MEDICAL DEVICES 审中-公开
标题翻译：用抗肿瘤药物治疗RAPAMYCIN类似物的方法
公开(公告)号：WO2008063319A3
公开(公告)日：2009-04-30
申请号：PCT/US2007021846
申请日：2007-10-12
申请人： ABBOTT LAB , TONER JOHN L , BURKE SANDRA E , CROMACK KEITH R , MACK MATTHEW
发明人： TONER JOHN L , BURKE SANDRA E , CROMACK KEITH R , MACK MATTHEW
IPC分类号： A61L31/16
CPC分类号： A61L31/16 , A61F2/91 , A61F2250/0067 , A61L2300/416 , A61L2300/45
摘要： A medical device comprising a supporting structure capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may include one or more therapeutic agents or substances, with the carrier including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to. This drug can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.
摘要翻译：一种医疗装置，其包括能够包含或支撑药学上可接受的载体或赋形剂的支持结构，所述载体或赋形剂可以包含一种或多种治疗剂或物质，所述载体在其表面上包括涂层，并且所述包衣包含治疗物质，例如药物。适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。适用于本发明的药物包括但不限于此。该药物可以与另一种药物组合使用，包括选自抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些药物的组合。

6. 发明申请

WO2007047473A3 METHODS OF ADMINISTERING RAPAMYCIN ANALOGS WITH ANTI-INFLAMMATORIES USING MEDICAL DEVICES 审中-公开
标题翻译：用抗肿瘤药物治疗RAPAMYCIN类似物的方法
公开(公告)号：WO2007047473A3
公开(公告)日：2007-08-09
申请号：PCT/US2006040155
申请日：2006-10-12
申请人： ABBOTT LAB , TONER JOHN L , BURKE SANDRA E , CROMACK KEITH R , MACK MATTHEW
发明人： TONER JOHN L , BURKE SANDRA E , CROMACK KEITH R , MACK MATTHEW
IPC分类号： A61F2/00 , A61K31/44
CPC分类号： A61L31/16 , A61K31/192 , A61K31/4745 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/256 , A61L2300/416
摘要： A medical device comprising a supporting structure capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may include one or more therapeutic agents or substances, with the carrier including a coating on its surface, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures suitable for use include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to, This drug can be used in combination with another drug including those selected from anti-proliferative, anti-platelet, anti-inflammatory and anti-thrombotic agents; cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.
摘要翻译：一种医疗装置，包括能够包含或支持药学上可接受的载体或赋形剂的载体或赋形剂，所述载体或赋形剂可以包括一种或多种治疗剂或物质，所述载体包括其表面上的涂层，所述涂层包括治疗物质，例如药物。适合使用的支撑结构包括但不限于冠状动脉支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统的药物递送球囊。适用于本发明的药物包括但不限于：该药物可与包括选自抗增殖，抗血小板，抗炎和抗血栓形成剂的那些药物组合使用。细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些药物的组合。

7. 发明申请

WO2007046935A3 COMPOSITIONS, SYSTEMS, KITS, AND METHODS OF ADMINISTERING RAPAMYCIN ANALOGS WITH PACLITAXEL USING MEDICAL DEVICES 审中-公开
标题翻译：使用医疗设备用紫杉醇施用雷帕霉素类似物的组合物，系统，试剂盒和方法
公开(公告)号：WO2007046935A3
公开(公告)日：2007-07-05
申请号：PCT/US2006031879
申请日：2006-08-15
申请人： ABBOTT LAB , BURKE SANDRA E , CROMACK KEITH R , MACK MATTHEW , TONER JOHN L
发明人： BURKE SANDRA E , CROMACK KEITH R , MACK MATTHEW , TONER JOHN L
IPC分类号： A61F6/06
CPC分类号： A61L31/16 , A61K31/192 , A61K31/4745 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/256 , A61L2300/416
摘要： A system and compositions including zotarolimus and paditaxel are disclosed, as well as methods of delivery, wherein the drugs have effects that complement each other. Medical devices are disclosed which include supporting structures that include at least one pharmaceutically acceptable carrier or excipient, which carrier or excipient can include one or more therapeutic agents or substances, with the carrier including at least one coating on the surface thereof, and the coating associated with the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including antiproliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de- differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.
摘要翻译：公开了一种包含佐他莫司和紫杉醇的系统和组合物，以及递送方法，其中所述药物具有彼此互补的作用。公开了包括支撑结构的医疗装置，所述支撑结构包括至少一种药学上可接受的载体或赋形剂，所述载体或赋形剂可以包括一种或多种治疗剂或物质，其中所述载体在其表面上包含至少一个涂层，与治疗物质，例如药物一起使用。适用于本发明的医疗装置的支撑结构包括但不限于冠状动脉支架，外周支架，导管，动脉 - 静脉移植物，旁路移植物和脉管系统中使用的药物递送球囊。这些组合物和系统可以与其他药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药剂，细胞去分化抑制剂，抗血压药，基质金属蛋白酶抑制剂，细胞生长抑制药或这些与其他药物的组合。

8. 发明申请

WO2010093800A3 MULTIPLE DRUG DELIVERY FROM A BALLOON AND A PROSTHESIS 审中-公开
标题翻译：从气球和PROSTHESIS提供的多种药物
公开(公告)号：WO2010093800A3
公开(公告)日：2011-05-12
申请号：PCT/US2010023910
申请日：2010-02-11
申请人： ABBOTT LAB , TONER JOHN L , BURKE SANDRA E , CROMACK KEITH R , OEPEN RANDOLF VON
发明人： TONER JOHN L , BURKE SANDRA E , CROMACK KEITH R , OEPEN RANDOLF VON
IPC分类号： A61L29/16 , A61L31/16
CPC分类号： A61L31/16 , A61F2/91 , A61F2/958 , A61F2230/0054 , A61F2250/0067 , A61F2310/0097 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/606 , A61M25/10 , A61M2025/105
摘要： Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces.
摘要翻译：公开了用于从血管成形术球囊和诸如腔内支架之类的假体递送治疗剂的介入装置。本发明还涉及将有益试剂装载到球囊和装置上的方法以及将试剂从分开的表面递送的方法。本发明还涉及具有装载有第一有益试剂的假体表面的介入装置和装载有第二有益试剂的气囊表面。本发明还涉及一种将多种有益试剂装载到假体表面和球囊表面上的方法，以及制造用于从单独表面递送第一有益试剂和第二有益试剂的介入装置的方法。

9. 发明申请

WO2007111885A3 DELIVERY OF HIGHLY LIPOPHILIC AGENTS VIA MEDICAL DEVICES 审中-公开
标题翻译：通过医疗器械交付高效液相代谢物
公开(公告)号：WO2007111885A3
公开(公告)日：2007-12-06
申请号：PCT/US2007006916
申请日：2007-03-19
申请人： ABBOTT LAB , CROMACK KEITH R , TONER JOHN L , BURKE SANDRA E , KRASULA RICHARD W , SCHWARTZ LEWIS B
发明人： CROMACK KEITH R , TONER JOHN L , BURKE SANDRA E , KRASULA RICHARD W , SCHWARTZ LEWIS B
IPC分类号： A61L31/16
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/00 , A61L2300/416 , A61L2300/45 , A61L2300/604
摘要： An apparatus and system for delivering a lipophilic agent associated with a medical including : a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, wherein the first lipophilic agent is associated with the medical device, wherein the first lipophilic agent/medical device is placed adjacent to said body lumen, and wherein a therapeutically effective amount of the first lipophilic agent is delivered to a desired area within a subject. Furthermore, the invention relates to a method for improving patency in a subject involving placement of a medical device in a body lumen for treating and/or preventing adjacent diseases or maintaining patency of the body lumen.
摘要翻译：一种用于递送与医学相关联的亲脂剂的装置和系统，包括：医疗装置，能够穿透体腔的第一亲脂性试剂，其中第一亲脂性试剂的转移系数至少在统计学上显着至少约5,000，其中所述第一亲脂性试剂与所述医疗装置相关联，其中所述第一亲脂性试剂/医疗装置放置在所述体腔附近，并且其中治疗有效量的所述第一亲脂性试剂被递送至学科。此外，本发明涉及一种用于提高受试者通畅的方法，包括将医疗装置放置在体腔中，用于治疗和/或预防相邻疾病或维持体腔通畅。

10. 发明申请

WO2007047416A3 COMPOSITIONS AND METHODS OF ADMINISTERING RAPAMYCIN ANALOGS WITH PACLITAXEL USING MEDICAL DEVICES 审中-公开
标题翻译：使用医疗设备用紫杉醇施用雷帕霉素类似物的组合物和方法
公开(公告)号：WO2007047416A3
公开(公告)日：2007-11-08
申请号：PCT/US2006040027
申请日：2006-10-12
申请人： ABBOTT LAB , BURKE SANDRA E , CROMACK KEITH R , MACK MATTHEW , TONER JOHN L
发明人： BURKE SANDRA E , CROMACK KEITH R , MACK MATTHEW , TONER JOHN L
IPC分类号： A61F2/00 , A61K31/44
CPC分类号： A61L31/16 , A61K31/192 , A61K31/4745 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/256 , A61L2300/416
摘要： Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices comprising supporting structures capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.
摘要翻译：公开了包含紫杉醇和第二种药物如雷帕霉素，其类似物，衍生物，盐和酯的系统和组合物，以及其中药物具有互补作用的递送方法。包含能够包含或承载药学上可接受的载体或赋形剂的载体结构的医疗器械，该载体或赋形剂可以含有一种或多种治疗剂或物质，载体优选在其表面上包含涂层，并且包含治疗物质，例如药物。适用于本发明的医疗装置的支撑结构包括冠状动脉支架，外周支架，导管，动脉 - 静脉移植物，旁路移植物和脉管系统中使用的药物递送球囊。这些组合物和系统可以与其他药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药剂，细胞去分化抑制剂，抗血液流变剂，基质金属蛋白酶抑制剂，细胞抑制药物或这些与其他药物的组合。

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