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1. 发明公开

KR1020040080854A 참당귀로부터 데커신 및 데커시놀 안젤레이트를 추출하는 방법 失效
标题翻译：食品和药物组合物含有黑麦草提取物
公开(公告)号：KR1020040080854A
公开(公告)日：2004-09-20
申请号：KR1020030016220
申请日：2003-03-14
申请人： 주식회사 바이넥스 , 강재선 , 이백천
发明人： 강재선 , 김익환 , 정세영 , 손철환 , 김원석 , 박유수
IPC分类号： A23L1/30
摘要： PURPOSE: Provided are foods and pharmaceutical compositions containing Angelica gigas extract which are effective for alleviation of nephrotoxicity and diabetic hypertension. CONSTITUTION: The foods and pharmaceutical compositions containing Angelica gigas extract are characterized in that they are prepared by extracting and concentrating decursin and decursinol angelate contained in the Angelica gigas, Nakai to be formulated into an oral administration form such as tablet, capsule, liquid medicine and powdered form.
摘要翻译：目的：提供含有当归猕猴提取物的食品和药物组合物，其有效缓解肾毒性和糖尿病高血压。构成：含有当归提取物的食品和药物组合物的特征在于它们是通过提取和浓缩当归所含的当归的前胡素和当归酸，制成口服给药形式如片剂，胶囊，液体药物和粉状

2. 发明授权

KR100509843B1 참당귀로부터 데커신 및 데커시놀 안젤레이트를 추출하는 방법 失效
标题翻译：从当归提取提取物和当归酸前胡萝卜的方法
公开(公告)号：KR100509843B1
公开(公告)日：2005-08-24
申请号：KR1020030016220
申请日：2003-03-14
申请人： 주식회사 바이넥스 , 강재선 , 이백천
发明人： 강재선 , 김익환 , 정세영 , 손철환 , 김원석 , 박유수
IPC分类号： A23L1/30
摘要： 본 발명은 참당귀로부터 데커신 및 데커시놀 안젤레이트를 추출하는 방법에 관한 것으로, 더욱 상세하게는 한국이 원산지인 참당귀(
Angelica gigas, Nakai)를 이용하여 신장독성 경감 및 당뇨합병증에 따르는 신부전증의 억제효과, 당뇨성 고혈압에 효과를 보이는 참당귀 추출물을 함유하는 식품 및 약제학적 조성물을 제조하기 위하여 참당귀로부터 데커신 및 데커시놀 안젤레이트를 추출하는 방법에 관한 것이다.
이를 실현하기 위하여 본 발명은, 원료인 참당귀를 잘게 분쇄한 다음 분쇄한 참당귀에 에탄올을 첨가한 후 온도차이, 용해도 차이, 초음파기 또는 냉침방법을 이용하여 참당귀로부터 데커신 및 데커시놀 안젤레이트를 추출하는 것을 특징으로 한다.

3. 发明授权

KR100461859B1 옥시라세탐의 제조방법 失效
标题翻译： 옥시라세탐의제조방법
公开(公告)号：KR100461859B1
公开(公告)日：2004-12-14
申请号：KR1020020022150
申请日：2002-04-23
申请人： 주식회사 바이넥스 , 이백천
发明人： 박민수 , 강재선 , 안병근 , 김원석 , 박유수 , 손철훈
IPC分类号： C07D207/27
摘要： PURPOSE: A manufacturing method of oxiracetam is provided, thereby manufacturing oxiracetam at room temperature under mild condition in higher yield. CONSTITUTION: A manufacturing method of oxiracetam comprises the steps of: condensation of vinyl acetyl chloride of the formula 1 with glycine ethyl ester to prepare 3-butenoylamino-acetic ethyl ester of the formula 2: epoxylation of 3-butenoylamino-acetic ethyl ester of the formula 2 using HO-X in which X is halogen or CH2Cl2 to prepare an epoxy compound of the formula 3 as an intermediate; adding a base to the epoxy compound of the formula 3 for cyclization of the epoxy compound to form 5-membered ring of the formula 4; and dissolving the 5-membered ring of the formula 4 in ammonia water to prepare oxiracetam of the formula 5.
摘要翻译：目的：提供一种奥拉西坦的制造方法，由此在室温下在温和条件下以较高的收率制造奥拉西坦。构成：奥拉西坦的制造方法包括以下步骤：将式1的乙烯基乙酰氯与甘氨酸乙酯缩合制备式2的3-丁烯酰氨基 - 乙酸乙酯：将式2的3-丁烯酰氨基 - 乙酸乙酯环氧化使用其中X是卤素或CH 2 Cl 2的HO-X来制备式3的环氧化合物作为中间体; 向式3的环氧化合物中加入碱以使环氧化合物环化形成式4的5元环; 并将式4的5元环溶于氨水中以制备式5的奥拉西坦。

4. 发明公开

KR1020030086180A 바실러스 폴리퍼멘티쿠스를 함유한 동물용 사료 失效
标题翻译：含有BACILLUS POLYFERMENUS的动物饲料组合物
公开(公告)号：KR1020030086180A
公开(公告)日：2003-11-07
申请号：KR1020020024577
申请日：2002-05-03
申请人： 주식회사 바이넥스 , 이백천
发明人： 강재선 , 김원석 , 박유수 , 김혜진 , 전경동
IPC分类号： A23K1/00
CPC分类号： A23K10/16 , C12R1/07
摘要： PURPOSE: Provided is an animal fodder composition containing Bacillus polyfermenticus to increase egg-laying rate and birth rate as well as to improve death rate. CONSTITUTION: An animal fodder composition containing Bacillus polyfermenticus is characterized by containing 1x10¬8 cfu to 5x10¬10 cfu of Bacillus polyfermenticus/ton of animal fodder. Therefore. it gives increasing effect on egg-laying rate and birth rate and improving effect on death rate.
摘要翻译：目的：提供含有芽孢杆菌的动物饲料组合物，以提高产卵率和出生率以及提高死亡率。构成：含有芽孢杆菌的动物饲料组合物的特征在于含有1×10 8 cfu至5×10 -10 cfu的芽孢杆菌多巴胺/吨动物饲料。因此。对产卵率和出生率的影响越来越大，对死亡率的影响也越来越大。

5. 发明公开

KR1020030075003A 바실러스 폴리퍼멘티쿠스가 생산하는 박테리오신을 이용한헬리코박터 파이로리에 대한 적용 无效
标题翻译：由巴氏杆菌生产的细菌的用途用于控制或消除HELICOBACTER PYLORI
公开(公告)号：KR1020030075003A
公开(公告)日：2003-09-22
申请号：KR1020020014075
申请日：2002-03-15
申请人： 주식회사 바이넥스 , 이백천
发明人： 강재선 , 김원석 , 박유수 , 손철훈 , 김혜진 , 이백천
IPC分类号： A61K35/74
CPC分类号： A61K35/74
摘要： PURPOSE: A bacteriocin produced by Bacillus polyfermenticus showing direct antibacterial action against Helicobacter Pylori as a causative agent of gastritis is provided. Therefore, it can be used in the treatment of acid peptic disease such as gastritis and duodenal ulcers by oral administration. CONSTITUTION: A bacteriocin as an antimicrobial substance produced by Bacillus polyfermenticus controls or eradicates Helicobacter pylori. For an example, Bacillus polyfermenticus is cultured in a TBS(Difco laboratories) medium, Helicobacter pylori(KCTC 2948) is cultured in a Mueller hinton medium added with 10% bovine calf serum at 37deg.C under anaerobic conditions. Helicobacter pylori in the amount of 10¬6 cfu/ml is smeared to a solid medium and cultured, Bacillus polyfermenticus(10 microliter) remaining in a logarithmic growth phase is spotted and cultured. In the test, the inhibiting effect on the growth of Helicobacter pylori is distinctly observed.
摘要翻译：目的：提供由芽孢杆菌（polyfermenticus）产生的细菌素，其显示对幽门螺杆菌作为胃炎致病因子的直接抗菌作用。因此，可以通过口服治疗酸性消化性疾病如胃炎和十二指肠溃疡。构成：作为抗菌物质的细菌素，由芽孢杆菌多毛属发酵菌控制或根除幽门螺杆菌。例如，在TBS（Difco实验室）培养基中培养芽孢杆菌，在37℃，在厌氧条件下，在加入10％牛血清的Mueller hinton培养基中培养幽门螺杆菌（KCTC 2948）。将10〜6cfu / ml的幽门螺旋杆菌涂抹于固体培养基中并培养，保留在对数生长期的培养物（10微升）的芽孢杆菌。在试验中，幽门螺杆菌生长抑制作用明显。

6. 发明授权

KR100458487B1 바실러스 폴리퍼멘티쿠스를 함유한 동물용 사료 失效
标题翻译： 바실러스폴리퍼멘티쿠스를함유한동물용사료
公开(公告)号：KR100458487B1
公开(公告)日：2004-12-03
申请号：KR1020020024577
申请日：2002-05-03
申请人： 주식회사 바이넥스 , 이백천
发明人： 강재선 , 김원석 , 박유수 , 김혜진 , 전경동
IPC分类号： A23K1/00
摘要： PURPOSE: Provided is an animal fodder composition containing Bacillus polyfermenticus to increase egg-laying rate and birth rate as well as to improve death rate. CONSTITUTION: An animal fodder composition containing Bacillus polyfermenticus is characterized by containing 1x10¬8 cfu to 5x10¬10 cfu of Bacillus polyfermenticus/ton of animal fodder. Therefore. it gives increasing effect on egg-laying rate and birth rate and improving effect on death rate.
摘要翻译：目的：提供一种含有聚芽孢杆菌的动物饲料组合物，以提高产蛋率和出生率，并提高死亡率。组成：含有聚乙二醇发酵芽孢杆菌的动物饲料组合物的特征在于含有1×10 8至5×10 10 CFU聚乙二醇发酵菌/吨动物饲料。因此。增加产蛋率和出生率，提高对死亡率的影响。

7. 发明公开

KR1020030083466A 옥시라세탐의 제조방법 失效
标题翻译： OXIRACETAM的制备方法
公开(公告)号：KR1020030083466A
公开(公告)日：2003-10-30
申请号：KR1020020022150
申请日：2002-04-23
申请人： 주식회사 바이넥스 , 이백천
发明人： 박민수 , 강재선 , 안병근 , 김원석 , 박유수 , 손철훈
IPC分类号： C07D207/27
摘要： PURPOSE: A manufacturing method of oxiracetam is provided, thereby manufacturing oxiracetam at room temperature under mild condition in higher yield. CONSTITUTION: A manufacturing method of oxiracetam comprises the steps of: condensation of vinyl acetyl chloride of the formula 1 with glycine ethyl ester to prepare 3-butenoylamino-acetic ethyl ester of the formula 2: epoxylation of 3-butenoylamino-acetic ethyl ester of the formula 2 using HO-X in which X is halogen or CH2Cl2 to prepare an epoxy compound of the formula 3 as an intermediate; adding a base to the epoxy compound of the formula 3 for cyclization of the epoxy compound to form 5-membered ring of the formula 4; and dissolving the 5-membered ring of the formula 4 in ammonia water to prepare oxiracetam of the formula 5.
摘要翻译：目的：提供奥拉西坦的制造方法，由此在温和条件下以较高的产率在室温下制造奥拉西坦。构成：奥拉西坦的制备方法包括以下步骤：将式1的乙烯基乙酰氯与甘氨酸乙酯的缩合制备式2的3-丁烯酰氨基 - 乙酸乙酯：3-丁烯酰氨基 - 乙酸乙酯的环氧化式2使用其中X为卤素或CH 2 Cl 2的HO-X，以制备作为中间体的式3的环氧化合物; 向式3的环氧化合物加入碱，使环氧化合物环化形成式4的5元环; 并将式4的5元环溶解在氨水中以制备式5的奥拉西坦。

8. 发明公开

KR1020020085683A 흡수촉진제를 함유한 경구투여용 미립자 포접 약물의제조방법 无效
标题翻译：生产含有吸收增强剂的口服输送用微生物粘合剂
公开(公告)号：KR1020020085683A
公开(公告)日：2002-11-16
申请号：KR1020010025322
申请日：2001-05-09
申请人： 강재선
发明人： 강재선 , 안병근 , 전경동 , 김원석 , 이백천
IPC分类号： A61K9/14
CPC分类号： A61K47/6949 , A61K9/0053 , A61K47/183 , A61K47/28 , A61K47/34 , A61K47/42 , A61K47/6929
摘要： PURPOSE: A process of preparing a drug which is improved in dissolution and oral absorption characteristics by binding a drug which is unstable in the stomach and susceptible to disintegration during absorption to fine particles having a particle size of 10 to 12 μm, together with an absorption enhancer is provided which can prevent inconvenience and adverse side-effects associated with its use and increase bioavailability of drugs which cause its use value to degrade by the loss of activity when administered orally. CONSTITUTION: To improve biodegradability of salmon calcitonin, protein, peptide material and a drug, the drug is dissolved in a mixed solution of methanol, ethanol, acetone, isopropanol, etc. and then mixed with an absorption enhancer such as bile acid, bile salts, transferrin, folic acid, etc. and a biodegradable polymer. Thereafter, the mixed solution is dispersed in an aqueous solution, heated at 40deg.C for 1hr, centrifuged and dried.
摘要翻译：目的：制备药物的制备方法，其通过将吸收期间不稳定并容易崩解的药物与粒径为10〜12μm的细颗粒结合使用，吸收改善了溶出度和口服吸收特性，提供增强剂，其可以防止与其使用相关的不便和不良副作用，并增加药物的生物利用度，其通过口服给药时其活性丧失导致其使用价值降低。构成：为了提高鲑鱼降钙素，蛋白质，肽材料和药物的生物降解能力，将药物溶解在甲醇，乙醇，丙酮，异丙醇等的混合溶液中，然后与吸收增强剂如胆汁酸，胆汁盐，转铁蛋白，叶酸等，以及可生物降解的聚合物。此后，将混合溶液分散在40℃加热1小时的水溶液中，离心并干燥。

9. 发明授权

KR100943087B1 면역치료용 활성화 림프구 제조방법 有权
标题翻译：活化淋巴细胞免疫治疗的制备方法
公开(公告)号：KR100943087B1
公开(公告)日：2010-02-18
申请号：KR1020070046070
申请日：2007-05-11
申请人： 주식회사 바이넥스
发明人： 박순원 , 손영옥 , 손철훈 , 박유수 , 반정화 , 이경규 , 장정수 , 강치덕 , 김원석 , 안경출 , 이백천 , 김주인 , 박은경 , 최성희
IPC分类号： C12N5/071 , C12N5/02
CPC分类号： C12N5/0646 , A61K2035/124 , C12N2501/23 , C12N2501/24 , C12N2501/515
摘要： 본 발명은 말초혈액에 존재하는 림프구를 분리하여 시험관내에서 증식, 활성화시키는 활성화 림프구의 제조방법에 관한 것이다.
본 발명에 따르면, 사람의 말초혈액 림프구를 항 CD3 항체, IFN-γ 및 IL-2가 있는 상태에서 배양함으로써 고효율의 독성세포를 대량 배양할 수 있다. 본 발명의 제조방법으로 증식된 활성화 림프구의 경우, LAK cell의 주성분인 CD3-CD56+(자연살상세포 표지자)세포와 CIK cell의 주성분인 CD3+CD56+세포를 모두 포함하며 대량 배양할 수 있기 때문에 LAK cell과 CIK cell 단독으로 사용했을 때보다 훨씬 높은 항암 효과를 기대할 수 있다.
활성화 림프구, 동결 보존, 세포면역치료제, 인터루킨-2, 인터페론-감마, 항 CD3 항체

10. 发明授权

KR100765357B1 고스트 비브리오 앵귈라룸 및 이를 함유하는 비브리오증의예방용 백신 失效
标题翻译： GHOST VIBRIO ANGUILLARUM和VACCINE用于预防含有其的VIBRIOSIS
公开(公告)号：KR100765357B1
公开(公告)日：2007-10-10
申请号：KR1020060099244
申请日：2006-10-12
申请人： 부경대학교 산학협력단 , 주식회사 바이넥스
发明人： 김기홍 , 권세련 , 남윤권 , 김성구 , 정창화 , 박소진 , 김원석 , 이백천
IPC分类号： C12N15/63 , C12N1/21
摘要： A microorganism ghost Vibrio anguillarum and a vaccine for preventing vibriosis containing the same microorganism are provided to supply a new vibriosis-preventing vaccine having surface antigenicity similar to live Vibrio anguillarum and no pathogenicity without treatment with toxic chemicals such as formalin, so that productivity of cultured fishes is improved. A microorganism ghost Vibrio anguillarum PRKG(KFCC 11377P) is prepared by (a) transforming Vibrio anguillarum with a recombinant vector pRK-lambdaPR-cI-Elysis containing lambdaPR promoter/cI repressor and lysis E gene and culturing the transformed Vibrio anguillarum at 25-30 deg.C, (b) increasing culture temperature to 40-43 deg.C when cell density(OD600) of culture medium reaches at 0.2-0.25 and culturing the microorganism, and (c) obtaining the transformed Vibrio anguillarum when cell density reduction of culture medium is stopped.
摘要翻译：提供微生物幽灵弧菌弧菌和用于预防含有相同微生物的弧菌病的疫苗，以提供具有类似于活鳗弧菌的表面抗原性的新型弧菌预防疫苗，并且不用有毒的化学物质如福尔马林处理而无致病性，从而培养鱼改善了。通过（a）用含有λPR启动子/ cI阻遏物和裂解E基因的重组载体pRK-λPR-cI-Elysis转化鳗弧菌来制备微生物幽门弧菌PRKG（KFCC 11377P），并在25-30℃下培养转化的鳗弧菌（b）当培养基的细胞密度（OD600）达到0.2-0.25时，培养温度升至40-43℃，培养微生物，（c）当细胞密度降低时获得转化的鳗弧菌培养基停止。

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