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1. 发明专利

JP2015010081A マトリックスメタロプロテアーゼ活性阻害剤、皮膚外用剤、老化防止用皮膚外用剤、シワ防止用皮膚外用剤、慢性関節リウマチ及び他の疾患の治療又は予防剤有权
标题翻译：基质金属蛋白酶活性抑制剂，皮肤外用制剂，外用防老化皮肤外用制剂，防止皱纹皮肤外用制剂，治疗或预防感染性溃疡性结肠炎及其他疾病
公开(公告)号：JP2015010081A
公开(公告)日：2015-01-19
申请号：JP2013138863
申请日：2013-07-02
申请人：御木本製薬株式会社 , Mikimoto Pharmaceut Co Ltd , 国立大学法人東京大学 , Univ Of Tokyo , 国立大学法人東京大学
发明人： SUZUKI MICHIO , NAGASAWA HIROMICHI , MAEYAMA KAORU , HATTORI FUMIHIRO
IPC分类号： A61K8/98 , A61K8/64 , A61K35/56 , A61K38/00 , A61P1/02 , A61P1/04 , A61P3/10 , A61P9/10 , A61P17/00 , A61P19/02 , A61P19/08 , A61P29/00 , A61P31/18 , A61P35/00 , A61P35/04 , A61P43/00 , A61Q11/00 , A61Q19/08 , C12N9/99
摘要：【課題】本発明の目的はマトリックスメタロプロテアーゼを阻害する皮膚外用剤に関する。さらに詳しく述べればシワ防止、老化防止用の皮膚外用剤、さらには慢性関節リウマチや変形性関節症の滑膜及び慢性関節リウマチ、動脈硬化、変形性関節症、歯周疾患、異所性脈管形成、腫瘍性浸潤および転移、潰瘍形成、骨疾患、血管再閉塞、血管再狭窄、HIV感染症、または糖尿病合併症の治療および予防剤を得ることにある。【解決手段】二枚貝貝殻の靭帯および外套峡(中心部)に存在する13.6kDaのタンパク質がマトリックスメタロプロテアーゼ−2、−9、−12、−13を少量で阻害することがわかり、これを含む二枚貝貝殻の靭帯および外套峡(中心部)或いはそれらの抽出物が上記の課題を解決することがわかった。【選択図】なし
摘要翻译：要解决的问题：提供皮肤抑制基质金属蛋白酶的外用制剂，更详细地，获得防止皱纹的防治剂，防止皮肤老化的外用剂，此外，类风湿性关节炎或骨关节炎的滑膜和类风湿关节炎，动脉硬化，骨关节炎，牙周病，异位血管生成，肿瘤浸润和转移，溃疡，骨骼疾病，血管再闭塞，血管再狭窄，HIV感染或糖尿病并发症。解决方案：存在于韧带和发现双壳贝壳的中心部分以少量抑制基质金属蛋白酶2，-9，-12和-13。发现含有这种或其提取物的双壳贝壳的韧带和中心部分解决了上述问题。

2. 发明专利

JP2012120525A Nacreous layer formation-associated protein and gene encoding the same 有权
标题翻译： NACREOUS层形成相关蛋白和编码它们的基因
公开(公告)号：JP2012120525A
公开(公告)日：2012-06-28
申请号：JP2011028112
申请日：2011-02-14
申请人： Mikimoto Pharmaceut Co Ltd , Univ Of Tokyo , 国立大学法人東京大学 , 御木本製薬株式会社
发明人： WATABE SHUGO , ASAKAWA SHUICHI , KINOSHITA SHIGEHARU , NAGAI KIYOHITO , OKAMOTO KIKUHIKO , MAEYAMA KAORU
IPC分类号： C12N15/09 , C07K14/435
摘要： PROBLEM TO BE SOLVED: To provide a new protein associated with the formation of a nacreous layer in a mother-of-pearl shell, and to provide a gene encoding the protein.SOLUTION: The nacreous layer formation-associated protein encoded by a gene specifically expressing in the velarium part of the mantle and the pearl sack of the mother-of-pearl shell is the following proteins (a1) or (b1): (a1) is a protein comprising a specific amino acid sequence; and (b1) is a protein comprising an amino acid sequence obtained by deleting, substituting or adding one or several amino acids from, with or to the amino acid sequence, and associated with the formation of the nacreous layer.
摘要翻译：要解决的问题：提供与珍珠贝壳中形成珍珠层有关的新蛋白质，并提供编码该蛋白质的基因。解决方案：由特异性表达在地幔部分的基因和珍珠贝壳珍珠袋编码的珍珠层形成相关蛋白是以下蛋白质（a1）或（b1）：（ a1）是包含特定氨基酸序列的蛋白质; 和（b1）是包含通过从氨基酸序列中删除，取代或添加一个或几个氨基酸而获得的氨基酸序列的蛋白质，并且与该珠光层的形成有关。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2011173810A Method for producing cosmetic 有权
标题翻译：生产化妆品的方法
公开(公告)号：JP2011173810A
公开(公告)日：2011-09-08
申请号：JP2010037585
申请日：2010-02-23
申请人： Mikimoto Pharmaceut Co Ltd , 御木本製薬株式会社
发明人： YAMABE YUKIHISA , HIMEKOMATSU HITOMI , HIGUCHI FUMITO , NORO TETSUYA , TSUJI NOBUHIDE , MAEYAMA KAORU
IPC分类号： A61K8/00 , A61B5/00 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a cosmetic that permits extemporaneous preparation of a cosmetic meeting tastes and skin properties of a user, and permits evaluation of skin touch feelings and the like. SOLUTION: The method for producing a cosmetic comprises a plurality of steps including: a step of classifying skin properties into at least two types by a skin property classification method using the degree of skin characteristics as an index and further classifying each type into a plurality of small subdivisions according to the degree of skin characteristics; a step of preparing a basic sample cosmetic, for each of the plurality of classified subdivisions, corresponding thereto; and other steps. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供一种能够即时制备满足使用者的口味和皮肤特性的化妆品的化妆品的制造方法，能够评价皮肤的触觉感觉等。解决方案：化妆品的制造方法包括多个步骤，包括：通过使用皮肤特性度作为指标的皮肤特性分类方法将皮肤特性分类为至少两种类型的步骤，并将每种类型进一步分类为多个小细分根据皮肤特征的程度; 对与其对应的多个分类细分中的每一个准备基本样品化妆品的步骤; 和其他步骤。版权所有（C）2011，JPO＆INPIT

4. 发明专利

JP2014152152A Device for preparing original skin lotion corresponding to individual skin 有权
标题翻译：用于制备与个人皮肤相关的原始皮肤润肤剂的装置
公开(公告)号：JP2014152152A
公开(公告)日：2014-08-25
申请号：JP2013024284
申请日：2013-02-12
申请人： Mikimoto Pharmaceut Co Ltd , 御木本製薬株式会社 , Hashimoto Denshi Kogyo Kk , 橋本電子工業株式会社
发明人： MAEYAMA KAORU , NOMURA SHIGEO , ISHIKAWA TERUO , OKUNO AKIHIRO , HASHIMOTO MASATOSHI
IPC分类号： A61K8/18 , A61Q19/00 , B01F3/08 , B01F5/00 , B01F15/00 , B01F15/04
摘要： PROBLEM TO BE SOLVED: To provide a device for preparing a skin lotion corresponding to individual skin, capable of saving time and cost required to create a prepared skin lotion.SOLUTION: A stock skin lotion pipe individually connected to each stock skin lotion tank is connected to each long cylindrical mixing section. The connecting part between the mixing section and each stock skin lotion pipe is aligned in the longitudinal direction of the long cylindrical mixing section. Each stock skin lotion introduced into the mixing section is discharged to a bottle from outlet provided at one end of the longitudinal direction of the mixing section. Accordingly, the inner surface area of the mixing section becomes small, and the discharge of the skin lotion and a cleaning liquid to the outside from the mixing section becomes easy. Thus, the amount of the cleaning liquid and cleaning time, required to clean the mixing section performed after the discharge of the skin lotion corresponding to individual skin in the bottle.
摘要翻译：要解决的问题：提供一种用于制备对应于个人皮肤的皮肤洗剂的装置，其能够节省创造制备的皮肤洗剂所需的时间和成本。解决方案：连接到每个原液皮肤洗剂罐的股皮肤洗剂管被连接到每个长圆柱形混合段。混合部分和每个原料皮肤洗剂管之间的连接部分在长圆柱形混合部分的长度方向上对齐。引入混合部分的每种原料皮肤洗剂从混合部分纵向一端的出口排出到一瓶中。因此，混合部的内表面积变小，从混合部向外部排出皮肤洗剂和清洗液容易。因此，在对应于瓶子中的各个皮肤的皮肤洗液排出之后，清洗混合部分所需的清洗液量和清洗时间。

5. 发明专利

JP2012148903A Method for manufacturing hydroxyapatite 有权
标题翻译：制造羟基磷灰石的方法
公开(公告)号：JP2012148903A
公开(公告)日：2012-08-09
申请号：JP2011006538
申请日：2011-01-17
申请人： Mikimoto Pharmaceut Co Ltd , 御木本製薬株式会社
发明人： MAEYAMA KAORU , HATTORI FUMIHIRO , IZAWA KAZUO
IPC分类号： C01B25/32
摘要： PROBLEM TO BE SOLVED: To utilize shells generated in cultivation of shellfish, particularly pearl oyster, more highly than conventionally.SOLUTION: It is found that if hydroxyapatite is manufactured by the following method, a hydroxyapatite having a high moisture retention can be manufactured from shells, which can be utilized more highly than in the conventional case where only part thereof is utilized, and if utilized, the utilization is in a low-degree one as a calcium agent. The method includes heating and reacting CaHPOand/or CaHPO-HO with shells and/or a powder of pearl oyster at 70 to 90°C for 1 to 24 hours, and drying the reaction product at ≤80°C for 3 to 72 hours.
摘要翻译：要解决的问题：利用贝类养殖中产生的贝壳，特别是珍珠牡蛎，比传统上更高。解决方案：发现如果通过以下方法制造羟基磷灰石，则可以使用壳体制造具有高保湿性的羟基磷灰石，与仅使用其一部分的常规情况相比，可以更高效地利用，如果使用，则其作为钙剂是低度的。该方法包括加热和反应CaHPO 4 和/或CaHPO 4 -H 2 < SB> O与贝壳和/或珍珠牡蛎粉末在70〜90℃下反应1〜24小时，并将反应产物在≤80℃下干燥3〜72小时。版权所有（C）2012，JPO＆INPIT

6. 发明专利

JP2010105925A Skin keratinization-promoting agent 审中-公开
标题翻译：皮肤促进促进剂
公开(公告)号：JP2010105925A
公开(公告)日：2010-05-13
申请号：JP2008276990
申请日：2008-10-28
申请人： Juntendo , Mikimoto Pharmaceut Co Ltd , 学校法人順天堂 , 御木本製薬株式会社
发明人： NIYONSABA FRANCOIS , OGAWA HIDEOKI , OKAMOTO KIKUHIKO , MAEYAMA KAORU , HATTORI FUMIHIRO
IPC分类号： A61K8/98 , A61K8/64 , A61K35/56 , A61K38/00 , A61P17/16 , A61Q19/00 , A61Q19/08
摘要： PROBLEM TO BE SOLVED: To provide a new skin keratinization-promoting agent useful for improvement of barrier functions of the skin and prevention of skin ageing.
SOLUTION: The skin keratinization-promoting agent comprises hydrolyzed conchiolin. Thus, the skin keratinization-promoting agent exhibits effects for preventing skin ageing and for improving skin troubles.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供可用于改善皮肤屏障功能并防止皮肤老化的新型皮肤角质化促进剂。皮肤角质化促进剂包括水解的conchiolin。因此，皮肤角质化促进剂具有防止皮肤老化和改善皮肤问题的效果。版权所有（C）2010，JPO＆INPIT

7. 发明专利

JP2012167036A Raw material for food or cosmetic and food or cosmetic combining the same 有权
标题翻译：原料用于食品或化妆品，食品或化妆品组合
公开(公告)号：JP2012167036A
公开(公告)日：2012-09-06
申请号：JP2011027421
申请日：2011-02-10
申请人： Mikimoto Pharmaceut Co Ltd , Mie Univ , 国立大学法人三重大学 , 御木本製薬株式会社
发明人： KAKINUMA MAKOTO , MAEYAMA KAORU , HATTORI FUMIHIRO , OKAMOTO KIKUHIKO , NAGAI KIYOHITO
IPC分类号： A61K8/98 , A23L1/275 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To raise the additional value of a food or cosmetic, to use pearl or a pearl oyster shell more effectively, to improve the efficiency of pearl farming, and to contribute to the loss in weight of an industrial waste consequently.SOLUTION: It is found that the purpose can be attained by that the powder of the nacre of a yellow based pearl and/or a yellow based pearl oyster shell or the ingredient that fractionates the portion including the pigment of the powder is used as a food or a cosmetic raw material. Since these have the effect besides the efficacy as the pigment, they serves many uses.
摘要翻译：要解决的问题：为了提高食品或化妆品的附加价值，更有效地使用珍珠或珍珠牡蛎壳，提高珍珠养殖的效率，并有助于工业废物的重量损失所以。解决方案：发现目的是通过使用黄色珍珠和/或黄色珍珠牡蛎壳的珍珠粉的粉末或分解包含粉末颜料的部分的成分作为食品或化妆品原料。由于除了作为颜料的功效之外，它们具有效果，它们具有许多用途。版权所有（C）2012，JPO＆INPIT

8. 发明专利

JP2011168503A Manufacturing method of cosmetic 有权
标题翻译：化妆品制造方法
公开(公告)号：JP2011168503A
公开(公告)日：2011-09-01
申请号：JP2010031469
申请日：2010-02-16
申请人： Mikimoto Pharmaceut Co Ltd , 御木本製薬株式会社
发明人： YAMABE YUKIHISA , HIMEKOMATSU HITOMI , HIGUCHI FUMITO , NORO TETSUYA , TSUJI NOBUHIDE , MAEYAMA KAORU
IPC分类号： A61K8/34 , A61K8/37 , A61K8/73 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a manufacturing method of a cosmetic that permits preparation, at the time of application, of a cosmetic meeting to a user's taste and evaluation of its skin touch and the like. SOLUTION: The method comprises preparing five kinds of sample cosmetics and four kinds of cosmetics for adjustment, compounding them into a cosmetic by a simple operation at a place where counseling or advice is given on purchasing a cosmetic, and evaluating a skin touch or the like of the actual commodity. The method permits ready fine adjustment of the compounding ratio of ingredients, quick response to a demand of each user and the manufacture of a cosmetic of a higher satisfaction degree. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种化妆品的制造方法，其可以在使用时准备满足用户口味的化妆品和评价其皮肤接触等。解决方案：该方法包括制备五种样品化妆品和四种调理化妆品，在购买化妆品的地方提供咨询或咨询的地方，通过简单的操作将其复合成化妆品，并评估皮肤触感或类似的实际商品。该方法可以准确地调整配料配比，快速响应每个用户的需求以及制造更高满意度的化妆品。版权所有（C）2011，JPO＆INPIT

9. 发明专利

JP2011084420A compost 审中-公开
标题翻译：堆肥
公开(公告)号：JP2011084420A
公开(公告)日：2011-04-28
申请号：JP2009237043
申请日：2009-10-14
申请人： K Mikimoto & Co Ltd , Mikimoto Pharmaceut Co Ltd , 御木本製薬株式会社 , 株式会社ミキモト
发明人： NAGAI KIYOHITO , HIGUCHI KEITA , HONJO TSUNEO , MAEYAMA KAORU , HATTORI FUMIHIRO
IPC分类号： C05F1/00 , B09B3/00 , C05F11/00 , C05F15/00
CPC分类号： Y02A40/201 , Y02A40/202 , Y02A40/203
摘要： PROBLEM TO BE SOLVED: To promote utilization of waste produced during pearl culture so as to maintain a pearl oyster culturing environment enabling sustainable business that does not cause pollution of ocean, thereby reducing mortality of pearl oyster, promoting favorable growth of pearl oyster and preventing reduction in pearl yield. SOLUTION: Compost is produced using pearl oyster flesh residue and matters attached to pearl oyster as raw materials so as to improve the pearl oyster culturing environment, provided that the pearl oyster flesh residue is the part remaining after removing ligaments and extracting at least one chosen from collagen, glycogen, taurine, phospholipid sterols and ceramides. The compost of higher quality can be obtained by further adding pearl oyster shell to the raw materials. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：为了促进珍珠养殖废弃物的利用，保持珍珠牡蛎养殖环境，实现不造成海洋污染的可持续发展，从而降低珍珠牡蛎的死亡率，促进珍珠牡蛎的有利成长并防止珍珠产量降低。
解决方案：使用珍珠牡蛎肉渣和以珍珠牡蛎为原料的物质生产堆肥，以改善珍珠牡蛎培养环境，条件是珍珠牡蛎肉残留物是去除韧带后至少剩下的部分，至少提取一个选自胶原，糖原，牛磺酸，磷脂甾醇和神经酰胺。通过进一步添加珍珠牡蛎壳可以获得更高质量的堆肥。版权所有（C）2011，JPO＆INPIT

10. 发明专利

JP2010095464A Skin external preparation and its manufacturing method 审中-公开
标题翻译：皮肤外用制剂及其制造方法
公开(公告)号：JP2010095464A
公开(公告)日：2010-04-30
申请号：JP2008266816
申请日：2008-10-15
申请人： Mie Univ , Mikimoto Pharmaceut Co Ltd , 国立大学法人三重大学 , 御木本製薬株式会社
发明人： OKAMOTO KIKUHIKO , MAEYAMA KAORU , HATTORI FUMIHIRO , SAKAIDA KAZUNORI , NAGAI KIYOHITO , KANO SATORU
IPC分类号： A61K8/64 , A61K8/98 , A61K35/56 , A61K38/17 , A61P17/16 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a skin external preparation containing an acid-soluble protein present in a shell containing a nacreous layer and a method for manufacturing the same. SOLUTION: The skin external preparation comprises an acid-soluble protein obtained by extracting with an acid, a substance obtained by the decalcification of a shell containing a nacreous layer with a chelating agent or its hydrolysate and particularly, the chelating agent is an ethylenediaminetetraacetic acid salt and the acid is acetic acid. COPYRIGHT: (C)2010,JPO&INPIT

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