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    • 9. 发明公开
    • 항 c-Met 항체 적용 대상 선별을 위한 바이오마커
    • 用于识别应用抗C-MET抗体的主体的生物标记
    • KR1020150006756A
    • 2015-01-19
    • KR1020130130534
    • 2013-10-30
    • 삼성전자주식회사
    • 오영미김경아
    • C12Q1/34G01N33/563A61K39/35A61P35/00G01N33/574
    • C12Q1/6886A61K39/39558C07K16/28C07K16/32C07K16/40C07K2317/565C12Q2600/158C12Y304/19012G01N33/5011G01N33/574
    • Provided are a biomarker for selecting an object for application of an anti-c-Met antibody, a method for selecting an object for application of an anti-c-MET antibody including a step of measuring the level of ubiquitin hydrolase and/or genes encoding the same in a biological sample, a method for preventing and/or treating cancer including a step of administrating an anti-c-Met antibody to the selected object, a composition for coadministration including an anti-c-Met antibody and an inhibitor of ubiquitin hydrolase and/or genes encoding the same for preventing and/or treating a cancer, and a method for preventing and/or treating a cancer including a step of coadministrating an anti-c-Met antibody and an inhibitor of ubiquitin hydrolase and/or genes encoding the same. Provided in an embodiment of the present invention is a biomarker for selecting an object for application of an anti-c-Met antibody including ubiquitin hydrolase and/or genes encoding the same.
    • 提供了用于选择抗c-Met抗体应用的对象的生物标志物,用于选择抗c-MET抗体应用的对象的方法,包括测量泛素水解酶水平的步骤和/或编码 生物样品中相同的方法,用于预防和/或治疗癌症的方法,包括向选择的对象施用抗c-Met抗体的步骤,包含抗c-Met抗体和泛素抑制剂的共同给药组合物 水解酶和/或编码它们的基因用于预防和/或治疗癌症,以及预防和/或治疗癌症的方法,包括共同给予抗c-Met抗体和泛素水解酶和/或基因的抑制剂的步骤 编码相同。 在本发明的一个实施方案中提供了用于选择应用包含遍在蛋白水解酶的抗c-Met抗体的对象的生物标志物和/或编码其的基因。