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    • 7. 发明专利
    • Intestinal immune activation agents and anti-allergic agents
    • 空值
    • JP5367228B2
    • 2013-12-11
    • JP2007048536
    • 2007-02-28
    • 公立大学法人大阪府立大学富士産業株式会社
    • 千賀 木原麻衣子 長沢進一 北村誠 小崎
    • A61K36/18A61K36/00A61P37/04A61P37/08A61P43/00C08B37/00
    • PROBLEM TO BE SOLVED: To provide a novel intestinal tract immunoactivator and an antiallergic agent based on intestinal tract immunoactivating actions. SOLUTION: The intestinal tract immunoactivator comprises as an effective ingredient a white sweet potato (Ipomoea Batatas L.), preferably peelings and/or tuberous roots of the sweet potato or comprises as an effective ingredient extracts of the white sweet potato or of peelings and/or tuberous roots thereof, concretely arabinogalactan that has a skeleton composed of a β-1,6-bonded Gal sugar chain highly branched through a β-1,3-bond, where the Gal constituting the skeleton contains, as side chains bonded thereto, (1) αAraf bonded via an α-1,3-bond or (2) αAraf(1→5)αAraf bonded via an α-1,3-bond and (3) αRha(1→4)βGlcUA bonded via a β-1,6-bond to a part or all of the terminal Gal of the skeleton and has an average molecular weight of 100,000-200,000, preferably around 130,000-150,000, and has a rhamnose:glucuronic acid constitution ratio of nearly 1:1, an arabinose:galactose constitution ratio of nearly 1:2 and a rhamnose:arabinose constitution ratio of 1:(5-6). COPYRIGHT: (C)2008,JPO&INPIT
    • 要解决的问题:提供一种基于肠道免疫激活作用的新型肠道免疫激活剂和抗过敏剂。 解决方案:肠道免疫激活剂包括白薯(Ipomoea Batatas L.)作为有效成分,优选甘薯的去皮和/或块茎根,或包含作为有效成分的白色甘薯或 剥离和/或结节根,具体为阿拉伯半乳聚糖,其具有通过β-1,3-键高度支化的β-1,6键合的Gal糖链构成的骨架,其中构成骨架的Gal含有作为侧链的 (1)通过α-1,3-键的αAraf或通过α-1,3-键和(3)αRha(1→4)βGlcUA键合的(2)αAraf(1→5)αAraf键合的αAraf键合 通过β-1,6键至骨架末端Gal的一部分或全部,其平均分子量为100,000-200,000,优选约为130,000-150,000,并且具有近似1的鼠李糖:葡萄糖醛酸的构成比 :1,阿拉伯糖:半乳糖构成比接近1:2,鼠李糖:阿拉伯糖构成比为1:(5-6)。 版权所有(C)2008,JPO&INPIT