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1. 发明申请

WO2010129381A2 BALLOON COATING WITH DRUG TRANSFER CONTROL VIA COATING THICKNESS 审中-公开
标题翻译：通过涂层厚度进行药物转移控制的气泡涂层
公开(公告)号：WO2010129381A2
公开(公告)日：2010-11-11
申请号：PCT/US2010032900
申请日：2010-04-29
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , STANKUS JOHN J , PACETTI STEPHEN D
发明人： STANKUS JOHN J , PACETTI STEPHEN D
IPC分类号： A61L29/08
CPC分类号： A61L29/16 , A61L29/085 , A61L29/146 , A61L2300/416 , A61L2300/606
摘要： A coated medical device, such a balloon or stent. The coating includes a therapeutic agent having a thickness of the coating is between about 1.5 to 10 µm and less than 30% of the coating remains on the balloon post delivery to a vessel.
摘要翻译：涂覆的医疗装置，例如球囊或支架。该涂层包括具有约1.5至10微米至约小于30％的涂层厚度的治疗剂，并保留在气瓶柱输送至血管后。

2. 发明申请

WO2010147805A8 DRUG COATED BALLOON CATHETER AND PHARMACOKINETIC PROFILE 审中-公开
标题翻译：药物涂层气囊导管和药代动力学曲线
公开(公告)号：WO2010147805A8
公开(公告)日：2011-07-14
申请号：PCT/US2010037799
申请日：2010-06-08
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , STANKUS JOHN J , TROLLSAS MIKAEL , HOSSAINY SYED , ZHANG LIANGXUAN , BERGER ED , PACETTI STEPHEN D , TONER JOHN L
发明人： STANKUS JOHN J , TROLLSAS MIKAEL , HOSSAINY SYED , ZHANG LIANGXUAN , BERGER ED , PACETTI STEPHEN D , TONER JOHN L
IPC分类号： A61L29/14 , A61L29/16
CPC分类号： A61L29/16 , A61L29/08 , A61L29/085 , A61L29/141 , A61L2300/416 , A61L2300/606
摘要： A drug delivery balloon is provided comprising a balloon having a surface, and a coating disposed on at least a portion of the balloon surface, the coating including an cytostatic therapeutic agent, an excipient, and a plasticizer. In accordance with the present subject matter, at least 30% of the coating transfers from the balloon surface within two minutes after inflation of the balloon. Alternatively, at least 30% of the coating transfers from the balloon surface within one minute after inflation. The coating results in an effective pharmacokinetic profile of an cytostatic therapeutic agent in a vasculature or target tissue.
摘要翻译：提供了药物递送气囊，其包括具有表面的气囊和设置在气囊表面的至少一部分上的涂层，所述涂层包括细胞抑制剂治疗剂，赋形剂和增塑剂。根据本主题，在球囊充气后两分钟内至少30％的涂层从球囊表面转移。或者，至少30％的涂层在充气后一分钟内从球囊表面转移。涂层导致血管或靶组织中细胞抑制剂治疗剂的有效药代动力学特征。

3. 发明申请

WO2010027735A3 COATING ON A BALLOON COMPRISING A POLYMER AND A DRUG 审中-公开
标题翻译：涂布在包含聚合物和药物的球囊上
公开(公告)号：WO2010027735A3
公开(公告)日：2010-10-07
申请号：PCT/US2009054765
申请日：2009-08-24
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , PACETTI STEPHEN D , STANKUS JOHN
发明人： PACETTI STEPHEN D , STANKUS JOHN
IPC分类号： A61L29/08 , A61L29/16 , A61L31/02 , A61L31/16
CPC分类号： A61L29/16 , A61L29/085 , A61L2300/416 , A61L2300/602 , C08L33/08
摘要： A coating on a balloon of a medical device is provided. The coating comprises a drug and a polymer. Also provided are methods of forming and using the coating.
摘要翻译：提供医疗装置的球囊上的涂层。涂层包含药物和聚合物。还提供了形成和使用该涂层的方法。

4. 发明申请

WO2010147805A2 DRUG COATED BALLOON CATHETER AND PHARMACOKINETIC PROFILE 审中-公开
标题翻译：药物涂层气囊导管和药物动力学特征
公开(公告)号：WO2010147805A2
公开(公告)日：2010-12-23
申请号：PCT/US2010037799
申请日：2010-06-08
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , STANKUS JOHN J , TROLLSAS MIKAEL , HOSSAINY SYED , ZHANG LIANGXUAN , BERGER ED , PACETTI STEPHEN D , TONER JOHN L
发明人： STANKUS JOHN J , TROLLSAS MIKAEL , HOSSAINY SYED , ZHANG LIANGXUAN , BERGER ED , PACETTI STEPHEN D , TONER JOHN L
IPC分类号： A61L29/14
CPC分类号： A61L29/16 , A61L29/08 , A61L29/085 , A61L29/141 , A61L2300/416 , A61L2300/606
摘要： A drug delivery balloon is provided comprising a balloon having a surface, and a coating disposed on at least a portion of the balloon surface, the coating including an cytostatic therapeutic agent, an excipient, and a plasticizer. In accordance with the present subject matter, at least 30% of the coating transfers from the balloon surface within two minutes after inflation of the balloon. Alternatively, at least 30% of the coating transfers from the balloon surface within one minute after inflation. The coating results in an effective pharmacokinetic profile of an cytostatic therapeutic agent in a vasculature or target tissue.
摘要翻译：提供了药物递送球囊，其包括具有表面的球囊，以及设置在球囊表面的至少一部分上的涂层，所述涂层包括细胞抑制剂，赋形剂和增塑剂。根据本主题，至少30％的涂层在气球膨胀后两分钟内从气球表面转移。或者，至少30％的涂层在充气后一分钟内从气球表面转移。涂层导致脉管系统或靶组织中细胞抑制治疗剂的有效药代动力学特征。

5. 发明申请

WO2013151576A3 DELIVERY SYSTEM FOR SEGMENTED SCAFFOLDS 审中-公开
标题翻译：交付系统交付系统
公开(公告)号：WO2013151576A3
公开(公告)日：2014-03-27
申请号：PCT/US2012053969
申请日：2012-09-06
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , PAPP JOHN E , NGUYEN HUNG T , ELERATH JUSTIN K , HERABADI DION I , MARTINS MICHAEL T , KING KIRSTEN S , MUELLER SCOTT H , PELOQUIN COETA K , PACETTI STEPHEN D
发明人： PAPP JOHN E , NGUYEN HUNG T , ELERATH JUSTIN K , HERABADI DION I , MARTINS MICHAEL T , KING KIRSTEN S , MUELLER SCOTT H , PELOQUIN COETA K , PACETTI STEPHEN D
IPC分类号： A61F2/24 , A61F2/82 , A61F2/966
CPC分类号： A61F2/958 , A61F2/844 , A61F2/91 , A61F2/915 , A61F2/966 , A61F2002/826 , A61F2002/9583 , A61F2210/0076 , A61F2250/0019 , A61F2250/0039
摘要： System for delivery of endoprostheses with segmented scaffolds are disclosed. Preferred delivery systems comprise a delivery balloon (350) and two or more scaffold segments (351, 352, 353) crimped on the balloon. The segments can be separated by structures of the balloon (pre-pillowed bands) or structures placed on the balloon (spacers, bands, etc.). The system may comprise an outer sheath. Means causing the balloon to shorten when expanding are provided in some of the embodiments. In some embodiments the balloon comprises separate balloon chambers.
摘要翻译：公开了用分段支架递送内假体的系统。优选的递送系统包括递送球囊（350）和卷曲在球囊上的两个或更多个支架段（351,352,353）。可以通过球囊（预枕头带）或放置在球囊上的结构（间隔物，带等）的结构来分隔节段。该系统可以包括外护套。在一些实施例中提供了在膨胀时使气囊缩短的装置。在一些实施例中，气囊包括分离的球囊腔。

6. 发明申请

WO2013022851A3 CONTROLLING MOISTURE IN AND PLASTICIZATION OF BIORESORBABLE POLYMER FOR MELT PROCESSING 审中-公开
标题翻译：控制用于熔融加工的可生物降解聚合物的水分和塑化
公开(公告)号：WO2013022851A3
公开(公告)日：2013-07-11
申请号：PCT/US2012049775
申请日：2012-08-06
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , STEICHEN BETHANY , PACETTI STEPHEN D , GADA MANISH , GLAUSER THIERRY , KLEINER LOTHAR W , WANG YUNBING , OBERHAUSER JAMES P , DING NI
发明人： STEICHEN BETHANY , PACETTI STEPHEN D , GADA MANISH , GLAUSER THIERRY , KLEINER LOTHAR W , WANG YUNBING , OBERHAUSER JAMES P , DING NI
IPC分类号： B29C47/10 , B29B13/06 , B29C47/76 , B29C47/92
CPC分类号： B29C47/0078 , B29B13/06 , B29B13/065 , B29C47/0014 , B29C47/0021 , B29C47/0023 , B29C47/1018 , B29C47/1072 , B29C47/76 , B29C47/92 , B29C2947/922 , B29C2947/92228 , B29C2947/92342 , B29C2947/92695 , B29C2947/92704 , B29C2947/92723 , B29K2995/006
摘要： Methods and systems (150) for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon.
摘要翻译：公开了用于在挤出之前控制可生物降解和生物可再吸收的聚合物树脂的水分含量在允许聚合物树脂熔体增塑并低于上限以降低或防止分子量损失的下限之下的方法和系统（150）。进一步公开的方法涉及用二氧化碳和氟利昂进料到挤出机中的聚合物树脂的增塑。

7. 发明申请

WO2009140420A3 METHOD FOR ELECTROSTATIC COATING OF A MEDICAL DEVICE 审中-公开
标题翻译：医疗器械静电涂层方法
公开(公告)号：WO2009140420A3
公开(公告)日：2010-10-14
申请号：PCT/US2009043836
申请日：2009-05-13
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , KERRIGAN CAMERON K , PACETTI STEPHEN D
发明人： KERRIGAN CAMERON K , PACETTI STEPHEN D
IPC分类号： A61L31/14 , A61L31/16
CPC分类号： A61L31/08 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2420/02 , B05D1/007
摘要： A method for electrostatic coating of medical devices such as stents and balloons is described. The method includes applying a composition to a polymeric component of a medical device which has little or no conductivity. The polymeric component could be a material from which the body or a strut of the stent is made or could be a polymeric coating pre-applied on the stent. The polymeric component could be the balloon wall. A charge can then be applied to the polymeric component or the polymeric component can be grounded. Charged particles of drugs, polymers, biobeneficial agents, or any combination of these can then be electrostatically deposited on the medical device or the coating on the medical device. One example of the composition is iodine, iodine, iodide, iodate, a complex or salt thereof which can also impart imaging capabilities to the medical device.
摘要翻译：描述了诸如支架和气囊的医疗装置的静电涂覆方法。该方法包括将组合物施用于具有很少或不具有导电性的医疗器械的聚合物组分。聚合物组分可以是制造支架的主体或支柱的材料，或者可以是预先施加在支架上的聚合物涂层。聚合物组分可以是球囊壁。然后可以向聚合物组分施加电荷，或者聚合物组分可以接地。药物，聚合物，生物有益剂或它们的任何组合的带电颗粒然后可静电沉积在医疗装置或医疗装置上的涂层上。组合物的一个实例是碘，碘，碘化物，碘酸盐，其复合物或盐，其也可以赋予医疗装置成像能力。

8. 发明申请

WO2009142934A3 COATING COMPRISING AN AMORPHOUS PRIMER LAYER AND A SEMI-CRYSTALLINE RESERVOIR LAYER 审中-公开
标题翻译：包含不规则前置层和半结晶储层的涂层
公开(公告)号：WO2009142934A3
公开(公告)日：2010-09-10
申请号：PCT/US2009043379
申请日：2009-05-08
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , LIM FLORENCIA , TROLLSAS MIKAEL O , HOSSAINY SYED FAIYAZ AHMED , PACETTI STEPHEN D
发明人： LIM FLORENCIA , TROLLSAS MIKAEL O , HOSSAINY SYED FAIYAZ AHMED , PACETTI STEPHEN D
IPC分类号： A61L31/10 , A61L31/14
CPC分类号： A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/604 , A61L2300/606 , Y10T24/258 , C08L67/04
摘要： The present invention provides a coating comprising a reservoir layer comprising a semi-crystalline polymer and a primer layer comprising an amorphous polymer on an implantable device and methods of making and using the same.
摘要翻译：本发明提供一种包含储存层的涂层，其包含半结晶聚合物和在可植入装置上包含无定形聚合物的底漆层，以及制备和使用它的方法。

9. 发明申请

WO2010036537A3 COATINGS INCLUDING DEXAMETHASONE DERIVATIVES AND ANALOGS AND OLIMUS DRUGS 审中-公开
标题翻译：包括衍生物衍生物和模拟物和老式药物的涂料
公开(公告)号：WO2010036537A3
公开(公告)日：2010-12-02
申请号：PCT/US2009057033
申请日：2009-09-15
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , PACETTI STEPHEN D , TONER JOHN L , CROMACK KEITH R
发明人： PACETTI STEPHEN D , TONER JOHN L , CROMACK KEITH R
IPC分类号： A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
CPC分类号： A61L29/16 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/43 , A61L2300/45 , A61L2300/606 , C08L27/16
摘要： The present invention encompasses a coating on the surface of a substrate and the coated substrates. The coating includes a polymer, an olimus drug (sirolimus, everolimus, zotarolimus, etc.), and a dexamethasone derivative. The polymer may be a hydrophobic polymer, preferably a fluoropolymer, and more preferably a fluoropolymer with at least 25% vinylidene fluoride by weight.
摘要翻译：本发明包括在基底表面上的涂层和涂覆的基底。涂层包括聚合物，奥林匹克药物（西罗莫司，依维莫司，佐他莫司等）和地塞米松衍生物。聚合物可以是疏水性聚合物，优选含氟聚合物，更优选具有至少25重量％偏二氟乙烯的氟聚合物。

10. 发明申请

WO2008002632A3 CARBON COATING ON AN IMPLANTABLE DEVICE 审中-公开
标题翻译：涂在可植入装置上的碳涂层
公开(公告)号：WO2008002632A3
公开(公告)日：2008-07-10
申请号：PCT/US2007014981
申请日：2007-06-25
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , DING NI , MICHAL GENE , PACETTI STEPHEN D
发明人： DING NI , MICHAL GENE , PACETTI STEPHEN D
IPC分类号： A61L31/08 , A61L31/16
CPC分类号： A61L31/16 , A61L31/084 , A61L2300/606
摘要： A carbon coating on a stent having a bioactive agent covalently attached thereto and methods of making the same are described.
摘要翻译：描述了具有共价附着于其上的生物活性剂的支架上的碳涂层及其制备方法。

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