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1. 发明公开

KR1020010036444A 저밀도 지질 단백질에 대해 항산화 활성을 갖는 신규 리그난계 화합물 失效
标题翻译：具有低密度脂蛋白的抗氧化活性的LIGNAN化合物SAURURIN
公开(公告)号：KR1020010036444A
公开(公告)日：2001-05-07
申请号：KR1019990043467
申请日：1999-10-08
申请人： 한국생명공학연구원
发明人： 복성해 , 정태숙 , 안병태 , 이새봄 , 이은숙
IPC分类号： C07D317/48
摘要： PURPOSE: A lignan compound saururin A having antioxidant activity for lipoproteins having low density is provided, thereby the lignan compound can be used for the prevention and treatment of circulatory diseases including arteriosclerosis. CONSTITUTION: The lignan compound saururin A having antioxidant activity for lipoproteins having low density is represented by formula (1). The lignan compound saururin A is produced by the following steps of: extracting the powder of Saururus chinensis Baill roots with methanol; extracting the first extract with water, n-hexane and chloroform; separating the second extract by developing it on silica gel column chromatography using n-hexane and ethyl acetate mixed solvent as developing solvents; separating the eluate by developing it on reverse phase silica gel column chromatography using methanol as a developing solvent; and separating the eluate by developing it on silica gel column chromatography using chloroform and methanol mixed solvent as developing solvents.
摘要翻译：目的：提供一种具有低密度脂蛋白抗氧化活性的木脂素复合番茄红素A.因此，木脂素化合物可用于预防和治疗包括动脉硬化的循环系统疾病。构成：具有低密度脂蛋白的具有抗氧化活性的木酚素化合物类调节剂A由式（1）表示。木质素复合番茄红素A通过以下步骤制备：用甲醇提取中华白菜的粉末; 用水，正己烷和氯仿萃取第一次提取液; 使用正己烷和乙酸乙酯混合溶剂作为显影溶剂，通过硅胶柱色谱法分离第二提取物; 通过使用甲醇作为显影溶剂的反相硅胶柱色谱法分离洗脱液; 并通过硅胶柱色谱法分离洗脱液，使用氯仿和甲醇混合溶剂作为显影溶剂。

2. 发明授权

KR100254908B1 비타민 씨와 귤피 추출 농축액을 활성성분으로서 포함하는 3-하이드록시-3-메틸글루타릴 코에이 환원효소 활성 저해제 조성물 失效
标题翻译：含有VITAMIN C和CITRUS PEEL萃取物的3-羟基-3-甲基胆碱COA还原酶抑制组合物
公开(公告)号：KR100254908B1
公开(公告)日：2000-05-01
申请号：KR1019970055581
申请日：1997-10-28
申请人： 한국생명공학연구원
发明人： 복성해 , 정태숙 , 권병목 , 김영국 , 김성욱 , 배기환 , 박용복 , 황인규 , 문석식 , 권용국 , 안정아 , 손광희 , 최도일 , 최명숙 , 이은숙
IPC分类号： A61K31/375 , A61K36/752
摘要： PURPOSE: An HMG-CoA reductase inhibiting composition containing vitamin C and orange peel extract is provided, which is useful in the prevention and treatment of hyperlipidemia by decreasing blood cholesterol level. CONSTITUTION: The HMG-CoA reductase inhibiting composition is manufactured by following processes of; washing peel of tangerine of which origin is Korea, drying at normal temperature to get Aurantii Nobilis Pericarpium; adding 95% ethanol, keeping for 24hours at normal temperature, and filtering to get extracted solution and solid residue; extracting the solid residue two more times by the same process, gathering all the extracted solution together, and concentrating under decompression by a rotary vacuum evaporator to get a concentrated extract. The composition can be manufactured as pharmaceutical products and health care foods such as a beverage, a snack, a noodle, a vitamin complex, a candy, etc.
摘要翻译：目的：提供含有维生素C和橙皮提取物的HMG-CoA还原酶抑制组合物，其可用于通过降低血液胆固醇水平来预防和治疗高脂血症。构成：HMG-CoA还原酶抑制组合物通过以下方法制备：洗涤韩国橘子的橘皮，在常温下干燥得到Aurantii Nobilis Pericarpium; 加入95％乙醇，在常温下保持24小时，过滤得到提取液和固体残渣; 通过相同的过程再次提取固体残渣两次，将所有提取的溶液聚集在一起，并通过旋转式真空蒸发器减压浓缩，得到浓缩提取物。该组合物可以制造成药品和保健食品如饮料，小吃，面条，维生素复合物，糖果等。

3. 发明公开

KR1020000023557A 헤스페리딘 또는 헤스페레틴을 포함하는 아실 코에이:콜레스테롤-오-아실트랜스퍼레이즈 저해제 조성물 无效
标题翻译：用于含有赫赛霉素或雌二醇的胆固醇-O-酰基转移酶抑制剂组合物的组合物
公开(公告)号：KR1020000023557A
公开(公告)日：2000-04-25
申请号：KR1019990051434
申请日：1999-11-19
申请人： 한국생명공학연구원
发明人： 복성해 , 손광희 , 정태숙 , 권병목 , 김영국 , 최도일 , 김성욱 , 배기환 , 박용복 , 최명숙 , 황인규 , 문석식 , 권용국 , 안정아 , 이은숙
IPC分类号： A23L1/29
摘要： PURPOSE: A composition for cholesterol-O-acyltransferase(referred as "ACAT") inhibitor is provided, which reduces the amount of low density lipoprotein(LDL) cholesterol in blood and can be used for treatment and prevention of various cardiovascular diseases in the form of drug, food and drink. CONSTITUTION: A composition for inhibiting the activity of ACAT comprises hesperidin or hesperetin in effective amount. Hesperidin and hesperetin can be extracted from citrus fruit such as tangerine, orange, lemon, grape fruit, citron and hardy orange, or be synthesized by known method.
摘要翻译：目的：提供一种胆固醇-O-酰基转移酶（简称“ACAT”）抑制剂，可减少血液中低密度脂蛋白（LDL）胆固醇的含量，可用于治疗和预防各种心血管疾病的形式的药物，食物和饮料。构成：用于抑制ACAT活性的组合物包括有效量的橙皮苷或橙皮素。橙皮苷和橙皮素可以从桔子，橙子，柠檬，葡萄果实，柚子和强壮橙等柑橘类水果中提取，或者通过已知方法合成。

4. 发明公开

KR1019990039366A 대추추출물을포함하는콜레스테롤강하및콜레스테롤에스테르전이단백질저해용조성물 失效
标题翻译：用于抑制胆固醇降低的组合物和胆甾醇酯转移蛋白，包括枣提取物
公开(公告)号：KR1019990039366A
公开(公告)日：1999-06-05
申请号：KR1019970059425
申请日：1997-11-12
申请人： 한국생명공학연구원
发明人： 손광희 , 배기환 , 최명숙 , 권용국 , 이은숙 , 복성해 , 정태숙 , 박용복 , 안정아
IPC分类号： A61K36/725 , A61P3/06
摘要： 본 발명은 대추 추출물을 포함하는 콜레스테롤 에스테르 전이 단백질(cholesterol ester transfer protein, CETP) 활성 저해제 조성물에 관한 것으로, 본 발명의 조성물은 의약용 및 식품용 조성물을 포함한다. 본 발명의 조성물은 동물체내의 CETP 활성을 저해하여 혈중 콜레스테롤을 감소시키므로 각종 심혈관계 질환의 예방 및 치료제로서 또는 건강 식품의 성분으로서 유용하게 사용될 수 있다.

5. 发明授权

KR100368072B1 저밀도 지질 단백질에 대해 항산화 활성을 갖는 신규 리그난계 화합물 失效
标题翻译： 저밀도지질단백질에대해항산화활성을갖는신규리그난계화저밀
公开(公告)号：KR100368072B1
公开(公告)日：2003-01-24
申请号：KR1019990043467
申请日：1999-10-08
申请人： 한국생명공학연구원
发明人： 복성해 , 정태숙 , 안병태 , 이새봄 , 이은숙
IPC分类号： C07D317/48
摘要： PURPOSE: A lignan compound saururin A having antioxidant activity for lipoproteins having low density is provided, thereby the lignan compound can be used for the prevention and treatment of circulatory diseases including arteriosclerosis. CONSTITUTION: The lignan compound saururin A having antioxidant activity for lipoproteins having low density is represented by formula (1). The lignan compound saururin A is produced by the following steps of: extracting the powder of Saururus chinensis Baill roots with methanol; extracting the first extract with water, n-hexane and chloroform; separating the second extract by developing it on silica gel column chromatography using n-hexane and ethyl acetate mixed solvent as developing solvents; separating the eluate by developing it on reverse phase silica gel column chromatography using methanol as a developing solvent; and separating the eluate by developing it on silica gel column chromatography using chloroform and methanol mixed solvent as developing solvents.
摘要翻译：目的：提供一种具有低密度脂蛋白抗氧化活性的木酚素类化合物sa漆素A，因此可用于预防和治疗包括动脉硬化在内的循环系统疾病。构成：具有低密度脂蛋白抗氧化活性的木酚素类化合物sa漆素A由式（1）表示。通过以下步骤制备木酚素类化合物saururin A：用甲醇提取Saururus chinensis Baill根的粉末; 用水，正己烷和氯仿提取第一提取物; 通过使用正己烷和乙酸乙酯混合溶剂作为展开剂在硅胶柱色谱上展开来分离第二提取物; 通过在使用甲醇作为展开溶剂的反相硅胶柱色谱上展开来分离洗脱液; 并通过在硅胶柱色谱上展开使用氯仿和甲醇混合溶剂作为展开溶剂分离洗脱液。

6. 发明授权

KR100258582B1 대추 추출물을 포함하는 혈압 강하용 조성물 失效
标题翻译：用于减少包含JUJUBE提取物的血压的组合物
公开(公告)号：KR100258582B1
公开(公告)日：2000-05-15
申请号：KR1019990041276
申请日：1999-09-27
申请人： 한국생명공학연구원
发明人： 복성해 , 손광희 , 정태숙 , 배기환 , 박용복 , 최명숙 , 권용국 , 안정아 , 이은숙
IPC分类号： A23L1/29
摘要： PURPOSE: Composites containing jujube extract is provided to treat high blood pressure and to use for a health food by dropping blood pressure. CONSTITUTION: Jujubes are swollen in water, and acetone 1-1.5L and jujube 1kg are stirred at room temperature for 12-18 hours. The stirred liquid is filtered to get filtrate by using a filter. The filtrate is compressed and concentrated. Hexane 1-1.5L is added to the concentrate to separate into a water layer and a hexane layer. Ethyl acetate is added to the water layer containing active substances for separating into a water layer and an ethyl acetate layer. The collected ethyl acetate layer is concentrated and dried under a compressing condition.
摘要翻译：目的：提供含有枣提取物的复合材料，用于治疗高血压，并通过降低血压用于保健食品。构成：枣在水中溶胀，丙酮1-1.5L和枣1kg在室温下搅拌12-18小时。将搅拌的液体过滤以通过使用过滤器得到滤液。将滤液压缩并浓缩。将己烷1-1.5L加入浓缩物中以分离成水层和己烷层。将乙酸乙酯加入到含有活性物质的水层中以分离成水层和乙酸乙酯层。将收集的乙酸乙酯层浓缩并在压缩条件下干燥。

7. 发明授权

KR100258581B1 비타민 씨와 귤피 추출 농축액을 활성성분으로서 포함하는 3-하이드록시-3-메틸글루타릴 코에이 환원효소 활성 저해제 조성물 失效
标题翻译：含有维生素C和CITRUS PEELEXTRACT的3-羟基-3-甲基胆酸COA还原酶抑制酶
公开(公告)号：KR100258581B1
公开(公告)日：2000-05-15
申请号：KR1019990045735
申请日：1999-10-21
申请人： 한국생명공학연구원
发明人： 복성해 , 손광희 , 정태숙 , 권병목 , 김영국 , 최도일 , 김성욱 , 배기환 , 박용복 , 최명숙 , 황인규 , 문석식 , 권용국 , 안정아 , 이은숙
IPC分类号： A23L1/29
摘要： PURPOSE: Composites for inhibiting 3-Hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase activity are provided to drop blood cholesterol for the prevention and the treatment of high cholesterol by containing vitamin C and orange peel extract, vitamin C, hesperidin and naringin. CONSTITUTION: Orange peels are washed with water and dried at room temperature in the shade. Water or 95% ethanol is added to the dried orange peels to extract active substances at 5-140deg.C. The extract is injected to a blood cholesterol patient as much as 1-5g/1kg/day. The extract is added to foods or beverages for to impeding 3-Hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase activity, and drops blood cholesterol. The composites of the extract are varied by reaction time, reaction temperature, alcohol concentration, orange type and ripe rate.
摘要翻译：目的：提供用于抑制3-羟基-3-甲基戊二酰CoA（HMG-CoA）还原酶活性的复合材料，用于降低血液胆固醇，以预防和治疗高胆固醇，包含维生素C和橙皮提取物，维生素C，橙皮苷和柚皮苷。构成：橙皮用水洗涤，室内在阴凉处干燥。将水或95％乙醇加入到干燥的橙皮中以在5-140℃下提取活性物质。将提取物注射至血胆固醇患者多达1-5g / 1kg /天。将提取物加入到食品或饮料中以阻止3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶活性，并降低血液胆固醇。提取物的复合物根据反应时间，反应温度，酒精浓度，橙色类型和成熟率而变化。

8. 发明授权

KR100254528B1 대추추출물을포함하는콜레스테롤강하및콜레스테롤에스테르전이단백질저해용조성물 失效
标题翻译：用于减少胆固醇的组合物和抑制含有JUJUBE提取物的胆固醇转运蛋白
公开(公告)号：KR100254528B1
公开(公告)日：2000-05-01
申请号：KR1019970059425
申请日：1997-11-12
申请人： 한국생명공학연구원
发明人： 손광희 , 배기환 , 최명숙 , 권용국 , 이은숙 , 복성해 , 정태숙 , 박용복 , 안정아
IPC分类号： A61K36/725 , A61P3/06
摘要： PURPOSE: A composition containing Zizyphi fructus extract for drop of cholesterol and inhibition of cholesterol ester transfer protein(CETP) is provided, which decreases cholesterol in blood by inhibiting CETP activity in animal body, thereby being used as a medicine for prevention and treatment of various disease of circulatory organ or as an ingredient for health food. CONSTITUTION: A process for the preparation of composition containing Zizyphi fructus extract for drop of cholesterol and inhibition of cholesterol ester transfer protein(CETP) comprises the steps of: keeping Zizyphi Fructus soaked in water, and shaking for 4-24hrs after adding acetone; extracting Zizyphi Fructus with acetone, and filtering; concentrating the filtrate under decompression, adding hexane, and separating into water layer and hexane layer; adding ethyl acetate to water layer containing active ingredient, and separating into water layer and ethyl acetate layer; gathering ethyl acetate layer, concentrating under decompression and drying; refining the concentrate through reverse phase chromatography to get CETP activity inhibiting material.
摘要翻译：目的：提供含有降胆固醇和抑制胆固醇酯转运蛋白（CETP）的枸杞提取物的组合物，其通过抑制动物体内的CETP活性而降低血液中的胆固醇，从而用作预防和治疗各种各样的药物循环器官疾病或保健食品的成分。构成：含有Zizyphi fructus提取物的组合物用于降低胆固醇和抑制胆固醇酯转移蛋白（CETP）的方法包括以下步骤：将Zizyphi Fructus浸泡在水中，并在加入丙酮后摇动4-24小时; 用丙酮提取枣子，过滤; 减压浓缩滤液，加入己烷，分离成水层和己烷层; 向含有活性成分的水层中加入乙酸乙酯，分离成水层和乙酸乙酯层; 收集乙酸乙酯层，减压干燥浓缩; 通过反相色谱法精制浓缩物得到CETP活性抑制物质。

9. 发明授权

KR100352269B1 저밀도 지질 단백질에 대해 항산화 활성을 갖는 리그난계 화합물 有权
标题翻译：对低密度脂蛋白具有抗氧化活性的木质素型化合物
公开(公告)号：KR100352269B1
公开(公告)日：2002-09-12
申请号：KR1019990043468
申请日：1999-10-08
申请人： 한국생명공학연구원
发明人： 복성해 , 정태숙 , 안병태 , 이새봄 , 이은숙
IPC分类号： A61K31/065
摘要： 본발명은저밀도지질단백질에대해항산화활성을갖는리그난계화합물, 그의제조방법및 그를함유하는약학적조성물에관한것으로서, 구체적으로하기화학식 1로표시되는리그난계화합물, 삼백초로부터이 화합물을분리하여얻는방법및 이화합물을유효성분으로함유하는저밀도지질단백질에대한항산화제및 저밀도지질단백질의산화와관련된동맥경화를포함하는순환계질환의예방제및 치료제용약학적조성물에관한것이다. 상기식에서 R은 H , 알킬기또는벤질기를나타낸다.

10. 发明公开

KR1020010036445A 저밀도 지질 단백질에 대해 항산화 활성을 갖는 리그난계 화합물 有权
标题翻译：对低密度脂蛋白具有抗氧化活性的LIGNAN化合物
公开(公告)号：KR1020010036445A
公开(公告)日：2001-05-07
申请号：KR1019990043468
申请日：1999-10-08
申请人： 한국생명공학연구원
发明人： 복성해 , 정태숙 , 안병태 , 이새봄 , 이은숙
IPC分类号： A61K31/065
摘要： PURPOSE: A lignan compound having antioxidant activity to low density lipoprotein and a process for separating the compound from Saururus chinensis Baill are provided, which can be effectively used for the prevention and treatment of a circulatory disease such as arteriosclerosis by oxidation of low deinsity lipoprotein. CONSTITUTION: The pharmaceutical composition contains one or more compounds of a lignan compound of formula 1 having antioxidant activity to low density lipoprotein as an effective component, wherein the lignan compound is machilin D of formula 2 in which R is H. The machilin D is separated from Saururus chinensis Baill. In formula, R is H, alkyl or benzyl.
摘要翻译：目的：提供一种对低密度脂蛋白具有抗氧化活性的木脂素化合物，以及从中华白ensis中分离出化合物的方法，可有效地用于预防和治疗动物硬化的动物硬化，通过氧化低脱氧脂蛋白。组成：药物组合物含有一种或多种具有对低密度脂蛋白具有抗氧化活性的式1的木脂素化合物作为有效成分的化合物，其中木脂素化合物是其中R为H的式2的机械加工剂D.机械加工剂D分离来自Saururus chinensis Baill。在式中，R是H，烷基或苄基。

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