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    • 9. 发明公开
    • 인성장 호르몬의 안정화된 액상제제_
    • 稳定液体制备人体生长激素
    • KR1020000037747A
    • 2000-07-05
    • KR1019980052483
    • 1998-12-02
    • 동아쏘시오홀딩스 주식회사
    • 조영우이건일이성희김원배
    • A61K38/27A61P5/06
    • PURPOSE: A liquid preparation of human growth hormone is pharmaceutically stabilized as the decomposition reaction of growth hormone is minimized by adjusting the amount and kinds of buffer, stabilizer and preservative. CONSTITUTION: A pharmaceutically stabilized liquid preparation of human growth hormone comprises the followings: 1-10 mg/ml of human growth hormone, 5-100 mM of buffer selected from the group comprising sodium acetate, sodium glutamate, 5-100 mg/ml of stabilizer selected from mannitol, sodium chloride, 1-10 mg/ml of preservative, benzyl alcohol, 1-10 mg/ml of forming agent, polysorbate 20. The pH of the preparation is 5.5-6.5.
    • 目的:人体生长激素的液体制剂是药学上稳定的,因为通过调节缓冲液,稳定剂和防腐剂的量和种类使生长激素的分解反应最小化。 构成:药物稳定的人生长激素的液体制剂包括以下:1-10mg / ml人生长激素,5-100mM缓冲液,其选自乙酸钠,谷氨酸钠,5-100mg / ml的 选自甘露醇,氯化钠,1-10mg / ml防腐剂,苯甲醇,1-10mg / ml成形剂,聚山梨醇酯20的稳定剂。制剂的pH为5.5-6.5。