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1. 发明公开

KR1020100042768A 생분해성 고분자 미립구 및 그 제조방법 无效
标题翻译：一种可生物降解的微生物及其生产方法
公开(公告)号：KR1020100042768A
公开(公告)日：2010-04-27
申请号：KR1020080101911
申请日：2008-10-17
申请人： 동아쏘시오홀딩스 주식회사
发明人： 김태형 , 손미경 , 윤지혜 , 김윤지 , 권인호 , 양희창 , 이건일 , 곽현희 , 강수형
IPC分类号： A61K9/16 , C08J3/12 , C08L67/04
CPC分类号： A61K47/593 , A61K38/1703 , C08J3/12 , C08L67/04 , Y10S514/866
摘要： PURPOSE: A biodegradable polymer microsphere which is able to release pseudin-2 or analog thereof is provided to continuously release the pseudin or pseudin-2 analog and to improve treatment effect for diabetes. CONSTITUTION: A biodegradable polymer microsphere contains pseudin-2 or analog thereof, and biodegradable polymer and continuously releases the pseudin-2 or analog by controlling. The pseudin-2 or analog is natural type, recombination type or synthetic type. The biodegradable polymer is poly-L-lactic acid, poly-D-lactic acid-co-glycolic acid, poly-L-lactic acid-co-glycolic acid, or poly-D,L-lactic acid-co-glycolic acid. An amino acid sequence of the pseudin-2 or analog is one of sequence among sequence numbers 1-7. An agent for preventing and treating diabetes contains the biodegradable polymer microsphere.
摘要翻译：目的：提供能够释放假蛋白-2或其类似物的可生物降解的聚合物微球，以连续释放假蛋白或假蛋白-2类似物并改善糖尿病的治疗效果。构成：可生物降解的聚合物微球含有假蛋白2或其类似物和可生物降解的聚合物，并通过控制连续释放假蛋白-2或类似物。假蛋白-2或类似物是天然型，重组型或合成型。生物降解性聚合物是聚-L-乳酸，聚-D-乳酸 - 共 - 乙醇酸，聚-L-乳酸 - 共 - 乙醇酸，或聚-D，L-乳酸 - 共 - 乙醇酸。假蛋白-2或类似物的氨基酸序列是序列号1-7中的序列之一。用于预防和治疗糖尿病的药物含有可生物降解的聚合物微球。

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