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1. 发明专利

CA1292710C FLUORESCENT LABELS 未知
公开(公告)号：CA1292710C
公开(公告)日：1991-12-03
申请号：CA542828
申请日：1987-07-23
申请人： TONER JOHN L
发明人： TONER JOHN L
IPC分类号： C07D213/22 , C07C51/353 , C07C65/40 , C07C205/45 , C07C335/20 , C07D213/38 , C07D213/42 , C07D213/50 , C07D213/63 , C07D213/70 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/79 , C07D213/81 , C07D295/155 , C07D311/16 , C07D401/14 , C07D405/14 , C07D471/04 , C07D471/22 , G01N33/533 , G01N33/543 , G01N21/64
摘要： FLUORESCENT LABELS There are described stable fluorescent labels comprising a complex of Eu+3 and a chelating agent comprising a nucleus which is a triplet sensitizer having a triplet energy greater than that of Eu+3 and at least two heteroatom-containing groups which form coordinate complexes with Eu+3 and a third heteroatom-containing group or heteroatom in or appended to the triplet sensitizer. Labeled physiologically active materials useful in specific binding assays such as labeled antigens, haptens, antibodies, hormones and the like comprising the stable fluorescent labels having physiologically active materials adsorbed or bonded thereto are also described.

2. 发明专利

CA2026587A1 HEMISPHERAND INOPHORES PROVIDING INCREASED ASSAY PRECISION 未知
公开(公告)号：CA2026587A1
公开(公告)日：1991-11-22
申请号：CA2026587
申请日：1990-10-01
申请人： BAKOS VINCENT W , DANIEL DANIEL S , TONER JOHN L
发明人： BAKOS VINCENT W , DANIEL DANIEL S , TONER JOHN L
IPC分类号： C07D498/22 , G01N27/333 , G01N33/50 , C07D498/18 , G01N27/404
摘要： HEMISPHERAND IONOPHORES PROVIDING INCREASED ASSAY ION Sodium ion selective compositions which comprise an ion carrier, a compound capable of solvating the ion carrier, and a supporting matrix are disclosed. A lipophilic hemispherand compound represented by the structure: wherein R represents 2-decyl, 2-octyl; 3-octyl and cyclohexylmethyl.

3. 发明申请

WO2010147805A2 DRUG COATED BALLOON CATHETER AND PHARMACOKINETIC PROFILE 审中-公开
标题翻译：药物涂层气囊导管和药物动力学特征
公开(公告)号：WO2010147805A2
公开(公告)日：2010-12-23
申请号：PCT/US2010037799
申请日：2010-06-08
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , STANKUS JOHN J , TROLLSAS MIKAEL , HOSSAINY SYED , ZHANG LIANGXUAN , BERGER ED , PACETTI STEPHEN D , TONER JOHN L
发明人： STANKUS JOHN J , TROLLSAS MIKAEL , HOSSAINY SYED , ZHANG LIANGXUAN , BERGER ED , PACETTI STEPHEN D , TONER JOHN L
IPC分类号： A61L29/14
CPC分类号： A61L29/16 , A61L29/08 , A61L29/085 , A61L29/141 , A61L2300/416 , A61L2300/606
摘要： A drug delivery balloon is provided comprising a balloon having a surface, and a coating disposed on at least a portion of the balloon surface, the coating including an cytostatic therapeutic agent, an excipient, and a plasticizer. In accordance with the present subject matter, at least 30% of the coating transfers from the balloon surface within two minutes after inflation of the balloon. Alternatively, at least 30% of the coating transfers from the balloon surface within one minute after inflation. The coating results in an effective pharmacokinetic profile of an cytostatic therapeutic agent in a vasculature or target tissue.
摘要翻译：提供了药物递送球囊，其包括具有表面的球囊，以及设置在球囊表面的至少一部分上的涂层，所述涂层包括细胞抑制剂，赋形剂和增塑剂。根据本主题，至少30％的涂层在气球膨胀后两分钟内从气球表面转移。或者，至少30％的涂层在充气后一分钟内从气球表面转移。涂层导致脉管系统或靶组织中细胞抑制治疗剂的有效药代动力学特征。

4. 发明申请

WO2010093800A2 MULTIPLE DRUG DELIVERY FROM A BALLOON AND A PROSTHESIS 审中-公开
标题翻译：从气球和PROSTHESIS提供的多种药物
公开(公告)号：WO2010093800A2
公开(公告)日：2010-08-19
申请号：PCT/US2010/023910
申请日：2010-02-11
申请人： ABBOTT LABORATORIES , TONER, John, L. , BURKE, Sandra, E. , CROMACK, Keith, R. , OEPEN, Randolf, Von
发明人： TONER, John, L. , BURKE, Sandra, E. , CROMACK, Keith, R. , OEPEN, Randolf, Von
IPC分类号： A61L29/16
CPC分类号： A61L31/16 , A61F2/91 , A61F2/958 , A61F2230/0054 , A61F2250/0067 , A61F2310/0097 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/606 , A61M25/10 , A61M2025/105
摘要： Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces.
摘要翻译：公开了用于从血管成形术球囊和诸如腔内支架之类的假体递送治疗剂的介入装置。本发明还涉及将有益试剂装载到球囊和装置上的方法以及将试剂从分开的表面递送的方法。本发明还涉及具有装载有第一有益试剂的假体表面的介入装置和装载有第二有益试剂的气囊表面。本发明还涉及一种将多种有益试剂装载到假体表面和球囊表面上的方法，以及制造用于从单独表面递送第一有益试剂和第二有益试剂的介入装置的方法。

5. 发明申请

WO2007109372A3 DELIVERY OF HIGHLY LIPOPHILIC AGENTS VIA MEDICAL DEVICES 审中-公开
公开(公告)号：WO2007109372A3
公开(公告)日：2008-10-23
申请号：PCT/US2007007357
申请日：2007-03-22
申请人： ABBOTT LAB , CROMACK KEITH R , TONER JOHN L , BURKE SANDRA E , KRASULA RICHARD W , SCHWARTZ LEWIS B
发明人： CROMACK KEITH R , TONER JOHN L , BURKE SANDRA E , KRASULA RICHARD W , SCHWARTZ LEWIS B
IPC分类号： A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/00 , A61L2300/22 , A61L2300/416 , A61L2300/45
摘要： An apparatus and system for delivering a lipophilic agent associated with a medical device including: a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, wherein the first lipophilic agent is associated with the medical device, wherein the first lipophilic agent/medical device is placed adjacent to said body lumen, and wherein a therapeutically effective amount of the first lipophilic agent is delivered to a desired area within a subject. Furthermore, the invention relates to a method for improving patency in a subject involving placement of a medical device in a body lumen for treating and/or preventing adjacent diseases or maintaining patency of the body lumen.

6. 发明申请

WO2008045961A3 COMPOSITIONS AND METHODS OF ADMINISTERING RAPAMYCIN ANALOGS WITH PACLITAXEL USING MEDICAL DEVICES 审中-公开
标题翻译：使用医疗设备管理吡虫啉类似物的组合物和方法
公开(公告)号：WO2008045961A3
公开(公告)日：2008-08-28
申请号：PCT/US2007080987
申请日：2007-10-10
申请人： ABBOTT LAB , TONER JOHN L , BURKE SANDRA E , CROMACK KEITH R , MACK MATTHEW
发明人： TONER JOHN L , BURKE SANDRA E , CROMACK KEITH R , MACK MATTHEW
IPC分类号： A61K31/37 , A61K31/436 , A61P9/00
CPC分类号： A61K31/337 , A61K9/0024 , A61K31/436 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/45 , C07D498/18
摘要： Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices comprising supporting structures capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.
摘要翻译：公开了包含紫杉醇和第二药物如雷帕霉素，类似物，衍生物，盐和酯的系统和组合物，以及其中药物具有互补作用的递送方法。包含能够包含或支持药学上可接受的载体或赋形剂的支持结构的医疗装置，所述载体或赋形剂可以含有一种或多种治疗剂或物质，所述载体优选在其表面上包括涂层，所述包衣包括治疗物质，例如药物。适用于本发明的医疗装置的支撑结构包括冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。

7. 发明申请

WO2008045961A2 COMPOSITIONS AND METHODS OF ADMINISTERING RAPAMYCIN ANALOGS WITH PACLITAXEL USING MEDICAL DEVICES 审中-公开
标题翻译：使用医疗设备用紫杉醇施用雷帕霉素类似物的组合物和方法
公开(公告)号：WO2008045961A2
公开(公告)日：2008-04-17
申请号：PCT/US2007/080987
申请日：2007-10-10
申请人： ABBOTT LABORATORIES , TONER, John, L. , BURKE, Sandra, E. , CROMACK, Keith, R. , MACK, Matthew
发明人： TONER, John, L. , BURKE, Sandra, E. , CROMACK, Keith, R. , MACK, Matthew
CPC分类号： A61K31/337 , A61K9/0024 , A61K31/436 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/45 , C07D498/18
摘要： Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices comprising supporting structures capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.
摘要翻译：包括紫杉醇和第二药物如雷帕霉素，其类似物，衍生物，盐和酯的系统和组合物以及递送方法，其中药物具有彼此互补的作用。包含能够包含或承载药学上可接受的载体或赋形剂的载体结构的医疗器械，该载体或赋形剂可以含有一种或多种治疗剂或物质，载体优选在其表面上包含涂层，并且包含治疗物质，例如药物。适用于本发明的医疗装置的支撑结构包括冠状动脉支架，外周支架，导管，动脉 - 静脉移植物，旁路移植物和脉管系统中使用的药物递送球囊。这些组合物和系统可以与其他药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药剂，细胞去分化抑制剂，抗血液流变剂，基质金属蛋白酶抑制剂，细胞抑制药物或这些与其他药物的组合。

8. 发明申请

WO2007130366A2 SURFACE INTERACTIONS TO IMPROVE RETENTION OF MEDICAL DEVICES 审中-公开
标题翻译：表面相互作用改善医疗器械的保留
公开(公告)号：WO2007130366A2
公开(公告)日：2007-11-15
申请号：PCT/US2007010481
申请日：2007-04-30
申请人： ABBOTT LAB , TONER JOHN L , VON OEPEN RANDOLF
发明人： TONER JOHN L , VON OEPEN RANDOLF
IPC分类号： A61L29/08 , A61L29/14 , A61L31/10 , A61L31/14
CPC分类号： A61F2/958 , A61F2002/9583 , A61L29/085 , A61L29/14 , A61L31/08 , A61L31/10 , A61L31/14
摘要： A method for improving the retention between the surfaces of medical devices. The method includes coating a surface of one medical device such as a stent with a coating that includes a functional group and coating a surface of another medical device such as a balloon with a coating that includes an identical or different functional group. The method further includes interacting the coated surfaces to produce a plurality of bonds between the surfaces, thereby improving retention.
摘要翻译：一种用于改善医疗装置表面之间的保持性的方法。该方法包括用包括官能团的涂层涂覆诸如支架的一个医疗装置的表面，并用包括相同或不同官能团的涂层涂覆其它医疗装置例如气囊的表面。该方法还包括使涂覆的表面相互作用以在表面之间产生多个键，从而改善保留。

9. 发明申请

WO2007111925A3 ZOTAROLIMUS-CONTAINING DRUG DELIVERY SYSTEMS FOR IMPLANTATION INTO A BODY LUMEN OF A SUBJECT 审中-公开
标题翻译：含ZOTAROLIMUS的药物输送系统，用于植入身体的身体
公开(公告)号：WO2007111925A3
公开(公告)日：2007-11-15
申请号：PCT/US2007007090
申请日：2007-03-21
申请人： ABBOTT LAB , TONER JOHN L , BURKE SANDRA E , CROMACK KEITH R
发明人： TONER JOHN L , BURKE SANDRA E , CROMACK KEITH R
IPC分类号： A61K9/00 , A61F2/06 , A61K31/00 , A61L27/00 , A61L29/00 , A61L31/16
CPC分类号： A61K9/0019 , A61F2/91 , A61K31/192 , A61K31/4745 , A61L31/10 , A61L31/16 , A61L2300/256 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/45 , A61L2300/602
摘要： Systems and compositions comprising zotarolimus that are safer, more effective and produce less inflammation than rapamycin and paclitaxel systems are disclosed. Medical devices comprising supporting structures capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier including a coating on the surface thereof, and the coating having the therapeutic compounds, including, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.
摘要翻译：公开了包含佐他莫司的系统和组合物，其比雷帕霉素和紫杉醇系统更安全，更有效并且产生较少的炎症。医疗装置包括能够包含或支持药学上可接受的载体或赋形剂的载体结构的载体或赋形剂，所述载体或赋形剂可以包含一种或多种治疗剂或物质，载体包括其表面上的涂层，以及具有治疗化合物的涂层，包括例如药物。适用于本发明的医疗装置的支撑结构包括冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。

10. 发明申请

WO2007112006A2 DELIVERY OF HIGHLY LIPOPHILIC AGENTS VIA MEDICAL DEVICES 审中-公开
标题翻译：通过医疗器械交付高效液相代谢物
公开(公告)号：WO2007112006A2
公开(公告)日：2007-10-04
申请号：PCT/US2007007255
申请日：2007-03-22
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , CROMACK KEITH R , TONER JOHN L , BURKE SANDRA E , KRASULA RICHARD W , SCHWARTZ LEWIS B
发明人： CROMACK KEITH R , TONER JOHN L , BURKE SANDRA E , KRASULA RICHARD W , SCHWARTZ LEWIS B
IPC分类号： A61F2/24 , A61L29/16 , A61L31/14
CPC分类号： A61L31/16 , A61L15/44 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/22 , A61L2300/416 , A61L2300/45
摘要： An apparatus and system for delivering a lipophilic agent associated with a medical device including: a medical device, a first lipophilic agent capable of penetrating a body lumen, wherein the transfer coefficients of the first lipophilic agent is by an amount that is statistically significant of at least approximately 5,000, wherein the first lipophilic agent is associated with the medical device, wherein the first lipophilic agent/medical device is placed adjacent to said body lumen, and wherein a therapeutically effective amount of the first lipophilic agent is delivered to a desired area within a subject. Furthermore, the invention relates to a method for improving patency in a subject involving placement of a medical device in a body lumen for treating and/or preventing adjacent diseases or maintaining patency of the body lumen.
摘要翻译：一种用于递送与医疗装置相关联的亲脂剂的装置和系统，包括：医疗装置，能够穿透体腔的第一亲脂性试剂，其中第一亲脂性试剂的转移系数为统计学上显着的至少约5,000，其中所述第一亲脂性试剂与所述医疗装置相关联，其中所述第一亲脂性试剂/医疗装置放置在所述体腔附近，并且其中治疗有效量的所述第一亲脂性试剂被递送至课程。此外，本发明涉及一种用于提高受试者通畅的方法，包括将医疗装置放置在体腔中，用于治疗和/或预防相邻疾病或维持体腔通畅。

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