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    • 9. 发明公开
    • 골 충진 복합체 및 그 제조 방법
    • 骨填充复合物及其制备方法
    • KR1020080020223A
    • 2008-03-05
    • KR1020060083417
    • 2006-08-31
    • 포항공과대학교 산학협력단주식회사 메가젠임플란트
    • 한세광오은주박정규박광범류경호최석규양동준안현욱
    • A61F2/28
    • A61L27/46A61F2/28A61L2430/02C08L5/08
    • A bone filling complex and a preparing method for the same are provided to obtain a bone filling complex that has an excellent bone regenerating capacity and an excellent capacity of preventing conglutination. A bone filling complex includes a matrix and a bone derivative. The matrix contains hyaluronic acid derivative in the form of a hydrogel. The bone derivative is filled into the matrix. The hyaluronic acid derivative in the form of hydrogel is obtained by making suberate react with hyaluronic acid. The suberate is bis(Sulfosuccinimidyl) suberate. The suberate is coupled to the carbonyl group of the hyaluronic acid by interposing a liner therebetween. The liner contains at least two amino groups which are respectively coupled with the carboxyl group of the hyaluronic acid and the carbonyl group of the suberate.
    • 提供骨填充复合物及其制备方法以获得具有优异的骨再生能力和优异的预防粘连能力的骨填充复合物。 骨填充复合物包括基质和骨衍生物。 该基质含有水凝胶形式的透明质酸衍生物。 将骨衍生物填充到基质中。 水凝胶形式的透明质酸衍生物是通过使透明质酸与苯乙酸酯反应得到的。 辛二酸酯是双(磺基琥珀酰亚胺基)辛酸酯。 通过在其间插入衬垫,将辛二酸酯偶联至透明质酸的羰基。 衬里含有至少两个氨基,它们分别与透明质酸的羧基和辛二酸酯的羰基偶联。