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    • 6. 发明公开
    • TNF-α의 경쟁적 저해제로서 IGFBP-5의 용도
    • 使用IGFBP-5作为TNF-α的竞争性抑制剂
    • KR1020100079629A
    • 2010-07-08
    • KR1020080138164
    • 2008-12-31
    • 성균관대학교산학협력단
    • 이제호황재령허재호
    • A61K48/00C07K14/47C07K14/525A61P29/00
    • A61K38/1709G01N2333/7151
    • PURPOSE: A ligand which specifically binds to TNFR1 containing IGFBP-5 protein, mutant, and fragment thereof is provided to competitively suppress TNF-alpha without side effects and to prevent and treat cancer and inflammatory diseases. CONSTITUTION: A TNF-alpha inhibitor contains IGFBP(insulin-like growth factor binding protein-5) protein having an amino acid sequence of sequence number 2, mutant, fragment, or gene encoding the same as an active ingredient. The IGFBP-5 gene has a base sequence of sequence number 1. An IGFBP-5 vector contains IGFBP-5 gene. The IGFBP-5 fragment is an L-domain having an amino acid sequence of sequence number 4. A gene coding L-domain has a base sequence of sequence number 3. An apoptosis promoting agent contains IGFBP-5 protein having an amino acid sequence of sequence number 2, mutant, fragment, or gene encoding the same and TNFR1.
    • 目的:提供特异性结合含有IGFBP-5蛋白,突变体及其片段的TNFR1的配体,以竞争性地抑制TNF-α而无副作用并预防和治疗癌症和炎性疾病。 构成:TNF-α抑制剂含有具有序列号2的氨基酸序列,编码与活性成分相同的突变体,片段或基因的IGFBP(胰岛素样生长因子结合蛋白-5)蛋白。 IGFBP-5基因具有序列号1的碱基序列.IGBBP-5载体含有IGFBP-5基因。 IGFBP-5片段是具有序列号4的氨基酸序列的L结构域。编码L-结构域的基因具有序列号3的碱基序列。凋亡促进剂含有IGFBP-5蛋白,其具有氨基酸序列 序列号2,突变体,片段或编码其的基因和TNFR1。