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1. 发明申请

WO2007142738A3 COATINGS LAYERS FOR MEDICAL DEVICES AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：用于医疗装置的涂层及其制备方法
公开(公告)号：WO2007142738A3
公开(公告)日：2008-03-20
申请号：PCT/US2007009114
申请日：2007-04-13
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , LUDWIG FLORIAN N , HOSSAINY SYED FAIYAZ AHMED , SRIDHARAN SRINIVASAN , LEE CAROL
发明人： LUDWIG FLORIAN N , HOSSAINY SYED FAIYAZ AHMED , SRIDHARAN SRINIVASAN , LEE CAROL
IPC分类号： A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61L27/34 , A61L27/50 , A61L27/54 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61M31/002
摘要： Methods are disclosed for controlling the morphology and the release-rate of active agent from coating layers for medical devices comprising a polymer matrix and one or more active agents. The methods comprise fixing the morphology or phase distribution of the active agent prior to removing solvent from the coating composition. The coating layers can be used for controlled the delivery of an active agent or a combination of active agents.
摘要翻译：公开了用于控制活性剂从包含聚合物基质和一种或多种活性剂的医疗装置的涂层的形态和释放速率的方法。所述方法包括在从涂料组合物中除去溶剂之前固定活性剂的形态或相分布。涂层可用于控制活性剂或活性剂的组合的递送。

2. 发明申请

WO2007126606A3 CONTROLLED DEGRADATION AND DRUG RELEASE IN STENTS 审中-公开
标题翻译：控制降解和药物释放在STENTS
公开(公告)号：WO2007126606A3
公开(公告)日：2008-01-10
申请号：PCT/US2007006704
申请日：2007-03-16
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , LUDWIG FLORIAN N , ASTAFIEVA IRINA , GALE DAVID C , HOSSAINY SYED FAIYAZ AHMED
发明人： LUDWIG FLORIAN N , ASTAFIEVA IRINA , GALE DAVID C , HOSSAINY SYED FAIYAZ AHMED
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61F2/91 , A61F2210/0004 , A61F2250/003 , A61F2250/0068 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/604 , A61L2300/61 , B23K2203/42 , B23K2203/50
摘要： The invention provides for a stent for implanting in a bodily lumen comprising a degradable structural element including: an abluminal layer (510) comprising an active agent; and a luminal layer (520), wherein the abluminal layer has faster degradation rate than the luminal layer.
摘要翻译：本发明提供一种用于植入体内的支架，其包括可降解结构元件，所述支架包括：包含活性剂的中空层（510）和腔层（520），其中所述囊膜层比所述内腔层具有更快的降解速率。

3. 发明申请

WO2007118051A3 LIPID THERAPY 审中-公开
标题翻译：脂肪疗法
公开(公告)号：WO2007118051A3
公开(公告)日：2008-07-24
申请号：PCT/US2007065791
申请日：2007-04-02
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , KILPATRICK DEBORAH , HOSSAINY SYED FAIYAZ AHMED , ASTAFIEVA IRINA , LUDWIG FLORIAN N , CONSIGNY PAUL M , ELLIS JEFFREY T , LIM FLORENCIA
发明人： KILPATRICK DEBORAH , HOSSAINY SYED FAIYAZ AHMED , ASTAFIEVA IRINA , LUDWIG FLORIAN N , CONSIGNY PAUL M , ELLIS JEFFREY T , LIM FLORENCIA
IPC分类号： A61K38/00 , A61P9/10 , C07K14/755
CPC分类号： A61K38/1709 , A61K9/0019 , A61K9/1275 , A61K9/1617 , A61K9/1658 , A61M1/3472 , A61M1/3486 , A61M2202/0456 , A61K2300/00
摘要： A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo Al comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo Al and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCAl) transporter expression in macrophages and protect ABCAl from thiol-mediated degradation.
摘要翻译：一种方法，包括向血液中引入脱脂高密度脂蛋白（HDL）和生物活性剂。包含脱脂高密度脂蛋白（HDL）和适合于输送到血管中的辅助剂的组合物。包含Apo A1的组合物，其包含适于与细胞表面结合位点相互作用的疏水性配体。一种组合物，其包含Apo A1和选自用于增加巨噬细胞中ATP结合盒蛋白1（ABCA1）转运蛋白表达的一种试剂，并保护ABCA1免受硫醇介导的降解。

4. 发明申请

WO2008100847A2 DYNAMERS FOR THERAPEUTIC AGENT DELIVERY APPLICATIONS 审中-公开
标题翻译：用于治疗药物递送应用的动物
公开(公告)号：WO2008100847A2
公开(公告)日：2008-08-21
申请号：PCT/US2008053565
申请日：2008-02-11
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , HOSSAINY SYED FAIYAZ AHMED , LUDWIG FLORIAN N , TROLLSAS MIKAEL O , DAVALIAN DARIUSH
发明人： HOSSAINY SYED FAIYAZ AHMED , LUDWIG FLORIAN N , TROLLSAS MIKAEL O , DAVALIAN DARIUSH
IPC分类号： A61L27/18 , A61L27/50
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/00
摘要： Dynamers for use in therapeutic agent delivery systems are disclosed.
摘要翻译：公开了用于治疗剂递送系统的动力剂。

5. 发明申请

WO2008076847A2 REGIONAL DELIVERY OF THERAPEUTIC AGENTS FOR THE TREATMENT OF VASCULAR DISEASES 审中-公开
标题翻译：用于治疗血管疾病的治疗药物的区域性递送
公开(公告)号：WO2008076847A2
公开(公告)日：2008-06-26
申请号：PCT/US2007087487
申请日：2007-12-13
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , PACETTI STEPHEN D , CONSIGNY PAUL , HEIL RONALD W , LUDWIG FLORIAN N , DAVALIAN DARIUSH , ZHAO LI , ASTAFIEVA IRINA , WAN JINPING , EL-NOUNOU FOZAN , MURASE KATSUYUKI , HOSSAINY SYED FAIYAZ AHMED , BRIGHT RACHEL , ELLIS JEFFREY
发明人： PACETTI STEPHEN D , CONSIGNY PAUL , HEIL RONALD W , LUDWIG FLORIAN N , DAVALIAN DARIUSH , ZHAO LI , ASTAFIEVA IRINA , WAN JINPING , EL-NOUNOU FOZAN , MURASE KATSUYUKI , HOSSAINY SYED FAIYAZ AHMED , BRIGHT RACHEL , ELLIS JEFFREY
CPC分类号： A61M25/1002 , A61F2/82 , A61F2250/0067 , A61K31/27 , A61K31/44 , A61K31/56 , A61K31/66 , A61K38/1709 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/112 , A61L2300/216 , A61L2300/252 , A61L2300/40 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61L2300/62 , A61M25/10 , A61M37/0015 , A61M2025/105 , A61M2025/1086 , A61M2037/0023 , A61M2037/0061 , A61M2210/12
摘要： The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.
摘要翻译：本发明涉及用于治疗血管疾病的治疗剂的区域递送，其中区域递送是指将治疗有效量的治疗剂递送至血管的区域，该区域不仅包括受到损伤的组织而且包括非折磨组织受影响组织的外围也是如此。

6. 发明申请

WO2008109230A3 THERAPEUTIC COMPOSITION WITH ENHANCED ENDOTHELIUM TARGETING 审中-公开
标题翻译：具有增强内皮素靶向治疗组合物
公开(公告)号：WO2008109230A3
公开(公告)日：2008-10-23
申请号：PCT/US2008053707
申请日：2008-02-12
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , LUDWIG FLORIAN N , HOSSAINY SYED FAIYAZ AHMED , PACETTI STEPHEN D
发明人： LUDWIG FLORIAN N , HOSSAINY SYED FAIYAZ AHMED , PACETTI STEPHEN D
IPC分类号： A61K9/16 , A61K9/51 , A61K47/48
CPC分类号： A61K9/0087 , A61K47/6907 , A61K47/6911 , A61K47/6913 , A61K47/6915 , A61K47/6935 , B82Y5/00
摘要： A composition that includes nanoparticles with binding affinity for platelets, and methods for using this composition to treat vascular disease are disclosed.
摘要翻译：公开了包含对血小板具有结合亲和力的纳米颗粒的组合物，以及使用该组合物治疗血管疾病的方法。

7. 发明申请

WO2007143063A3 DRUG DELIVERY SPIRAL COIL CONSTRUCT 审中-公开
标题翻译：药物递送螺旋线圈结构
公开(公告)号：WO2007143063A3
公开(公告)日：2008-01-24
申请号：PCT/US2007012889
申请日：2007-05-31
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , KLEINE KLAUS , GALE DAVID C , EL-NOUNOU FOZAN , HOSSAINY SYED FAIYAZ AHMED , LUDWIG FLORIAN N
发明人： KLEINE KLAUS , GALE DAVID C , EL-NOUNOU FOZAN , HOSSAINY SYED FAIYAZ AHMED , LUDWIG FLORIAN N
IPC分类号： A61M31/00 , A61F2/00 , A61F2/06 , A61F2/88
CPC分类号： A61M31/002 , A61F2/88 , A61F2/885 , A61F2250/0039 , A61F2250/0067
摘要： An implantable medical device is disclosed having a helical construct including a set of spiral coils for local in vivo application of a therapeutic substance in a biological lumen. The helical construct is configured to apply less than 0.75 Bar of pressure to the biological lumen wall. The helical construct can have at least two sets of spiral coils having opposing helical directions. The device can be used for the treatment of vascular disorders such as restenosis and vulnerable plaque.
摘要翻译：公开了一种植入式医疗装置，其具有螺旋构造，其包括用于在生物腔内局部体内施用治疗物质的一组螺旋线圈。螺旋结构被配置为向生物腔壁施加小于0.75巴的压力。螺旋结构可以具有至少两组具有相反螺旋方向的螺旋线圈。该装置可用于治疗血管疾病如再狭窄和易损斑块。

8. 发明申请

WO2007133382A3 METHODS, COMPOSITIONS AND DEVICES FOR TREATING LESIONED SITES USING BIOABSORBABLE CARRIERS 审中-公开
标题翻译：方法，组合物和使用生物可降解载体处理裂解位点的装置
公开(公告)号：WO2007133382A3
公开(公告)日：2008-01-10
申请号：PCT/US2007009526
申请日：2007-04-18
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , KLEINER LOTHAR W , HOSSAINY SYED , ASTAFIEVA IRINA , PACETTI STEPHEN , GLAUSER THIERRY , DESNOYER JESSICA , LUDWIG FLORIAN N
发明人： KLEINER LOTHAR W , HOSSAINY SYED , ASTAFIEVA IRINA , PACETTI STEPHEN , GLAUSER THIERRY , DESNOYER JESSICA , LUDWIG FLORIAN N
IPC分类号： A61K9/00 , A61L31/16
CPC分类号： A61K9/0019 , A61K9/143 , A61K9/1611 , A61L31/148 , A61L31/16 , A61L2300/602
摘要： Methods and compositions for the sustained release of treatment agents to treat an occluded blood vessel and affected tissue and/or organs are disclosed. Porous or non-porous bioabsorbable glass, metal or ceramic bead, rod or fiber particles can be loaded with a treatment agent, and optionally an image-enhancing agent, and coated with a sustained-release coating for delivery to an occluded blood vessel and affected tissue and/or organs by a delivery device.
摘要翻译：公开了用于持续释放治疗剂以治疗闭塞的血管和受影响的组织和/或器官的方法和组合物。多孔或无孔生物可吸收玻璃，金属或陶瓷珠，棒或纤维颗粒可以加载处理剂和任选的图像增强剂，并涂覆有持续释放的涂层以递送至闭塞的血管并受影响组织和/或器官通过递送装置。

9. 发明申请

WO2007143116A3 IMPLANTABLE MEDICAL DEVICES FABRICATED FROM BRANCHED POLYMERS 审中-公开
标题翻译：从分支聚合物制成的可植入医疗器械
公开(公告)号：WO2007143116A3
公开(公告)日：2008-08-21
申请号：PCT/US2007012981
申请日：2007-06-01
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , WANG YUNBING , GALE DAVID C , HUANG BIN , TROLLSAS MIKAEL O , GLAUSER THIERRY , LUDWIG FLORIAN N
发明人： WANG YUNBING , GALE DAVID C , HUANG BIN , TROLLSAS MIKAEL O , GLAUSER THIERRY , LUDWIG FLORIAN N
IPC分类号： A61L27/18 , A61L31/06
CPC分类号： A61L27/14 , A61L27/18 , A61L31/06 , C08L67/04
摘要： Implantable medical devices fabricated from branched polymers are disclosed.
摘要翻译：公开了由支化聚合物制造的可植入医疗器械。

10. 发明申请

WO2008013743A3 METHODS FOR INHIBITING REPERFUSION INJURY 审中-公开
标题翻译：抑制再灌注损伤的方法
公开(公告)号：WO2008013743A3
公开(公告)日：2008-07-03
申请号：PCT/US2007016432
申请日：2007-07-19
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , MICHAL EUGENE T , CALLAS PETER L , LUDWIG FLORIAN N
发明人： MICHAL EUGENE T , CALLAS PETER L , LUDWIG FLORIAN N
IPC分类号： A61K31/4433 , A61K31/56 , A61M25/00 , A61P9/10
CPC分类号： A61M25/104 , A61M2025/1095
摘要： A method that includes introducing a catheter assembly to an obstructed region of a blood vessel lumen and recanalizing the obstructed region with the catheter assembly is disclosed. Prior to or during recanalization, a treatment agent may be delivered through the catheter assembly to a vessel region downstream to the obstructed region. The treatment agent may have a property that will inhibit reperfusion injury. Alternatively, a medical device may be introduced to an obstructed region of a blood vessel lumen and the obstructed region recanalized with the medical device. The treatment agent may be delivered to a vessel region downstream to the obstructed region. The treatment agent may include at least one of an immunosuppresant and an antioxidant. In other methods, a delivery cannula may be introduced to an unperfused region of an occluded vessel without disrupting the occlusion and the treatment agent having a property that will inhibit reperfusion injury may be delivered to the unperfused region through the delivery cannula. After delivering the treatment agent, the occluded vessel may be recanalized by advancing an angioplasty device into the occluded vessel.
摘要翻译：公开了一种方法，该方法包括将导管组件引入血管内腔的阻塞区域并用导管组件重新阻塞阻塞区域。在再通之前或再通过期间，可以通过导管组件将治疗剂递送至受阻区域下游的脉管区域。治疗剂可能具有抑制再灌注损伤的性质。或者，可以将医疗装置引入血管腔的阻塞区域，并且利用医疗装置对阻塞区域进行再通。处理剂可被输送至受阻区域下游的容器区域。治疗剂可以包括免疫抑制剂和抗氧化剂中的至少一种。在其他方法中，可将输送套管引入闭塞血管的未灌注区域而不破坏闭塞，并且具有抑制再灌注损伤性质的治疗剂可通过输送套管输送至未灌注区域。在递送治疗剂之后，可以通过将血管成形术装置推进到闭塞的血管中来使闭塞的血管再通。

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