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1. 发明公开

KR1020080109243A 항당뇨 활성을 나타내는 패과식물의 추출물 有权
标题翻译：异烟肼具有抗糖尿病活性的提取物
公开(公告)号：KR1020080109243A
公开(公告)日：2008-12-17
申请号：KR1020070057318
申请日：2007-06-12
申请人： 재단법인 제주테크노파크
发明人： 김기옥 , 이주엽 , 한종헌 , 김미량 , 오유성 , 강민철 , 고광효 , 진호경 , 김행범 , 김봉석 , 엄병헌
IPC分类号： A61K36/03 , A61P3/10
摘要： The extracts of the Ishigeaceae plant showing the antidiabetic activity is provided. A pharmaceutical composition comprising the extracts of the Ishigeaceae plant is provided to improve anti-diabetic and anti-oxidative activities. The Ishigeaceae plant extract for prevention and improvement of diabetes is obtained from the Ishigeaceae plant, and is prepared by washing Ishige sinicola; dipping the washed Ishige sinicola in 70% ethanol and agitating it at room temperature for 2-3 days; filtering the leached product of Ishige sinicola to prepare the crude extract; and sequentially fractioning the crude extract with n-hexane, ethylacetate, and butanol to obtain fractions.
摘要翻译：提供了表现出抗糖尿病活性的菊科植物的提取物。提供了包含藤本科植物提取物的药物组合物以改善抗糖尿病和抗氧化活性。石鳖科植物提取物用于预防和改善糖尿病是从石ae科植物获得的，并且通过洗涤中washing皮制备; 将洗涤的Ishige sinicola浸入70％乙醇中，并在室温下搅拌2-3天; 过滤中华白兰地浸出物，制备粗提物; 并用正己烷，乙酸乙酯和丁醇依次对粗提物进行分级，得到级分。

2. 发明授权

KR101042005B1 비목나무 유래 화합물, 이의 분리 방법 및 이를 함유하는 피부 미백용 조성물 有权
标题翻译：来自林氏赤藓红的化合物，其分离方法和包含其的皮肤美白组合物
公开(公告)号：KR101042005B1
公开(公告)日：2011-06-16
申请号：KR1020090090696
申请日：2009-09-24
申请人： 재단법인 제주테크노파크
发明人： 김기옥 , 고려경 , 강민철 , 진영준 , 한종헌 , 최호민 , 고광효 , 김봉석 , 진호경 , 진경희 , 정용환 , 이남호
IPC分类号： C07C43/205 , A61K8/33 , A61K8/97 , A61Q19/02
摘要： 본 발명은 비목나무 유래 화합물, 이의 분리 방법 및 이를 함유하는 피부 미백용 조성물에 관한 것으로, 더욱 상세하게는 비목나무(
Lindera erythrocarpa ) 추출물의 용매 분획물로부터 분리한 화합물과 이의 분리 방법 및 상기 화합물을 함유함으로써 멜라닌 생합성을 억제할 수 있는 피부 미백용 조성물에 관한 것이다.
페닐프로판(phenylpropane) 화합물, 비목나무, 추출물, 용매분획, 미백, 멜라닌, 티로시나제

3. 发明授权

KR100864203B1 미백활성을 나타내는 제주아그배 추출물 有权
标题翻译：具有白藜芦醇活性的黄芪提取物
公开(公告)号：KR100864203B1
公开(公告)日：2008-10-17
申请号：KR1020070044570
申请日：2007-05-08
申请人： 재단법인 제주테크노파크
发明人： 김기옥 , 이주엽 , 한종헌 , 김봉석 , 강민철 , 김미량 , 고광효 , 진호경 , 김행범 , 김세재
IPC分类号： A61K8/97 , A61Q19/02
CPC分类号： A61K8/97 , A61K36/73 , A61Q19/02 , Y10S514/844 , Y10S514/857
摘要： A composition comprising the extract of Malus micromalus Makino is provided to whiten the skin by inhibiting melanin biosynthesis and activity of tyrosinase, suppress oxidation and inflammation, and improve economical efficiency and safety of use by using natural plant. A composition for whitening the skin comprises the extract of Malus micromalus Makino which is prepared by washing leaf, branch, flower or fruit of Malus micromalus Makino with water, drying it with hot wind of 40 deg. C for 3 days, pulverizing the dried Malus micromalus Makino, dipping the pulverized Malus micromalus Makino in 70% ethanol and stirring it at room temperature for 2-3 days, filtering the stirred solution to obtain the crude extract of Malus micromalus Makino, and fractionating the crude extract with other solvent with different polarity.
摘要翻译：通过抑制黑色素生物合成和酪氨酸酶的活性，抑制氧化和炎症，提高使用天然植物的经济效益和使用安全性，提供含有马蹄芥属提取物的组合物。用于使皮肤美白的组合物包括通过用水洗涤马鞭草的叶子，分枝，花或果实制备的马蹄芥的提取物，用40℃的热风干燥。 3天，粉碎干燥的马蹄豆，将粉碎的Malus micromalus Makino浸在70％乙醇中并在室温下搅拌2-3天，过滤搅拌溶液，得到Malus micromalus Makino粗提物，分馏粗提物与其他溶剂具有不同的极性。

4. 发明公开

KR1020110032931A 비목나무 유래 화합물, 이의 분리 방법 및 이를 함유하는 피부 미백용 조성물 有权
标题翻译：来自LINDERA ERYTHROCARPA的化合物，其分离方法和包含其的皮肤白化组合物
公开(公告)号：KR1020110032931A
公开(公告)日：2011-03-30
申请号：KR1020090090696
申请日：2009-09-24
申请人： 재단법인 제주테크노파크
发明人： 김기옥 , 고려경 , 강민철 , 진영준 , 한종헌 , 최호민 , 고광효 , 김봉석 , 진호경 , 진경희 , 정용환 , 이남호
IPC分类号： C07C43/205 , A61K8/33 , A61K8/97 , A61Q19/02
摘要： PURPOSE: A Lindera erythrocarpa-derived compound is provided to obtain a composition for skin whitening showing melanin inhibitory activity higher than existing albutin known as a whitening agent. CONSTITUTION: A method for separating a Lindera erythrocarpa-derived compound comprises the steps of: extracting Lindera erythrocarpa in a solvent to obtain Lindera erythrocarpa extracts; partitioning the Lindera erythrocarpa extracts into hexane, methylene chloride, ethyl acetate, and butanol to obtain solvent fractions; partitioning the Lindera erythrocarpa extracts by performing a primary silicagel column chromatography using hexane and ethyl acetate as a solvent; and applying a secondary silica gel column chromatography to the extracts using a mixed solvent of hexane and ethyl acetate.
摘要翻译：目的：提供一种来源于林德拉克罗car甙的化合物，以获得一种皮肤美白组合物，其显示比已知的作为增白剂的已有的琥珀酸高的黑色素抑制活性。构成：分离林多鱼赤藓醇衍生化合物的方法，包括以下步骤：在溶剂中提取枸杞子，获得枸杞子赤芍提取物; 将Lindera erythrocarpa提取物分配到己烷，二氯甲烷，乙酸乙酯和丁醇中，得到溶剂级分; 通过使用己烷和乙酸乙酯作为溶剂进行初级硅胶柱色谱法分离林德罗氏赤霉素提取物; 并使用己烷和乙酸乙酯的混合溶剂，在萃取液中进行二次硅胶柱色谱。

5. 发明公开

KR1020110022013A 송악 추출물을 함유하는 미백 화장료 조성물 无效
标题翻译：化妆品组合物，用于包含HEDERA RHOMBEA的提取物的皮肤白化
公开(公告)号：KR1020110022013A
公开(公告)日：2011-03-04
申请号：KR1020110007040
申请日：2011-01-24
申请人： 재단법인 제주테크노파크
发明人： 김기옥 , 한종헌 , 고광효 , 이정아 , 김행범 , 강민철 , 이주엽 , 김봉석 , 고영국 , 진호경 , 안승현 , 진희철 , 이건국 , 이강태
IPC分类号： A61K8/97 , A61Q19/02 , A61Q19/00
CPC分类号： A61K8/97 , A61K36/25 , A61K2236/333 , A61K2236/51 , A61Q19/02 , Y10S514/844
摘要： PURPOSE: A method for preparing Hedera rhombea extract which suppresses melanogenesis and tyrosinase activity is provided to treat melasma, dots, freckles, or hyperpigmentation during pregnancy. CONSTITUTION: A whitening cosmetic composition contains 25-100ug/ml of Hedera rhombea as an active ingredient. A method for preparing ethyl acetate from Hedera rhombea comprises: a step of washing and drying Hedera rhombea by hot air; a step of pulverizing Hedera rhombea; a step of precipitating pulverized Hedera rhombea in an organic solvent, leaching, and filtering; a step of repeating leaching and filtering two or three times; a step of decompressing and freeze-drying to obtain a powder; and a step of partitioning the Hedera rhombea extract with ethyl acetate. The organic solvent is 70% ethanol.
摘要翻译：目的：提供一种抑制黑色素生成和酪氨酸酶活性的Hedera rhombea提取物的方法，用于治疗怀孕期间的黑斑病，斑点，雀斑或色素沉着过度。构成：美白化妆品组合物含有25-100ug / ml Hedera rhombea作为活性成分。一种从海棠菱形体制备乙酸乙酯的方法，包括：用热空气洗涤和干燥新西兰菱形的步骤; 粉碎Hedera rhombea的一个步骤; 在有机溶剂中沉淀粉红色的菱形菱形的步骤，浸出和过滤; 重复浸出过滤两三次的步骤; 减压和冷冻干燥以获得粉末的步骤; 和用乙酸乙酯分配Hedera菱形提取物的步骤。有机溶剂为70％乙醇。

6. 发明授权

KR100791282B1 미백활성을 나타내는 노루참나물 추출물 有权
标题翻译：具有白色活性的PIMPINELLA KOMAROVII提取物
公开(公告)号：KR100791282B1
公开(公告)日：2008-01-04
申请号：KR1020070019697
申请日：2007-02-27
申请人： 재단법인 제주테크노파크
发明人： 김기옥 , 한종헌 , 김봉석 , 강민철 , 김미량 , 고광효 , 이주엽 , 진호경 , 엄병헌
IPC分类号： A61K8/97 , A61Q19/02
CPC分类号： A61K8/97 , A61K2236/333 , A61Q19/02 , Y10S514/844
摘要： An extract of Pimpinella komarovii is provided to secure excellent whitening effect and excellent antioxidative and anti-inflammatory activities. And a composition comprising the same as an effective ingredient is provided. An extract of Pimpinella komarovii with whitening activity is characterized in that it is prepared by hot-wind drying washed Pimpinella komarovii at a temperature of 40 deg.C, crushing the dried Pimpinella komarovii, dipping the crushed material of the Pimpinella komarovii in 70% ethanol with agitating for 2-3 days at room temperature, filtering the leachate using a filter to prepare a crude extract, and fractioning the crude extract using n-hexane, ethylacetate, and butanol in sequence. A composition for whitening, improving and preventing inflammatory diseases or antioxidizing comprises the extract of Pimpinella komarovii as an effective ingredient.
摘要翻译：提供Pimpinella komarovii的提取物以确保优异的美白效果和优异的抗氧化和抗炎活性。并提供包含与有效成分相同的组合物。具有增白活性的金丝桃提取物的特征在于通过在40℃的温度下热风干燥洗涤的Pimpinella komarovii制备，粉碎干燥的Pimpinella komarovii，将Pimpinella komarovii的破碎物质浸入70％乙醇在室温下搅拌2-3天，使用过滤器过滤渗滤液以制备粗提物，并按顺序使用正己烷，乙酸乙酯和丁醇对粗提物进行分馏。用于增白，改善和预防炎性疾病或抗氧化的组合物包括作为有效成分的Pimpinella komarovii的提取物。

7. 发明授权

KR101162761B1 비만 예방 또는 치료용 조성물 有权
标题翻译：用于预防或治疗肥胖的组合物
公开(公告)号：KR101162761B1
公开(公告)日：2012-07-05
申请号：KR1020080007278
申请日：2008-01-23
申请人： 재단법인 제주테크노파크
发明人： 김기옥 , 한종헌 , 고광효 , 이정아 , 김행범 , 강민철 , 이주엽 , 김봉석 , 진호경 , 안승현 , 진희철
IPC分类号： A61K31/35 , A61K31/352 , A61K36/752 , A61P3/04
摘要： 본 발명은 비만 예방 또는 치료용 조성물에 관한 것으로, 구체적으로는 미성숙 감귤 추출물 또는 이로부터 분리한 리모시트린-3-글루코즈(limocitrin-3-glucose), 8-메톡시 퀘르세틴 3-오-[6”-(3”′-하이드록시-3”′-메틸-글루타로일)-베타-디-글루코피라노시드] (8-Methoxy Quercetin 3-
O -[6”-(3”'-hydroxy-3”'-methyl-glutaroyl)-
β -D-glucopyranoside]), 퀘르세틴3-오-[6”-(3”′-하이드록시-3”′-메틸-글루타로일)-베타-디-글루코피라노시드] (Quercetin 3-
O -[6”-(3”'-hydroxy-3”'-methyl-glutaroyl)-
β -D-glucopyranoside]) 및 5,6,7,8,3',4'-헥사메톡시퀘르세틴3-오-[6”-(3”'-하이드록시-글루타로일)-베타-디-글루코피라노시드](5,6,7,8,3',4'-HexaMethoxyQuercetin3-O-[6”-(3”'-hydroxy-3”'-methyl-glutaroyl)-β-D-glucopyranoside])로 이루어진 군으로부터 선택된 하나 이상의 화합물을 포함하는 비만 예방 또는 치료용 조성물에 관한 것이다. 또한, 본 발명은 상기 비만 예방 또는 치료용 조성물을 포함하는 약제학적 조성물 및 건강 기능성 식품에 관한 것이다.
온주밀감, 미성숙과, 비만

8. 外观设计

KR3006281210000S 有权
公开(公告)号：KR3006281210000S
公开(公告)日：2012-01-11
申请号：KR3020110046715
申请日：2011-11-07
申请人： 재단법인 제주테크노파크
设计人： 김기옥 , 고광효 , 진호경

9. 外观设计

KR3006281200000S 有权
公开(公告)号：KR3006281200000S
公开(公告)日：2012-01-11
申请号：KR3020110046714
申请日：2011-11-07
申请人： 재단법인 제주테크노파크
设计人： 김기옥 , 고광효 , 진호경

10. 发明公开

KR1020090020216A 그물바탕말속 추출물을 포함하는 미백용 조성물 无效
标题翻译：含有DICTYOTA萃取物的组合物
公开(公告)号：KR1020090020216A
公开(公告)日：2009-02-26
申请号：KR1020070084778
申请日：2007-08-23
申请人： 재단법인 제주테크노파크
发明人： 김기옥 , 강민철 , 이주엽 , 한종헌 , 진호경 , 김행범 , 김봉석 , 안승현
IPC分类号： A61K8/97 , A61Q19/02
CPC分类号： A61K8/97 , A61K36/03 , A61K2236/333 , A61Q19/02 , Y10S514/844
摘要： A whitening composition containing the extract of Dictyota is provided to improve the inhibitory activity of tyrosinase in the cell and inhibitory activity of melanin formation, so that the composition is usable for the functional cosmetics. The whitening composition contains the extract of Dictyota which is prepared by washing the brown algae of Dictyota with the flowing water; drying the brown algae of Dictyota at 40 deg. C for 3 days and pulverizing it; extracting the pulverized product with 70% ethanol at room temperature for 2-3 days; filtering the extract; repeating the extracting and filtering process 2-3 times; concentrating the filtered solution under reduced pressure, and freeze-drying the concentrate to prepare the crude extract; and fractionating the crude extract with solvent having different polarity sequentially.
摘要翻译：提供含有Dictyota提取物的增白组合物，以改善酪氨酸酶在细胞中的抑制活性和黑色素形成的抑制活性，使得该组合物可用于功能性化妆品。美白组合物含有Dictyota的提取物，其通过用流动的水洗涤Dictyota的棕色藻类而制备; 在40度干燥Dictyota的棕色藻类。 C 3天，粉碎; 用70％乙醇在室温下萃取粉碎产物2-3天; 过滤提取物; 重复提取和过滤2-3次; 在减压下浓缩过滤的溶液，并冷冻干燥浓缩物以制备粗提取物; 并用依次具有不同极性的溶剂对粗提物进行分馏。

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