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1. 发明申请

WO2007126606A3 CONTROLLED DEGRADATION AND DRUG RELEASE IN STENTS 审中-公开
标题翻译：控制降解和药物释放在STENTS
公开(公告)号：WO2007126606A3
公开(公告)日：2008-01-10
申请号：PCT/US2007006704
申请日：2007-03-16
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , LUDWIG FLORIAN N , ASTAFIEVA IRINA , GALE DAVID C , HOSSAINY SYED FAIYAZ AHMED
发明人： LUDWIG FLORIAN N , ASTAFIEVA IRINA , GALE DAVID C , HOSSAINY SYED FAIYAZ AHMED
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61F2/91 , A61F2210/0004 , A61F2250/003 , A61F2250/0068 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/604 , A61L2300/61 , B23K2203/42 , B23K2203/50
摘要： The invention provides for a stent for implanting in a bodily lumen comprising a degradable structural element including: an abluminal layer (510) comprising an active agent; and a luminal layer (520), wherein the abluminal layer has faster degradation rate than the luminal layer.
摘要翻译：本发明提供一种用于植入体内的支架，其包括可降解结构元件，所述支架包括：包含活性剂的中空层（510）和腔层（520），其中所述囊膜层比所述内腔层具有更快的降解速率。

2. 发明申请

WO2007145961A2 MICROPOROUS COATING ON MEDICAL DEVICES 审中-公开
标题翻译：医疗器械微波涂层
公开(公告)号：WO2007145961A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/013264
申请日：2007-06-05
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC. , KLEINER, Lothar, W. , HOSSAINY, Syed, Faiyaz, Ahmed , ASTAFIEVA, Irina , PACETTI, Stephen, D. , GLAUSER, Thierry , DESNOYER, Jessica, Renee
发明人： KLEINER, Lothar, W. , HOSSAINY, Syed, Faiyaz, Ahmed , ASTAFIEVA, Irina , PACETTI, Stephen, D. , GLAUSER, Thierry , DESNOYER, Jessica, Renee
IPC分类号： A61L27/30 , A61L27/54 , A61L31/08 , A61L31/16
CPC分类号： A61L27/30 , A61L27/54 , A61L27/56 , A61L31/082 , A61L31/088 , A61L31/146 , A61L31/16 , A61L2300/606 , A61L2300/608 , C23C4/18 , C23C26/00 , C23C28/00 , C23C28/322 , C23C28/3225 , C23C28/345 , C23C28/36
摘要： Microporous ceramic, metallic or glassy coating on a medical device comprising a bioactive agent for controlled release of the agent and methods of making and using the same are provided.
摘要翻译：提供了一种医疗装置上的微孔陶瓷，金属或玻璃状涂层，其包含用于药剂控制释放的生物活性剂及其制备和使用方法。

3. 发明申请

WO2007118051A2 LIPID THERAPY 审中-公开
标题翻译：脂肪疗法
公开(公告)号：WO2007118051A2
公开(公告)日：2007-10-18
申请号：PCT/US2007/065791
申请日：2007-04-02
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC. , KILPATRICK, Deborah , HOSSAINY, Syed Faiyaz Ahmed , ASTAFIEVA, Irina , LUDWIG, Florian, N. , CONSIGNY, Paul, M. , ELLIS, Jeffrey, T. , LIM, Florencia
发明人： KILPATRICK, Deborah , HOSSAINY, Syed Faiyaz Ahmed , ASTAFIEVA, Irina , LUDWIG, Florian, N. , CONSIGNY, Paul, M. , ELLIS, Jeffrey, T. , LIM, Florencia
IPC分类号： A61K38/00 , C07K14/55 , A61P9/10
CPC分类号： A61K38/1709 , A61K9/0019 , A61K9/1275 , A61K9/1617 , A61K9/1658 , A61M1/3472 , A61M1/3486 , A61M2202/0456 , A61K2300/00
摘要： A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo Al comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo Al and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCAl) transporter expression in macrophages and protect ABCAl from thiol-mediated degradation.
摘要翻译：一种方法，包括向血液中引入脱脂高密度脂蛋白（HDL）和生物活性剂。包含脱脂高密度脂蛋白（HDL）和适合于输送到血管中的辅助剂的组合物。包含Apo A1的组合物，其包含适于与细胞表面结合位点相互作用的疏水性配体。一种组合物，其包含Apo A1和选自用于增加巨噬细胞中ATP结合盒蛋白1（ABCA1）转运蛋白表达的一种试剂，并保护ABCA1免受硫醇介导的降解。

4. 发明申请

WO2013184020A1 A DETECTOR FOR RADIATION, PARTICULARLY HIGH ENERGY ELECTROMAGNETIC RADIATION 审中-公开
标题翻译：用于辐射，特别高能量电磁辐射的探测器
公开(公告)号：WO2013184020A1
公开(公告)日：2013-12-12
申请号：PCT/RU2012/000450
申请日：2012-06-08
申请人： SIEMENS AKTIENGESELLSCHAFT , ASTAFIEVA, Irina Mikhailovna , HEID, Oliver , HUGHES, Timothy
发明人： ASTAFIEVA, Irina Mikhailovna , HEID, Oliver , HUGHES, Timothy
IPC分类号： H01J47/02
CPC分类号： G01T1/185 , G01T1/2006 , H01J47/02 , H01J47/024
摘要： The invention refers to a detector for radiation, particularly high energy electromagnetic radiation. The detector comprises a converting section including a cathode (3) for converting the radiation (P) incident on the converting section in electrons (E) by the photoelectric effect. The detector further includes a gas electron multiplier (4) for generating an electron avalanche from electrons (E) which are generated by the converting section and enter the gas electron multiplier (4), the gas electron multiplier (4) comprising a first electrode (5), a dielectric layer (6) and a second electrode (7), the first electrode (6) being disposed at a first side of the dielectric layer (6) adjacent to the converting section and the second electrode (7) being disposed at a second side of the dielectric layer (6) opposite to the first side. The gas electron multiplier (4) comprises a number of holes (9) filled with gas, said holes (9) extending through the first electrode (5), the dielectric layer (6) and the second electrode (7). Moreover, the detector includes a detector anode (8) adjacent to the second electrode (7) for detecting the electron avalanche. The detector according to the invention is characterized in that the detector anode (8) extends at each hole (9) of the gas electron multiplier (4) from the second electrode (7) over the hole (9) such that the hole (9) is covered at one side completely by the detector anode (8).
摘要翻译：本发明涉及用于辐射的检测器，特别是高能量电磁辐射。检测器包括转换部分，其包括用于通过光电效应将入射在转换部分上的辐射（P）转换成电子（E）的阴极（3）。检测器还包括用于从电子（E）产生电子雪崩的气体电子倍增器（4），其由转换部分产生并进入气体电子倍增器（4），气体电子倍增器（4）包括第一电极（ 5），介电层（6）和第二电极（7），所述第一电极（6）设置在所述电介质层（6）的与所述转换部分相邻的第一侧并且所述第二电极（7）被布置在与第一侧相对的电介质层（6）的第二侧。气体电子倍增器（4）包括填充有气体的多个孔（9），所述孔（9）延伸穿过第一电极（5），电介质层（6）和第二电极（7）。此外，检测器包括与用于检测电子雪崩的第二电极（7）相邻的检测器阳极（8）。根据本发明的检测器的特征在于，检测器阳极（8）在气孔电子倍增器（4）的每个孔（9）处从第二电极（7）延伸穿过孔（9），使得孔（9））被检测器阳极（8）完全覆盖在一侧。

5. 发明申请

WO2013157975A1 RADIATION DETECTOR 审中-公开
标题翻译：辐射探测器
公开(公告)号：WO2013157975A1
公开(公告)日：2013-10-24
申请号：PCT/RU2012/000301
申请日：2012-04-18
申请人： SIEMENS AKTIENGESELLSCHAFT , ASTAFIEVA, Irina Mikhailovna , HEID, Oliver , HUGHES, Timothy
发明人： ASTAFIEVA, Irina Mikhailovna , HEID, Oliver , HUGHES, Timothy
IPC分类号： H01J47/02
CPC分类号： H01J47/02
摘要： A radiation detector (112) in which primary electrons (11) are released into a gas by ionizing radiation and drifted to a collection electrode by means of an electric field, the radiation detector (112) including a gas electron multiplier (101) comprising at least one field condensing area adapted to produce a local electric field amplitude enhancement proper to generate in the gas an electron avalanche from one of the primary electrons (11), the gas electron multiplier (101) operating thus as an amplifier of given gain for the primary electrons (11), the at least one field condensing area comprising a hole (105) arranged in an insulator (103) having a face with a metal cladding (104) facing a cathode (106) of the radiation detector (112), characterized in that the insulator (103) is directly arranged on at least one elementary anode (108) delimiting the hole (105) of the at least one field condensing area so that the at least one field condensing area is arranged as a blind hole (105) in the composite of the at least one elementary anode (108) and the insulator (103) having the metal cladding (104).
摘要翻译：一种辐射检测器（112），其中通过电离辐射将一次电子（11）释放到气体中并通过电场漂移到收集电极，所述辐射检测器（112）包括气体电子倍增器（101）至少一个场致冷区域适于产生适当的局部电场振幅增强，以在气体中产生来自主电子（11）之一的电子雪崩，气体电子倍增器（101）作为用于初级电子（11），所述至少一个场致冷区域包括布置在绝缘体（103）中的孔（105），所述绝缘体具有面与所述辐射探测器（112）的阴极（106）的金属包层（104）其特征在于，所述绝缘体（103）被直接布置在限定所述至少一个场致冷区域的所述孔（105）的至少一个基本阳极（108）上，使得所述至少一个场致冷区域被布置为盲孔 105）在至少一个基本阳极（108）和具有金属包层（104）的绝缘体（103）的复合材料中。

6. 发明申请

WO2009070209A3 SUSTAINED RELEASE OF APO A-I MIMETIC PEPTIDES AND METHODS OF PRODUCING THEM 审中-公开
标题翻译：可持续发布APO A-I型胶原蛋白及其生产方法
公开(公告)号：WO2009070209A3
公开(公告)日：2009-07-16
申请号：PCT/US2008012767
申请日：2008-11-14
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , MURASE KATSUYUKI , HOSSAINY SYED F A , ASTAFIEVA IRINA , ZHAO LI , MA HONG
发明人： MURASE KATSUYUKI , HOSSAINY SYED F A , ASTAFIEVA IRINA , ZHAO LI , MA HONG
IPC分类号： A61K9/14 , A61K9/16 , A61K38/17
CPC分类号： C07K7/08 , A61F2/95 , A61K9/1075 , A61K9/127 , A61K38/00 , A61L29/16 , A61L2300/25 , A61L2300/802 , A61M25/1011 , A61M2025/0086 , A61M2025/105 , A61M2025/1075 , C07K7/06 , C07K14/775
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.
摘要翻译：一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入所述特定区域或血管周围部位的血管壁中，其中所述肽具有使所述肽有效反转的性质胆固醇运输。包含载体载脂蛋白AI（apo AI）合成肽或apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸序列以与各种apo AI模拟肽或内源性载脂蛋白AI类似物的顺序相反的顺序，或内源性apo AI的螺旋1和螺旋9的嵌合体。

7. 发明申请

WO2008076847A2 REGIONAL DELIVERY OF THERAPEUTIC AGENTS FOR THE TREATMENT OF VASCULAR DISEASES 审中-公开
标题翻译：用于治疗血管疾病的治疗药物的区域性递送
公开(公告)号：WO2008076847A2
公开(公告)日：2008-06-26
申请号：PCT/US2007087487
申请日：2007-12-13
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , PACETTI STEPHEN D , CONSIGNY PAUL , HEIL RONALD W , LUDWIG FLORIAN N , DAVALIAN DARIUSH , ZHAO LI , ASTAFIEVA IRINA , WAN JINPING , EL-NOUNOU FOZAN , MURASE KATSUYUKI , HOSSAINY SYED FAIYAZ AHMED , BRIGHT RACHEL , ELLIS JEFFREY
发明人： PACETTI STEPHEN D , CONSIGNY PAUL , HEIL RONALD W , LUDWIG FLORIAN N , DAVALIAN DARIUSH , ZHAO LI , ASTAFIEVA IRINA , WAN JINPING , EL-NOUNOU FOZAN , MURASE KATSUYUKI , HOSSAINY SYED FAIYAZ AHMED , BRIGHT RACHEL , ELLIS JEFFREY
CPC分类号： A61M25/1002 , A61F2/82 , A61F2250/0067 , A61K31/27 , A61K31/44 , A61K31/56 , A61K31/66 , A61K38/1709 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/112 , A61L2300/216 , A61L2300/252 , A61L2300/40 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61L2300/62 , A61M25/10 , A61M37/0015 , A61M2025/105 , A61M2025/1086 , A61M2037/0023 , A61M2037/0061 , A61M2210/12
摘要： The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.
摘要翻译：本发明涉及用于治疗血管疾病的治疗剂的区域递送，其中区域递送是指将治疗有效量的治疗剂递送至血管的区域，该区域不仅包括受到损伤的组织而且包括非折磨组织受影响组织的外围也是如此。

8. 发明申请

WO2009025926A3 NANOPARTICLE-COATED MEDICAL DEVICES AND FORMULATIONS FOR TREATING VASCULAR DISEASE 审中-公开
标题翻译：用于治疗血管疾病的纳米涂层医疗装置和制剂
公开(公告)号：WO2009025926A3
公开(公告)日：2010-06-03
申请号：PCT/US2008067015
申请日：2008-06-13
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , LUDWIG FLORIAN N , HOSSAINY SYED F A , MURASE KATSUYUKI , ZHAO LI , ASTAFIEVA IRINA
发明人： LUDWIG FLORIAN N , HOSSAINY SYED F A , MURASE KATSUYUKI , ZHAO LI , ASTAFIEVA IRINA
IPC分类号： A61L27/34 , A61L27/54 , A61L31/08 , A61L31/16 , A61L31/18
CPC分类号： A61L31/10 , A61K9/1075 , A61K9/127 , A61K9/51 , A61L31/16 , A61L2300/624 , A61L2300/626 , A61L2400/12
摘要： Nanoparticle-coated medical devices, nanoparticle-containing formulations and methods of using for treating a vascular disease are disclosed.
摘要翻译：公开了纳米颗粒涂覆的医疗装置，含纳米颗粒的制剂和用于治疗血管疾病的方法。

9. 发明申请

WO2007145961A3 MICROPOROUS COATING ON MEDICAL DEVICES 审中-公开
标题翻译：医疗器械微波涂层
公开(公告)号：WO2007145961A3
公开(公告)日：2008-07-31
申请号：PCT/US2007013264
申请日：2007-06-05
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , KLEINER LOTHAR W , HOSSAINY SYED FAIYAZ AHMED , ASTAFIEVA IRINA , PACETTI STEPHEN D , GLAUSER THIERRY , DESNOYER JESSICA RENEE
发明人： KLEINER LOTHAR W , HOSSAINY SYED FAIYAZ AHMED , ASTAFIEVA IRINA , PACETTI STEPHEN D , GLAUSER THIERRY , DESNOYER JESSICA RENEE
IPC分类号： A61L31/14 , A61L27/56
CPC分类号： A61L27/30 , A61L27/54 , A61L27/56 , A61L31/082 , A61L31/088 , A61L31/146 , A61L31/16 , A61L2300/606 , A61L2300/608 , C23C4/18 , C23C26/00 , C23C28/00 , C23C28/322 , C23C28/3225 , C23C28/345 , C23C28/36
摘要： Microporous ceramic, metallic or glassy coating on a medical device comprising a bioactive agent for controlled release of the agent and methods of making and using the same are provided.
摘要翻译：提供了一种医疗装置上的微孔陶瓷，金属或玻璃状涂层，其包含用于药剂控制释放的生物活性剂及其制备和使用方法。

10. 发明申请

WO2007146001A2 COATINGS FOR IMPLANTABLE MEDICAL DEVICES FOR CONTROLLED RELEASE OF A HYDROPHILIC DRUG AND A HYDROPHOBIC DRUG 审中-公开
标题翻译：用于控制释放氢化IC IC G G G G G G G G G G G G G G G G G G G
公开(公告)号：WO2007146001A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/013327
申请日：2007-06-05
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC. , GLAUSER, Thierry , ASTAFIEVA, Irina , HOSSAINY, Syed Faiyaz Ahmed
发明人： GLAUSER, Thierry , ASTAFIEVA, Irina , HOSSAINY, Syed Faiyaz Ahmed
IPC分类号： A61L31/16
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/25 , A61L2300/416 , A61L2300/45 , A61L2300/602 , C08L75/04 , C08L33/14
摘要： Provided herein is a coating that includes cRGD for endothelial cells and methods of making and using the same.
摘要翻译：本文提供了包含内皮细胞的cRGD及其制备和使用方法的涂层。

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