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1. 发明授权

KR100368072B1 저밀도 지질 단백질에 대해 항산화 활성을 갖는 신규 리그난계 화합물 失效
标题翻译： 저밀도지질단백질에대해항산화활성을갖는신규리그난계화저밀
公开(公告)号：KR100368072B1
公开(公告)日：2003-01-24
申请号：KR1019990043467
申请日：1999-10-08
申请人： 한국생명공학연구원
发明人： 복성해 , 정태숙 , 안병태 , 이새봄 , 이은숙
IPC分类号： C07D317/48
摘要： PURPOSE: A lignan compound saururin A having antioxidant activity for lipoproteins having low density is provided, thereby the lignan compound can be used for the prevention and treatment of circulatory diseases including arteriosclerosis. CONSTITUTION: The lignan compound saururin A having antioxidant activity for lipoproteins having low density is represented by formula (1). The lignan compound saururin A is produced by the following steps of: extracting the powder of Saururus chinensis Baill roots with methanol; extracting the first extract with water, n-hexane and chloroform; separating the second extract by developing it on silica gel column chromatography using n-hexane and ethyl acetate mixed solvent as developing solvents; separating the eluate by developing it on reverse phase silica gel column chromatography using methanol as a developing solvent; and separating the eluate by developing it on silica gel column chromatography using chloroform and methanol mixed solvent as developing solvents.
摘要翻译：目的：提供一种具有低密度脂蛋白抗氧化活性的木酚素类化合物sa漆素A，因此可用于预防和治疗包括动脉硬化在内的循环系统疾病。构成：具有低密度脂蛋白抗氧化活性的木酚素类化合物sa漆素A由式（1）表示。通过以下步骤制备木酚素类化合物saururin A：用甲醇提取Saururus chinensis Baill根的粉末; 用水，正己烷和氯仿提取第一提取物; 通过使用正己烷和乙酸乙酯混合溶剂作为展开剂在硅胶柱色谱上展开来分离第二提取物; 通过在使用甲醇作为展开溶剂的反相硅胶柱色谱上展开来分离洗脱液; 并通过在硅胶柱色谱上展开使用氯仿和甲醇混合溶剂作为展开溶剂分离洗脱液。

2. 发明授权

KR100352269B1 저밀도 지질 단백질에 대해 항산화 활성을 갖는 리그난계 화합물 有权
标题翻译：对低密度脂蛋白具有抗氧化活性的木质素型化合物
公开(公告)号：KR100352269B1
公开(公告)日：2002-09-12
申请号：KR1019990043468
申请日：1999-10-08
申请人： 한국생명공학연구원
发明人： 복성해 , 정태숙 , 안병태 , 이새봄 , 이은숙
IPC分类号： A61K31/065
摘要： 본발명은저밀도지질단백질에대해항산화활성을갖는리그난계화합물, 그의제조방법및 그를함유하는약학적조성물에관한것으로서, 구체적으로하기화학식 1로표시되는리그난계화합물, 삼백초로부터이 화합물을분리하여얻는방법및 이화합물을유효성분으로함유하는저밀도지질단백질에대한항산화제및 저밀도지질단백질의산화와관련된동맥경화를포함하는순환계질환의예방제및 치료제용약학적조성물에관한것이다. 상기식에서 R은 H , 알킬기또는벤질기를나타낸다.

3. 发明公开

KR1020010036445A 저밀도 지질 단백질에 대해 항산화 활성을 갖는 리그난계 화합물 有权
标题翻译：对低密度脂蛋白具有抗氧化活性的LIGNAN化合物
公开(公告)号：KR1020010036445A
公开(公告)日：2001-05-07
申请号：KR1019990043468
申请日：1999-10-08
申请人： 한국생명공학연구원
发明人： 복성해 , 정태숙 , 안병태 , 이새봄 , 이은숙
IPC分类号： A61K31/065
摘要： PURPOSE: A lignan compound having antioxidant activity to low density lipoprotein and a process for separating the compound from Saururus chinensis Baill are provided, which can be effectively used for the prevention and treatment of a circulatory disease such as arteriosclerosis by oxidation of low deinsity lipoprotein. CONSTITUTION: The pharmaceutical composition contains one or more compounds of a lignan compound of formula 1 having antioxidant activity to low density lipoprotein as an effective component, wherein the lignan compound is machilin D of formula 2 in which R is H. The machilin D is separated from Saururus chinensis Baill. In formula, R is H, alkyl or benzyl.
摘要翻译：目的：提供一种对低密度脂蛋白具有抗氧化活性的木脂素化合物，以及从中华白ensis中分离出化合物的方法，可有效地用于预防和治疗动物硬化的动物硬化，通过氧化低脱氧脂蛋白。组成：药物组合物含有一种或多种具有对低密度脂蛋白具有抗氧化活性的式1的木脂素化合物作为有效成分的化合物，其中木脂素化合物是其中R为H的式2的机械加工剂D.机械加工剂D分离来自Saururus chinensis Baill。在式中，R是H，烷基或苄基。

4. 发明授权

KR100365388B1 신남산 유도체를 포함하는 고농도 혈중 지질-관련 질환의 예방 및 치료용 조성물 失效
标题翻译： 신남산유도체를포함하는고농도혈중지질 - 관련질환의예방및치료용조성물
公开(公告)号：KR100365388B1
公开(公告)日：2003-01-15
申请号：KR1019990039480
申请日：1999-09-15
申请人： 한국생명공학연구원
发明人： 복성해 , 정태숙 , 배기환 , 박용복 , 최명숙 , 문석식 , 권용국 , 이은숙 , 현병화 , 최양규 , 이철호 , 이새봄 , 박영배 , 김효수
IPC分类号： A61K31/185
摘要： PURPOSE: Cinnamic acid derivatives inhibit deposition of atherosclerosis disk by accumulation of macrophage-lipid complexes on artery epithelial cells, decrease the concentration of cholesterol and neutral lipid in blood and GOT and GPT serum, inhibit fatty liver and protect liver function. CONSTITUTION: Provided is a pharmaceutical composition or food and beverage composition which contains cinnamic acid derivatives or salts thereof with carriers. Cinnamic acid represented by formula 1a and 1b, wherein R1, R2, R3, R4 and R5 are independently hydrogen, hydroxy, or C1-C4alkoxy group; R6 is C5-C7cycloalkyl group having substituted groups selected from hydrogen, C1-C4alkyl, hydroxy, alkoxy or carboxyl group; are extracted from apple, tea, potato, coffee, strawberry, blueberry, cherry, plum, grape or a kind of nut, or chemically synthesized. Cinnamic acid derivatives formulated as medicine and food additives which are useful for prevention and treatment of diseases such as artherosclerosis, hyperlipidemia, angina and apoplexy.
摘要翻译：目的：肉桂酸衍生物通过在动脉上皮细胞上积累巨噬细胞 - 脂质复合物来抑制动脉粥样硬化盘的沉积，降低血液中胆固醇和中性脂质以及GOT和GPT血清的浓度，抑制脂肪肝和保护肝功能。组成：提供了含有肉桂酸衍生物或其盐与载体的药物组合物或食物和饮料组合物。由式1a和1b表示的肉桂酸，其中R1，R2，R3，R4和R5独立地为氢，羟基或C1-C4烷氧基; R6是具有选自氢，C1-C4烷基，羟基，烷氧基或羧基的取代基的C5-C7环烷基; 从苹果，茶叶，马铃薯，咖啡，草莓，蓝莓，樱桃，李子，葡萄或一种坚果中提取，或化学合成。肉桂酸衍生物配制成药物和食品添加剂，用于预防和治疗动脉粥样硬化，高脂血症，心绞痛和中风等疾病。

5. 发明公开

KR1020000023161A 신남산 유도체를 포함하는 고농도 혈중 지질-관련 질환의 예방 및 치료용 조성물 失效
标题翻译：用于预防和治疗含有血清酸性衍生物的血液中脂质相关疾病高度浓度的组合物
公开(公告)号：KR1020000023161A
公开(公告)日：2000-04-25
申请号：KR1019990039480
申请日：1999-09-15
申请人： 한국생명공학연구원
发明人： 복성해 , 정태숙 , 배기환 , 박용복 , 최명숙 , 문석식 , 권용국 , 이은숙 , 현병화 , 최양규 , 이철호 , 이새봄 , 박영배 , 김효수
IPC分类号： A61K31/185
摘要： PURPOSE: Cinnamic acid derivatives inhibit deposition of atherosclerosis disk by accumulation of macrophage-lipid complexes on artery epithelial cells, decrease the concentration of cholesterol and neutral lipid in blood and GOT and GPT serum, inhibit fatty liver and protect liver function. CONSTITUTION: Provided is a pharmaceutical composition or food and beverage composition which contains cinnamic acid derivatives or salts thereof with carriers. Cinnamic acid represented by formula 1a and 1b, wherein R1, R2, R3, R4 and R5 are independently hydrogen, hydroxy, or C1-C4alkoxy group; R6 is C5-C7cycloalkyl group having substituted groups selected from hydrogen, C1-C4alkyl, hydroxy, alkoxy or carboxyl group; are extracted from apple, tea, potato, coffee, strawberry, blueberry, cherry, plum, grape or a kind of nut, or chemically synthesized. Cinnamic acid derivatives formulated as medicine and food additives which are useful for prevention and treatment of diseases such as artherosclerosis, hyperlipidemia, angina and apoplexy.
摘要翻译：目的：肉桂酸衍生物通过在动脉上皮细胞上积累巨噬细胞 - 脂质复合物抑制动脉粥样硬化盘的沉积，降低血液和GOT和GPT血清中胆固醇和中性脂质的浓度，抑制脂肪肝并保护肝功能。构成：提供含有肉桂酸衍生物或其盐与载体的药物组合物或食品和饮料组合物。由式1a和1b表示的肉桂酸，其中R 1，R 2，R 3，R 4和R 5独立地是氢，羟基或C 1 -C 4烷氧基; R6是具有选自氢，C1-C4烷基，羟基，烷氧基或羧基的取代基的C5-C7环烷基; 从苹果，茶，马铃薯，咖啡，草莓，蓝莓，樱桃，李子，葡萄或一种坚果中提取，或化学合成。配制成药物和食品添加剂的肉桂酸衍生物可用于预防和治疗动脉粥样硬化，高脂血症，心绞痛和中风等疾病。

6. 发明公开

KR1020010036444A 저밀도 지질 단백질에 대해 항산화 활성을 갖는 신규 리그난계 화합물 失效
标题翻译：具有低密度脂蛋白的抗氧化活性的LIGNAN化合物SAURURIN
公开(公告)号：KR1020010036444A
公开(公告)日：2001-05-07
申请号：KR1019990043467
申请日：1999-10-08
申请人： 한국생명공학연구원
发明人： 복성해 , 정태숙 , 안병태 , 이새봄 , 이은숙
IPC分类号： C07D317/48
摘要： PURPOSE: A lignan compound saururin A having antioxidant activity for lipoproteins having low density is provided, thereby the lignan compound can be used for the prevention and treatment of circulatory diseases including arteriosclerosis. CONSTITUTION: The lignan compound saururin A having antioxidant activity for lipoproteins having low density is represented by formula (1). The lignan compound saururin A is produced by the following steps of: extracting the powder of Saururus chinensis Baill roots with methanol; extracting the first extract with water, n-hexane and chloroform; separating the second extract by developing it on silica gel column chromatography using n-hexane and ethyl acetate mixed solvent as developing solvents; separating the eluate by developing it on reverse phase silica gel column chromatography using methanol as a developing solvent; and separating the eluate by developing it on silica gel column chromatography using chloroform and methanol mixed solvent as developing solvents.
摘要翻译：目的：提供一种具有低密度脂蛋白抗氧化活性的木脂素复合番茄红素A.因此，木脂素化合物可用于预防和治疗包括动脉硬化的循环系统疾病。构成：具有低密度脂蛋白的具有抗氧化活性的木酚素化合物类调节剂A由式（1）表示。木质素复合番茄红素A通过以下步骤制备：用甲醇提取中华白菜的粉末; 用水，正己烷和氯仿萃取第一次提取液; 使用正己烷和乙酸乙酯混合溶剂作为显影溶剂，通过硅胶柱色谱法分离第二提取物; 通过使用甲醇作为显影溶剂的反相硅胶柱色谱法分离洗脱液; 并通过硅胶柱色谱法分离洗脱液，使用氯仿和甲醇混合溶剂作为显影溶剂。

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